To compare outcomes and incidence of adverse events (AE) of colistin versus tigecycline for treatment of patients with carbapenem-resistant Retrospective study. Records of 111 patients with microbiologically confirmed CRAB osteomyelitis were analyzed. Colistin (34 cases) and tigecycline (31 cases) were the main drugs used for treatment of extremely-drug resistant (XDR) isolates. Patients who received these two antimicrobials were compared according to baseline features (sex, age, length of hospital stay, Charlson index, presence of comorbidities or immunosuppression, previous renal disease, smoking, alcoholism or use of illicit drugs, previous orthopedic surgery on affected limb, topography of infection, classification of osteomyelitis, ASA score, infection related to pressure ulcer or neuropathic foot, presence of implant, need for soft tissue repair or negative pressure therapy and previous antimicrobial use), clinical outcome after 12 months of treatment (remission of infection was considered the favorable outcome; recurrence of infection, amputation and death were considered unfavorable outcomes; loss of follow-up was analyzed separately) and AE during treatment (impaired renal function; liver abnormalities; nausea; skin rash; neurological abnormalities and other events in general). Quantitative variables were described using summary measures and compared using Student's t or Mann-Whitney tests. Qualitative characteristics were described with absolute and relative frequencies and compared using chi-square or exact tests (Fisher's exact or likelihood ratio test).Aim
Method
Determine the incidence of surgical site infections (SSI) after intramedullary nailing (IN) of femoral and tibial diaphyseal fractures and evaluate possible risk factors. Prospective observational cohort study. SSI was defined according to CDC-NHSN criteria and surveillance period for the occurrence of infection was 12 months instead of the 90 days currently recommended. Incidence was calculated as the ratio between the number of patients with SSI and total number of patients. Analysis of potential risk factors included patients-related factors (age, gender, body mass index, active foci of infection, immunosuppressive conditions, ASA score, alcohol or illicit drug abuse, smoking, polytrauma, etiology of fracture, type of fracture if closed or open, classification of fracture according to Müller AO, Tcherne classification for closed fractures, Gustilo-Anderson classification and duration of bone exposure for open fractures, previous stay in other healthcare services, use of external fixator, previous surgical manipulation at same topography of fracture, use of blood products); environmental and surgical-related factors (surgical wound classification, duration of surgery, hair removal, intraoperative contamination, antimicrobial use, presence of drains, hypothermia or hypoxia in the perioperative period, type of IN used, reaming, need for muscle or skin flap repair, use of negative pressure therapy) and microbiota-related factors (presence of preoperative colonization by Aim
Method
