The purpose of the present study is to determine a correlation between articular cartilage changes and underlying bone contusions in ACL-deficient knees. Analysis of surgical and MRI findings in thirty-seven knees shows that medial femoral condyle and medial tibial plateau bone contusions, present in 30% of ACL injuries, correlate strongly with articular cartilage damage, irrespective of meniscal status. Although lateral compartment bone contusions are more commonly seen following injury, we have not found this to be associated with the status of the overlying cartilage. Degenerative changes in the ACL-deficient knee are multifactorial, but medial compartment bone contusions may be an important contributor that warrants further investigation. Despite successful reconstruction of the anterior cruciate ligament, many patients eventually develop osteoarthritis, suggesting that something in addition to mechanical instability may contribute. The purpose of the present study is to determine a correlation between articular cartilage changes and underlying bone contusions in ACL-deficient knees. Between January 2002 and March 2003, sixty-eight knees consecutively underwent ACL reconstruction at our institution. Presence and location of bone contusions on MRI were noted, and correlated to presence of articular cartilage changes and meniscal pathology witnessed during surgery. Of the sixty-eight knees operated, thirty-one were excluded because of either: pre-existing arthritis, previous surgery, presence of multiple ligament injury, or absence of bone contusions on MRI. In the analysis of the thirty-seven remaining knees, bone contusions were present on the medial tibial plateau and medial femoral condyle in 30%, on the lateral tibial plateau in 84%, and on the lateral femoral condyle in 73%. Articular cartilage damage is most commonly seen on the medial femoral condyle, irrespective of meniscal status. Analysis using Fisher’s Exact test shows that medial femoral condyle (p=0.026) and medial tibial plateau articular cartilage damage (p= 0.011) is strongly correlated with presence of underlying bone contusions. No association was found between lateral compartment articular cartilage status and presence of bone contusions. Although lateral compartment bone contusions are common following ACL injuries, we have not found an association with cartilage damage. Degenerative changes in the ACL-deficient knee are multifactorial, but medial compartment bone contusions may be an important contributor.