Introduction: Several factors render plain X-ray radiographs of the hip unsuitable for bone mineral density measurements, mainly variability in X-ray exposure levels and soft tissue surrounding the bone. We present modification of proximal femur digital radiographs to compensate for these interfering factors.

Methods: The study population consisted of 99 women, in three groups: 1 – elderly, sustaining a fracture of the neck of the femur. 2 – elderly, without a fracture. 3 – young. Each patient’s hip was radiographed with a brass step-wedge for standard reference. Dual-Energy X-ray Absorptiometry (DEXA) of the same hip was performed. On each radiograph, Regions Of Interest (ROIs) of the proximal femur were determined in concordance with ROI of the DEXA, together with three soft tissue regions surrounding the bone. Mean gray level was measured for each ROI.

Results: The difference in gray level of the ROI within the proximal femur was not statistically significant between the groups. Correction of bone gray level to exposure level by dividing the gray level of the ROI to that of the step wedge, resulted in statistically significant difference between group 1 and either group 2 or group 3. Similar results were obtained by correction of bone gray level to soft tissue gray level. Using this method, multiple R² of 0.62 was found predicting the DEXA value from the gray level of each ROI.

Conclusions: After correction to the exposure level and to the soft tissue surrounding the bone, a plain digital radiograph of the pelvis can provide valuable information concerning the bone mineral content of the proximal femur. These preliminary results warrant further research aimed at exploring the potential value of this fast, accessible and relatively inexpensive technique to diagnose osteoporosis and the prediction of future fractures.

Introduction: Bone strength is determined by several factors including bone mineral density and the geometrical structure of bone tissue. Plain X-ray is not used regularly for bone mineral density measurements due to different x-ray exposure used for each patient. The different radiation energies have major effects on the optical density of the obtained films. Therefore dual energy X-ray absorptiometry (DEXA) is the golden standard for bone density estimation. However it is relatively expensive and relatively inaccessible.

Objective: To evaluate a new computerized analysis of digitized plain radiographs of the proximal femur to allow the evaluation of bone mineral density in human subjects.

Material and Methods: 14 people hospitalized for proximal femoral fracture had their uninvolved proximal femur BMD estimated with a DEXA in the 5 typical regions defined by the DEXA test. Plain proximal femur radiographs of these patients were taken with a standard wedge and digitized into the computer to generate a digital image. The gray levels in the digital image were analyzed and normalized to yield the mineral content at the 5 regions defined by DEXA. The data obtained were correlated with the DEXA results.

Results: The correlation between BMD (DEXA) and gray level measurement of the proximal femur (R=0.261) was not significant. This correlation was significantly improved after modification of the gray levels to 0.549 (P< 0.032).

Conclusion: This computerized analysis and modification of gray levels in digitized radiographs improved significantly the possibility to evaluate bone mineral density of the proximal femur from plain X-rays.