The SRS-22 is a valid instrument for the assessment of the health related quality of life of patients with Idiopathic scoliosis. The purpose of this study is to evaluate the reliability and validity of the adapted Greek version of the refined Scoliosis Research Society-22 Questionnaire. Following the steps of cross – cultural the adapted Greek version of the SRS-22 questionnaire and a validated Greek version of the SF-36 questionnaire were mailed to 68 patients treated surgically for Idiopathic Scoliosis with a mean age at the time of operation 16.2 years and a mean age at the time of evaluation 21.2 years respectively. A 2nd set of questionnaires was mailed in 30 patients within 30 days from the 1st set. Reliability assessment was determined by estimating Cronbach’s a and intraclass correlation coefficient (ICC) respectively. Concurrent validity was evaluated by comparing SRS-22 domains with relevant domains in the SF-36 questionnaire using Pearson’s Correlation Coefficient (r). The calculated Cronbach’s a of internal consistency for three of the corresponding domains (pain 0.85; mental health 0.87; self image 0.83) were very satisfactory and for two domains (function/activity 0.72 and satisfaction 0.67) were good. The ICC of all domains of SRS-22 questionnaire was high (ICC>
0.70). Considering concurrent validity all correlations demonstrated high correlation coefficient. The adapted Greek version of the SRS-22 questionnaire is valid and reliable and can be used for the assessment of the outcome of the treatment of the Greek speaking patients with idiopathic scoliosis