Methods

Eight-week-old wild-type (WT) and type 2 diabetic (db/db) mice were divided into four groups without or with metformin treatment (WT met(-/+), Db met(-/+)). Mice received daily intraperitoneal administration of metformin and were killed at 12 and 14 weeks of age. Fibrosis morphology and its related genes and proteins were evaluated. Fibroblasts were extracted from the capsules of 14-week-old mice, and the expression of fibrosis-related genes in response to glucose and metformin was evaluated in vitro.

Materials and Methods

This study included with 50 knees of the 43 patients (6 males, 37 females) who had undergone TKA with ADLER GENUS system from March 2015 to January 2017. The mean age was 71.1±8.1 years. All patients were diagnosed with medial osteoarthritis of the knee. All implants was cruciate substituted type (CS type) and mobile bearing insert.

We developed a new ligament balancer that could be fixed to the tibia with keel and insert trial could be rotated on the paddle. We measured the medial and lateral soft tissue balance during TKA with the new balancer. The A-P position of the balancer was fixed on tibia in parallel with the Akagi line (A-P axis 0 group) and 20 degrees internal rotation (IR group) and 20 degrees external rotation (ER group). Soft tissue balance was measured in extension and 90 degrees of knee flexion on each rotational position.

Results

The mean angle of valgus and varus in IR group, 0 group and ER group were 4.6±2.2 degrees varus, 1.9±1.6 degrees varus and 0.4±2.4 degrees varus respectively in extension, and 5.5±3.0 degrees varus, 2.1±2.2 degrees varus and 0.7±3.2 degrees varus respectively in 90 degrees of knee flexion. There were significant differences between three groups in extension (p<0.0001) and flexion (p<0.0001). In other words, when the balancer was fixed on tibia with internal rotation against the Akagi line, the soft tissue balance indicated medial tightness. Conversely, when the balancer was fixed on tibia with external rotation against the Akagi line, the soft tissue balance showed lateral tightness.

The insert trial significantly rotated to opposite side against the position of balancer fixed.

Materials and Methods

In a previous study (Cho et al., 2016), the generations of cold flow into the screw holes in the metal acetabular cup were observed on the backside of the retrieved UHMWPE acetabular cup liners as shown in Figure 1. We focused on the screw holes in the metal acetabular cup (Figure 2) as a factor influencing the wear behavior of polyethylene liner in hip prosthesis. In this study, computer simulations of the generation of cold flow into the screw holes were performed using the finite element method (FEM) in order to investigate the influence of the screw holes in the metal acetabular cup on the mechanical state and wear behavior of polyethylene liner in hip prosthesis.

Materials and Methods

In a previous study (Cho et al., 2016), it was found that roundness (out-of-roundness) of the retrieved UHMWPE acetabular cup liner [Figure 1(a)] had a tendency to increase with increasing roundness of the retrieved metal femoral head [Figure 1(b)]. It appears that roundness of the femoral head contributes to increase of wear of the polyethylene liners. We focused on the roundness of femoral head as a factor influencing the wear of polyethylene liner in hip prosthesis. In this study, further roundness measurements for 5 retrieved metal femoral heads were performed by using a coordinate measuring machine. The elasto-plastic contact analyses between femoral head and polyethylene liner using the finite element method (FEM) were also performed in order to investigate the influence of femoral head roundness on the mechanical state and wear of polyethylene liner in hip prosthesis.

Materials and Methods

The wear and/or failure characteristics of 33 retrieved UHMWPE acetabular cup liners of hip prostheses were examined in this study. The retrieved liners had an average in vivo duration of 193.8 months (75 to 290 months). Several examples of the retrieved liners are shown in Figure 1. The elasto-plastic contact analyses between metal femoral neck and polyethylene liner and between metal femoral head and polyethylene liner using the finite element method (FEM) were also performed in order to investigate the factors influencing the wear and/or failure mechanism of the polyethylene liner in hip prosthesis.

Methods

In a previous study (Cho et al., 2016), we pointed out the generation of cold flow into the screw holes on the backside of the retrieved UHMWPE acetabular cup liner as shown in Figure 1. The primary purpose of this study was to investigate the influence of the cold flow into the screw holes on the wear of the polyethylene liner in hip prosthesis. In this study, computer simulations of the generation of cold flow were performed using the finite element method (FEM) in order to propose the design criteria about the cold flow of the hip prosthesis for improving the wear resistance of the polyethylene liner. We especially focused on the influence of polyethylene thickness and contact surface conformity on the generation of cold flow into the screw hole.

Methods

This study consists of 117 knees. On the AP view radiograph of the tibia, three distance and two angle parameters were measured. Those were tibial articular surface width, distance between medial edge of the tibial articular surface and Point T, distance from TA to Point T. Angle between TM and TA, and the varus inclination angle of the tibial articular surface relative to the perpendicular line to TA.

Materials and methods

Computed tomography (CT) images of 100 knees with tibiofemoral osteoarthritis in 100 patients were prospectively collected. All patients were diagnosed as varus-type osteoarthritis with no destructive patellar deformity.

Fifty patients were male and 50 female. The average male age was 70.8±14.6 (mean ± SD) years and the average female age was 73.3±6.7 years. Forty nine knees were right and 51 knees were left. The average height of males was 162.6±7.4 cm and that of females 149.6±5.7 cm. Males were significantly taller than females.

The CT scan was performed with 2mm-interval slices in the vertical plane to the long axis of femoral shaft. Every CT image was examined to determine the maximum distance between the medial and lateral femoral epicondyle (inter-epicondylar distance, IED) along the epicondylar axis. The maximum patellar width and thickness were also measured at the image which had these maximum distances, while patellar cartilage thickness in anteroposterior diameter was not measured in this study.

For evaluating the patellar size, each measured value was divided by IED and calculated each ratio. The ratio of patellar width to patellar thickness was also calculated. All parameters were compared between males and females.

Statistical software Statview ver.5.0 (SAS Institute Inc.) was used for all analyses with significance being set at the 5% level.

Materials and Methods

This study was conducted with forty cases (20 cases of metal bipolar hemiarthroplasty (4 males, 16 females), 20 cases of ceramic bipolar hemiarthroplasty (2 males, 18 females)) from November 2012 to November 2014. Average age was 80.8±7.5 years for the metal bipolar group and 79.3±10.5 years for the ceramic bipolar group. We obtained motion pictures from standing position to maximum abduction in flexion by fluoroscopy then analyzed by 2D–3D image matching method. The motion range of the “Shell angle”, “Stem neck angle” and the “Stem neck and shell angle” has been compared between the metal bipolar group and the ceramic bipolar group (Fig. 1).

Results

Metal bipolar showed greater variability of the Stem neck angle and Shell angle than ceramic bipolar. Six of the twenty cases reached unilateral oscillation angle of 37 degrees in metal bipolar. In other words, 30% of metal bipolar group revealed neck-shell impingement. No case reached oscillation angle of 58 degrees in ceramic bipolar group. There was no significant difference between the metal bipolar group and the ceramic bipolar group with respect to the difference of minimum and maximum angle of Stem neck angle (movement range of the stem neck) and Shell angle (movement range of the bipolar cup). On the other hand, difference of minimum and maximum angle of the Stem neck and shell angle (movement range of the inner head) was significantly greater in the metal bipolar group than the ceramic bipolar group. Movement, range of bipolar shell was significantly greater than that of inner head in both groups (Table 1).

Method:

500 PS-TKAswith the Stryker NRG system in 408 cases were assessed. There were 83 male knees and 417 female knees, and 472 OA knees and 28 RA knees. This study was performed in Japan, and almost all OA knees had varus deformities. In each case, the sizes of the femoral and tibial components were measured on radiographs. The measured sizes represented those of the measured bone resection. TKA was performed by the gap control technique using a tensor/balancer with 30 inch-pounds expansion strength, and the sizes of the femoral and tibial components (used size) were recorded.

Methods

Lateral X-ray films were taken at 90 degrees flexion before and after TKA using fluoroscopy in 87 patients (95 knees) (Fig. 1a, b). The components and surgical technique for TKA were Scorpio NRG (Stryker) and the modified gap control technique, respectively. The Insall-Salvati ratio (ISR) and the Labelle-Laurin method (LL) were measured as parameters of patellar height (Fig. 1c, d). Posterior condylar offset (PCO) (Fig. 1e), the distance from the anterior femoral line to the tibial tuberosity (TA), and the distance from the tibial tuberosity to the posterior condyle of the femur [TP; {TA-F (the length of the femoral condyle)}] (Fig. 1f) were examined as parameters that could be associated with the change in patellar height. All parameters were divided by patellar length to compensate for the expansion rate in each photograph. The mean LL/P, PCO/P, TA/P, and TP/P before TKA were set at 100%.

Materials and Methods

We performed THA using DAA to 104 patients (114 hips) joints from August 2006 to April 2009 and identified for seventy five patients (eighty four hips) that imaging of the postoperative CT was possible. The orientation of acetabular sockets were performed using an alignment guide which assumed an operating table an axis from August 2006 to September 2008 (A group), and using an alignment guide which assumed a pelvis an axis from October 2008 to May 2009(B group). A group were thirty eight patients (forty four hips), and B group were twenty eight (thirty). There were two men and thirty six women in A group, and one man and twenty seven women in B group. The average age of both groups was 66 years old. The objective angle of the acetabular socket was performed as angle guide of abduction of 45° and anteversion of 20°. The orientation of the acetabular socket converted the angle of postoperative CT into radiographic angle, and measured it. For sixteen hips in B group, both angle guide was used, and there were measured a difference of two angle guide in the acetabular operation as movement of the pelvis. The examination item assumed it the mean values of angle for the acetabular socket in both groups, precision to set up the acetabular socket to planned orientation within ±5 °and a mean difference of two angle guides of sixteen hips in B group.