LCPD can cause femoral head deformity and osteoarthritis requiring total hip replacement (THR). Currently, there is little data on how patients are functioning after a THR from patients’ perspective. The purpose of this study was to collect a large patient-reported outcome data set on adults with LCPD, including those who had a THR, using a Web-survey method and to compare their outcomes to a normative population. An English REDCap-based survey was built and made available on a LCPD study group website. The survey included childhood and adult LCPD history, SF-36 Health Survey, and the Hip Disability and Osteoarthritis Outcome Score (HOOS). Statistical analysis included t-test and linear and proportional odds regressions. Of the 1182 participants who completed the survey, 261 participants (89 M, 172 F) had a THR. The mean age at survey was 44.6±12.4 years (range 20–79). The mean duration since THR was 7.2±8 years (median 4, range 0–43). Gender and age matched analysis showed that THR participants had significantly lower HOOS Quality-of-Life and Sports scores (p<0.0001) for all age groups in comparison to a normative cohort. In women, the HOOS Symptoms, Daily Living, and Pain scores were also significantly lower in the <55 age groups (p<0.05). Similarly, SF-36 scores were significantly lower (p<0.05) in female <45 age groups in 5 out of 8 SF-36 scales. Overall, hip dysplasia and the number of years-from-THR were the main factors associated with worse SF-36 and HOOS scores. In comparison to the non-THR participants, THR participants had higher scores in some of the HOOS and SF-36 scales. LCPD participants with THR had significantly worse HOOS and SF-36 scores in most of the scales studied than a normative cohort, especially in women. There is significant disability even after a THR, warranting continued efforts to improve treatment and outcome.
Pelvic flexion and extension in different body positions can affect acetabular orientation after total hip arthroplasty, and this may predispose patients to dislocation. The purpose of this study was to evaluate functional acetabular component position in total hip replacement patients during standing and sitting. We hypothesize that patients with degenerative lumbar disease will have less pelvic extension from standing to sitting, compared to patients with a normal lumbar spine or single level spine disease. A prospective cohort of 20 patients with primary unilateral THR underwent spine-to-ankle standing and sitting lateral radiographs that included the lumbar spine and pelvis using EOS imaging. Patients were an average age of 58 ± 12 years and 6 patients were female. Patients had (1) normal lumbar spines or single level degeneration, (2) multilevel degenerative disc disease or (3) scoliosis. We measured acetabular anteversion (cup relative to the horizontal), sacral slope angle (superior endplate of S1 relative to the horizontal), and lumbar lordosis angles (superior endplates of L1 and S1). We calculated the absolute difference in acetabular anteversion and the absolute difference in lumbar lordosis during standing and sitting (Figure 1).Introduction
Methods
Resveratrol is a polyphenolic compound commonly found in the
skins of red grapes. Sirtuin 1 (SIRT1) is a human gene that is activated
by resveratrol and has been shown to promote longevity and boost
mitochondrial metabolism. We examined the effect of resveratrol
on normal and osteoarthritic (OA) human chondrocytes. Normal and OA chondrocytes were incubated with various concentrations
of resveratrol (1 µM, 10 µM, 25 µM and 50 µM) and cultured for 24,
48 or 72 hours or for six weeks. Cell proliferation, gene expression,
and senescence were evaluated.Background
Methods
Whole blood metal ion level and clinical outcomes of ceramic-on-metal bearing were comparable to ceramic-on-ceramic THA in this prospective randomized controlled trial. We randomized 150 consecutive THA cases at one institution into two groups: Group I and Group II. Group I, 75 cases, received a THA using ceramic-on-metal couplings and Group II, 75 cases, received ceramic-on-ceramic bearing THA. The implant differed only in the bearing surfaces used. We compared the serum levels of cobalt (Co) and chromium (Cr) and functional outcome scores preoperatively, and at 2, 6, and 12 months postoperatively.Introduction:
Methods:
Complete wear-out of Polyethylene (PE) liner results in severe metallosis following articulation of the artificial head with the acetabular metal shell. We postulated that an adverse response can be led to surrounding bone tissue and new implant after revision surgery because the amount of PE wear particle is substantial and the metal particles are infiltrated in this catastrophic condition. We evaluated clinical characteristics and the survival rate of revision total hip arthroplasty (THA) performed in patients with severe metallosis following failure of PE liner. Between January 1996 and August 2004, severe metallosis following complete wear-out of PE liner were identified during revision THA in 28 hips of 28 patients. One patient had died at 7 days after surgery and 3 patients could not be reached at 5 year follow-up. Twenty-four hips of 24 patients (average age, 47.5 years) were followed for at least 6.5 years (average, 11.3 years; range, 6.5–15.9 years) and were evaluated. The mean time interval between prior surgery and the index revision surgery was 9.6 years (range, 4.0–14.3 years). The indications for revision surgery were osteolysis around well-fixed cup and stem in 22 hips and osteolysis with aseptic loosening of the cup in 2 hips. Bubble sign was observed on preoperative radiograph in 10 hips. Total revision, cup revision, and solitary bearing change were performed in 13, 10, and one hip respectively. A cementless implant was used in 23 hips and acetabular reinforcement ring was used in one. Clinical evaluation was performed using Harris hip scores and Kaplan-Meier survival analysis was performed. Multivariate analysis was performed with age, gender, BMI, bone defect type, existence of bubble sign and type of revision surgery as variables to evaluate the association with osteolysis or loosening.Purpose
Materials and Methods
Melorheostosis is a very rare mesenchymal dysplasia of bone, characterized by sclerosing hyper-pigmentation appearances on the bone, may involve the adjacent soft tissues and lead to joint pain, limitation of joint motion and stiffness as a result of abnormal ossifications and soft tissue contractures, due to periarticular fibrosis. It is well known to tend to affect only one limb, but multifocal involvement, such as multiple limbs, spine and rib, has been extremely rarely reported. A variety of treatment options have been tried so far, none being specific surgical treatments. Here we present a case of a 43-year-old man who sustained melorheostosis with multifocal involvement including the axial skeleton and a whole entire lower limb. He had painful swelling of his left lower limb and mainly complained of difficulty walking due to severe hip pain and knee stiffness, which persisted for 20 years and was aggravated during the last 5 years. Total hip arthropasty [Fig. 1] was done first, and then total knee arthroplasty [Fig. 2, 3] was performed. During operation, there were difficulties in bone cutting and implant insertion due to mixed pattern of hard sclerotic portion and osteoporotic portion despite complete synovectomy and sufficient soft tissue release. He was eventually free of pain during walking and able to walk without a crutch and joint motion of hip and knee was substantially improved after surgery. We found that hip pain and contracture due to osteoarthritis and knee contracture secondary to multifocal melorheostosis could be successfully treated by total hip and knee arthroplasty. To the best of our knowledge, this is the first reporting the total joint arthroplasty performed in the patients with multifocal melorheostosis.
Osteonecrosis of the femoral head occurs in young patients. The preservation of the hip joint is vitally important, because hip arthroplasty does not guarantee satisfactory long-term results in young and active patients. Curved intertrochanteric varus osteotomy is one of several joint preserving procedures used for this disease. Between June 2004 and June 2007, 52 patients (55 hips) who had osteonecrosis of the femoral head were treated with curved intertrochanteric varus osteotomy. There were 29 men and 23 women who had a mean age at the time of osteotomy of 33 years (range, 18 to 52 years). The osteotomy was fixed with a 120 degree compression hip screw in the first 34 hips and with a 95 degree dynamic condylar screw in the remaining 21 hips. Clinical evaluation was performed using the scoring system of Merle d'Aubigne et al.Introduction
Methods
Ceramic-on-ceramic couplings are an attractive alternative bearing surface to eliminate or reduce problems related to polyethylene wear debris. Past disappointing experiences with alumina-ceramic bearings have led to many improvements in the manufacture and the design of ceramic implants. The purpose of this study was to report the results of contemporary alumina-on-alumina total hip arthroplasties (THAs) with regard to wear, osteolysis, and fracture of the ceramic in patients with osteonecrosis of the femoral head. Between February 1998 and October 2003, 365 patients (432 hips) with osteonecrosis of the femoral head underwent cementless total hip arthroplasty using contemporary alumina bearings. There were 243 men and 122 women who had a mean age at the time of index operation of 43 years (range, 18 to 65 years). They were evaluated clinically and radiographically at 5 to 10 years (average, 7 years). During the follow-up, special regards were addressed to wear, periprosthetic osteolysis and ceramic failure.Introduction
Methods
Advanced stage and a large area of necrotic bone are known risk factors for failure after transtrochanteric rotational osteotomy of the hip in patients with osteonecrosis. The purpose of this study was to determine whether there were other risk factors for failure of this osteotomy. One hundred and five patients (113 hips) underwent transtrochanteric anterior rotational osteotomy for femoral head osteonecrosis and were followed for a mean period of 51 months post-operatively. Radiographic failure was defined as secondary collapse or osteoarthritic change. Multivariate analysis with the use of a Cox proportional-hazards frailty model was performed to assess factors that influenced the secondary collapse and osteophyte formation. A Kaplan-Meier product-limit method was performed to estimate survival.Introduction
Methods
Subchondral insufficiency fractures of the femoral head (SIFFH) occur with normal or physiological stress in patients with poor bone quality. We evaluated the clinical characteristics of SIFFH. Nine cases of SIFFH were treated and followed up for an average of 9 months. Femoral head collapse (FHC) on radiographs was classified as minimal (< 2 mm), moderate (2-4 mm), and severe (> 4 mm). The severity of osteopenia was scored by Singh index (SI). Other characteristics of SIFFH were ascertained by assessing the clinical course as well as Body Mass Index (BMI) and magnetic resonance imaging (MRI).Introduction
Methods
In osteonecrosis of the femoral head (ONFH), reduction in the size, or complete resolution of the necrotic lesion has been reported to occur spontaneously without any specific treatment. Recently, there was a report that the reduction was time-dependent. We evaluated the change in the size of necrotic lesions of ONFH using magnetic resonance imaging (MRI) more than 10 years after the initial diagnosis. Fifteen hips in 13 patients with atraumatic ONFH who had been followed-up for more than 10 years were enrolled in this study. They were categorized into two groups; A Simple Observation Group and a Multiple Drilling Group. The Simple Observation Group included 6 hips in 5 patients treated non-operatively. There were 3 men and 2 women who had an average age of 42 years at the time of their initial diagnosis. Initial Ficat and Arlet stages were I in 2 cases, IIA in 3 cases, and IIB in 1 case. The Multiple Drilling Group included 9 hips in 9 patients treated surgically with multiple drilling. They were all men who had an average age of 38 years at the time of operation. There were 2 cases of stage I and 7 cases of stage IIA. The necrotic lesion size change was evaluated by comparing the last follow-up MRI images with the initial images. All of the coronal, sagittal, and axial plane images were reviewed by 2 orthopaedic surgeons and a radiologist. The lesion size change was determined by means of consensus of the reviewers. The lesion size change was defined when it was detected in more than 2 planes.Introduction
Methods
There was used cement in first generation total ankle arthroplasty, but first generation of ankle arthroplasty was abandoned because of aseptic loosening of component. For the treatment of aseptic loosening of ankle arthroplasty, there had been many methods. One of methods of revisional ankle arthroplasty is the ankle arthodesis. The authors report a case of revisional ankle arthroplasty using allograft with hybrid external fixation. 45 year old male had surgery of cemented total ankle arthroplasty on his right ankle 20 years ago. He went to our clinics because of motionless and pain of his right ankle. He got the mild pain on his right ankle after 5 years surgery. His pain was managed by oral NSAIDS for 15 years. The pain was aggravated recently. There were osteophytes on posterior aspect of ankle joint and radiolucency around the implant, subtalar arthrosis at the radiograph. There was also sclerosis around the ankle joint. The authors decided revisional surgery. At the operative findings, we can see the loosening of talar and tibial component and large posterior osteophyte bridging between remained talus and tibial bone. There were no infection signs. After remove the implant, there was big space remained. For the regaining the limb length, we used femoral head allograft. The graft was fixed with 6.5 mm cannulated screws and addition fixed with ilizarov external fixation. Also additional auto bone graft from the osteophytes was applied. Compression over the ilizarov external fixation was done at the end of the operation. Weight bearing was allowed immediate after surgery. Ilizarov ring was removed 6 weeks after surgery. At the 3 months after surgery, bony union was obtained on radiographs. AOFAS score was improved from 30 to 70 6 mo after surgery. There was no pain on his right ankle. Patient satisfied with arthrodesis with allograft at final follow-up.
The purpose of this study is to compare the two prosthesis which were used for total ankle arthroplasty. From Sept. 2003 to Jun 2007, 13 patients and 14 ankles that could be follow up more than 2 years. Semiconstrained type (Group I, 7cases) and Unconstrained type (Group II, 7cases) were used for total ankle arthroplasty. Mean age was 63.2 year-old, 12 ankles are men and 2 ankles were women. Mean follow up periods were 31.1 months. The criteria to compare the clinical result were postoperative range of motion (ROM), AOFAS foot score and residual bone stock of medial malleolus. Postoperative ROM of group I was 37.5±7.1 degree and of group II was 51.4±8.9. Postoperative AOFAS score of group I was 76.1±13.8 and of group II was 86.0±5.7. Residual bone stock in medial malleolus of group I was 6.1mm±0.7 and of group II was 11.5mm±0.9. Total number of complication in our study was 9 cases. 3 cases were a malleolar fracture, two occurred at intra-operation, the other at follow-up period. Re-operation was done in 6 cases, 3 cases were calcaneal corrective osteotomy, 2 cases were resection of a heterotopic bone and one case was pedicular flap operation for skin problem. In our hospital, mobile bearing type prosthesis showed good result than a semiconstrained type in respect of ROM improvement and of residual bone stock in medial malleolus. AOFAS score between two groups showed no definite difference. But small number of patients and short term follow up period is a defect in our study, afterward more population and long term follow up period are needed.
