This study evaluated target tissue concentrations of double dose cefuroxime administered intravenously as either one 15 min infusion of 3,000 mg (Group 1) or two single 15 min infusions of 1,500 mg administered 4 h apart (Group 2). Sixteen pigs were randomised into two groups of eight. Cortical and cancellous bone, synovial fluid of the knee joint and subcutaneous adipose tissue concentrations were measured based on sampling via microdialysis. Plasma samples were collected as a reference. Comparison of the groups was based on time with concentrations above relevant minimal inhibitory concentrations (Aim
Method
Pyogenic spondylodiscitis remains a therapeutic challenge, as demonstrated by divergent treatment guidelines. The combination of moxifloxacin and rifampicin may be an attractive treatment option for cases caused by staphylococci; however, previous studies have reported a reduction in plasma concentrations of moxifloxacin when co-administered with rifampicin. The magnitude of this reduction in spinal tissues is not known. We aimed to investigate the interaction of rifampicin on moxifloxacin tissue concentrations in vertebral cancellous bone, intervertebral disc and subcutaneous adipose tissue in steady-state conditions using microdialysis in a porcine model. Twenty female pigs were randomized into two groups of ten pigs: Group A received moxifloxacin 400 mg orally once daily for three days preoperatively. Group B received moxifloxacin 400 mg orally for three days preoperatively combined with rifampicin 450 mg twice daily for seven days preoperatively. Measurements were obtained from plasma, vertebral cancellous bone, intervertebral disc and subcutaneous adipose tissue for 24 h. Microdialysis was applied for sampling in solid tissues.Aim
Method
Differences of dynamic (extension vs. flexion) coronal alignment in osteoarthritic (OA) knees undergoing primary total knee arthroplasty (TKA) remain poorly studied. Prospectively collected measurements of dynamic coronal alignment using an imageless computer-navigation system (Stryker©) during primary TKA were analysed. Coronal alignment was represented by the hip-knee-ankle angle and determined at maximal extension and 90° flexion before making any bony cuts or ligamentous releases. Measurements were subgrouped according to coronal alignment in extension as varus (≤-3°), neutral (>−3°, <+3°) or valgus (≥+3°).Background
Methods
To assess the efficacy of a combined orthoplastic approach to the management of severe grade III fractures of the lower limb, we looked at the functional and radiological outcome of 100 consecutive fractures from a specialist centre. A prospective analysis was performed on 100 consecutive open tibial fractures (98 patients). An early decision was made by a specialist multidisciplinary team as to whether the injured limb was reconstructable. In the reconstruction group there were 84 Gustilo grade IIIB/C injuries. Definitive skeletal stabilisation was most commonly with a circular frame (60%) or intramedullary nail (20%). The mean time to union was 26 weeks for diaphyseal fractures, 20 weeks for metaphyseal fractures and 10 weeks for ankle fractures. There was one aseptic non-union which is still undergoing treatment. The anterolateral thigh free flap was the most common soft tissue reconstruction used (42%). There were minimal surgical complications and only one free flap failure. Mean time to follow-up was 24 months. The mean limb functional score (modified enneking) was 83% of that of the normal limb and was not influenced by the site of fracture or type of fixation. The mean SF-36 score was 75 and there was a high return to employment (70%). In the primary amputation group there were 16 grade IIIB/C injuries. Mean time to follow-up was 38 months. The mean SF-36 score for the below knee amputees was 58 and there was again a high return to employment (58%). In the reconstruction group there is a 99% limb salvage rate with infection-free union to date and no delayed amputations. A higher return to functional activity/employment was achieved in the reconstruction group compared to the primary amputation group. Our results demonstrate that by using a combined orthoplastic approach in a specialist centre excellent results can be achieved for all patients presenting with severe open lower limb injuries.
If excellence in patient care is to be our aim and priority then serious deviations from this path must be defined and dealt with early in the life and practice of any surgeon. ‘Red flags’ are often seen in training years but should have been recognised and dealt with prior to selection (or even undergraduate years). Dealing with the dysfunctional or incompetent ‘registered surgeon’ may not be quite as simple, however, and is doubly difficult if the ‘surgeon of concern’ seeks to ‘cross borders’ or seek registration in other countries/states. Although registration boards/councils have been the ‘gate-keepers’ of this process in the past, the complexity and volume of work has expanded enormously. The legal system has been involved (with great and good effect in some instances) but perhaps to the detriment of the process and certainly in a form that becomes a serious impediment to rapid resolution of the problem both in time and cost. In Australia, states and territories have set up Commissions that may be more effective. Legislatively, the ‘Health Quality and Complaints Commission’ in Queensland was set up to deal with complaints about medical/surgical health care delivery in all sectors of the community. The author looks at the ways in which surgeons' input into these structures might assist and substantially improve the processes by which the continuing problems surrounding poor surgical practice and professional behaviour may be effectively dealt with in a time- and cost-effective manner.
