The aim of the research was to improve the results of complex ray diagnostics and monitoring in the treatment stages of patients with malignant neoplasms of soft tissues and bones using ultrasound dopplerography (US-dopplerography). US-dopplerography data in 38 patients with tumors of soft tissues and bone tumors with infiltrated soft tissues are studied in the course of treatment. The following criteria were investigated by dopplerography: arterio-venous blood-flow, venous blood-flow, maximal velocity (Vmax) of blood, minimal velocity (Vmin) of blood, index of resistance (IR), pulse index (PI). In 7of 38 patients US-dopplerography was performed repeatedly in dynamics. In 2 patients with fibrosarcoma character of neoplasm tissue blood-flow changed: in 1 patient after combined chemo- and ray-therapy neoplasm tissue blood-flow was not registered practically, in the 2nd patient indices of blood-flow decreased after chemotherapy. In 8 patients presented with fibrosarcoma blood-flow was not detected in the structure of neoplasm, and in 3 patients with the same diagnosis moderate peripheral blood-flow in the neoplasm was revealed. In one patient with osteosarcoma parameters of blood-flow in soft tissues infiltration were not changed even after 4 courses of chemotherapy. In the second patient parameters of blood-flow increased after 1st course of chemotherapy treatment, and after 3rd course blood-flow in the damaged area practically could not be detected. In 2 patients, presented with neuroblastoma and Khodjkin’s lymphoma, parameters of blood-flow decreased until complete disappearance after 2 courses of chemotherapy. In one patient with rhabdomyosarcoma blood-flow indices did not actually change in the process of treatment. Parameters of US-dopplerography in dynamic control can serve as an indicator in the treatment efficacy assessment in patients with soft tissue and bone tumors.