Acetabular component malposition during total hip Arthroplasty (THA) increases the risk of dislocation, reduces the range of motion, and can be the cause of early wear and loosening. Variability in implant alignment also affects the result of THA. The purpose of this study was to compare acetabular cup positioning of three different approaches in THA. Three different approaches for cementless THA were studied in 108 operations. The direct anterior approach was used in 56, the anterolateral approach in 32 and the posterolateral approach in 50. The same cementless cup was used in all cases. The same surgeon performed all procedures with mini-incision surgery, using different approaches. To determine the accuracy of the cups, the inclination and anteversion angles were measured with a CT-investigation of the pelvis. There were no statistical differences between the three groups regarding means of the inclination and anteversion angles. But a significant range of variance, the lowest variations being in the group of the direct anterior approach, the highest in the group of the anterolateral approach.