We compare the difference in expression profiles of miRNAs during fracture healing between adult and aged female mice. This study reveals the possibility to improve impaired fracture healing in aged females by regulating key miRNAs at early stage. Impaired fracture healing in aged female skeleton is still a clinical challenge (Holroyd et al., Summary
Introduction
The purpose is to observe the clinical effects of sodium hyaluronate injection plus herbal fumigation in the treatment of knee osteoarthritis. 58 patients(73knees)were treated by sodium hyaluronate injection plus herbal fumigation with a treatment course of five weeks and after a fellow-up of 6–36 months, the average fellow-up time was 12.1 months, the curative effect showed that 39 patients was excellent (52knees), 11 patients was fine (15knees), 4 patients was midst (5knees), 1 patient was bad (1knees), and the total fineness rate was 91.78%. Sodium hyaluronate injection plus herbal fumigation in the treatment of early metaphase of knee osteoarthritis, which had a better curative effect, less adverse reaction, and worth to extend clinical application.
The purpose of this investigation was to prospective compare the results of artificial femoral head replacement with those of treatment with a DHS internal fixation for unstable intertrochanteric fractures in elderly patients. Sixty-one cases of aged patients with intertrochanteric fractures were randomized into two treatment groups. All patients were followed for a minimum of four years from 9.1999 to 4.2003, 29 patients were treated with artificial femoral head replacement, the other were treated with DHS internal fixation. The clinical results of two ways for the treatment of aged patients with intertrochanteric fractures were observed. There were no significant differences between the groups in terms of functional outcomes, blood loss, or units of blood transfused. Patients treated with artificial femoral head replacement had a shorter hospital stay and operative time, less time to weight-bearing, fewer general complications, and lower mortality rate compared with those treated with the DHS internal fixation. We conclude that in elderly patients with an unstable intertrochanteric femoral fracture, a artificial femoral head replacement provides superior clinical outcomes but no advantage with regard to functional outcome when compared with a DHS internal fixation.
To investigate the effect of bilateral total hip replacement for patients with ankylosed hip joints caused by late ankylosing spondylitis (AS) and to discuss its related pre- and post-operation rehabilitation problems. Data of 20 patients with ankylosed hip joints caused by late AS undergone total hip replacement (40 hips) were reviewed. Among the total 14 patients (28 hips) undergone bilateral total hip replacement, other 6 patients (12 hips) undergone twice operations. We used Harris score, assessment of the joint pain, range of motion to make sure the curative effect of the operative strategy. The mean duration of follow-up was 3. 8 years, all hip joints function was improved, and the flexion deformity of the involved hips were disappeared. The range of hip flexion were 75°–105°(average 86. 2°), and the range of hip extension were 5°–15°(average 8. 7°), the average Harris score was from 32.8 pre-operation improved to 88.2 post-operation, the patients experienced no pain on their hips, the pain of the knee and the lower back complained before the treatment were obviously relieved. Bilateral total hip replacement is an effective treatment for ankylosed hip joint caused by late ankylosing spondylitis, early rehabilitation intervention is useful for the functional recovery of the joints Bipolar Hemiarthroplasty Using Non-cemented Femoral Stem in Non-traumatic Osteonecrosis of the Femoral Head Nine to Nineteen years Follow-up
