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Bone & Joint Open
Vol. 1, Issue 3 | Pages 13 - 18
1 Mar 2020
Png ME Fernandez MA Achten J Parsons N McGibbon A Gould J Griffin X Costa ML

Aim

This paper describes the methods applied to assess the cost-effectiveness of cemented versus uncemented hemiarthroplasty among hip fracture patients in the World Hip Trauma Evaluation Five (WHiTE5) trial.

Methods

A within-trial cost-utility analysis (CUA) will be conducted at four months postinjury from a health system (National Health Service and personal social services) perspective. Resource use pertaining to healthcare utilization (i.e. inpatient care, physiotherapy, social care, and home adaptations), and utility measures (quality-adjusted life years) will be collected at one and four months (primary outcome endpoint) postinjury; only treatment of complications will be captured at 12 months. Sensitivity analysis will be conducted to assess the robustness of the results.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_12 | Pages 18 - 18
1 Mar 2013
Griffin X Chaudhry M Parsons N McArthur J Costa M
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Autologous bone graft has been used in the treatment of complex bone defects for more than a century. Morbidity associated with the harvest of this bone graft has led orthopaedic surgeons to seek alternative therapies in the treatment of long bone non-unions.

The aim of this study was to determine whether the use of demineralised bone matrix as a bone healing adjunct improves clinical outcomes in adult patients with long bone non-union. A systematic search was carried out of the peer-reviewed English language literature to identify all relevant studies. The search strategy returned a total of 47 studies. Five of these studies were relevant to the research question. The studies were critically assessed and where appropriate combined in a meta-analysis.

4 non-comparative studies and one comparative study were reviewed. An overall estimate of the rate of union for the five studies was 86% (95%CI: 71–94%). The one comparative study demonstrated the relative risk (RR) of healing was not significantly better than in patients treated with autologous bone graft; RR=1.03 (95%CI 0.96–1.12).

There are limited data to support the use of demineralised bone matrix in the treatment of long bone non-union. Demineralised bone matrix is likely to be similarly effective to other treatments in the management of non-union. This study confirms the clinical and ethical requirements to proceed with a randomised controlled trial to test the effectiveness of this intervention.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 550 - 550
1 Nov 2011
Morris FD Griffin X Griffin D
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Introduction: Injuries to the ligamentum teres are being recognised more often with developments in imaging, such as MR arthrography, and the increasing use of hip arthroscopy. But they are difficult to diagnose, and it is not clear how best to treat them. Little is known about the mechanism of injury, nor the potential impact on hip stability of such injuries. The relationship between capsular and ligamentous contributions to stability has not been investigated.

Methods: We examined the movement of the ligamentum teres in intact, fully reduced, cadaveric hip specimens by trans osseus arthroscopy. The movement of the ligamentum teres was captured with video throughout the excursion of the hip joint. The influence of restraining capsular structures was determined by sequential transection and repeat excursion testing. Ligamentum teres injuries were generated by extreme movements, and compared with clinically observed injuries.

Results: The action of the ligamentum teres was successfully recorded in by video. The ligament was found to be the principal restraint to external rotation in extension and abduction. Injuries generated by forced rotation in this position resembled those seen in clinical practice.

Conclusion: Knowledge of the action of the ligamentum teres will improve our understanding of injury to this structure. It helps to identify described mechanisms which should raise suspicion of such an injury, and may help to design investigation and treatment protocols.