Summary Statement

Demineralised bone matrix augmented tendon-bone fixations in the animal model show less scar tissue and an enthesis morphology closer to the physiologic one which may lead to a more resistant repair construct.

Animal studies examining tendon-bone healing have demonstrated that the overall structure, composition, and organization of direct type entheses are not regenerated following repair. We examined the effect of Low-Intensity Pulsed Ultrasound (LIPUS) on tendon-bone healing. LIPUS may accelerate and augment the tendon-bone healing process through alteration of critical molecular expressions.

Eight skeletally mature wethers, randomly allocated to either control group (n=4) or LIPUS group (n=4), underwent rotator cuff surgery following injury to the infraspinatus tendon. All animals were sacrificed 28 days post surgery to allow examination of early effects of LIPUS. Humeral head – infraspinatus tendon constructs were harvested and processed for histology and immunohistochemical staining for BMP2, Smad4, VEGF and RUNX2. All the growth factors were semiquantitative evaluated. T-tests were used to examine differences which were considered significant at p < 0.05. Levene's Test (p < 0.05) was used to confirm variance homogeneity of the populations.

The surgery and LIPUS treatment were well tolerated by all animals. Placement of LIPUS sensor did not unsettle the animals. Histologic appearance at the tendon-bone interface in LIPUS treated group demonstrated general improvement in appearance compared to controls. Generally a thicker region of newly formed woven bone, morphologically resembling trabecular bone, was noted at the tendon-bone interface in the LIPUS-treated group compared to the controls. Structurally, treatment group also showed evidence of a mature interface between tendon and bone as indicated by alignment of collagen fibres as visualized under polarized light. Immunohistochemistry revealed an increase in the protein expression patterns of VEGF (p = 0.038), RUNX2 (p = 0.02) and Smad4 (p = 0.05) in the treatment group. There was no statistical difference found in the expression patterns of BMP2. VEGF was positively stained within osteoblasts in newly formed bone, endothelial cells and some fibroblasts at the interface and focally within fibroblasts around the newly formed vessels. Expression patterns of RUNX2 were similar to that of BMP-2; the staining was noted in active fibroblasts found at the interface as well as in osteoblast-like cells and osteoprogenitor cells. Immunostaining of Smad4 was present in all cell types at the healing interface.

The results of this study indicate that LIPUS may aid in tendon to bone healing process in patients who have undergone rotator cuff repair. This treatment may also be beneficial following other types of reconstructive surgeries involving the tendon-bone interface.

The diagnosis and treatment of disorders of the long head of the biceps tendon remains controversial. There is uncertainty as to the role of the long head of biceps and it can be difficult to determine whether the patient's pathology is coming from the biceps or other adjacent structures. In addition, the appropriate type of treatment remains controversial.

We retrospectively reviewed the files of the senior author's experience in over 4000 arthroscopic shoulder procedures. We examined cases involving isolated biceps pathology, excluding those patients with rotator cuff tears and labral pathology, involving 92 biceps tenotomies and 103 biceps tenodeses.

Our analysis supports the benefit of clinical examination over all types of radiological investigations. The benefits and technique of biceps tenodesis is described including surgical technique. Irritation by PLA interference screw is examined. A paradigm is put forward to help in diagnosis and management of these lesions.

Long head of biceps pathology is a significant cause of shoulder pain in association with other shoulder problems and in isolation. Biceps tenodesis and tenotomy is an efficacious way of dealing with this pathology.

The management of shoulder instability has changed a great deal in the last five years due to a better understanding of the biomechanics of the shoulder and the use of arthroscopic surgery.

It is essential to understand the anatomy of the labrum and bony structures of the shoulder joint, as well as the contribution of these structures as well as the Rotator Cuff to stability in the different positions of the arm. The history and examination still remains the most important diagnostic tool and a thorough history and examination cannot be over-emphasised.

MR Arthrography is the investigation of choice in confirming the diagnosis of instability while a CT scan may be required if there is significant bony damage.

The most controversial topic is that of the first time dislocator. If there is a significant labral tear then the options of an arthroscopic labral repair or external rotation brace need to be considered. In the absence of a labral tear then physiotherapy is the treatment of choice.

For recurrent dislocators, the results of arthroscopic labral repairs with capsular plication techniques are approaching those of the gold standard open stabilisation. If, however, there is significant bony damage to the glenoid or humeral head then a bone block procedure may be the treatment of choice.

Rotator Cuff tears need to be excluded in older patients with instability and often in such cases an arthroscopic procedure to deal with the Rotator Cuff and Labrum can be done simultaneously.

The transosseous equivalent/Suture Bridge or TOE/SB repair has received much attention in recent years as more shoulder surgeons transition to all arthroscopic rotator cuff repairs. The purpose of this study was to compare the biomechanical behaviour of several variants of the Suture Bridge repair performed by the authors.

Four different Suture Bridge constructs were performed six times on 24 sheep infraspinatus tendon humerus constructs. The first group was a standard Suture Bridge with two medial mattress stitches with knots (KSSB4). The second group had four medial mattress stitches with knots and was called KDSB8. The third group had two medial mattress stitches without knots and was called USBFT4. These first three repairs used two medial 5.5 mm Bio-Corkscrew FT Anchors and two lateral 3.5 mm PushLock Anchors (Arthrex). The fourth repair had two medial mattress stitches without knots and used all Pushlocks and was called USBP4.

The repairs were then analysed for failure force, cyclic creep and stiffnessafter. Cycling was performed from 10 to 100 N at 1 Hz for 500 cycles. Following cyclic testing a single cycle pull to failure at 33 mm/sec was performed. The constructs were also observed for failure mechanism and gap formation using digital video recording.

The KDSB8 repair with a mean failure force of 456.9N was significantly stronger than the USBP4 repair at 299.7N (P=0.023), the KSSB4 repair at 295.4N (P=0.019) and lastly the USBFT4 repair at 284.0N (P=0.011). There was no statistical difference between the measured failure force for the two mattress stitch KSSB4 repair with knots and the knotless two mattress stitch repairs USBFT4 and USBP4. There was not a statistical difference between any of the repairs for measured stiffness and cyclic creep. However, the KDSB8 repair showed no discernable gap formation or movement at the footprint during cyclic testing. The KSSB4, USBFT4 and USBP4 repairs demonstrated bursal sided gap formation in the range of 1 to 3 mm.

Based on the results of this study the transosseous equivalent/Suture Bridge repair with four stitches tied in the medial row and maximal lateral suture strand utilization (KDSB8 TOE/SB) is the strongest. The KDSB8 also appeared to show less bursal sided gap formation and greater footprint stability than the other Suture Bridge constructs tested.

Introduction: A cosmetic deformity does not always occur after a biceps tenotomy. The anatomical restraints preventing distal excursion of the long head of biceps tendon following tenotomy have not previously been described. This study aims to evaluate the biceps sheath and its potential role as a restraint to distal excursion of the biceps following tenotomy.

Methods: Fifteen fresh cadaveric specimens were dissected free of overlying soft tissues to reveal the rotator cuff, biceps sheath and long head of biceps muscle belly and tendon. Eight specimens were used for gross anatomical analysis. Measurements of the length of the biceps sheath on the humeral (bone) side and tendon side were made using a digital caliper (Mitutoyo, Japan). The long head of biceps tendon was then released from the glenoid labrum and the excursion of the stump relative to the rim of the articular surface measured. The biceps sheaths of two specimens were used for histological analysis.

Seven specimens were used for mechanical analysis. A humeral osteotomy was performed distal to the insertion of pectoralis major, leaving intact the biceps sheath and the muscle belly of long head of biceps. The proximal humerus was attached to a custom-designed jig and the muscle belly of biceps grasped in cryogenic grips. Specimens were loaded on an MTS 858 Bionix mechanical testing machine (MTS Systems, MN) in uniaxial tension at a rate of 1 mm/sec until failure was observed.

Results: The biceps sheath surrounds the long head of biceps tendon and inserts into the bone of the proximal humerus. It is trapezoidal in cross-section, with a mean length of 75.1 mm on the bone side and 49.3 mm on the tendon side. The average excursion of the stump was to within 2.8 mm of the rim of the articular surface.

Histological examination of the biceps sheath revealed membranous tissue consisting of loose soft tissue with fat and blood vessels. Synovial tissue was also identified. The sheath was seen to loosely attach to the biceps tendon, with a more intimate attachment to the periosteum.

The mean force to pull the long head of biceps tendon out of the sheath 102.7 N (range 17.4 N–227.6 N)

Discussion: The biceps sheath is a consistent structure intimately associated with the biceps tendon. It appears to contain blood vessels which provide nutrition to the tendon, similar to the vincula of flexor digitorum pro-fundus. Mechanical testing reveals that a substantial force is sometimes required to pull the biceps tendon from the sheath. This may explain why biceps tenotomy does not routinely result in a “Popeye” biceps.

Surgeons often protect Tendon-bone reconstructions such as rotator cuff repairs by off loading them. We investigated the effect of limb position and boundary conditions in an in-vitro rabbit patella tendon-bone repair model. Patella tendons were repaired back to the tibia in eight hindlimb cadavers with 2 mitek anchors(Mitek, Westwood, MA) and 3-0 Ethibond (Ethicon, Sommerville, NJ) using two techniques, one involving simple sutures and the other involving crossing over between the sutures. A loading mechanism through the patella tendon was constructed using static weights over a pulley mechanism. The contact area and force at the PT-bone interface were measured using a TekScan pressure sensor (6911, TekScan, South Boston, MA). The contact footprint (area and normal force) was acquired under four configurations: (1) knee full extension with interface unloaded, (2) knee 45° flexion with interface unloaded, (3) knee full flexion with interface loaded by limb weight alone, (4) tendon loaded with limb weight and 20N force applied through tendon loading mechanism. The contact area force footprint changed substantially between the different suture techniques and loading configurations. Crossing over of sutures appears to provide an increased and more evenly distributed force across the tendon-bone interface. Repair off-loading was accompanied by a decrease in the contact footprint force and pressure. The force in both suture techniques increased with increasing flexion angle and was substantially increased by both bearing the weight of the dependent limb and by an axial load in the patellar tendon. Off loading a repair may not provide optimal environment for healing.

Aim: To define the contact force and contact area at the glenoid labrum-bone interface between suture sites in an open transosseous Bankart repair, and to assess how these contact parameters are altered by tying adjacent sutures to each other.

Methods: Twelve capsulolabral avulsion lesions were created in fresh-frozen human shoulder specimens and were repaired using a standard transosseous suture technique. The contact forces and contact areas were measured at the labrum-bone interface between sutures before and after repair. Using the free suture ends, either a single or double strand knot was then tied between adjacent suture sites and the contact parameters were measured again.

Results: The contact forces and contact areas under the soft tissue bridges between transosseous sutures were mildly increased during repair (before repair: average force=5.53g, area=2.25mm²; after repair: force=11.7g, area=3.13mm²). However, both the contact forces and areas increased significantly when a single or double strand of suture was tied over the soft tissue bridge. The double strand technique resulted in a significantly greater increase in contact forces and areas than the single strand technique (single strand average force=70.1g, area=6.75mm²; double strand average force=95.15g, area=8.0mm² p< 0.05).

Conclusions: The contact parameters between labrum and bone in a Bankart repair were increased when the suture strands from adjacent transosseous repair sites were linked. Increasing contact force or contact area may improve healing at the bone-soft tissue interface, and may reduce the risk of “spot welding” repairs. This, in turn, may reduce the failure rate of Bankart repairs.

Introduction: The revision of a resection arthroplasty of the hip to total hip arthroplasty is a demanding procedure with higher complication rates than those of primary hip arthroplasty.

Aim: To evaluate the outcome of revising resection arthroplasties and thereby assist in deciding which patients would benefit from the procedure.

Methods: We reviewed the experience of an orthopaedic surgeon (WJMB) who performed revisions of resection arthroplasties to total hip arthroplasties for 10 patients from 1990 to 1999. The reason for resection arthroplasty was established or suspected infection in all patients.

Results: The time since the resection arthroplasty ranged from 12 to 36 months, with an average of 14.7 months. The Harris hip scores with the resection arthroplasties ranged from 21 to 44 with an average of 38.3. The follow-up ranged from one to eight years with an average of 4.2 years. Five patients had died from other causes at the time of the study. The Harris hip scores at the latest follow-up ranged from 46 to 89 with an average of 66.

The complications included instability requiring a constrained acetabular liner, an intra-operative femoral fracture requiring a long-stem prosthesis, the breaching of a femoral cortex by a prosthesis requiring a revision and recurrence of infection in a patient who was non-compliant with the prescribed antibiotics.

Conclusions: The revision of a resection arthroplasty to a total hip arthroplasty is a demanding procedure with a high complication rate and prolonged recovery. Revising only those patients with poorly functioning resection arthroplasties optimises the possibility of a positive surgical outcome, being an improvement in pain and function.

Aim: Radio-frequency treatment is used clinically in unstable joints to reduce the length of the supporting soft tissues to help provide stability. The mechanical properties after treatment have not been adequately studied. Since there is a change in the tissues’ ultra-structure with treatment we hypothesised that different collagenous tissues may have varying responses to radio-frequency treatment.

Methods: Ovine extensor tendons and cadaveric gleno-humeral capsules were tested on a MTS machine to investigate the dynamic and failure properties before and after radio-frequency treatment. Three radio- frequency treatments of different power (5, 10 and 20W) were used and two different treatment times (10s and 30s) to investigate the effects of treatment power and time on changes in the mechanical properties.

Results: The tissue shortening that was produced in the tendons and capsules was progressive with increases in treatment wattage and time. The tendon failure-force and stiffness were significantly reduced by the radio-frequency treatment but no significant changes were found in the capsules. Considering the dynamic properties only, the tendons showed significant changes with treatment. The mechanical properties were significantly different between control and treated groups but not between the treatment settings.

Conclusions: The tissue type altered the effect of radio-frequency treatment on the mechanical properties. Varying the treatment wattage and time did not significantly alter the changes observed with the largest difference being between control and treated tissue at any treatment setting. Therefore, radio frequency was proven to shorten collagenous tissues in a predictable manner but changes to the mechanical properties depend on the tissue type.

Introduction: Uncemented humeral components rely heavily on initial stability and fixation as a function of the design of the implant. Concerns over initial torsional stability of humeral components have motivated the development of a variety of design concepts.

Aim: To investigate the torsional stability of two types of cementless humeral shoulder prostheses.

Methods: Twelve fresh-frozen cadaveric humeri were cleaned of all soft tissues and prepared for reconstruction with the two types of cementless humeral shoulder prostheses. The humeri were embedded in a low melting point alloy and tested in a servohydraulic-testing machine. The loading applied to the humeri was a controlled angle loading regime at ± 1.5 degrees for 150 cycles. Torque versus time was measured, and the exponential time constant was calculated.

Results: The Z implant displayed overall a tightening effect, and a positive time constant. Whereas the G implant displayed a negative time constant, i.e. a loosening of the implant.

Discussion: These differences reflect the initial stability achieved immediately following surgery and may have important implications for bone in-growth and long-term stability.

Introduction: Hip instability is a complex and challenging problem. In experienced units, up to 4% of patients undergoing total hip arthroplasty will require revision surgery to treat hip instability, with only 60% of these treatments being successful. Many authors reporting results with various constrained systems available have described dislocation rates post implantation of the constrained component of 4% to 29%.

Method: The thirteen patients who underwent placement of a constrained component as a revision procedure in our unit from 1989 to 2000 were reviewed.

Results: The indications for revision surgery included recurrent dislocation in eight and intraoperative instability in five revision hip arthroplasties. No patients were lost to follow up. The average follow-up was 43 months(range 14 to 121). The average age at time of surgery was 73 years(range: 52 to 84 years). No component has been revised. The average hip score after revision surgery was 72(range: 52 to 89). There have been no episodes of dislocation of the constrained arthroplasty. In seven cases the constrained arthroplasty was implanted into a previously placed well fixed shell.

Conclusion: Constrained acetabular components were a highly effective tool in the treatment of hip instability.