Introduction: Conservative treatment of humeral diaphyseal fractures yields reliable union rates with satisfactory clinical outcome. The high incidence of shoulder complications following intramedullary fixation of humeral fractures has led clinicians to consider other less invasive treatment modalities. There is a growing body of evidence supporting the role of functional bracing in the conservative management of these fractures.

Aims: To compare the outcome of patients with humeral fractures treated non-operatively using functional bracing and those treated by internal fixation.

Methods: Retrospective clinical and radiographic study of two groups of patients with humeral diaphyseal fractures matched for age, sex and mechanism of injury. The study group consisted of 46 patients who had presented to our institution between January 1999 and July 2002 with closed diaphyseal humeral fractures. Mean follow-up was 21 months 96–42 months). Patients were assessed for pain, range of motion, return to work and sporting activities. Group 1 comprised of patients who underwent functional bracing whereas Group 2 underwent internal fixation. There were 12 males and 10 females in Group 1, with a mean age of 42 (16–75 years). Group 2 comprised 13 males and 11 females, with a mean age of 37 years (20–80 years). Fourteen patients were treated with antegrade locked intramedullary nailing, whereas 10 patients underwent plate osteosynthesis. All functional braces were specifically moulded and customised for each patient by the senior upper limb occupational therapist. Three patients were lost to follow-up (Group 2).

Results: All patients treated with functional bracing went on to union at an average of 13 weeks (10–18 weeks). There were no major complications in this group. Two patients had residual loss of shoulder range of motion. Two patients had radial nerve palsies at presentation, which recovered fully. Of the twenty-one patients treated operatively, four required further procedures. Three patients had removal of IM nails with ORIF and bone grafting. One patient went on to non-union following ORIF, and had subsequent bone grafting. Eight patients developed restricted shoulder function, four requiring manipulations under anaesthesia.

Conclusion: Functional bracing of humeral diaphyseal fractures is a safe, non-invasive treatment providing reliable outcome and high rates of union. In this retrospective study, we found the results following functional bracing to be superior to that following internal fixation. Close supervision and patient compliance with treatment and rehabilitation is empiric to a satisfactory outcome in these patients.

Two hundred patients with Adhesive Capsulitis according to Codman’s criteria were treated with manipulation under anaesthetic and hydraulic distension by the senior author. The procedure and subsequent rehabilitation was uniform for all patients. The average age at time of procedure was sixty years (range 36–91 years). Follow-up was performed using a self-assessment booklet which we devised to examine outcome in the following areas: Pain Visual Analogue Score, Ten Activities of Daily Living, Ability to Sleep & Lie on Affected Shoulder, Range of Motion and overall satisfaction. The average length of follow-up was sixty-two months (range 12–125 months). One hundred and forty-five patients were available for follow-up and completed the assessment correctly.

Results: There were no operative complications in this group. Pain was significantly decreased from a mean pre-operative pain visual analogue score of 7.9 to 1.4 post-operatively. Shoulder pain causing difficulty sleeping was reduced from 85% of patients pre-operatively to 15% post-operatively. Range of motion was assessed in comparison to pre-operative values of the affected side and current values of the unaffected side. Regarding patient satisfaction 90% of patients were improved post-operatively, 7.5% unchanged and 1.5% felt that their symptoms were worse following the procedure. The procedure was well tolerated and 97% of patients would have the procedure again. Patients who had the procedure within nine months following onset of symptoms had better long-term range of motion and functional outcome than those who had a greater delay in treatment. Our results indicate manipulation and hydraulic distension is a safe effective treatment for adhesive capsulitis and that a more favourable outcome is achieved if it is performed at an early stage.

The pathogenesis of frozen shoulder remains unclear. Fibroblast proliferation has been implicated in the pathogenesis with subsequent fibrosis of the capsule. We studied patients undergoing manipulation under anaesthesia for frozen shoulder. All fitted Codman’s criteria for the diagnosis. Normal saline was injected and then aspirated from 14 patients undergoing manipulation under anaesthesia for treatment of frozen shoulder and from 15 patients undergoing shoulder arthroscopy for other pathology. Human fibroblasts were cultured from sections of human anterior abdominal wall obtained from patients undergoing elective surgery. The effect of frozen shoulder aspirate versus normal control on human fibroblast proliferation and apoptosis was measured. Cellular proliferation was determined using the Promega celltitre 96TM non-radioactive cell proliferation assay.

Results: Proliferation of human fibroblasts was significantly increased in the cells treated with aspirate obtained from frozen shoulder patients versus both negative control (growth medium only) and control (normal shoulder aspirate) at concentrations of 105, 25% and 50%. This increase in proliferation was in a dose dependent manner, with the most significant increase seen in cells treated with a 505 concentration of frozen shoulder aspirate. Apoptosis was unregulated at all concentrations of shoulder aspirate, but only achieves statistical significance at 255 and 505 concentrations.

Conclusion: This study supports the hypothesis that frozen shoulder results from alteration in fibroblast regulation. Pharmacological modulation of fibroblast proliferation may be a potential therapeutic option.

Dupuytren’s contracture is characterised by abnormal fibroblast proliferation and extracellular matrix deposition in the palmar fascia. Fibroblast proliferation and matrix deposition in connective tissues are regulated by cytokines. A number of cytokines including transforming growth factor beta (TGFβ), basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF) and epidermal growth factor (EGF) are known to have potent anabolic effects on connective tissue. The aim of this study was to investigate the role played by anabolic cytokines in the pathogenesis of Dupuytren’s disease.

Twelve specimens of Dupuytren’s contracture and six control specimens of palmar fascia obtained from patients undergoing carpal tunnel release were cultured using a serumless method under standard conditions for 72 h. Levels of TGFβ-1, bFGF, PDGF and EGF in the medium were estimated using an enzyme linked immunoabsorbent assay technique.

Neither Dupuytren’s tissue nor control palmar fascia produced any EGF. The mean (±S.D.)levels of bFGF, PDGF and TGFβ-1 produced by cultured palmar fascia were: 1270 ± 832, 74 ± 24, < 7, and for Dupuytren’s tissue were 722 ± 237, 139 ± 76.6, 645 ± 332, respectively. The levels of PDGF and TGFβ-1 were significantly higher in Dupuytren’s tissue.

PDGF is produced in increased amounts by Dupuytren’s tissue. This may contribute to the fibroblast proliferation and increased ECM deposition observed in this condition. TGFβ-1 is not produced by normal palmar fascia but is produced in large amounts by Dupuytren’s tissue. The major physiologic role of TGFβ-1 is to stimulate formation of fibrous tissue. It plays a major role in wound healing and also in pathological conditions where fibrosis is a prominent feature. Inappropriate production of TGFβ-1 in the palmar fascia in Dupuytren’s disease may play a central role in initiating and stimulating the abnormal fibroblast proliferation and collagen synthesis seen in this condition.

The pathogenesis of frozen shoulder remains unclear. Fibroblast proliferation has been implicated in the pathogenesis with subsequent fibrosis of the capsule. We studied patients undergoing manipulation under anaesthesia for frozen shoulder. All fitted Codman’s criteria for the diagnosis. Normal saline was injected and then aspirated from 15 patients undergoing manipulation under anaesthesia for treatment of frozen shoulder and from 15 patients undergoing shoulder arthroscopy for other pathology. Human fibroblasts were cultured from sections of human anterior abdominal wall obtained from patients undergoing elective surgery. The effect of frozen shoulder aspirate versus normal control on human fibroblast proliferation and apoptosis was measured. Cellular proliferation was determined using the Promega celltitre 96TM non-radioactive cell proliferation assay.

Proliferation of human fibroblasts was significantly increased in the cells treated with aspirate obtained from frozen shoulder patients versus both negative control (growth medium only) and control (normal shoulder aspirate) at concentrations of 105, 25% and 50%. This increase in proliferation was in a dose dependent manner, with the most significant increase seen in cells treated with a 505 concentration of frozen shoulder aspirate. Apoptosis was upregulated at all concentrations of shoulder aspirate, but only achieves statistical significance at 255 and 505 concentrations.

This study supports the hypothesis that frozen shoulder results from alteration in fibroblast regulation.