Finite element analysis (FEA) has been applied for the biomechanical analysis of acetabular dysplasia, but not for biomechanical studies of periacetabular osteotomy (PAO) or those performing analysis taking into consideration the severity of acetabular dysplasia. This study aimed to perform biomechanical evaluation of changes in stress distribution following PAO and to determine the effect of the severity of developmental dysplasia of the hip (DDH) using three-dimensional FEA. A normal model was designed with a 25° center-edge (CE) angle and a 25° vertical-center-anterior margin (VCA) angle. DDH models were designed with CE and VCA angles each of 10, 0, or −10°. Post-PAO models were created by separating each DDH model and rotating the acetabular bone fragment in the anterolateral direction so that the femoral head was covered by the acetabular bone fragment, with CE and VCA angles each at 25°. Compared to the normal hip joint model, the DDH models showed stress concentration in the acetabular edge and contacting femoral head, and higher stress values; stress increased with decreasing CE and VCA angles. Compared to the DDH models, the post-PAO models showed near-normal patterns of stress distribution in the acetabulum and femoral head, with stress concentration areas shifted from the lateral to medial sides. Stress dispersion was especially apparent in the severe acetabular dysplasia models. PAO provided greater decreases in the maximum values of von Mises stress in the load-bearing area of the acetabulum and femoral head when applied to the DDH models of higher degrees of severity, although the values increased with increasing severity of DDH. PAO is expected to provide biomechanical improvement of the hip joint, although the results also suggest a limitation in the applicability of PAO for the patients with severe acetabular dysplasia.
We have previously investigated an association between the genome copy number variation (CNV) and acetabular dysplasia (AD). Hip osteoarthritis is associated with a genetic polymorphism in the aspartic acid repeat in the N-terminal region of the asporin ( Acetabular coverage of all subjects was evaluated using radiological findings (Sharp angle, centre-edge (CE) angle, acetabular roof obliquity (ARO) angle, and minimum joint space width). Genomic DNA was extracted from peripheral blood leukocytes. Agilent’s region-targeted high-density oligonucleotide tiling microarray was used to analyse 64 female AD patients and 32 female control subjects. All statistical analyses were performed using EZR software (Fisher’s exact probability test, Pearson’s correlation test, and Student’s Objectives
Methods
Excessive acetabular coverage is the most common cause of pincer-type
femoroacetabular impingement. To date, an association between acetabular
over-coverage and genetic variations has not been studied. In this
study we investigated the association between single nucleotide
polymorphisms (SNPs) of paralogous Homeobox (HOX)9 genes and acetabular
coverage in Japanese individuals to identify a possible genetic
variation associated with acetabular over-coverage. We investigated 19 total SNPs in the four HOX9 paralogs, then
focused in detail on seven of those located in the 3’ untranslated
region of Objectives
Methods
Total hip arthroplasty for developmental dysplasia of the hip (DDH) remains a difficult and challenging problem. How to reconstruct acetabular deficiencies has become increasingly important. One of the major causes inducing loosening of acetabular reinforcement ring with hook (Ganz ring) is insufficient initial stability. In this study, three-dimensional finite element models of the pelvis with different degrees of bone defect and acetabular components were developed to investigate the effects of the number of screws, screw insert position (Fig. 1), and bone graf quality on the initial stability under the peak load during normal walking. The size of pelvic bone defect, the number of screws and the position of screws were varied, according to clinical experience, to assess the change of initial stability of the Ganz ring. The Ganz ring was placed in the true acetabulum and the acetabular cup was cemented into the Ganz ring with 45 degrees abduction and 15 degrees of screws. The Insert position, nodes on the sacroiliac joint and the pubic symphysis were fixed in all degrees of freedom as the boundary condition. The peak load during normal walking condition was applied to the center of the femoral head (Fig. 2). According to the Crowe classification, as the degree of acetabular dysplasia was increased, the relative micromotion between the Ganz ring and pelvis was also increased. The peak micromotion increased as the stiffness of bone graft decreased. Increasing the numbers of screws, the relative micromotion tended to be reduced and varied the screw insertion position that affects the relative micromotion in the Ganz ring-pelvic interface (Fig. 3). This study showed that increasing the number of inserted screws can reduce the relative micromotion. Both the insert position and graft bone property affect the stability of the Ganz ring while the insert position has a greater impact. The current study is designed to lay the foundation for a biomechanical rationale that will support the choice of treatment.
