35 patients with an infected total knee arthroplasty were operated with a two-stage revision protocol including the use of custom hand-made antibiotic loaded articulating spacers. Spacers were built intraoperatively, without specific tools, regarless the defect being considered cavitary or segmentary. Patients were allowed to walk with an orthosis. Range of motion (ROM) with the articulating spacer averaged 80° and after reimplantation 106.5°. All but two patients in our series were treated with a combination of antibiotics including rifampicin and the antibiotics used in the spacers constituted from 7.5% of its final weight. Reimplantation was successfully performed in 33 out of 35 cases at an average time of 10.2 weeks, excluding a patient were we had to wait 2.5 years. An extended exposure at reimplantation was necessary in 21% of the patients (five “Q-snip” and two anterior tibial tuberosity osteotomies).