Ilizarov frame removal often occurs in the outpatient setting, and previous data has shown it can be a painful experience. Frames with a total of four or more olive wires or half-pins in combination yielded increased pain scores at frame removal.

Sublingual fentanyl provides rapid onset, short acting analgesia for painful procedures such as dressing changes in burns patients. We hypothesised that administration of sublingual fentanyl, prior to frame removal would improve patients' pain scores.

Twenty-one patients were given 100 mcg sublingual fentanyl prior to frame removal. Their pain scores were documented on an 11-point (0–10) numeric visual scale before, immediately after, 15 and 30 minutes after frame removal, and the following day. The same nurse specialist removed all the frames. Nitrous oxide was available for patients if they needed further analgesia.

The majority of frames were removed from tibia. The average patient age was 40.8 years. Each frame had a median of 9 wires (range 2–17), and 4 olives (2–8). Eight frames had half pins (range 1–4, median 2). Fourteen patients used nitrous oxide in addition to fentanyl.

Overall, the average pain score was 3.1. This peaked at 7.5 immediately after frame removal, but 15 minutes following removal the average was 2.5. Patients who had supplementary nitrous oxide had higher pain scores throughout (though not beforehand), although these differences were not statistically significant.

Four patients (19%) reported adverse effects following administration, but none required medical intervention.

Patients' pain scores averaged 2.52 within 15 minutes of removal, compared with 5.25 from our previous review. This suggests that fentanyl may be beneficial in frame removal, but our sample size was small, and more research is needed in this area.