It is known that the delayed diagnosis of Essex-Lopresti injury can lead to devastating results concerning the function of the upper extremity. The aim of our study is to suggest methods of early diagnosis and treatment based on our experience on ten patients who were treated for this rare injury. We studied 10 patients (9 male and 1 female), average 36,5 years old (25–53) who sustained comminuted fracture of the radial head, isolated (3 patients) or with concomitant injury of the ipsilateral (3 patients) or the contralateral upper extremity (4 patients). Initially, 8 patients were treated with excision and 2 with internal fixation of the radial head and radioulnar transfixing pin. Gradually, they all developed subluxation of the DRUJ and they were treated for established Essex-Lopresti injury, 1–7 months after initial injury. Six patients were treated with reduction of radioulnar length (ulnar shortening osteotomy, with or without distraction with an external fixator) and TFC suturing. In 4 patients the radial head was replaced with a metallic implant, joint levelling and TFC suturing. The results were estimated after an average follow-up of 67 months (1–10 years) based on radiological (radioulnar equivalence) and clinical criteria (wrist and elbow range of motion, forearm rotation and grip strength). Excellent results were achieved in 4 patients who underwent metallic radial head replacement. Conversely, in the rest patients the radioulnar discrepancy relapsed in various degrees but the radiological result does not correlate with the clinical picture. We concluded that early diagnosis is necessary but not the only prerequisite for a good long-term result. Replacement of the radial head with titanium implant, offers good result at least in the short and mid-term period.