Aims. Our aim was to investigate occurrence of senescent cells directly in tendon tissue biopsies from patients with chronic shoulder tendinopathies, and to correlate senescence with Enhancer of zeste 2 (EZH2) expression, the functional subunit of the epigenetic master regulator polycomb repressive complex. Methods. Human proximal long head of biceps tendons from patients with different chronic shoulder pathologies (n = 22), and controls from patients with humerus fracture (n = 6) and pathology (n = 4), were histologically scored for degeneration and analyzed for gene and protein expression of tendon specific factors, senescence markers, and EZH2. Tissues were further exposed to senotherapeutic compounds and the USA Food and Drugs Administration-approved selective EZH2 inhibitor EPZ-6438 and their senescence-associated secretory phenotype (SASP) assessed. Results. Expression of senescence markers (CDKN2A/p16, CDKN2D/p19) and EZH2 was significantly higher in tendinopathies compared to fracture or healthy tissue controls and positively correlated with the degree of tissue degeneration. Immunofluorescent stainings demonstrated colocalization of p16 and p19 with EZH2 in tenocytes. Treatment of tendon biopsies with EPZ-6438 reduced secretion of a panel of SASP factors, including interleukin-6 (IL6), IL8, matrix metalloproteinase-3 (MMP3) or GRO1, similarly to the senotherapeutic compound AG490. Conclusion. We demonstrate that senescence traits accumulate in pathological tendon tissues and positively correlate with tissue degeneration. Increased expression of CDKN2A/p16 and CDKN2D/p19 coincides with EZH2 expression, while its inhibition decreased the secretion of SASP factors, indicating a possible regulatory role of EZH2 in tenocyte senescence in tendinopathies. Reduction of cellular senescence, e.g. with EPZ-6438, opens ways to new potential therapeutic approaches for enhancing regeneration in chronic tendinopathies. Cite this article: Bone Joint Res 2025;14(2):143–154

The function of the upper extremity is highly dependent on correlated motion of the shoulder. The shoulder can be affected by several diseases. The most common are: rotator cuff tear (RCT), shoulder instability, shoulder osteoarthritis and fractures. Rotator cuff disease is a common disorder. It has a high prevalence rate, causing high direct and indirect costs. The appropriate treatment for RCT is debated. The American Academy Orthopaedic Surgeons guidelines state that surgical repair is an option for patients with chronic, symptomatic full-thickness RCT, but the quality of evidence is unconvincing. Thus, the AAOS recommendations are inconclusive. We are performing a randomized controlled trial to compare surgical and conservative treatment of RCT, in term of functional outcomes, rotator cuff integrity, muscle atrophy and fatty degeneration. Shoulder instability occurs when the head of the upper arm bone is forced out of the shoulder socket. Shoulder instabilities have been classified according to the etiology, the direction of instability, or on combinations thereof. The Thomas and Matsen classification, which is currently the most commonly utilized classification, divides shoulder instability events into the traumatic, unidirectional, Bankart lesion, and surgery (TUBS) and the atraumatic, multidirectional, bilateral, rehabilitation, and capsular shift (AMBRI) categories. The acquired instability overstress surgery (AIOS) category was then added. Surgical procedures for shoulder instability includes arthroscopic capsuloplasty, remplissage, bone block procedure or Latarjet procedure. Reverse total shoulder arthroplasty (RTSA) represents a good solution for the management of patients with osteoarthritis or fracture of the proximal humerus, with associated severe osteoporosis and RC dysfunction.

Purpose

The introduction of alternate care provider roles is at the forefront of many new health human resource strategies and is one of the key approaches in reducing orthopaedic wait times in Canada. The present study was part of a formal evaluation of an expanded role for physiotherapists which included referral triage, comprehensive assessment and development of a management plan and post-surgical follow-ups. Specifically, we examined the efficacy and role of an Advanced Practice Physiotherapist (APP) with respect to reduction in wait times to care for patients with shoulder complaints referred to an orthopaedic surgeon with subspecialty in shoulder reconstruction.

Primary synovial chondromatosis (PSC) is a rare benign disorder characterised by development of foci of cartilage in the synovial membrane of the joint, bursa or tendon sheath that was first described by Reichel in 1900. The disorder has traditionally been considered as a metaplastic condition, but was recently assoicated with structural chromosomal abnormalities, suggesting a neoplastic origin. The aim of the present study was to evaluate the clinical, arthroscopic and histopathological aspects of PSC involving both the glenohumeral joint and tendon sheath of the biceps.

An 18-year-old, right-hand dominant boy presented with right shoulder pain. There was no history of trauma. Pain began in his shoulder about 1 year prior to his clinical visit. Physical examination revealed an active range of motion of the affected side measuring 90 ° of abduction and 150° of forward flexion; internal rotation to the greater trochanter of the hip and external rotation were slightly limited. Plain radiographs revealed multiple calcific nodules in the right glenohumeral joint, the subcoracoid recess, and anterior to the humeral head. There appeared to be mild degenerative changes in the gleno-humeral joint.

Magnetic resonance imaging was performed to assess the location of the loose bodies and evaluate intra-articular degenerative changes. It demonstrated multiple loose bodies within the glenohumeral joint, the proximal tendon sheath of the biceps, and also in the subscapularis bursa. There was irregularity involving the anterior aspect of the humeral head consistent with erosive changes.

The patient underwent arthroscopic surgery to remove the loose bodies, arthroscopic partial synovectomy and decompression of the biceps tendon sheath, with removal of multiple loose bodies. For partial synovectomy a motorized suction-cutting device alternated between anterior and posterior portals. The biceps tendon was identified through an anterior deltopectoral incision and multiple loose bodies were removed from within the tendon sheath. Specimens for histological analyses were stained with haematoxylineosin (H& E) and safranin-O. Polyclonal anti-type II collagen was used at 1:100 dilution for immunohistological analyses

At 2–year follow-up examination the patient was asymptomatic and there was no clinical or radiographic evidence of recurrence. Lobulated areas of hyaline cartilage just below the synovial surface were easily identified. Chondrocytes were clustered together in nests and were not uniformly distributed throughout the ground substance. Safranin-O staining showed evident meta-chromasia of the cartilaginous matrix. Immunolabelling for type II collagen was observed in cartilaginous areas with marked cytoplasmic staining.

We believe that arthroscopy is an easy and safe method for the management of this disorder and that the support of an experienced pathologist is necessary to avoid differential diagnostic problems with the uncommon malignant transformation.

Introduction. Quantification of daily upper-limb activity is a key determinant in evaluation of shoulder surgery. For a number of shoulder diseases, problem in performing daily activities have been expressed in terms of upper-limb usage and non-usage. Many instruments measure upper-limb movement but do not focus on the differentiations between the use of left or right shoulder. Several methods have been used to measure it using only accelerometers, pressure sensors or video-based analysis. However, there is no standard or widely used objective measure for upper-limb movement. We report here on an objective method to measure the movement of upper-limb and we examined the use of 3D accelerometers and 3D gyroscopes for that purpose.

Methods. We studied 8 subjects with unilateral pathological shoulder (8 rotator cuff disease: 53 years old ± 8) and compared them to 18 control subjects (10 right handed, 8 left handed: 32 years old ± 8, younger than the patient group to be almost sure they don_t have any unrecognized shoulder pathology). The Simple Shoulder Test (SST) and Disabilities of the Arm and Shoulder Score (DASH) questionnaires were completed by each subject.

Two modules with 3 miniature capacitive gyroscopes and 3 miniature accelerometers were fixed by a patch on the dorsal side of the distal humerus, and one module with 3 gyroscopes and 3 accelerometers were fixed on the thorax. The subject wore the system during one day (8 hours), at home or wherever he/she went. We used a technique based on the 3D acceleration and the 3D angular velocities from the modules attached on the humerus.

Results. As expected, we observed that for the stand and sit postures the right side is more used than the left side for a healthy right-handed person(idem on the left side for a healthy left-handed person). Subjects used their dominant upper-limb 18% more than the non-dominant upper-limb. The measurements on patients in daily life have shown that the patient has used more his non affected and non dominant side during daily activity if the dominant side = affected shoulder. If the dominant side ≠ affected shoulder, the difference can be showed only during walking period.

Discussion-Conclusion. The technique developed and used allowed the quantification of the difference between dominant and non dominant side, affected and unaffected upper-limb activity. These results were encouraging for future evaluation of patients with shoulder injuries, before and after surgery. The feasibility and patient acceptability of the method using body fixed sensors for ambulatory evaluation of upper limbs kinematics was shown.

Background. Shoulder pain limits range of motion (ROM) and reduces performing activities of daily living (ADL). Objective assessment of shoulder function could be of interest for diagnosing shoulder pathology or functional assessment of the shoulder after therapy. The feasibility of 2 wearable inertial sensors for functional assessment to differentiate between healthy subjects and patients with unilateral shoulder pathology is investigated using parameters as asymmetry. Methods. 75 subjects were recruited into this study and were measured for at least 8 h a day with the human activity monitor (HAM) sensor. In addition, patients completed the Disability of the Arm, Should and Hand (DASH) score and the Simple Shoulder Test (SST) score. From 39 patients with a variety of shoulder pathologies 24 (Age: 53.3 ± 10.5;% male: 62.5%) complete datasets were successfully collected. From the 36 age-matched healthy controls 28 (Age: 54.9 ± 5.8;% male = 57.1%) full datasets could be retrieved. Activity parameters were obtained using a self-developed algorithm (Matlab). Outcome parameters were gyroscope and accelerometry-based relative and absolute asymmetry scores (affected/unaffected; dominant/non-dominant) of movement intensity. Results & Discussion. The absolute and relative asymmetry scores of the accelerometry-based intensity results for a threshold of > 0.1 g (AUC 0.821 and AUC 0.827) proved to be slightly more distinctive to the gyroscope-based intensity results for a threshold of > 10 deg/s (AUC 0.807 and 0.795) to distinguish between the healthy group and the shoulder group. Asymmetry (< 1%) was nearly absent in healthy controls (5/56 subjects) using the accelerometry-based intensity (> 0.1g) results but common in patients (29/48 subjects). A moderate, significant correlation was found between the asymmetry scores and the DASH score, thus complementary use is advised. The asymmetry scores had no correlation to the SST score. Conclusion. Ambulant assessment of shoulder activity using human activity monitors, containing a gyroscope and accelerometer, during ADL is feasible. The accelerometry-based and gyroscope-based absolute and relative asymmetry scores are promising parameters to diagnose or assess function of the shoulder. A moderate correlation was found between the DASH score and the activity monitor parameters, suggesting both could be used complementary to assess function

Aims

This study aimed to define the histopathology of degenerated humeral head cartilage and synovial inflammation of the glenohumeral joint in patients with omarthrosis (OmA) and cuff tear arthropathy (CTA). Additionally, the potential of immunohistochemical tissue biomarkers in reflecting the degeneration status of humeral head cartilage was evaluated.

Aims

The primary aim of this prospective, multicentre study is to describe the rates of returning to golf following hip, knee, ankle, and shoulder arthroplasty in an active golfing population. Secondary aims will include determining the timing of return to golf, changes in ability, handicap, and mobility, and assessing joint-specific and health-related outcomes following surgery.

Aims

The objective of this study was to compare simulated range of motion (ROM) for reverse total shoulder arthroplasty (rTSA) with and without adjustment for scapulothoracic orientation in a global reference system. We hypothesized that values for simulated ROM in preoperative planning software with and without adjustment for scapulothoracic orientation would be significantly different.

Aims

The survival of humeral hemiarthroplasties in patients with relatively intact glenoid cartilage could theoretically be extended by minimizing the associated postoperative glenoid erosion. Ceramic has gained attention as an alternative to metal as a material for hemiarthroplasties because of its superior tribological properties. The aim of this study was to assess the in vitro wear performance of ceramic and metal humeral hemiarthroplasties on natural glenoids.

Aims

The aim of this study was to report long-term clinical outcomes of a modern convertible metal-backed glenoid (MBG) in total shoulder arthroplasty (TSA).

The relevance of physical activity (PA) for general health and the value of assessing PA in the free-living environment especially for assessing orthopaedic conditions and outcome are discussed. Available methods for assessing PA such as self-reports, trackers, phone apps and clinical grade monitors are introduced. An overview of devices such as accelerometers for research quality assessments is given and aspects for choosing them such as wear location, usability or study population are reviewed. Basic principles to derive mobility parameters from the PA related sensor signals are presented. The symposium explains mobility parameters, their types, definitions, validity, analysis and those with particular relevance to assess orthopaedic conditions. The application of activity monitors is orthopaedic patient studies is demonstrated in various examples such as knee and hop osteoarthritis and total joint arthroplasty, in frail elderly subjects at fall risk or patients with shoulder pathologies

Purpose: The diagnosis and treatment of superior labral antero posterior (SLAP) lesions is a controversial subject in shoulder pathology. The aim of this retrospective study was to evaluate the strength of association between clinical assessment (O’Brien test), standard MRI, and arthroscopic identification of a SLAP lesion. Method: Patients who underwent isolated arthroscopic treatment of a SLAP lesion by two senior orthopaedic surgeons between 2004 and 2007 were included in this study. Pre-operatively, all had a standard MRI and the outcome of O’Brien test had been documented. Sensitivity of these measures in detecting a SLAP lesion confirmed through arthroscopy were calculated independently and combined. The relationship between O’Brien test and standard MRI are also presented. Results: Forty-five patients were included in this study. The O’Brien test demonstrated a sensitivity of 42% (true positive) in detecting a SLAP lesion while sensitivity of the standard MRI was only 13%. The sensitivity of the O’Brien test and standard MRI when considered together was 47%, only slightly higher than the O’Brien test alone. The association between the O’Brien test and standard MRI in identifying a SLAP lesion as measured by the phi correlation coefficient was −0.19 which suggests little to no relationship (p = 0.095). Conclusion: The current study illustrates the difficulties in accurately diagnosing a SLAP lesion pre-operatively. Previously documented sensitivity of the O’Brien test in identifying a SLAP lesion was not replicated herein. Furthermore, this study draws into question the practice of patient’s undergoing a standard MRI for SLAP lesion identification because the added value from this investigation was nominal. A standard MRI is often requested when the diagnosis is not certain or to exclude other shoulder pathology. If, however, a SLAP lesion is suspected clinically in absence of other shoulder pathology, then a diagnostic tool other than standard MRI may be more meaningful. Some literature suggests MRI arthrogram may be useful in diagnosing a SLAP lesion but access to this tool can be limited

Intra-articular shoulder pathology has been recognised in more detail following widespread use of shoulder arthroscopy. The purpose of this epidemiological study is to present the incidence and exact type of SLAP lesions in our operated population and to correlate them with the presence of other shoulder lesions. Between 2004 and 2010 425 patients underwent shoulder arthroscopy in our department (311 for rotator cuff tears or subacromial impingement, 102 for shoulder instability, 12 for SLAP lesions). Eighty-two SLAP lesions (19.2% overall) were recognized during these procedures. In 44 cases the lesion was SLAP type I (53.6%), in 10 type II (12.2%), in 1 type III (1.2%), in 1 type IV (1.2%), in 24 type V (29.26%) and finally in 2 type VI (2.43%). In more detail SLAP I lesions were associated in 8 patients with subacromial impingement syndrome, in 33 with RC tear and in 3 patients with anterior instability. Type II, III and IV were preoperatively diagnosed, while type V and VI lesions were found in patients with chronic anterior shoulder instability. SLAP lesions are diagnosed more accurately during shoulder arthroscopy rather than with plain shoulder MRI scan. In our study population only 12 cases were accurately diagnosed with a pre-operative MRI scan, while the remaining 70 cases were missed. Additionally, there was significant correlation between rotator cuff problems and SLAP I lesions, while chronic shoulder instability was associated with SLAP V and VI (25.4% of patients with instability). Shoulder arthroscopy not only has changed SLAP lesion diagnosis and treatment but also reveals the correlation of various SLAP lesion types with specific shoulder pathologies

The age spectrum for patients undergoing shoulder arthroplasty is broadening. Many younger patients now demonstrate shoulder pathology precluding non-arthroplasty reconstruction. The senior population is living longer and “younger”. Therefore, the demands of this patient population to participate in an active lifestyle are growing. Patients with osteoarthritis, cuff tear arthropathy, post-traumatic arthropathy, avascular necrosis, and even forms of inflammatory arthropathy present seeking not only return to simple activities of daily living but the ability to participate in aerobic recreational activities and even work activities which can stretch the limits of shoulder arthroplasty in the physiologic environment of the shoulder. This presentation will provide an overview of patient demands, concerns and activity level following shoulder arthroplasty. We will provide a prospective of allowable, recommended and discouraged activities depending on the underlying source of pathology in the type of arthroplasty implants employed. An overview of our four phases of rehabilitation protocol will be presented focusing on phase four, “work in sports hardening”

A variety of challenging shoulder pathology will be presented to a panel of expert shoulder surgeons for their diagnostic evaluation, decision making, surgical management and aftercare. They will discuss the decision making processes and management options to consider in striving to obtain optimal outcomes

Aims

The aim of this study was to determine whether there is a correlation between the grade of humeral osteoarthritis (OA) and the severity of glenoid morphology according to Walch. We hypothesized that there would be a correlation.

Reverse total shoulder arthroplasty (RTSA) has improved the lives of many patients with complex shoulder pathology including rotator cuff arthropathy, glenoid bone defects, post-traumatic arthritis and failed non-constrained total shoulder arthroplasty. However, this non-anatomic replacement has a very different complication profile than has been observed with non-constrained shoulder arthroplasty and the revision of RTSA can be extremely challenging. The purpose of this talk is to review some of the typical complications observed in RTSA including instability, infection, stress fractures, peri-prosthetic fractures and glenoid failures, and discuss the treatment options for dealing with these difficult problems

An Extended Scope Practitoner Physiotherapist (ESP) developed a problem shoulder clinic to support the physiotherapy management of patients with shoulder pathology across one healthcare trust. The impact of the clinic on the management of patients and their onward referral to a shoulder surgeon was evaluated. Physiotherapists had access to a problem shoulder clinic that was managed by an ESP with a special interest in shoulders. The clinic provided assessment and advice on the management of patients with shoulder pathology who were receiving physiotherapy treatment. Throughout a three-year period the opinion of the ESP was sought on 256 patients. 69 patients were seen in a face-to-face consultation, the remainder were diuscussed with their treating physiotherapist and advice was offered. 211 patients were managed and discharged through the physiotherapy service. The ESP referred 45 patients to the shoulder surgeon, of which 53% underwent surgery; 20% are awaiting investigations, 22% were managed with injection therapy and five per cent were discharged. The problem shoulder clinic was shown to be a valuable addition to the clinical mentoring system in physiotherapy. It proved to be an important gate-keeping mechanism between physiotherapy and consultant care as 82% of patients referred to the clinic were managed within physiotherapy. The clinic also proved to be an effective means of identifying patients requiring surgery. Of those that were referred to the shoulder surgeon only five per cent were discharged with no further intervention. A planned development as a consequence of this evaluation is a physiotherapy advocate for shoulders for each outlying hospital within the trust. The aim of this will be to strengthen communication links between the shoulder surgeon and physiotherapy departments over a wide geographic area and to facilitate prompt identification of patients in need of referral to the shoulder surgeon

To provide a comprehensive radiographic, clinical, and functional description of the shoulder in Apert Syndrome. A cohort of nine Apert Syndrome patients (ages nine to twenty-seven) followed at a tertiary care facility was included in this prospective study. Patients were clinically assessed with physical examination and completion of two validated functional assessment tools, the Shoulder Pain and Disability Index (SPADI) and AAOS Paediatrics Questionnaire (PODCI). Radiographs were obtained of both shoulders and a standardised protocol MRI was performed on the dominant shoulder of all participants. All patients had some degree of functional impairment attributable to their shoulder pathology. Physical examination consistently revealed reduced forward flex-ion and abduction. Radiographic findings were similar to previous reports, with pervasive osseous dysplasia of the shoulder joint. Medial humeral head hypoplasia was seen in eight out of nine patients and greater tuberosity overgrowth in seven out of nine patients. MR imaging of the shoulder, not previously performed in a cohort of Apert patients, allowed better delineation of abnormalities seen radiographically such as a central glenoid cleft, seen in eight out of nine patients. It also revealed a new finding of inferior glenoid inclination (seven out of nine patients), which has not been described in the literature. Very few soft tissue or degenerative abnormalities were demonstrated. The findings of this study confirm that patients with Apert Syndrome are functionally impaired by their shoulder pathology, which may have a similar clinical impact as the more well-described hand and foot anomalies. The global functioning of patients with Apert syndrome is equivalent to patients with juvenile rheumatoid arthritis. The shoulder range of motion in Apert patients is decreased, most significantly in flexion and abduction. Radiographs confirmed previous imaging findings of glenohumeral dysplasia. The novel MRI component demonstrated consistent inferior glenoid inclination, which may be a significant factor in their shoulder impairment. MR imaging revealed no significant soft tissue or degenerative abnormalities to account for their clinical disability. These findings have potential relevance in the surgical and clinical management of these patients