Introduction: Surgeons treating tibial fractures by the Ilizarov Method are faced with the diagnostic dilemma of determining whether a fracture has united to remove the frame safely. Methods: Considering frame removal we use three criteria:. Consideration of natural history of the injury – characteristics of the injury and existing knowledge of healing times. The appearance of remodelling bridging callus (often endosteal) on anteroposterior and lateral radiographs. Clinical behaviour of the injured limb within a dynamised frame – after 1 and 2 are met, rods connecting the rings stabilising the fracture are loosened. The frame is removed when the patient can stand on the affected limb and dynamised frame without pain, and after weightbearing without pain on the dynamised frame for 3–4 weeks. Results: Premature frame removal was identified in 2/106 tibial fractures treated with Ilizarov frames. In both cases subsequent CT scanning identified a healed fibula and stiff non-union of the tibia. In both, original fracture geometry was complex, with fracture lines outwith the planes of radiographic assessment. Timely frame removal in104/106 (98%). Discussion: In both cases of premature removal the frame was reapplied to achieve union. Premature removal must be balanced against the patient’s desire to have their cumbersome fixator removed at the earliest opportunity. It is said “It is better to leave a frame on one month too long than to remove it a day too soon”, but this merely emphasises that timing of frame removal remains an art rather than an exact science. Marsh and Montgomery have previously suggested use of CT scanning to assess union in peri-articular fractures. We recommend that in high energy tibial fractures whose fracture pattern geometry lies outwith the antero-posterior and lateral radiograph views, a CT scan should be considered to detect stiff non-union and avoid premature frame removal

The purpose of this study was to determine the incidence of revision total knee replacement (TKR) within 5 years of the index procedure at a large multi-surgeon unit using a single prosthesis and to determine the cause of failure of those implants. This was a retrospective review of all primary Kine-max Plus TKR performed at the Avon Orthopaedic Center between 1.1.1990 and 1.1.2000. Cases were identified that required revision arthroplasty in any form within 5 years of the index procedure. Case notes and Xrays were reviewed to determine causes of failure. There were 2826 primary Kinemax Plus TKR performed during the study period. Of these 20 were known to have required revision surgery within 5 years. 8 were revised for deep infection of the prosthesis and 12 for aseptic causes. The overall incidence of premature failure of the Kinemax Plus TKR at 5 years was 0.71%. The incidence of aseptic premature failure at 5 years was 0.42%. Detailed examination of the clinical records indicated that some form of technical error at the time of the index arthroplasty was responsible for the early failure of 6 prostheses. This equates to 0.21% of the procedures performed. Aseptic loosening of the remaining 6 cases could not be attributed to a specific cause

Purpose of the study: Little work has been reported on the effects of BMP on bone healing after distraction and the data available in the literature are contradictory. The type of BMP as well as the optimal dose remain to be defined. We present the results and complications linked with the use of different doses of rhBMP-2 in a model of osteogenesis in distraction. Material and methods: Fifteen subadult New Zealand rabbits were selected at random and divided into three groups. On day 0, a mediodiaphyseal tibial osteotomy was cut and an M103 fixation implanted. In group I (5 rabbits), 750μg of rhBMP-2 with a type I collagen sponge (Inductos, Medtronic) were deposited on the osteotomy site. In group II (5 rabbits), 350 μg were deposited on the collagen sponge and in group III (controls, 5 rabbits), nothing was deposited. After the 7-day latency period, distraction was conducted for 21 days (0.5 mm(12hr). At the second week of distraction, the callus was analysed on the x-rays and ultrasounds and a weekly absorptiometry was obtained. The animals were sacrificed three weeks after healing was confirmed. Results: Quantitative radiographic assay showed significantly superior grading (Kirker-Head) in groups I and II (p< 0.05) compared with group III. The qualitative analysis showed premature healing of the regenerate preventing completion of the distraction (pin distortion) for 3/5 rabbits in group I and 1/5 in group II. Bone mineral content was superior in groups I and II in all times studied than in group III (p< 0.05). The difference was also significant between groups I and II (p=0.0087) demonstrating an expected dose effect. Discussion: Premature healing was achieved for the majority of animals in group I, underlining the importance of the dose of BMP used to stimulate bone healing after callotasis. The undesirable effect thus obtained should be taken into account in the clinical context. A dose of 100 μg/kg (350 μg, group III) appears to suffice in this model and defines the upper dose limit. Differed application of the compound (after distraction) should be useful and should be studied. Conclusion: The dose of rhBMP-2 used to stimulate bone healing is an essential parameter that should be defined for each experimental model. The dose effect of rhBMP-2 is demonstrated in this particular model

We found the ABG cementless hip has excessive acetabular wear and premature failure due to osteolysis. In 60 patients implanted at mean age 56 years, 66 hips (mean follow up 48 months), 7 were revised and 7 have severe acetabular osteolysis. In some this is entirely asymptomatic. There was significant association with osteolysis, length of follow up and wear but no correlation between wear and acetabular component position, age, liner thickness, and use of ceramic or CoCr heads. We recommend regular lifelong radiological review of these hips and suspension of use of this prosthesis until a wider review is undertaken

Freezing cold injuries (Frostnip and Frostbite) (FCI) have become uncommon in UK military personnel relative to non-freezing cold injuries (NFCI, ‘trench foot’). However if unidentified or inappropriately treated they may lead to avoidable medical downgrading or discharge. JSP 539 recommends delay or avoidance of surgical debridement where possible. An anonymised retrospective audit was performed of FMED7 medical reports of cases seen in the Institute of Naval Medicine Cold Injury Clinic (CIC) between July 2002 and January 2014 inclusive. In all 149 FCI cases were identified, 71 affected hands only of which 34 were bilateral, and 58 affected feet only, 34 of those being bilateral. A total of 17 patients had injured both hands and feet, with 10 bilateral. Royal Marines accounted for half of these cases, with the Army making up a further third, and the Royal Navy and RAF making up the remainder. Most FCI were found to have occurred in Norway, with Marine ranks being most commonly affected. Ten cases underwent surgery: aspiration of blisters, debridement of tissue, or amputation. Seven of these procedures took place prematurely, which appeared detrimental to recovery. No patients required fasciotomy. FCI are uncommon, but in arctic conditions their risk rises dramatically. The best treatment is conservative where possible following JSP 539 guidelines and consultation with CIC should occur at the earliest possibility. The Potential benefits of surgery must be weighed against problems of injured tissue healing and expert opinion should be obtained

Purpose: To evaluate the real effectiveness of orthopaedic prenatal diagnosis. Introduction: Sonographic early detection of fetal club foot, spine abnormalities like “spina bifida” or spondylocostal ‘” dysostosis, limb discrepancy have been often reported in prenatal orthopaedic diagnosis. But in all these cases the role of the orthopaedic surgeon is secondary: In the case reported the joined evaluation of obstetrician and orthopaedic surgeon was able to anticipate delivery, avoid a severe and constrictive amniotic band on the lover limb which might cause an amputation of the ankle and foot. Material and methods: At 25th week of pregnancy a morphologic sonographic examination was carried out in a Caucasian healthy woman. It demonstrated an healthy male fetus presenting a constrictive amniotic band on the distal right leg causing a mild oedema of the foot. Four weeks later the oedema of ankle and feet was dramatically increased and on the distal tibia an initial notch on the cortex was observed. The risk of self-amputation in utero was high, so a decision to bring forward delivery was made by a obstetrician, and paediatrician orthopaedic surgeon. In the last two weeks of uterine life the fetus was treated to obtain a satisfactory lung maturity and at 32nd week a caesarean delivery was carried out. The baby, normal, (agar score 7–9, 2750 kg.) presented a tremendous oedema of the dorsal foot causing a complete disappearance of normal shape. The skin constriction was detected on the distal leg deeply extended to the bone. An X -ray early performed showed a lesion of the anterior margin of the tibia. A Sonographic Doppler of the distal leg was able to demonstrate vascular normality so at the age of two days the baby was admitted to the plastic and reconstructive surgery for the release of the amniotic band and for reductive surgery of foot’s redundant tissue. The follow-up was good with a temporary oedema post-surgery. In 60 days the appearance of the foot was satisfactory normal. Discussion: The ultrasonographic prenatal diagnosis of an amniotic band in the reported case probably has been able to avoid an amputation of the distal lower limb. The aim of this communication is to stress the role of the prenatal diagnosis in paediatric orthopaedic to emphasize the importance of early detection of congenital skeletal abnormalities. Severe and stiff club-foot, congenital “genu recurvatum” and amniotic band as. well, ought to be treated as soon as possible. Therefore, when diagnosed in selected pregnancies, if the fetus is healthy and the lung maturity is obtained with corticosteroIds and sulfactante factor sommmlstratlon, we advise a premature delivery never before 32nd week of intrauterine life. At this stage the deformities are less stiff and every treatment (manipulation, bandage, casting) offers better results and less risk

Aims: To evaluate the early midterm outcomes of primary total hip arthroplasty (THA) using Hydroxyapatite (HA)-coated on smooth surface acetabular component with 28 mm metal head on polyethylene liner articulation. Methods: Seventy primary THA in 63 patients with HA-coated acetabular component were performed consecutively between June 1993 and August 1996. Fifty-four cases were eligible for follow-up of average 71 months (48–104) and the mean age of index operation was 49 years (23–71). The clinical results were analyzed by modiþed Harris hip score, and the radiologic evaluation in terms of stability, polyethylene wear rate (Dorr method), osteolysis around acetabular component was done. Results: Mean Harris hip score improved from 50.9 to 82.2 at the last follow-up. Excellent or good results were found in 38 cases (70%). Eight cases (15%) were unstable radiologically. Pelvic osteolysis was found at 18 cases (33%). The mean polyethylene wear rate was 0.146 mm/year (0.01–0.45). Wear rate of hip dyaplasia was greater than osteonecrosis signiþcantly (p< 0.05). Seven cases (13%) were revised (5 mechanical failures, 2 deep infections). Any bone ongrowth was not found during revision surgery for loose components. Complications included 5 heterotrophic ossiþcations, 2 deep infections, and 1 nonrecurrent dislocation. Conclusion: Primary THA using HA-coated on smooth surface acetabular component showed unsatisfactory clinical results, accelerated polyethylene wear rate accompanying high incidence of osteolysis, and high loosening rate due to lack of bony ongrowth at early midterm.

ERAS (Enhanced recovery after surgery) programs have been widely adopted in elective orthopaedic practice. Early discontinuation of Intravenous (IV) fluids in order to promote mobilisation and subsequent discharge is a key feature of such programs. However concerns have been raised regarding whether such an approach results in an increased risk of acute kidney injury (AKI).

We set out to determine the incidence of AKI in patients undergoing hip or knee arthroplasty treated as part of an ERAS program where IV fluids are removed before leaving the recovery room. Investigate whether there is a difference in incidence between patients with a pre-operative eGFR ≥ 60 or < 60 (ml/min/1.73m2). In addition to whether patients who sustain an AKI have a longer post-operative hospital stay.

The pre and post-operative blood results of patients undergoing elective total hip and total knee replacements were retrospectively analysed to determine whether they had suffered an AKI during admission. The patient's notes were reviewed for other known causes of peri-operative AKI and the length of their hospital stay.

The overall Incidence of AKI was 9.4%. There was a significant association found between pre-operative eGFR and development of an AKI p = 0.002. The incidence of AKI was 5.8% in patients with a pre-operative eGFR ≥ 60 vs 33.3% in those with an eGFR < 60. The development of an AKI was associated with a longer hospital stay p = 0.042. The median length of hospital stay was 7 days for those who suffered an AKI vs 5 days for those who did not.

Patients undergoing elective lower limb arthroplasty with a pre-operative eGFR < 60 treated as part of an ERAS program where fluids are discontinued before leaving the recovery room are at high risk of developing an AKI. Further studies are required to ascertain whether a longer duration of IV fluids is effective in reducing the incidence of AKI in this group.

Cerebral Palsy (CP) is a group of disorders that affect movement and posture caused by injury to the developing brain. While prematurity and low birth weight are common causes in developed countries, birth asphyxia, kernicterus, and infections have been identified as predominant aetiologies in Africa. There is, however, very little information on the aetiology of CP in South Africa. The purpose of this study was to determine the aetiology, severity, and topographical distribution of CP in children undergoing orthopaedic surgery at our tertiary paediatric unit. A retrospective folder review was performed for patients with CP that underwent orthopaedic surgery from July 2018 to June 2022. Data was collected on perinatal circumstances, aetiology or risk factors for developing CP, severity of disability as classified by the Gross Motor Function Classification Scale (GMFCS) and topographical distribution. Descriptive analysis was performed. Two-hundred-and-thirty-four patients were included in the analysis. No specific aetiology could be identified in 51 (21.9%) patients. Hypoxic ischaemic encephalopathy (HIE) accounted for 23.6% of patients and was the most common aetiology across the different categories except for patients graded as GMFCS 2, in whom prematurity was the most common aetiology. Congenital brain malformations (10.5%) and cerebral infections, including HIV encephalopathy (11.4%) were the next most frequent aetiologies, followed by prematurity (7.6%), ischaemic stroke (6.8%) and intraventricular haemorrhage (6.3%). Fifty-two percent of patients were classified as GMFCS 4 or 5. There was a predominance of quadriplegic patients (37%) compared to hemiplegics (29%), diplegics (30%) and monoplegics (4%). Most patients undergoing orthopaedic surgery for musculoskeletal sequelae of CP were severely disabled quadriplegic patients in whom HIE was the predominant cause of CP. This emphasises the need for intervention at a primary care level to decrease the incidence of this frequently preventable condition

Aging impairs the regenerative capacity of musculoskeletal tissues and is associated with poor healing outcomes. PolgA. D257A/D257A. (PolgA) mice present a premature aging phenotype due to the accumulation of mitochondrial DNA (mtDNA) point mutations at rates 3 – 5 fold higher compared to wild type mice. Consequently, PolgA mice exhibit the premature onset of clinically-relevant musculoskeletal aging characteristics including frailty, osteo-sarcopenia, and kyphosis. I will present our recent findings on the use of PolgA mice to investigate the effects of aging on the regenerative capacity of bone. In particular, I will focus on the mechano-sensitivity of the regenerative process in aged bone environments and the opportunities it presents for clinical translation of mechanical intervention therapies

Salter-Harris II fractures of the distal tibia affect children frequently, and when they are displaced present a treatment dilemma. Treatment primarily aims to restore alignment and prevent premature physeal closure, as this can lead to angular deformity, limb length difference, or both. Current literature is of poor methodological quality and is contradictory as to whether conservative or surgical management is superior in avoiding complications and adverse outcomes. A state of clinical equipoise exists regarding whether displaced distal tibial Salter-Harris II fractures in children should be treated with surgery to achieve anatomical reduction, or whether cast treatment alone will lead to a satisfactory outcome. Systematic review and meta-analysis has concluded that high-quality prospective multicentre research is needed to answer this question. The Outcomes of Displaced Distal tibial fractures: Surgery Or Casts in KidS (ODD SOCKS) trial, funded by the National Institute for Health and Care Research, aims to provide this high-quality research in order to answer this question, which has been identified as a top-five research priority by the British Society for Children’s Orthopaedic Surgery. Cite this article: Bone Joint J 2023;105-B(5):471–473

Shoulder arthroplasty is effective at restoring function and relieving pain in patients suffering from glenohumeral arthritis; however, cortex thinning has been significantly associated with larger press-fit stems (fill ratio = 0.57 vs 0.48; P = 0.013)1. Additionally, excessively stiff implant-bone constructs are considered undesirable, as high initial stiffness of rigid fracture fixation implants has been related to premature loosening and an ultimate failure of the implant-bone interface2. Consequently, one objective which has driven the evolution of humeral stem design has been the reduction of stress-shielding induced bone resorption; this in-part has led to the introduction of short stems, which rely on metaphyseal fixation. However, the selection of short stem diametral (i.e., thickness) sizing remains subjective, and its impact on the resulting stem-bone construct stiffness has yet to be quantified. Eight paired cadaveric humeri (age = 75±15 years) were reconstructed with surgeon selected ‘standard’ sized and 2mm ‘oversized’ short-stemmed implants. Standard stem sizing was based on a haptic assessment of stem and broach stability per typical surgical practice. Anteroposterior radiographs were taken, and the metaphyseal and diaphyseal fill ratios were quantified. Each humerus was then potted in polymethyl methacrylate bone cement and subjected to 2000 cycles of compressive loading representing 90º forward flexion to simulate postoperative seating. Following this, a custom 3D printed metal implant adapter was affixed to the stem, which allowed for compressive loading in-line with the stem axis (Fig.1). Each stem was then forced to subside by 5mm at a rate of 1mm/min, from which the compressive stiffness of the stem-bone construct was assessed. The bone-implant construct stiffness was quantified as the slope of the linear portion of the resulting force-displacement curves. The metaphyseal and diaphyseal fill ratios were 0.50±0.10 and 0.45±0.07 for the standard sized stems and 0.50±0.06 and 0.52±0.06 for the oversized stems, respectively. Neither was found to correlate significantly with the stem-bone construct stiffness measure (metaphysis: P = 0.259, diaphysis: P = 0.529); however, the diaphyseal fill ratio was significantly different between standard and oversized stems (P < 0.001, Power = 1.0). Increasing the stem size by 2mm had a significant impact on the stiffness of the stem-bone construct (P = 0.003, Power = 0.971; Fig.2). Stem oversizing yielded a construct stiffness of −741±243N/mm; more than double that of the standard stems, which was −334±120N/mm. The fill ratios reported in the present investigation match well with those of a finite element assessment of oversizing short humeral stems3. This work complements that investigation's conclusion, that small reductions in diaphyseal fill ratio may reduce the likelihood of stress shielding, by also demonstrating that oversizing stems by 2mm dramatically increases the stiffness of the resulting implant-bone construct, as stiffer implants have been associated with decreased bone stimulus4 and premature loosening2. The present findings suggest that even a small, 2mm, variation in the thickness of short stem humeral components can have a marked influence on the resulting stiffness of the implant-bone construct. This highlights the need for more objective intraoperative methods for selecting stem size to provide guidelines for appropriate diametral sizing. For any figures or tables, please contact the authors directly

Tendon is a bradytrophic and hypovascular tissue, hence, healing remains a major challenge. The molecular key events involved in successful repair have to be unravelled to develop novel strategies that reduce the risk of unfavourable outcomes such as non-healing, adhesion formation, and scarring. This review will consider the diverse pathophysiological features of tendon-derived cells that lead to failed healing, including misrouted differentiation (e.g. de- or transdifferentiation) and premature cell senescence, as well as the loss of functional progenitors. Many of these features can be attributed to disturbed cell-extracellular matrix (ECM) or unbalanced soluble mediators involving not only resident tendon cells, but also the cross-talk with immigrating immune cell populations. Unrestrained post-traumatic inflammation could hinder successful healing. Pro-angiogenic mediators trigger hypervascularization and lead to persistence of an immature repair tissue, which does not provide sufficient mechano-competence. Tendon repair tissue needs to achieve an ECM composition, structure, strength, and stiffness that resembles the undamaged highly hierarchically ordered tendon ECM. Adequate mechano-sensation and -transduction by tendon cells orchestrate ECM synthesis, stabilization by cross-linking, and remodelling as a prerequisite for the adaptation to the increased mechanical challenges during healing. Lastly, this review will discuss, from the cell biological point of view, possible optimization strategies for augmenting Achilles tendon (AT) healing outcomes, including adapted mechanostimulation and novel approaches by restraining neoangiogenesis, modifying stem cell niche parameters, tissue engineering, the modulation of the inflammatory cells, and the application of stimulatory factors. Cite this article: Bone Joint Res 2022;11(8):561–574

Aims. There is ambiguity surrounding the degree of scaphoid union required to safely allow mobilization following scaphoid waist fracture. Premature mobilization could lead to refracture, but late mobilization may cause stiffness and delay return to normal function. This study aims to explore the risk of refracture at different stages of scaphoid waist fracture union in three common fracture patterns, using a novel finite element method. Methods. The most common anatomical variant of the scaphoid was modelled from a CT scan of a healthy hand and wrist using 3D Slicer freeware. This model was uploaded into COMSOL Multiphysics software to enable the application of physiological enhancements. Three common waist fracture patterns were produced following the Russe classification. Each fracture had differing stages of healing, ranging from 10% to 90% partial union, with increments of 10% union assessed. A physiological force of 100 N acting on the distal pole was applied, with the risk of refracture assessed using the Von Mises stress. Results. Overall, 90% to 30% fracture unions demonstrated a small, gradual increase in the Von Mises stress of all fracture patterns (16.0 MPa to 240.5 MPa). All fracture patterns showed a greater increase in Von Mises stress from 30% to 10% partial union (680.8 MPa to 6,288.6 MPa). Conclusion. Previous studies have suggested 25%, 50%, and 75% partial union as sufficient for resuming hand and wrist mobilization. This study shows that 30% union is sufficient to return to normal hand and wrist function in all three fracture patterns. Both 50% and 75% union are unnecessary and increase the risk of post-fracture stiffness. This study has also demonstrated the feasibility of finite element analysis (FEA) in scaphoid waist fracture research. FEA is a sustainable method which does not require the use of finite scaphoid cadavers, hence increasing accessibility into future scaphoid waist fracture-related research. Cite this article: Bone Jt Open 2023;4(8):612–620

Aims. Hip dysplasia (HD) leads to premature osteoarthritis. Timely detection and correction of HD has been shown to improve pain, functional status, and hip longevity. Several time-consuming radiological measurements are currently used to confirm HD. An artificial intelligence (AI) software named HIPPO automatically locates anatomical landmarks on anteroposterior pelvis radiographs and performs the needed measurements. The primary aim of this study was to assess the reliability of this tool as compared to multi-reader evaluation in clinically proven cases of adult HD. The secondary aims were to assess the time savings achieved and evaluate inter-reader assessment. Methods. A consecutive preoperative sample of 130 HD patients (256 hips) was used. This cohort included 82.3% females (n = 107) and 17.7% males (n = 23) with median patient age of 28.6 years (interquartile range (IQR) 22.5 to 37.2). Three trained readers’ measurements were compared to AI outputs of lateral centre-edge angle (LCEA), caput-collum-diaphyseal (CCD) angle, pelvic obliquity, Tönnis angle, Sharp’s angle, and femoral head coverage. Intraclass correlation coefficients (ICC) and Bland-Altman analyses were obtained. Results. Among 256 hips with AI outputs, all six hip AI measurements were successfully obtained. The AI-reader correlations were generally good (ICC 0.60 to 0.74) to excellent (ICC > 0.75). There was lower agreement for CCD angle measurement. Most widely used measurements for HD diagnosis (LCEA and Tönnis angle) demonstrated good to excellent inter-method reliability (ICC 0.71 to 0.86 and 0.82 to 0.90, respectively). The median reading time for the three readers and AI was 212 (IQR 197 to 230), 131 (IQR 126 to 147), 734 (IQR 690 to 786), and 41 (IQR 38 to 44) seconds, respectively. Conclusion. This study showed that AI-based software demonstrated reliable radiological assessment of patients with HD with significant interpretation-related time savings. Cite this article: Bone Jt Open 2022;3(11):877–884

Premature growth arrests are an infrequent, yet a significant complication of physeal fractures of the distal radius in children and adolescents. Through early diagnosis, it is possible to prevent clinical repercussions of the anatomical and biomechanical alterations of the wrist. Their true incidence has not been well established, and there exists no consensual systematic monitoring plan for minimising its impacts. The main objective was to evaluate the prevalence of growth arrests after a physeal distal radius fracture. The secondary objective was to identify risk factors in order to better guide clinicians for a systematic follow-up. All patients seen between 2014–2016 in a tertiary orthopaedic clinic were retrospectively reviewed. Inclusion criteria were (one) a physeal fracture of the distal radius (two) adequate clinical/radiological follow-up. Descriptive, Chi-square and binary logistic regression analyses were carried out using SPSS software. One hundred ninety patients (mean age: 12 ± 2.8 years) fulfilled the inclusion criteria. Forty percent (n=76) of the fractures were treated by closed reduction. Premature growth arrest was seen in 6.8% (n=13) and diagnosed at a mean of 10 months post trauma. The logistic regression showed that the initial translation percentage (>30%) (p 25) (p increase the risk of growth arrest. After adjusting for concomitant ipsilateral ulnar injuries, a positive association between physeal complications and fracture manipulation was detected (76.9%, p=0.03). A non-significant trend between premature growth arrest and associated ulnar injury was observed (p=0.054). No association was identified for trauma velocity, fracture type, gender and age, and growth complications. A prevalence of 6.8% of growth arrest was found after a physeal fracture of the distal radius. Fractures presenting with an initial coronal translation > 30% and/or angulation > 25 from normal, as well as those treated by manipulation, have been shown to be at risk for a premature growth arrest of the distal radius. This study highlights the importance of a systematic follow-up after a physeal fracture of the distal radius especially for patients with a more displaced fracture who had a closed reduction performed. An optimal follow-up period should be over 10 months to optimize the detection of growth arrest and treat it promptly, thereby minimizing negative clinical consequences

Introduction and Objective. Scaphoid waist fractures (SWF) are notable in upper limb trauma and predominantly occur in young men. Morbidities associated with SWF include fracture non-union, premature arthritis and humpback deformity. Delayed treatment and non-adherence to fracture immobilisation increases likelihood of these complications. There is evidence that men engage in negative health behaviours such as delayed help-seeking. The Scaphoid Waist Internal Fixation for Fractures Trial (SWIFFT) conducted interviews in individuals who had sustained a SWF. Although SWIFFT showed multiple social determinants for the overall injury and healing experience, a key factor this novel study considers is age and sex. This study aimed to analyse interview data from young male participants in SWIFFT to help distinguish the experience of SWF in young men, through exploring the influence of masculinity. Materials and Methods. A purposive sample of 12 young male participants were selected from SWIFFT. These participants were enrolled from a possibility of 13 different centres across Britain. There were 17 semi-structured interviews produced from these participants, and this was thought to be sufficient for data saturation. These interviews were evaluated through deductive thematic analysis with an open-coding approach, with respondents’ experiences being compared against themes documented in men's health literature. The “Braun and Clarke (2006) Six Phases of Thematic Analysis” methodology was adopted to perform this. Results. There were three thematic models developed in the data set, which then were further divided into subthemes. Model 1: Negative Health Behaviour Prior to Treatment, model 2: Feeling Frail and model 3: Need for Speed. Model 1 corroborated that participants were inclined to sustain the injury as a result of risk-taking and would subsequently hesitate to seek treatment. Model 2 indicated that as a result of the injury, respondents were unable to engage in physical activities and activities of daily living. Respondents exercised caution to varying extents after sustaining a SWF. Model 3 highlighted that interviewees were prone to non-adherence with fracture immobilisation and in hindsight resumed employment prematurely. Conclusions. The findings of this study demonstrate that masculinity is significantly influential on the experience of SWF in young men. This was indicated through the results of thematic analysis strongly corresponding with behaviours established in men's health literature. Educational interventions could be of value in addressing behaviours observed in this population group, such as delayed help-seeking and non-compliance with fracture immobilisation. Further work in patient education and concordance with treatment after sustaining a SWF may be beneficial to longer term outcomes. In turn, this may reduce complications associated with SWF in young men

Acetabular morphology and orientation differs from ethnic group to another. Thus, investigating the natural history of the parameters that are used to assess both was a matter of essence. Nevertheless, clarification the picture of normal value in our society was the main aim of this study. However, Acetabular head index (AHI) and center edge angle (CEA) were the most sensitive indicative parameters for acetabular dysplasia. Hence, they were the main variables used in evaluation of acetabular development. A cross-sectional retrospective study that had been done in a tertiary center. Computed tomography abdomen scouts’ radiographs of non-orthopedics patients were included. They had no history of pelvic or hips’ related symptoms or fractures in femur or pelvis. Images’ reports were reviewed to exclude those with tumors in the femur or pelvic bones. A total of 81 patients was included with 51% of them were males. The mean of age was 10.38± 3.96. CEA was measured using Wiberg technique, means of CEA were 33.71±6.53 and 36.50±7.39 for males and females, respectively. Nonetheless, AHI means were 83.81±6.10 and 84.66±4.17 for males and females, respectively. On the other hand, CEA was increasing by a factor 0.26 for each year (3-18, range). In addition, positive significant correlation was detected between CEA and age as found by linear regression r 2 0.460 (f(df1,79) =21.232, P ≤0.0001). Also, Body mass index (BMI) was positively correlated with CEA r 0.410, P 0.004). This study shows that obesity and aging are linked to increased CEA. Each ethnic group has its own normal values that must be studied to avoid premature diagnosis

Although bone morphogenetic protein 2 (BMP-2) has been FDA-approved for spinal fusion for decades, its disadvantages of promoting osteoclast-based bone resorption and suboptimal carrier (absorbable collagen sponge) leading to premature release of the protein limit its clinical applications. Our recent study showed an excellent effect on bone regeneration when BMP-2 and zoledronic acid (ZA) were co-delivered based on a calcium sulphate/hydroxyapatite (CaS/HA) scaffold in a rat critical-size femoral defect model. Therefore, the aim of this study was to evaluate whether local application of BMP-2 and ZA released from a CaS/HA scaffold is favorable for spinal fusion. We hypothesized that CaS/HA mediated controlled co-delivery of rhBMP-2 and ZA could show an improved effect in spinal fusion over BMP-2 alone. 120, 8-week-old male Wistar rats (protocol no. 25-5131/474/38) were randomly divided into six groups in this study (CaS/HA, CaS/HA + BMP-2, CaS/HA + systemic ZA, CaS/HA + local ZA, CaS/HA + BMP-2 + systemic ZA, CaS/HA + BMP-2 + local ZA). A posterolateral spinal fusion at L4 to L5 was performed bilaterally by implanting group-dependent scaffolds. At 3 weeks and 6 weeks, 10 animals per group were euthanized for µCT, histological staining, or mechanical testing. µCT and histological results showed that the CaS/HA + BMP-2 + local ZA group significantly promoted bone regeneration than other treated groups. Biomechanical testing showed breaking force in CaS/HA + BMP + local ZA group was significantly higher than other groups at 6 weeks. In conclusion, the CaS/HA-based biomaterial functionalized with bioactive molecules rhBMP-2 and ZA enhanced bone formation and concomitant spinal fusion outcome. Acknowledgements: Many thanks to Ulrike Heide, Anna-Maria Placht (assistance with surgeries) as well as Suzanne Manthey & Annett Wenke (histology)

Introduction. Osteoarthritis (OA) often results from joint misloading, which affects chondrocyte calcium signaling through mechano-sensitive receptors such as Piezo1, -2, and TRPV4. Activation of Piezo1, especially under inflammatory conditions, can trigger premature chondrocyte apoptosis. Intra-articular glucocorticoid therapy, while beneficial against inflammation and pain in osteoarthritis, may induce oxidative stress and chondrotoxicity at higher doses. This study aims to assess the effects of glucocorticoids, particularly triamcinolone, on chondrocyte elasticity and mechanosignaling. Method. Chondrocytes isolated from articular condyles obtained from patients undergoing knee replacement surgery (n= 5) were cultured for 7 days in triamcinolone acetonide (TA) at different concentrations (0.2µM – 2mM). Cytoskeletal changes were assessed by F-actin labeling. Cell elasticity was measured using atomic force microscopy (AFM). Labeling cells (n=6 patients) with the calcium-sensitive dye (Fluo-4) enabled monitoring changes in intracellular calcium fluorescence intensity during guided single-cell mechanical indentation (500 nN) by AFM. Result. Cell exposure to 2 mM TA led to cell death and crystallization of TA in the cell culture media. However, the concentration of TA for intra-articular application is 46 times higher at 92.1 mM (40 mg/ml). The maximal pharmacological effect on viable cells was observed at 0.2 mM. AFM results showed a significant decrease of elasticity (p<0.001), alongside significantly higher calcium intensities both prior to and during mechanical stimulation in the TA-treated samples (p<0.05). Conclusion. Administration of TA significantly impacts the mechanical properties of chondrocytes, reducing cellular elasticity while simultaneously enhancing calcium-dependent mechanosensitivity. This data suggests a correlation between glucocorticoid-induced changes in cell elasticity and cell mechanosensitivity. Finding ways to minimize the effect of glucocorticoids on cell mechanosensitivity could help to make future therapies safer and reduce side effects