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Aims. Slipped capital femoral epiphysis (SCFE) is one of the most common hip diseases of adolescence that can cause marked disability, yet there is little robust evidence to guide treatment. Fundamental aspects of the disease, such as frequency, are unknown and consequently the desire of clinicians to undertake robust intervention studies is somewhat prohibited by a lack of fundamental knowledge. Methods. The study is an anonymized nationwide comprehensive cohort study with nested consented within the mechanism of the British Orthopaedic Surgery Surveillance (BOSS) Study. All relevant hospitals treating SCFE in England, Scotland, and Wales will contribute anonymized case details. Potential missing cases will be cross-checked against two independent external sources of data (the national administrative data and independent trainee data). Patients will be invited to enrich the data collected by supplementing anonymized case data with patient-reported outcome measures. In line with recommendations of the IDEAL Collaboration, the study will primarily seek to determine incidence, describe case mix and variations in surgical interventions, and explore the relationships between baseline factors (patients and types of interventions) and two-year outcomes. Discussion. This is the first disease to be investigated using the BOSS Study infrastructure. It provides a robust method to determine the disease frequency, and a large unbiased sample of cases from which treatment strategies can be investigated. It may form the basis for definitive robust intervention studies or, where these are demonstrated not to be feasible, this may be the most robust cohort study


The Bone & Joint Journal
Vol. 104-B, Issue 4 | Pages 519 - 528
1 Apr 2022
Perry DC Arch B Appelbe D Francis P Craven J Monsell FP Williamson P Knight M

Aims

The aim of this study was to inform the epidemiology and treatment of slipped capital femoral epiphysis (SCFE).

Methods

This was an anonymized comprehensive cohort study, with a nested consented cohort, following the the Idea, Development, Exploration, Assessment, Long-term study (IDEAL) framework. A total of 143 of 144 hospitals treating SCFE in Great Britain participated over an 18-month period. Patients were cross-checked against national administrative data and potential missing patients were identified. Clinician-reported outcomes were collected until two years. Patient-reported outcome measures (PROMs) were collected for a subset of participants.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 596 - 596
1 Oct 2010
Krizancic M Drobnic M Strazar K Zupanc O
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Background: Slipped capital femoral epiphysis (SCFE) is an important orthopaedic problem which emerges in early adolescence. Not clearly identified factors in the growth zone of proximal femur produce slip in which the femoral head remains in the acetabulum and femoral shaft rotates outwards and backwards. This occurs usually in one but occasionally in both hips. As we assumed that in Department of orthopaedic surgery in Ljubljana half of Slovenian adolescent population with SCFE was treated, we could calculate epidemiological data for SCFE for whole Slovenian population. Patients and Methods: In retrospectively study we analysed patients treated operatively at Department of orthopaedic surgery in Ljubljana between 1.1.1970 and 31.12.2006. The data about sex, age and side of the slips were collected. We calculated average age at occurance, ratio boys to girls, and predominance of left or right side. For determination of SCFE incidence in Slovenia, we used the attack rate method which is the sum of annual incidences of SCFE in age interval when the slips occur calculated for each one-year group. Results: There were 224 patients, 126 boys and 98 girls presenting with SCFE between 1970 and 2006 treated in Department of orthopaedic surgery in Ljubljana. The average age of boys was 12.9 and the age of girls 11.6 years (range: 8–16 years). On the average the age was 11.3 years. Slipped capital femoral epiphysis appeared more frequently on the left side (58%) than on the right side (31%). In 11% of cases the slips were bilateral. Incidence per 1000 adolescents extrapolated to Slovenian population (attack rate method) was 0,796 ‰ for boys, 0,667 ‰ for girls and 0,734 ‰ for entire endangered population. Yearly incidence of SCFE was thus 0,089 ‰ for boys and 0,073 ‰ for girls. Discussion: Epidemiological data for SCFE in Slovenia are comparable to those found in Sweden and is difficult to compare with other countries, where different statistical methods were used. Risk of getting SCFE in critical period for boys is 1:1265 and for girls: 1:1499. Risk for whole critical population is 1:1362. It is interesting that our study showed marked increase in the number of boys with SCFE in recent years. Boys to girls ratio has changed from 1:1 in years 1970 to 1994 (Zupanc in sod. 2002) to 1,29:1 in our study


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_8 | Pages 19 - 19
1 Aug 2020
Morash K Gauthier L Orlik B El-Hawary R Logan K
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Slipped capital femoral epiphysis (SCFE) is traditionally treated with in situ fixation using a threaded screw, leading to physeal arrest while stabilizing the femoral head. Recently, there has been interest in alternative methods of fixation for SCFE, aiming to allow growth and remodelling of the femoral neck postoperatively. One such option is the Free Gliding SCFE Screw (Pega Medical), which employs a telescopic design intended to avoid physeal compression. The objective of this study is to evaluate radiographic changes of the proximal femur following in situ fixation using the Free Gliding SCFE Screw. This study retrospectively evaluated 28 hips in 14 consecutive patients who underwent in situ hip fixation using the Free Gliding SCFE Screw between 2014 and 2018. Initial postoperative radiographs were compared to last available follow-up imaging. Radiographic assessment included screw length, articulotrochanteric distance (ATD), posterior sloping angle (PSA), alpha angle, head-neck offset (HNO) and head-shaft angle (HSA). Of the 28 hips reviewed, 17 were treated for SCFE and an additional 11 treated prophylactically. Average age at surgery was 11.7 years, with an average follow-up of 1.44 years. Screw length increased by 2.3 mm (p < 0.001). ATD decreased from 25.4 to 22.2 mm (p < 0.001). Alpha angle decreased from 68.7 to 59.8 degrees (p = 0.004). There was a trend towards an increase in HNO (p = 0.07). There was no significant change in PSA or HAS. There were three complications (two patients with retained broken guide wires, and one patient requiring screw removal for hip pain). With use of the Free Gliding SCFE Screw, there was evidence of screw expansion and femoral neck remodelling with short-term follow-up. More research is required to determine the long-term impact of these changes on hip function, and to aid in patient selection for this technology


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_5 | Pages 10 - 10
1 Jul 2020
Saito M Kuroda Y Khanduja V
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Background. Slipped capital femoral epiphysis (SCFE) creates a complex deformity of the hip that can result in cam type of femoroacetabular impingement (FAI), which may in turn lead to the early development of osteoarthritis of the hip. The purpose of this study was to evaluate the existing literature reporting on the efficacy of hip arthroscopic treatment of patients with FAI secondary to SCFE. Methods. A systematic computer search was conducted based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines using Embase, PubMed (Medline), and Cochrane Library up to November 2019. Data such as patient demographics, surgical outcomes and complications that described arthroscopic surgery following FAI secondary to SCFE were retrieved from eligible studies. Two authors independently reviewed study inclusion and data extraction with independent verification. Results. Following filtration, seven studies were included in this review comprising 96 patients (100 hips). The mean age was 14.9 years (SD, 2.7), and 54.2% of the cases were male. Eighty seven percent patients had undergone previous procedures at the first diagnosis of SCFE. Slip severity at the time of performing hip arthroscopy was mild for 54%, moderate for 31% and severe deformity for 15%. The mean alpha angle corrections was 32.0° (SD, 6.0°), and the mean improvement of internal rotation angle at 90° flexion was 23.6° (sd, 9.5°). ModifiedHarris Hip Scores (mHHS) was most reported (n = 3 studies; 38 hips) of the clinical outcomes, and the mean improvement of mHHS was 22.0 (sd, 3.6). Complication rates were 10%, and revision rate was 6.0%. Conclusion. Patients with FAI secondary to SCFE undergoing arthroscopic treatment demonstrate improved improvement in clinical outcome, rotation of the hip and correction of the alpha angle. It remains to be seen whether this eventually leads to prevention of OA and avoiding arthroplasty in this group of patients


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_1 | Pages 79 - 79
1 Jan 2018
Maranho D Davila A Novais E Kim Y Millis M
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Slipped capital femoral epiphysis (SCFE) is associated with a spectrum of proximal femoral deformity and femoroacetabular impingement (FAI). Little attention has been given, however, to the possible effect of SCFE on remaining hip growth. Our observation that some acetabula in hips with SCFE have various dysmorphology led us to evaluate the growth of the hip in our patients with SCFE. We performed an IRB-approved retrospective study of our intramural SCFE database which identified 108 hips with unilateral SCFE, at least 2 years of radiographic followup, and closure of triradiate cartilage, greater trochanter and proximal femoral physis. The contralateral non-SCFE hip was used as control. Average age at presentation was 12.3 y. 49 patients were male, 59 female. Statistically significant differences were noted between SCFE and control hip both at both presentation and last followup(FU): Mean LCEA lower in SCFE hip at presentation by 0.97 degree; increasing to 4.36 degrees at last FU(p<0.0001). No difference noted in mean Tonnis roof angle at presentation, but at last FU SCFE hips had mean roof angle difference of 3.2 degrees higher than control(p<.0001). In some of our SCFE patients, acetabular deformity has impacted treatment. Ongoing studies may clarify risk factors for the development of problematic acetabular deformity associated with SCFE and perhaps allow prevention of secondary acetabular deformity


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_11 | Pages 2 - 2
1 Jun 2017
Herngren B Stenmarker M Vavruch L Hagglund G
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Purpose. Slipped capital femoral epiphysis (SCFE) is the most common hip disorder in children 9–15 years old. The epidemiology for SCFE in the total population of Sweden has not yet been described. Methods. In a prospective cohort study, we analysed pre- and postoperative radiographs and medical records for all children treated for SCFE in Sweden 2007–2013, and noted demographic data, severity of slip, and surgical procedures performed. Results. We identified 379 Swedish children with primary SCFE 2007–2013; 162 girls, median age 12 (7–15) years, and 217 boys, median age 13 (4–17) years. The cumulative incidence was 45.8/100 000 for girls and 58.2/100 000 for boys. As an initial symptom, 66% of the children had hip/groin pain and 12% knee pain. At first presentation, 7% of the children had bilateral SCFE. Prophylactic fixation was performed in 43% . Of the remaining children, 21% later developed a contralateral slip. Fixation with implants permitting further growth of the femoral neck was used in 90% of the children. Femoral neck osteotomy was performed for 11 hips. Of 34 treating hospitals, only three treated > 3 children with SCFE annually. Conclusions. The cumulative incidence 2007–2013 in the total population in Sweden showed a mild increase for girls. The male-to-female ratio was lower than previously described for Sweden. Prophylactic fixation was performed in 43% of the children. Fixation with an implant that allows further growth was used for 90% of the children. Most hospitals in Sweden treat < 2 children annually


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 599 - 599
1 Oct 2010
Solayar G Dodds M Mulhall K
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Slipped capital femoral epiphysis (SCFE) is the most common hip disorder in adolescents and its incidence is on the increase. Obesity is purported to be a significant risk factor in the pathogenesis of this condition. Measurements for weight and BMI’s are good techniques in identifying children at risk and those who are obese. In this retrospective review, we provide clear evidence of a relationship between SCFE and obesity based on weight-to-age percentiles. 64 patients with radiologically diagnosed SCFE were compared with 88 controls without histories of hip pathology. In the SCFE group, 45.3% were above the 95th percentile as opposed to 12.1% in the control group (P=< 0.0001). In addition, the obesity risk group (85–95th percentile) numbers were much higher in the SCFE group (15.6%) compared to controls (7.7%) (P=< 0.0001). Obesity is a modifiable risk factor in most cases and thus, identifying children at risk using weight-to-age percentile charts correcting for gender is potentially beneficial in reducing the incidence of SCFE


Bone & Joint Research
Vol. 6, Issue 8 | Pages 472 - 480
1 Aug 2017
Oduwole KO de SA D Kay J Findakli F Duong A Simunovic N Yen Y Ayeni OR

Objectives

The purpose of this study was to evaluate the existing literature from 2005 to 2016 reporting on the efficacy of surgical management of patients with femoroacetabular impingement (FAI) secondary to slipped capital femoral epiphysis (SCFE).

Methods

The electronic databases MEDLINE, EMBASE, and PubMed were searched and screened in duplicate. Data such as patient demographics, surgical technique, surgical outcomes and complications were retrieved from eligible studies.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 10 - 11
1 Mar 2010
Scharschmidt T Weiner D Jacquet R Lowder E Schrickel T Landis W
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Purpose: Slipped capital femoral epiphysis (SCFE) is a poorly understood condition impacting adolescents. Its consequences can be severe, even where there is early recognition and treatment is implemented. Prior studies have suggested that the etiology may be related to abnormal collagen comprising the growth plate cartilage, but no investigations have analyzed collagen or other structural proteins on a molecular level in the affected tissue. This study evaluates expression of mRNA for key structural proteins obtained from growth plate chondrocytes of patients suffering SCFE. Method: The work utilizes laser capture microdissection (LCM) techniques followed by reverse transcription polymerase chain reaction (RT-PCR) to determine if a change or abnormality in type II collagen and/or aggrecan gene expression may be involved in weakening the physis, a characteristic of the pathology. With these techniques, correlation of chondrocyte spatial location and gene expression can be made to provide greater insight into this pathology and a more complete understanding of growth plate biology in general. Results: Downregulation of both type II collagen and aggrecan was found in the growth plates of SCFE subjects when compared to age-matched controls. Expression levels for type II collagen mRNA of SCFE patients were less than 14% of their counterpart controls. SCFE aggrecan levels averaged only 26% of control expression. Conclusion: The significant decreases in type II collagen and aggrecan expression would drastically affect the quantity, distribution, and organization of both components in SCFE growth plates. Such abnormal changes may contribute to the cause of a slip although possibly they may be the result of a slip. This is the first study using novel LCM and RT-PCR to determine specific gene expression levels for two principal structural proteins comprising the growth plates of human subjects suffering SCFE


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 318 - 318
1 Jul 2008
Shah G Singer G
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Introduction: Metal on metal hip resurfacing is a bone conserving procedure with excellent medium term results. A retrospective audit of 150 consecutive Birmingham Hip resurfacings, performed by a single surgeon at a DGH was carried out. Materials and Methods: We report 150 hip resurfacings implanted between June 2001 to June 2004. There were 99 male and 51 female hips. The mean age was 50.7 years (38–75years). Range of follow up was 6 months to 45 months (average 20.1 months). Pre operative diagnosis was Osteoarthritis (n=135), osteonecrosis(n=8),traumatic(n=2),dysplasia(n=3),Slipped capital femoral epiphysis (n=1) and ankylosing spondylitis (n=1). Al hips were implanted via the posterior approach. Clinical assessment, by postal questionnaire, was by pre and post-operative Oxford Hip scores (OHS) and X-rays were reviewed. Results: Range of follow up was 6 months to 42 months (average 20.1 months). No patient was lost to follow up. The mean pre operative Oxford hip score was 41 (r=27–56). The score was 15.1 (r=12–29) at the time of questionnaire. Complications included: One femoral neck fracture at 3 months requiring revision to a stemmed “big ball” THR, one deep infection requiring early wash out with salvage of the hip prosthesis, (both the patients are now doing well. OHS 13 and 15 respectively) and one asymptomatic stress fracture of femoral neck, which healed without intervention (OHS 12). There was one dislocation in a neuropathic hip requiring bracing. (OHS 29). There was one retained alignment pin needing removal. Otherwise patients were highly satisfied with the operation with excellent function and Hip scores. Conclusion: Our study has demonstrated that, in the short term and in young age group, this prosthesis gives excellent functional results, with an acceptably low complication rate. Long term surveillance of these patients will provide further data to compare our results with specialist centres


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 244 - 245
1 May 2009
Davidson D Anis A Brauer C Mulpuri K
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Slipped capital femoral epiphysis (SCFE) is the most common pediatric hip disorder. The most devastating complication is development of avascular necrosis of the femoral head. In order to reduce the potential for this complication occurring following delayed contralateral SCFE, there has been consideration in the literature of prophylactic pinning of the contralateral hip. The objective of this study was to determine the cost-effectiveness of this treatment strategy. The outcome probabilities and utilities utilised in a decision analysis of prophylactic pinning of the contralateral hip in SCFE, reported by Kocher et al, were used in this study. Costing data, reported in 2005 Canadian dollars, was obtained from our institution. Using this data, an economic evaluation was performed. The time horizon was four years, so as to follow the adolescents to skeletal maturity. Discounting was performed at 3% per year. Sensitivity analyses were conducted to determine the effect of variation of the outcome probabilities and utilities. In all analyses, prophylactic pinning resulted in cost savings but lower utility, compared to the currently accepted strategy of observation of the contralateral hip. The results were most sensitive to an increase in the probability of a delayed contralateral SCFE to 27%. Using the base case analysis, the incremental cost-effectiveness ratio was $7856.12 per utility gained. Using the most sensitive probability of a delayed contralateral SCFE of 27%, the incremental cost-effectiveness ratio was $27,252.92 per utility gained. The results of this study demonstrated overall cost savings with prophylactic treatment, however the utility was lower than the standard treatment of observation. For both the base case and sensitivity analysis, the incremental cost-effectiveness ratio was less than the accepted threshold of $50,000 per quality adjusted life year gained. It should be noted that the use of a four year time horizon excluded consideration of the costs related to total hip arthroplasty for the sequelae of AVN. A prospective, randomised controlled trial, with an accompanying economic evaluation, is required to definitively answer the question of the cost-effectiveness of this treatment. On the basis of this cost-effectiveness analysis, prophylactic pinning of the contralateral hip in SCFE cannot be recommended. A prospective, randomised controlled trial, with an accompanying economic evaluation, is required to definitively answer the question of the cost-effectiveness of this treatment


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 597 - 597
1 Oct 2010
Mavcic B Antolic V Iglic A Kralj-Iglic V Krizancic M Zupanc O
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Slipped capital femoral epiphysis is an important orthopaedic problem of early adolescence. Many hypotheses about its etiology have been proposed; still the underlying mechanisms are not clearly understood. The aim of our paper is to examine radiographic characteristics of hips at risk for slipped capital epiphysis. Two groups of hips were compared: a group of 100 asymptomatic hips contralateral to the slipped ones and a group of 70 age- and gender-matched healthy hips. The hips contralateral to the slipped ones were assumed to have identical morphology to the preslip-page morphology of the slipped hips. In each hip the following radiographic parameters were measured: the inter-hip distance, the femoral neck length/width, the pelvic height, the pelvic width, the femoral head radius, the coordinates of the abductor muscles trochanteric attachment, the inclination of the femoral epiphyseal growth plate, the femoral neck-shaft angle and the Wiberg center-edge angle. Subjects with hips at risk for slipping had significantly higher body weight (590 vs. 500 N; p < 0.001), larger diameter of the femoral neck (38.6 vs 37.3 mm; p = 0.027), higher (138.9 vs. 134.6 mm; p = 0.022) and wider pelvis (53.8 vs. 48.7 mm; p < 0.001) and more laterally placed abductor muscles trochanteric attachment. There were no significant differences in the inter-hip distance, the femoral head radius, the femoral neck length and the femoral neck-shaft angle angle. Hips contralateral to the slipped ones had a more vertically inclined physeal angle (55.4 vs. 63.2 degrees; p < 0.001) in comparison to the healthy hips. The Wiberg centre-edge angle of the hips contralateral to the slipped ones was on average 7% larger from the healthy group (34.7 vs. 32.2 degrees; p = 0.003). Children with hips at risk for slipping had larger pelvices and femora with more vertically inclined femoral epiphyseal growth plate. In addition, one cannot overlook the significant difference in the body weight between the age- and gender-matched groups of our study, confirming previous findings on the role of body weight in SCFE. It is therefore possible that anatomical changes may be a downstream effect of bone remodelling caused by altered loading during growth and development. This may suggest that the predisposition of the hip to slipping occurs earlier in the patient’s lifetime and that targeted radiographic examinations in obese individuals could reveal changes in pelvic geometry even before adolescence. Considering the high rates of bilateral involvement, our results could be used to predict the need for preventive fixation of asymptomatic hips after the capital femoral epiphysis has slipped in the contralateral hip


Bone & Joint Open
Vol. 4, Issue 6 | Pages 408 - 415
1 Jun 2023
Ramkumar PN Shaikh HJF Woo JJ Haeberle HS Pang M Brooks PJ

Aims

The aims of the study were to report for a cohort aged younger than 40 years: 1) indications for HRA; 2) patient-reported outcomes in terms of the modified Harris Hip Score (HHS); 3) dislocation rate; and 4) revision rate.

Methods

This retrospective analysis identified 267 hips from 224 patients who underwent an hip resurfacing arthroplasty (HRA) from a single fellowship-trained surgeon using the direct lateral approach between 2007 and 2019. Inclusion criteria was minimum two-year follow-up, and age younger than 40 years. Patients were followed using a prospectively maintained institutional database.


Bone & Joint Open
Vol. 2, Issue 12 | Pages 1089 - 1095
21 Dec 2021
Luo W Ali MS Limb R Cornforth C Perry DC

Aims

The Patient-Reported Outcomes Measurement Information System (PROMIS) has demonstrated faster administration, lower burden of data capture and reduced floor and ceiling effects compared to traditional Patient Reported Outcomes Measurements (PROMs). We investigated the suitability of PROMIS Mobility score in assessing physical function in the sequelae of childhood hip disease.

Methods

In all, 266 adolscents (aged ≥ 12 years) and adults were identified with a prior diagnosis of childhood hip disease (either Perthes’ disease (n = 232 (87.2%)) or Slipped Capital Femoral Epiphysis (n = 34 (12.8%)) with a mean age of 27.73 years (SD 12.24). Participants completed the PROMIS Mobility Computer Adaptive Test, the Non-Arthritic Hip Score (NAHS), EuroQol five-dimension five-level questionnaire, and the Numeric Pain Rating Scale. We investigated the correlation between the PROMIS Mobility and other tools to assess use in this population and any clustering of outcome scores.


Bone & Joint 360
Vol. 8, Issue 5 | Pages 40 - 41
1 Oct 2019


Bone & Joint 360
Vol. 1, Issue 4 | Pages 29 - 31
1 Aug 2012

The August 2012 Children’s orthopaedics Roundup360 looks at: whether 3D-CT gives a better idea of coverage than plain radiographs; forearm fractures after trampolining accidents; forearm fractures and the Rush pin; the fractured distal radius; elastic stable intramedullary nailing for long-bone fractures; aponeurotic recession for the equinus foot; the torn medial patellofemoral ligament and the adductor tubercle; slipped capital femoral epiphysis; paediatric wrist arthroscopy; and Pirani scores and clubfoot.


Bone & Joint Research
Vol. 1, Issue 10 | Pages 245 - 257
1 Oct 2012
Tibor LM Leunig M

Femoroacetabular impingement (FAI) causes pain and chondrolabral damage via mechanical overload during movement of the hip. It is caused by many different types of pathoanatomy, including the cam ‘bump’, decreased head–neck offset, acetabular retroversion, global acetabular overcoverage, prominent anterior–inferior iliac spine, slipped capital femoral epiphysis, and the sequelae of childhood Perthes’ disease.

Both evolutionary and developmental factors may cause FAI. Prevalence studies show that anatomic variations that cause FAI are common in the asymptomatic population. Young athletes may be predisposed to FAI because of the stress on the physis during development. Other factors, including the soft tissues, may also influence symptoms and chondrolabral damage.

FAI and the resultant chondrolabral pathology are often treated arthroscopically. Although the results are favourable, morphologies can be complex, patient expectations are high and the surgery is challenging. The long-term outcomes of hip arthroscopy are still forthcoming and it is unknown if treatment of FAI will prevent arthrosis.