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Bone & Joint Research
Vol. 6, Issue 10 | Pages 584 - 589
1 Oct 2017
den Teuling J Pauwels B Janssen L Wyers C Janzing HMJ van den Bergh J Morrenhof JW

Objectives. The goal of this study is to investigate the relation between indicators of osteoporosis (i.e., bone mineral density (BMD), and Cortical Index (CI)) and the complexity of a fracture of the proximal humerus as a result of a low-energy trauma. Methods. A retrospective chart review of 168 patients (mean age 67.2 years, range 51 to 88.7) with a fracture of the proximal humerus between 2007 and 2011, whose BMD was assessed at the Fracture Liaison Service with Dual Energy X-ray Absorptiometry (DXA) measurements of the hip, femoral neck (FN) and/or lumbar spine (LS), and whose CI and complexity of fracture were assessed on plain anteroposterior radiographs of the proximal humerus. Results. No significant differences were found between simple and complex fractures of the proximal humerus in the BMD of the hip, FN or LS (all p > 0.3) or in the CI (p = 0.14). Only the body mass index was significantly higher in patients with a complex fracture compared with those with a simple fracture (26.9 vs 25.2; p = 0.05). Conclusion. There was no difference in BMD of the hip, FN, LS or CI of the proximal humerus in simple compared with complex fractures of the proximal humerus after a low-energy trauma. Factors other than the BMD and CI, for example body mass index, may play a more important role in the complexity of this fracture. Cite this article: J.W.A.M. den Teuling, B.S. Pauwels, L. Janssen, C.E. Wyers, H. M. J. Janzing, J.P.W. van den Bergh, J. W. Morrenhof. The Influence of bone mineral density and cortical index on the complexity of fractures of the proximal humerus. Bone Joint Res 2017;6:584–589. DOI: 10.1302/2046-3758.610.BJR-2017-0080


Abstract. Reverse shoulder arthroplasty (RSA) is being increasingly used for complex, displaced fractures of the proximal humerus. The main goal of the current study was to evaluate the functional and radiographic results after primary RSA of three or four-part fractures of the proximal humerus in elderly patients. Between 2012 and 2020, 70 consecutive patients with a recent three- or four-part fracture of the proximal humerus were treated with an RSA. There were 41 women and 29 men, with a mean age of 76 years. The dominant arm was involved in 42 patients (60%). All surgeries were carried out within 21 days. Displaced three-part fracture sustained in 16 patients, 24 had fracture dislocation and 30 sustained a four-part fracture of the proximal humerus. Patients were followed up for a mean of 26 months. The mean postoperative OSS at the end of the follow-up period was 32.4. The mean DASH score was 44.3. Tuberosity non-union occurred in 18 patients (12.6%), malunion in 7 patients (4.9%), heterotopic ossification in 4 patients (2.8%) and scapular notching in one patient. Anatomical reconstruction was achieved in 25 patients (17.5%), the influence of greater tuberosity healing on shoulder function could not be demonstrated. Heterotopic ossification seems to affect OSS and QDASH, we found statistically significant relation between HO and clinical outcomes. Patients with heterotopic ossification had significantly lower postoperative scores on DASH and OSS (P = .0527). Despite expecting good functional outcome with low complication rate after RSA, the functional outcome was irrespective of healing of the tuberosities


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 91 - 91
1 Mar 2008
Guy P Stone J McCormack R O’Brien P
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We reviewed the results of sixteen patients with three and four part proximal humerus fractures treated with the Locking Proximal Humerus Plate (LPHP) in two trauma centres. All fractures were radiographically healed by six weeks. We found a high rate of fixation failure 4/16 cases within two weeks of surgery and range of motion results similar to previously reported techniques. This device has not demonstrated its clear superiority when used in trauma centres which commonly treat proximal humerus fractures. A randomised control trial comparing it to classical techniques and using outcome-based measures would seem appropriate. Proximal humerus fractures with poor functional outcomes are expected to increase in frequency owing to an active ageing population. New angle stable devices have been developed to address the frequently associated osteoporosis and loss of fixation. This study reviews the early experience of fixation with an angle stable device, the LPHP (Synthes Canada). Three and four part fractures treated with the LPHP were identified from the database of two trauma centres. Demographics, patient activity level, mechanism of injury, fracture type were collected. Early complications, maintenance of reduction, and ROM were reviewed. Sixteen fractures treated with the LPHP. Male to female ratio was 1.3:1. Mean age was 51.5 (29–77) Activity: 12/16 sedentary, 4/16 manual labourers. Mechanism: four Low and twelve High-energy injuries. Fracture classification: Five three part, and Eleven four part fractures. Early complications: one wound haematoma,one re-operation for intra-articular hardware, and four of sixteen pts pulled off the greater tuberosity fixation within two weeks of surgery. Union was achieved in all sixteen by six weeks. The mean forward elevation was 60° at six weeks and 80° at three months. This review of the early experience with the LPHP shows a significant rate of fixation failure (4/16 cases) and functional ROM results similar to other previously described techniques. Although a “learning curve effect” is possible, this device has not demonstrated clear superiority with surgeons who commonly treat proximal humerus fractures. A randomised control trial comparing it to classical techniques would seem appropriate


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_11 | Pages 4 - 4
1 Nov 2022
Adapa A Shetty S Kumar A Pai S
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Abstract. Background. Fractures Proximal humerus account for nearly 10 % of geriatric fractures. The treatment options varies. There is no consensus regarding the optimal treatment, with almost all modalities giving functionally poor outcomes. Hence literature recommends conservative management over surgical options. MULTILOC nail with its design seems to be a promising tool in treating these fractures. We hereby report our early experience in the treatment of 37 elderly patients. Objectives. To evaluate the radiological outcome with regards to union, collapse, screw back out/cut through, implant failures, Greater tuberosity migration. To evaluate the functional outcome at the end of 6 months using Constant score. Study Design & Methods. All patients aged >65 years who underwent surgery for 3,4-part fracture proximal humerus using the MULTILOC nail were included in the study after consent. Pre – existing rotator cuff disease were excluded. Within the time frame, a total of 39 patients underwent the said surgery. 2 patients were lost to follow up. All the measurements were taken at the end of 6 months and results tabulated and analysed. Results. Union was achieved in all the 37 patients. There were no varus collapse or screw backout/cut through seen in any of the patients. There was Greater tuberosity migration in 1 patient who underwent revision surgery at 6 weeks. All the patients got a minimum of 70 degrees of abduction and forward flexion. We had 29 excellent, 6 good, 2 fair and none poor results as per Constant scoring system. Study done in Tejasvini Hospital & SSIOT Mangaluru India


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_1 | Pages 23 - 23
1 Jan 2017
Inyang A Dey R Mutsvangwa T Roche S Sivarasu S
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The morphology of the proximal part of the humerus varies largely. Morphometric features characterizing the three-dimensional geometry of the proximal humerus have revealed a wide difference within individuals. These parameters include head size, radius of curvature, inclination angle, retroversion angle, offsets and neck-shaft angle. Different implant designs have been adapted so as to make provision for these anatomical variations. However, the optimal design criteria are yet to be established. Implant design is one of the main factors determining the success of Total Shoulder Arthroplasty (TSA) since slight modifications in the implant anatomy could have significant biomechanical effects. Therefore, this study investigates the three-dimensional morphometric parameters of the South African proximal humerus which will serve as a basis for designing a new Total Shoulder Prosthesis for the South African population. Sixteen South African (SA) fresh cadaveric humeri (8 left, 8 right; 8 paired) were used in this study. The data consisted of 6 men and 2 women with ages ranging from 32 to 55 years (43.13 ±8.51). The humeri were scanned using a Computer Tomography (CT) scanner. The Digital Imaging and Communications in Medicine (DICOM) files from the CT data were imported into medical modelling software, MIMICS for reconstruction. The 3D reconstructed model of the humeri as an STL file was used for further processing. The STL data were generated as a cloud of points in a CAD software, SolidWorks. These were then remodeled by defining the detailed Referential Geometric Entities (RGEs) describing the anatomical characteristics. Anatomical reference points were defined for the anatomical neck plane, the epiphyseal sphere and the metaphyseal cylinder. Also, axes were defined which comprises of the humeral head axis and the metaphyseal axis. Thereafter, the posterior offsets medial offsets and the inclination angles were measured based on the RGEs. The posterior offset varied from 0.07 mm to 2.87 mm (mean 1.20 mm), the medial offset varied from 4.40 mm to 8.45 mm (mean 6.50 mm) while the inclination angle varied from 114.00º to 133.87º (mean 121.05º). The outcome of the study showed that the shape and dimensions of the proximal humerus varies distinctively. The articular surface is not a perfect sphere and differs independently with respect to the inclination angles. In addition, variations were noticeable in the medial and lateral offsets. The morphometric data on the African shoulder is very limited and this study will significantly contribute to the shoulder data repository for the SA population. The morphometric parameters measured in this study will be useful in designing a South African shoulder prosthesis that mimics the native shoulder hence eliminating post-surgical complications


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 221 - 221
1 Mar 2010
Rosenfeldt M French J Gray D Flint M
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The proximal humerus is the third most common site for primary sarcoma of bone. Since the 1970’s the treatment of primary bone sarcoma has changed from amputation to limb salvage. This has been due to advances in chemotherapy, imaging and surgical techniques. The literature has shown that the survival after limb salvage is similar to that of amputation. The optimum method of reconstruction of the shoulder remains controversial. The aim of our study was to review the cases of primary bone sarcoma of the proximal humerus treated at Middlemore Hospital. The New Zealand Bone Tumour Registry was searched for all lesions of the proximal humerus, with the diagnosis of chondrosarcoma, Ewing’s sarcoma or osteosarcoma. These records were reviewed for presentation status, biopsy, and type of reconstruct ion, chemotherapy, complications and recurrence. Outcomes measured in months of disease free survival and overall survival. The Bone Tumour Registry identified 29 patients who were treated at Middlemore Hospital with the primary diagnosis of Ewing’s sarcoma, chondrosarcoma or osteosarcoma of the proximal humerus. Results were available for 26 of the 29 patients (90% follow-up). Of these 29 patients six had chondrosarcoma, four Ewing’s sarcoma and 19 osteosarcoma. The patients with chondrosarcoma had an average age of 50 years. three patients were treated with endoprosthesis (mean survival 48 months) and one with vascularised fibula reconstruction (status 27 months ANED). Of the four patients with Ewing’s sarcoma, two had surgical reconstruction, one with intercalary allograft reconstruction (status 96 months ANED) and one with endoprosthesis (status 84 months ANED). The 19 patients with osteosarcoma had an average age 27 years, 15 patients were treated surgically. Three had endoprosthetic reconstruction (mean survival 29 months), two allograft prosthetic composite reconstruction (mean survival 23 months), three vascularised fibula reconstruction (mean survival 217 months), one total shoulder replacement and proximal humeral autograft (status 68 months ANED), one hemiarthroplasty (status 21 months DOD) and one proximal humeral allograft (status 31 months ANED). 4 patients were treated with primary amputation (mean survival 55.25 months). The mean overall survival for limb salvage surgery in our institution is 74 months compared to 55.25 months for amputation; this is consistent with the published literature. Function of a salvaged upper limb is superior to amputation. A salvaged limb is socially and emotionally more acceptable for patients than amputation. Limb salvage remains the priority in the treatment of primary bone tumours of the proximal humerus


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 380 - 380
1 Sep 2005
Volpin G Shtarker H Kaushanski A Shachar R Daniel M
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Introduction: The treatment of fractures of the proximal humerus is still controversial. Conservative treatment may result in severe disability due to malunion and shoulder stiffness. Open reduction and rigid fixation requires extensive soft tissue exposure, which may results in a high incidence of avascular necrosis of the proximal humerus. We present our experience with “minimal invasive” surgical techniques of such fractures. Materials & Methods: This study consists of 128 Pts. (52 M, 76 F, 18–84 year old, mean 53.5Y) followed for 2–7 years (mean 3.5Y), treated by closed reduction and percutaneous pinning (55), by ORIF and minimal osteosynthesis by screws (27), by ORIF with rigid plates (7), and by hemiarthroplasty of the proximal humerus (39). Patients were evaluated by the Neer’s shoulder grading score and radiographs. Results: Overall results were excellent and good in 85% of patients with 2, and 3 parts fractures of the proximal humerus treated by “minimal invasive” fixation techniques, with some better results in less comminuted fractures. 9/14 young patients with 4 part fractures had good functional results. The other 5 patients had poor results and 3 of them developed AVN of the humeral head. 75% of the patients treated by hemiarthroplasty had satisfactory results. They were almost free of pain, but most of them had only a moderate improvement in shoulder motion. Discussion: Based on this study it seems that “minimal osteosynthesis” by K.W. techniques, lag screws or rush pins, by closed or open reduction, remains as the first optional treatment of complex fractures of the shoulder, even in young patients with a 4 part fracture. In the elderly, hemiarthroplasty should be considered in such pathology as the treatment of choice


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XIV | Pages 34 - 34
1 Apr 2012
Lehner B Depeweg D Egermann M Raiss P
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Aim. The aim of this study was to analyze our results using a modular endoprosthetic replacement system (MUTARS) for bone tumours of the proximal humerus. Methods. Thirty-nine patients were treated with a MUTARS endoprosthesis of the proximal humerus. Mean follow-up was 38 months (3-138 months). Most operations were necessitated by metastasis (n=30); surgery for a primary tumour (n=9) was less frequent. The Enneking score and the active ranges of motion for shoulder flexion, abduction, and external rotation were recorded. Complete refixation of the rotator cuff was possible in 23 cases. Radiographs also were obtained. Results. Patient survival was 77% at 2 years and 45% at 11.5 years after surgery. The survival rate of the limb was 90% at 11.5 years. The mean Enneking score was 19 points (range 7-27 points). The mean shoulder flexion was 34 degrees (range 0-90 degrees), abduction 33 degrees (range 0-90 degrees), and external rotation 12 degrees (range 10-50 degrees). Patients with a complete rotator cuff repair showed a significant better range of motion compared to patients with a partial or no repair (p<0.015). No signs of implant loosening were observed on postoperative radiographs. Seven complications occurred, five of them leading to implant revision. At 11.5 years after surgery, the survival rate for the whole cohort without complications was 72%, without revision of the implant 70%. Conclusion. Replacement of the proximal humerus with MUTARS endoprosthesis is a viable treatment option for bone tumours with satisfying results


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 106 - 106
1 Mar 2008
Laflamme G Berry G Gagnon S Beaumont P
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Although new locking plates allows for secure fixation of osteoporotic fractures in the proximal humerus, extensive soft tissue dissection is needed for their insertion. We report on a prospective clinical trial of the first thirty patients treated with plating of the proximal humerus though a minimally invasive percutaneous approach. All fractures healed within the first 6 months with no avascular necrosis or axillary nerve injury. At the latest follow-up, the median Constant score was sixty-eight and the mean DASH score was twenty-seven. This study suggests that percutaneous plating can be a safe and effective method of fixation. To evaluate the safety and efficacy of minimally invasive plating of the proximal humerus using validated disease-specific measures. Percutaneous insertion of a locking proximal humerus plate is safe and produces good early functional and radiologic outcomes. Plate fixation of the proximal humerus fractures may now be more desirable with the use of a biological approach by limiting surgical insult and allowing accelerated rehabilitation. All fractures healed within the first six months with no loss of correction. Two reoperations were needed to remove intra-articular screws placed too long. No infection or avascular necrosis were seen. At the lastest follow-up, the median Constant score was sixty-eight points, with an age ajusted score of seventy-six. The mean DASH score was twenty-seven points. Only age was independantly predictive of both the Constant and DASH functional scores. During a period of one year, thirty patients were operated with use of the LCP proximal humerus plate (Synthes) through a 3cm lateral deltoid splitting approach and a second 2 cm incision at the deltoid insertion. The axillary nerve was palped and easily protected during insertion. Only two-part (N=22) and three-part impacted valgus type (N=8) were included in this study since they can be reduced indirectly thru this percutaneous technique. The average follow-up was thirteen months (eight to twenty months). All patients had the Constant and DASH evaluations


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 40 - 40
1 Mar 2009
Farron A Cikes A Brenn S Wettstein M Chevalley F
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Introduction: Locking plates and screws have been developed to increase stability of internal fixation in osteoporotic bone. The anatomic design should also facilitate the fracture’s reduction in complex cases. The aim of this study was analyse the results of locking plates used for fractures of the proximal humerus and to look for specific complications. Method: Forty four patients (mean age 60; 28 males and 16 females) were treated with a locking plate (Philos, Synthes-Sratec Medical, Switzerland) for trauma of the proximal humerus. There were fourteen 2-part (32%), ten 3-part (23%), ten valgus impacted 4-part (23%), 3 classical 4-part (7%) fractures and 7 non-unions (15%). Five patients presented an associated gleno-humeral dislocation. Patients were reviewed clinically and radiologically at a mean follow-up of 21 months (6–42). A particular attention was paid to the occurrence of specific complications. Results: A deep infection occurred in two patients (4,5%); two others lost the reduction (4,5%), and one broke his plate (2,3%). We observed 9 cases (20,5%) of avascular necrosis. Six patients (13,6%) had an impaction of the fracture with secondary intraarticular protrusion of the locked screws, which induced a secondary glenoid wear. The impaction sometimes occurred even without any evidence of AVN. Protrusion of screws were more frequent in elderly patients or in cases of non-union. Revision surgery (18 operations) was performed in 16 patients (36%) : 9 isolated material removal; 3 revisions for loss of reduction and malposition of the plate; 2 debridement including implantation of a cement spacer with antibiotics; 4 arthroplasties (2 hemi and 2 total shoulder prostheses). Conclusions: Proximal humerus locking plates and screws, designed to improve stability in osteoporotic bone, may have specific complications. They do not prevent fracture’s impaction, resulting in an intraarticular protrusion of the locked screws, which may induce a severe secondary wear of the glenoid. This phenomenon could be due to the direction of the forces and stresses applied on the humeral head, which is mainly parallel to the screws and not perpendicular to them. Accordingly, patients operated on with proximal humerus locking plates should be regularly controlled. In case of progressive humeral head impaction, the material should be removed before it damages the glenoid


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 294 - 295
1 Nov 2002
Volpin G
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Introduction: The treatment of fractures of the proximal humerus is still controversial. Conservative treatment may result in severe disability due to malunion and shoulder stiffness. Open reduction and rigid fixation requires extensive soft tissue exposure, which may result in a high incidence of avascular necrosis of the proximal humerus. Today, many authors are in the opinion that “minimal osteosynthesis” of such fractures is preferable to rigid fixation. It may be achieved by K.W. techniques, lag screws, rush pins, percutaneous pinning or percutaneous external fixation. This study reviews our experience with comminuted fractures of the proximal humerus treated by different minimal invasive techniques of fixation, using functional evaluation and radiological assessment. Materials and methods: This study consists of 76 patients with comminuted fractures of the proximal humerus (33 M, 44 F, 18–89 year old, mean 52/5Y) with follow-up of 2–6 years (mean 3.5Y). They were treated by minimal invasive surgical techniques: 53 of them by closed reduction and percutaneous pinning and the remaining 23 by ORIF and minimal osteosynthesis. All patients were evaluated by Neer’s shoulder grading score and radiographs. Results: Overall results were excellent and good in 85% of patients with 2, and 3 parts fractures of the proximal humerus, treated either by closed or open minimal osteosynthesis techniques, with some better results in less comminuted fractures. 9/13 (69%) of young patients with 4 part fractures treated by closed percutaneous minimal fixation had good functional results. In four other patients the clinical results were poor and two of them developed AVN of the humeral head. 5/8 (62.5%) of young patients with 4 part fractures treated by ORIF and minimal fixation had good functional results. In three other patients the clinical results were poor and one of them developed AVN of the humeral head. Conclusions: Based on this study it seems that “minimal osteosynthesis” by K.W. techniques and by lag screws, by closed or open reduction, remains as the first optional treatment of complex fractures of the shoulder, even in young patients with a 4 part fracture


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 154 - 154
1 Sep 2012
Lim Fat D Kennedy J Galvin R O'brien F Mullett H
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Title. 3D distribution of cortical bone thickness in the proximal humerus, implications for fracture management. Introduction. CT imaging is commonly used to gain a better understanding of proximal humerus fractures. the operating surgeon however has a limited capacity to evaluate the internal bone geometry from these clinical CT images. our aim was to use clinical CT in a novel way of accurately mapping cortical bone geometry in the proximal humerus. we planned to experimentally define the cortico-cancellous border in a cadaveric study and use CT imaging software to map out cortical thickness distribution in our specimens. Methodology. With ethical approval we used fifteen fresh frozen human proximal humeri. These were stripped of all soft tissue and transverse CT images taken with a GE VCT Lightspeed scanner. The humeral heads were then subsequently resected to allow access to the methaphyseal area. Using currettes, cancellous bone was removed down to hard cortical bone. Another set of CT images of the reamed specimen were then taken. Using Mimics imaging software[Materialise, Leuven] and a CAD interface, 3-matic [Materialise, Leuven], we built 3D model representations of our intact and reamed specimens. We first had to define an accurate CT density threshold for visualising cortical contours. We then analysed cortical thickness distribution based on that experimented threshold. Results. we were able to statistically determine the CT threshold, in Hounsfield Units, that represents the cortico-cancellous interface in the proximal humerus. Our 3D colour models provide an accurate depiction of the distribution of cortical thickness in the proximal humerus. Discussion/Conclusions. Our Hounsfield value for the cortico-cancellous interface in the proximal humerus agrees with a similar range of 400 to 800 HU reported in the literature for the proximal femur. Knowledge of regional variations in cortical bone thickness has direct implications for basic science studies on osteoporosis and its treatment, but is also important for the orthopaedic surgeon since our decision for treatment options is often guided by local bone quality


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 294 - 294
1 Nov 2002
Velkes S Jakim I
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Fractures of the proximal humerus occur predominantly in the elderly patient population. There has been a tendency over the last 15 years to perform surgical procedures to reduce and hold these fractures while the bone and soft tissue heal. The osteoporotic nature of the bone does not allow adequate fixation of the bone and therefore fixation techniques are inadequate to allow optimal soft tissue rehabilitation. A study was performed to observe the results of non-surgically treated displaced fractures of the proximal humerus in the elderly. The encouraging results are presented and discussed. Non-surgical management of displaced fractures of the proximal humerus achieves a good functional shoulder although not normal in this predominantly sedentary population. The question arises as to quality of function after surgical management of these difficult fractures compared to non surgical management and if surgical management is indicated in these elderly usually frail patients with low demand from their shoulders


Bone & Joint Research
Vol. 5, Issue 10 | Pages 470 - 480
1 Oct 2016
Sabharwal S Patel NK Griffiths D Athanasiou T Gupte CM Reilly P

Objectives. The objective of this study was to perform a meta-analysis of all randomised controlled trials (RCTs) comparing surgical and non-surgical management of fractures of the proximal humerus, and to determine whether further analyses based on complexity of fracture, or the type of surgical intervention, produced disparate findings on patient outcomes. Methods. A systematic review of the literature was performed identifying all RCTs that compared surgical and non-surgical management of fractures of the proximal humerus. Meta-analysis of clinical outcomes was performed where possible. Subgroup analysis based on the type of fracture, and a sensitivity analysis based on the type of surgical intervention, were also performed. Results. Seven studies including 528 patients were included. The overall meta-analysis found that there was no difference in clinical outcomes. However, subgroup and sensitivity analyses found improved patient outcomes for more complex fractures managed surgically. Four-part fractures that underwent surgery had improved long-term health utility scores (mean difference, MD 95% CI 0.04 to 0.28; p = 0.007). They were also less likely to result in osteoarthritis, osteonecrosis and non/malunion (OR 7.38, 95% CI 1.97 to 27.60; p = 0.003). Another significant subgroup finding was that secondary surgery was more common for patients that underwent internal fixation compared with conservative management within the studies with predominantly three-part fractures (OR 0.15, 95% CI 0.04 to 0.63; p = 0.009). Conclusion. This meta-analysis has demonstrated that differences in the type of fracture and surgical treatment result in outcomes that are distinct from those generated from analysis of all types of fracture and surgical treatments grouped together. This has important implications for clinical decision making and should highlight the need for future trials to adopt more specific inclusion criteria. Cite this article: S. Sabharwal, N. K. Patel, D. Griffiths, T. Athanasiou, C. M. Gupte, P. Reilly. Trials based on specific fracture configuration and surgical procedures likely to be more relevant for decision making in the management of fractures of the proximal humerus: Findings of a meta-analysisBone Joint Res 2016;5:470–480. DOI: 10.1302/2046-3758.510.2000638


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 141 - 141
1 Mar 2006
Volpin G Shtarker H Kaushanski A Shachar R
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Introduction: Management of displaced comminuted fractures of the proximal humerus in the elderly is still controversial. Conservative treatment may result in severe disability due to malunion and shoulder stiffness. Rigid fixation of these fractures by plates may offer stability in anatomic position, but requires in most cases extensive soft tissue exposure and may result in a relatively high incidence of avascular necrosis of the humeral head. Therefore, many authors are today of the opinion that hemiarthroplasty of the shoulder joint in such fractures is preferable to rigid fixation. This study reviews our experience with hemiartroplasty of the shouldere in elderly patients with comminuted fractures of the proximal humerus. Material & Methods: This study consists of 39 Pts. (27F, 12M; 72–89 year old, mean 76.5Y; 12 with 3 parts fractures and 27 with 4 parts fracture) treated by hemiarthroplasty of the proximal humerus. Patients were followed for 2–8 years (mean 4Y), and evaluated by the Neer‘s shoulder grading score and radiographs. Results: 74% of the patients treated by hemiarthroplasty had satisfactory results. They were almost free of pain, but most of them had only a moderate improvement in shoulder motion (active abduction or flexion of 110–130 degrees were observed in 4/39, of 90–110 degrees in 7/39, of 50–90 degrees in 17/39 and of 30–50 degrees in 11/29). Conclusions: Based on this study it seems that pain relief by hemiarthroplasty may be achieved in most older patients with comminuted fractures of the proximal humerus, but the gain in shoulder function is relatively limited


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_I | Pages 57 - 57
1 Mar 2002
Anract P Ouaknine M Charrousset C Babinet A Jeanrot C Tomeno B
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Purpose: Primary bone tumours located in the upper limb are mainly found in the proximal portion of the humerus. Tumour resection raises difficult situations due to the sacrifice of the cuff tendons. We propose a decision making scheme for determining the best reconstruction strategy. Material and methods: This retrospective analysis was based on 35 cases (19 massive prostheses, ten composite prostheses, three inverted prostheses and three composite arthrodeses). All the clinical and radiographic data were reviewed to examine function, active motion, pain, and use of the upper limb in everyday activities. Results: Massive humeral prostheses provided a technically simple solution but produced mediocre functional results: painless shoulder without active motion, but preservation of elbow and forearm function. Composite humeral prostheses (prosthesis + allograft) did not, in our experience provide any gain in function compared with massive prostheses. Allografts were resorbed after four to five years. Composite arthrodesis with allograft and vascularised fibular graft provided a mobile shoulder with a useful amplitude and a pain free joint. Results persisted. The inverted Delta prostheses (Grammont) covered with allografts and with preservation of the rotator cuff tendons offered an interesting alternative with functional results superior to arthrodesis and similar to those with shoulder prostheses implanted for degenerative disease. The persistence of the glenoid anchorage remains uncertain. Conclusions: We use the following scheme for reconstruction of the proximal humerus. Resection of the proximal humerus with preservation of the deltoid in patients in good general health: inverted composite prosthesis. Resection of the proximal humerus without preservation of the deltoid in patients in poor general health: composite arthrodesis. Resection of the proximal humerus in patients in very poor general health when complex surgery with long post-operative care is not possible: massive prosthesis


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_12 | Pages 29 - 29
1 Mar 2013
Malal JG Mayne AIW Noorani AM Kent M Smith M Guisasola I Brownson P
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The aim of the study was to assess the medium term outcome for complex proximal humeral fractures treated with the long proximal humeral internal locking system (PHILOS) plate fixation.

All patients who had long PHILOS plate fixation of proximal humerus fractures with metaphyseal or diaphyseal extension over a three year period at our institution were included in the study. Patients had their case notes and radiographs reviewed. Patients were also contacted to assess functional outcome using the Visual Analogue Scale (VAS) for pain, DASH, Oxford shoulder score (OSS) and Stanmore Percentage of Normal Shoulder Assessment (SPONSA).

Out of an initial cohort of 34 patients, 1 died, 2 patients had unrelated illnesses resulting in them being unable to complete the assessment and 6 were lost to follow-up, leaving 25 patients (74%) for review. All patients had proximal humeral fractures with metaphyseal or diaphyseal extension requiring long plate osteosynthesis. One patient had the procedure for non union following initial treatment with an intra medullary nail and the rest were acute injuries. The patients were followed up after a mean of 27 months (range 11–60). The length of plate used varied from 5 to 12 holes for the shaft region.

There was 1 wound infection. 3 patients had non unions which required bone grafting and revision internal fixation. At final follow-up, mean pain was 3.6 (95% Confidence Interval 2.5–4.8) with only 4 patients having residual pain greater than 5 on the VAS scale. Mean DASH score was 41.2 (95% CI 32.0–50.4), mean OSS was 29.1 (95% CI 24.3–33.9) and mean SPONSA was 63.9% (95% CI 50.8–77.2)

The long PHILOS plate appears to represent a good treatment option for complex proximal humerus fractures with favourable medium term results and few complications.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_II | Pages 136 - 136
1 Feb 2004
Escribá-Urios I Majò J Roca D Gracia I Doncel A
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Introduction and Objectives: This study analyses the results of our experience in reconstruction of high-grade sarcomas of the proximal humerus. Materials and Methods: A total of 37 patients were treated from March 1983 to December 2001. Average age was 24 years (19–38), with 21 males and 16 females, all presenting with high-grade sarcomas of the proximal humerus. The primary tumour was osteosarcoma in 49% (n=18) of cases, chondrosarcoma in 22% (n=8), Ewing’s sarcoma in 13% (n=5), parosteal sarcoma in 8% (n=3), malignant fibrous histiocytoma in 5% (n=2), and adamantinoma in 3% (n=1). All cases were classified as Type 1 Malawer resections (intraarticular resections of the proximal humerus). Results: During this period, scapulohumeral or scapulothoracic disarticulation was performed in 32% of cases (12 patients). In the remaining 68% (25 cases), limb salvage surgery was performed (relative limb salvage rate: 67.5%). In terms of reconstruction type, 6 cases received megaprotheses, and the remaining 19 cases received osteoarticular allografts of the humerus. Four of the 25 patients had reconstructions with sufficient follow-up time to be considered survivors without recurrence. Results were “acceptable” based on the Enneking-MTS functional scale (overall movement arcs in all directions between 60–120° with tolerable subluxations.) From a subjective point of view, all the patients obtained good results in terms of physical health and mobility of distal joints. No analysis was done of survival due to the varied nature of the neoplasias and adjuvant therapies. The main complication was fracture of the osteoarticular allograft, which occurred in 4 of 19 cases (21%). Subluxation was practically constant throughout our series but was of relatively minor clinical significance. Discussion and Conclusions: The results obtained in this study in terms of local and functional control are similar to those reported in the literature. In spite of the poor functional results for the shoulder joint, the functional results for distal joints and the cosmetic appearance of the extremity are satisfactory. However, the high rate of allograft fractures forces us to reconsider our reconstruction technique, placing priority on a mixed reconstruction using both allograft and mega-prosthesis


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_2 | Pages 100 - 100
1 Jan 2016
Kenmoku T Miyajima G Higashiyama R Takahira N Takaso M
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Introduction. Proximal humeral fracture occurs most frequently in elderly and usually unite within 12 weeks. Malunion is more common than nonunion. And even if nonunion occurs, we usually treat it by the blade plate. Norris et al. reported hemiarthroplasty is indicated for severe degenerative changes of the articular surface, osteonecrosis of the humeral head, or osteopenia severe enough to jeopardize fixation in order patients. Therefore, it is not common that hemiarthroplasty is used for primary treatment of the proximal humeral pseudoarthrosis. We report a case of proximal humerus pseudoarthrosis which was treated by hemiarthroplasty. Case. A patients is 75 years old male. He was injured by falling from ladder. He was diagnosed proximal humeral fracture Neer type2. After he was followed conservatively for one year, he was referred to our hospital. In X-ray film and CT, the humeral head was scraped by the humeral shaft that was tucked inward to humeral head.(Figure 1) In MRI, rotator cuff muscles were left. The fatty infiltration was stage 1 in the Gourtallier classification. (Figure 2)And osteoarthritis of shoulder was not so severe. Therefore, we decided to do hemiarthroplasty. We used the SMR implant (Lima Corporate, Milano, Italy). Surgical reconstruction was done using a deltpectral approach. Lesser tuberosity was cut from greater tuberosity with subscaplaris muscle. We used the cementless stem. Each fragments and stem was fixed using FiberWire (Arthrex, Florida USA), after autograft which scraped from the reseceted humeral head was stuffed. After the operation, the shoulder was fixed by brace for 4weeks. The passive ROM exercise was started from 21 days later. The Active ROM exercise was started at 28 days later. Three months later, the pseudoarthrosis united successfully. (Figure 3) The active flexion was improved from 20 degrees to 110 degrees. The active abduction was from 20 degrees to 90 degrees. USLA score was improved from 10 to 26. Discussion. In this case, the pseudoarthrosis is united successfully. Therefore, the cementless hemiarthroplasty is useful for treatment for the proximal humerus pseudoarthrosis with severe humeral head bone defect


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_II | Pages 112 - 113
1 Feb 2003
Kumar D Grimer RJ Tillman RM Carter SR
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Reconstruction of the shoulder joint following resection of the proximal humerus for bone tumours remains controversial. We report the long term functional results of the simplest form of reconstruction – an endoprosthesis. One hundred patients underwent endoprosthetic replacement of the proximal humerus between 1976 and 1998. Thirty eight had osteosarcoma, 17 had chondrosarcoma, 16 had metastases and 9 had Ewing’s sarcoma. Mean age was 36 years (range 10 to 80 yrs). Survivorship of patients and prostheses were calculated. Function was assessed using the Musculoskeletal tumour society (MSTS) and Toronto extremity salvage (TESS) scoring systems. Thirty patients could come to the clinics for MSTS scoring and 38 out of 49 alive patients replied to the TESS questionnaires sent out to them. The overall survival of the patients was 42% at 10 years. Local recurrence (LR) arose in 16 patients, being most common in chondrosarcoma (26%) and osteosarcoma (22%) and arose in 50% of patients with these tumours who had marginal excisions. Of these 16 patients, 8 had forequarter amputations whilst the remainder had excisions and radiotherapy. Mean time to LR was 12 months and all but two of these 16 patients subsequently died within a mean of 18 months. The prostheses proved reliable and dependable. Only 9 required further surgery of any sort, 2 needing minor surgery to correct subluxation and 7 needing revisions, one for infection after radiotherapy and six for loosening – three after trauma. The survivorship of the prosthesis without any further surgery was 86. 5% at 20years. The survivorship of the limb without amputation was 93% at 20 years. The functional outcome was very predictable. Most patients had only 45 degrees of abduction although three patients had normal movements. The mean MSTS functional score was 79% and the mean TESS score was also 79%. There was a high level of patient satisfaction but difficulty was encountered especially in lifting and in all activities above shoulder height. Endoprosthetic replacement of the proximal humerus is a predictable procedure providing reasonable function of the arm below shoulder height. The endoprostheses have proved highly dependable with a low re-operation rate. There is a high risk of local recurrence after inadequate surgery which should be avoided if possible