Aims. Scapular notching is thought to have an adverse effect on the outcome of reverse total shoulder arthroplasty (RTSA). However, the matter is still controversial. The aim of this study was to determine the clinical impact of scapular notching on outcomes after RTSA. Methods. Three electronic databases (PubMed, Cochrane Database, and EMBASE) were searched for studies which evaluated the influence of scapular notching on clinical outcome after RTSA. The quality of each study was assessed. Functional outcome scores (the Constant-Murley scores (CMS), and the American Shoulder and Elbow Surgeons (ASES) scores), and postoperative range of movement (forward flexion (FF), abduction, and external rotation (ER)) were extracted and subjected to meta-analysis. Effect sizes were expressed as weighted mean differences (WMD). Results. In all, 11 studies (two level III and nine level IV) were included in the meta-analysis. All analyzed variables indicated that scapular notching has a negative effect on the outcome of RTSA . Statistical significance was found for the CMS (WMD –3.11; 95% confidence interval (CI) –4.98 to –1.23), the ASES score (WMD –6.50; 95% CI –10.80 to –2.19), FF (WMD –6.3°; 95% CI –9.9° to –2.6°), and abduction (WMD –9.4°; 95% CI –17.8° to –1.0°), but not for ER (WMD –0.6°; 95% CI –3.7° to 2.5°). Conclusion. The current literature suggests that patients with scapular notching after RTSA have significantly worse results when evaluated by the CMS, ASES score, and range of movement in flexion and abduction. Cite this article: Bone Joint J 2020;102-B(11):1438–1445

The condylopatellar notch (CPN) represents the border between the patellofemoral articulation and the tibiofemoral articulation [Pao, 2001]. This could be a valuable landmark for establishing the boundaries of unicompartmental knee replacements. Its location on the distal femur has been described radiographically, but it has not, to our knowledge, been quantified with respect to anatomic landmarks [Hoffelner, 2015]. This study seeks to leverage a large database of computed tomography (CT) scans to quantify the location of the CPN with respect to well established anatomic landmarks of the knee. The analysis presented here used the custom CT based program SOMA (SOMA V.4.3.3, Stryker, Mahwah, NJ). SOMA contains a large database of 3D models created from CT scans. Anatomic analysis and implant fitting tools were also integrated into SOMA to perform morphometric analyses. 986 healthy distal femurs were analyzed. A coordinate system was established from the femoral head center, the intercondylar notch, and a morphological flexion axis (MFA). The MFA was created by iteratively fitting circles to the posterior condyles and creating and axis through the circles' centers. The sagittal plane was created normal to this axis and through the notch. A plane was created from the femoral head center and the flexion axis. A coronal plane was created from this plane and a point on the anterior cortex sulcus. Points were placed on a template bone model in the medial and lateral extents of the surface depressions of both the medial and lateral aspect of the CPN, where the depression of the CPN is most distinct. These points were then mapped to each of the 986 femoral specimens via a shape correspondence model. A line is created between the pairs of points representing the medial and lateral CPN's. The coordinates of the points are measured with respect to sagittal and coronal planes (Figure 1). Means and standard deviations of the anterior-posterior (AP) and medial-lateral (ML) coordinates of the CPN points are calculated. The mean coordinates for the lateral CPN line are (4.8±1.6, −33.6±6.8) and (29.1±5.4, −18.7±4.8). The mean coordinates for the lateral CPN are (−20.7±3.8, −2.2±4.4) and (−6.5±1.6, −29.7±3.2). The means with error bars representing two standard deviations are plotted on a scatter plot (Figure 2). Boxes representing the location of the CPN line for 95% of the population are included on the plots. Until now, the location of this anatomic feature of the knee has not been quantified with respect to known anatomical landmarks. The location of the CPN could serve as a valuable landmark for determining the border between the tibiofemoral and patellofemoral articulations. This data can be used to locate the CPN and inform the planning and design of compartmental knee replacements. For any figures or tables, please contact authors directly (see Info & Metrics tab above).

We hypothesised that an independent Notch Trial is essential on the same lines as other Component Trials-Femoral, Tibial and Patellar - in posterior stabilised total knee arthroplasty. Therefore we evolved Notch Trial to visually ascertain the adequacy of intercondylar resection and eliminate the possibility of femoral intercondylar fractures. We undertook a retrospective study to evaluate Notch Trial by the frequency of the need to remove osteophytes or file uneven surfaces in intercondylar resection by using the detachable box part of the trial femoral component, assess occurrence of distal femoral intercondylar fractures and demonstrate Notch Trial in posterior stabilised total knee replacement. We studied 206 patients, 113 females and 93 males, who underwent consecutive primary posterior stabilised total knee replacements applying Notch Trial between 2000 and 2008 in a District General Hospital under our team. Outcome Measurements were 1) frequency of the need to remove osteophytes or file uneven surfaces in intercondylar resection and 2) occurrence of distal femoral intercondylar fractures intraoperatively or on postoperative radiographs. We had to remove the osteophytes and file the cut surfaces in 183 (88.88%) of patients after Notch Trial. We had no distal femoral intercondylar fractures intraoperatively or on postoperative radiographs. Notch Trial allows the surgeon to directly visualise and ascertain the adequacy and precise fit of femoral notch cut with cam part of femoral component to ensure a press fit femoral component in condylar posterior cruciate substituting total knee replacement. Notch Trial prior to Femoral Component Trial effectively pre-empts intraoperative distal femoral intercondylar fractures. We recommend that Notch Trial should become part of the protocol for cruciate substituting total knee replacement and implants of all companies should have the option of a detachable box component for Notch Trial

Purpose: We hypothesised that independent Notch Trial is essential on same lines as other Component Trials – Femoral, Tibial and Patellar – in posterior stabilised total knee arthroplasty and evolved Notch Trial to visually ascertain adequacy of intercondylar resection and eliminate femoral intercondylar fractures. We undertook a retrospective study to evaluate Notch Trial by the frequency of the need to remove osteophytes or file uneven surfaces in intercondylar resection by using detachable box part of trial femoral component and occurrence of distal femoral intercondylar fractures. Methods & Results: We studied 206 patients, 113 females and 93 males, who underwent consecutive primary posterior stabilised total knee replacements applying Notch Trial between 2000 and 2008 under our team. Outcome Measurements were. frequency of osteophyte removal or filing uneven surfaces in intercondylar resection and. distal femoral intercondylar fractures intraoperatively or on postoperative radiographs. We had to remove osteophytes and file cut surfaces in 183 (88.88%) patients after Notch Trial. We had no distal femoral intercondylar fractures. Conclusions: Notch Trial allows the surgeon to directly visualise and ascertain adequacy and precise fit of femoral notch cut with cam part to ensure press fit femoral component in condylar posterior cruciate substituting total knee replacement. Notch Trial prior to Femoral Component Trial effectively pre-empts intraoperative distal femoral intercondylar fractures. We recommend that Notch Trial should become part of the protocol for cruciate substituting total knee replacement and implants of all companies should have the option of a detachable box component for Notch Trial

The shape of the glenoid can vary between pear and oval, depending on the presence of a glenoid notch. We measured the glenoid notch angle (the angle between the superior and inferior part of the anterior glenoid rim) in 53 embalmed cadavers and investigated its relationship with the labral attachment to the glenoid at that point. The attachment of the anterosuperior labrum at the site of the glenoid notch was classified as tight or loose or, in some cases, there was a sublabral foramen. The anterior labrum was then removed and digital images perpendicular to the glenoid notch were taken. Using a digital image analysis program, the angle of the glenoid notch was measured. In 37 shoulders (70%) the attachment of the labrum at the site of the glenoid notch was assessed as tight and in eight (15%) as loose. In eight shoulders (15%) a sublabral foramen was found. The mean glenoid notch angle was 153° in the loosely attached group, 159° in the sublabral foramen group and 168° in the group with a tight attachment. The presence of a glenoid notch was noted only when the glenoid notch angle was less than 170°. The glenoid notch angle is related to the attachment of the labrum. In the presence of a glenoid notch, there is more likely to be a loosely attached labrum or sublabral foramen. The loose attachment of the anterosuperior labrum may be a predisposing factor in traumatic anterior instability

Multiple myeloma (MM) is an incurable hematological tumor stemming from malignant plasma cells. MM cells accumulate in the bone marrow (BM) and shape the BM niche by establishing complex interactions with normal BM cells, boosting osteoclasts (OCLs) differentiation and causing bone disease. This unbalance in bone resorption promotes tumor survival and the development of drug resistance. The communication between tumor cells and stromal cells may be mediated by: 1) direct cell-cell contact; 2) secretion of soluble factors, i.e. chemokines and growth factors; 3) release of extracellular vesicles/exosomes (EVs) which are able to deliver mRNAs, miRNAs, proteins and metabolites in different body district. Primary CD138+ MM cells were isolated from patients BM aspirates. MM cell lines were cultured alone in complete RPMI-1640 medium or co-cultured with murine (NIH3T3) or human (HS5) BMSC cell lines or murine Raw264.7 monocytes in DMEM medium supplemented with 10% V/V FBS. Silencing of Jagged1 and Jagged2 was obtained by transient expression of specific siRNAs or by lentiviral transduction using a Dox-inducible system (pTRIPZ). EVs were isolated using differential ultracentrifugation. EVs concentration and size were analyzed using Nano Track Analysis (NTA) system. The uptake of PKH26-labelled MM-derived EVs by HS5 or Raw264.7 was measured after 48 hours by confocal microscopy and flow cytometry. Osteoclast (OCL) differentiation of Raw264.7 cells was induced by 50ng/ml mRANKL, co-culturing with MM cells, CM or EVs. OCLs were stained by TRAP Kit and counted. Bone resorption was assessed by Osteo Assay Surface plates. Flow cytometric detection of apoptotic cells was performed after staining with Annexin V. Gene expression was analyzed by qRT-PCR, while protein levels were determined using flow cytometry ELISA or WB. Notch oncogenic signaling is dysregulated in several hematological and solid malignancies. Notch receptors and ligands are key players in the crosstalk between tumor cells and BM cells. We have demonstrated that: 1) the dysregulated Jagged ligands on MM cells trigger the activation of Notch receptors in the nearby stromal cells by cell-cell contact. This results in the release of anti-apoptotic and growth stimulating factors, i.e. IL6 and SDF1; 2) MM cells promote the development of bone lesions boosting osteoclast differentiation by secreting soluble factors (i.e. RANKL) and by the activation of Notch signaling mediated by direct contact with osteoclast precursors; 3) Finally, we present evidences that EVs play a crucial role in the dysregulated interactions of MM cells with the microenvironment and that Notch signaling regulates their release and participate in this cross-talk. These evidences supports the hypothesis that Jagged targeting on MM cells may interrupt the communication between tumor cells and the surrounding milieu, blocking the activation of the oncogenic Notch pathway and finally resulting in the a reduction of MM-associated bone disease and drug resistance

Objective. In this study, we aim to compare total bone amount extracted in total knee arthroplasty in implant design and the bone amount extracted through intercondylar femoral notch cut. Material and Method. In this study, we implemented 10 implants on a total of 50 sawbones from 5 different total knee arthroplasty implant brands namely Nex-Gen Legacy (Zimmer, Warsaw, IN, USA), Genesis 2 PS (Smith&Nephew, Memphis, TN, USA), Vanguard (Biomet Orthopedics Inc., Warsaw, IN, USA), Sigma PS (De Puy, Johnson&Johnson, Warsaw, IN, USA), Scorpio NRG PS (Stryker Co., Kalamazoo, USA). Equal or the closest sizes of each brand on anteroposterior plane were selected, and cuts were made following standard technique(see Fig 1 and 2). Extracted bone pieces were measured in terms of volume and length on three planes, and statistically analysed. The volume of all pieces available after each femoral incision was measured according to Archimedes’ principles. Furthermore, the volume of each intercondylar femoral notch pieces was measured separately from other pieces but with the same method. The measurement of intercondylar femoral notch pieces on 3 planes (medial-lateral, anterior-posterior, superior-inferior) was made using Kanon slide gauge (Ermak Ltd, Istanbul, TR). Femoral notch incision pieces were scanned with CAD/CAM technology using three-dimensional scanner 1 SeriesTM (Dental Wings Inc, Montreal, QC, Canada), and the measurements were confirmed with DWOS CAD 4.0.1 software (Dental Wings Inc, Montreal, QC, Canada)(see figure 3a-e). The volume of 10 intercondylar femoral notch pieces performed through the set of each brand was averaged, and considered as the incision volume of that particular brand. Results. The comparison made by excluding femoral notch cuts did not produce any statistically significant difference between the amounts of bone extracted. The least volumetric value measured in extracted intercondylar femoral notch cut was obtained using Vanguard (3,6±0,4 cm3). The gradually increasing volumes were obtained from Nex-Gen (3,7±0,5 cm3), Sigma (5,7±0,4 cm3), Genesis 2 (6,3±0,3 cm3) and Scorpio NRG (6,7±0,7 cm3), respectively. There was no statistical difference between Genesis 2 and Scorpio NRG, and between Nex-Gen and Vanguard. Conclusion. There are significant differences among implant designs in terms of preserving bone stock, and much of these differences stems from intercondylar femoral notch incision

Purpose: This study was conducted to analyse the importance of the Malgaigne notch and its position on standard x-rays taken in internal rotation or on arthroscan in patients treated for anterior instability of the shoulder. Our purpose was to search for criteria perdictive of outcome of arthroscopic stabilisation of the shoulder joint using the Bankart method. Material and methods: Fifty-four patients were reviewed to determine the postoperative Duplay score. Mean follow-up was 68 months (32–100). Mean age at surgery was 29 years. We divided the patients into three populations as a function of preoperative symptoms: population A two dislocations or more, population B one dislocation then episodes of subluxation, population C no dislocation but pain. We divided this population according to the Duplay score. Group 1 patients had a fair or poor outcome, Group 2 patients had a good or excellent outcome. We reviewed 54 radiograms using patterns of increasing size (mm by mm) to assess the radius of the humeral head and the depth of the notch. We evaluate the reproducibility of this method by comparing the readings of ten senior orthopaedic surgeons. There were no false positives or false negatives. Variance of the measures taken by the ten surgeons was 0.67 at 1.31 mm, a small variance. We compared the ratio between the radius of the humeral head and the depth of the notch in the different groups. Results: The Malgaigne notch was significantly deeper in population A (19%) than in population B (14%) or population C (14.3%). This suggests that the size of the notch has an effect on symptomatology of shoulder instability. The notch was also significantly deeper in group 1 patients (fair or poor outcome) (21%) than in group 2 (good or excellent outcome) (16%) (p=0.05). Discussion: Beyond a threshold set at 15%, there were 54% fair or poor results. The position of the notch in height was significantly different in population A compared with populations B and C (p=0.01). It appears to be higher in case of true recurrent dislocation. We did not demonstrate any statistical link between the position of the notch on the CT scan and surgical outcome. This study demonstrates the importance of information on the internal rotation images in choosing the proper type of surgery for shoulder instability

Background: The orientation and the position of glenoid are two factors which have been pointed out as a cause of notch in case of reverse shoulder arthroplasty (RSA). Our hypothesis is that the notch is mostly depending on the relationship between the humerus and the glenoid. Material and method: The inclusion criteria of this prospective study were: RSA with a 2 years minimum follow up, pre and post op x-rays of good quality to allow accurate measurements, a minimum of 3 x-rays regularly separated in the first 2 years. On these x-rays, done at rest, we have analyzed: the vertical orientation of the glenoid, the degree of abduction of the humerus, the gleno-metaphyseal angle (GMA) which represents the relationship between glenoid and humerus. Sixty one shoulders in 60 patients (57 females, 7 males) have been included. The mean age was 74,6 y.o (56–82) and the mean body mass index (BMI) was 25,4 (16–36). Results: The patients with a notch had a significant correlation with a lower BMI (p< 0,001), a more upward pre op orientation of glenoid (p< 0,01), a less downward post op orientation of the glenoid, a lower degree of abduction of the humerus (p< 0,01), a lower GMA (p< 0,001) that means either that the humerus is less abducted or that the glenoid is orientated more upward or both. In addition we found a strongly correlation between the BMI and the degree of abduction of humerus which is lower if the BMI is low (p< 0,001). We studied the evolution of the angles and we noted that there was no difference during the first 3 months. After 3 months, the GMA stayed stable in patients without notch but was decreasing during the first year in those with a notch. Discussion: The occurrence of a notch is strongly increased in patients with a lower BMI because of a less degree of abduction of the humerus, mostly if the glenoid is orientated upward. So the relationship between humerus and glenoid is more important to analyse than position of glenoid alone. The BMI is another important factor to take into account in case of indication of RSA because the risk of occurrence of a notch is quite higher

Introduction:. Successful total joint arthroplasty requires accruate and reproducible acetabular component position. Acetabular component malposition has been associated with complications inlcuding dislocation, implant loosening, and increased wear. Recent literature had demonstrated that high-volume fellowship trained arthroplasty surgeons are in the “safe zone” for cup inclination and anteversion only 47% of the time. (1) Computer navigation has improved accuracy and reproducibility but remains expensive and cumbersome to many hospital and physicians. Patient specific instrumentation (PSI) has been shown to be effective and efficient in total knee replacements. The purpose of this study was to determine in a cadaveric model the anteversion and inclination accuracy of acetabular guides compared to a pre-operitive plan. Methods:. 8 fresh-frozen cadaveric pelvis specimens underwent Computer Tomography (CT) in order to create a 3D reconstruction of the acetabulum. Based on these 3D reconstruction, a pre-operative plan was made positioning the patient specific acetabulum guides at 40 degrees of inclination and 20 degrees of anteversion in the pelvis.(Figure 1) The guides were created based on the specific bony morphology of the acetabular notch and rim. The guides were created using a 3D printer which allowed for precise recreation of the virtual model. 7 cadaveric specimens underwent creation and implantation of a acetabular guide specific to each specimens bony morphology. Ligamentum, pulvinar, and labum were removed for each cadaver prior to implantation to prevent soft tissue obstruction. The guides were inserted into the acetabular notch with the final position based on the fit of the guide in the notch. (Figure 2) Post-implantation CT was then performed and inclination and anteversion of the implanted guide measured and compared to the preoperative plan. Results:. In 7 cadaveric specimens post-implantation CT scans were performed and anteversion and inclindation of each guide was calculated and compared to pre-operative plan of 20 degrees anteversion and 40 degrees of inclincation. On average, anteversion in the 7 cadavers measured 20.9 degrees with a standard deviation of 1.8 degrees. Inclincation measured 37.8 degrees with a standard deviation of 3.5 degrees. (Figure 3). Discussion and Conclusion:. This study demonstrates a proof of concept that patient specific acetabular guides based on pre-operative CT scans and implanted in the human pelvis accurately reproduce the preoperative plan. Guide position was 20.9 degrees of anteversion and 37.8 degrees of inclination with a SD of 1.8 and 3.5 degrees respectively. Soft tissue obstruction may result in increased error in some specimens. This study demonstrates that patient specific models can be made and implanted based on notch fit geometry. Further study is currently underway to using a instrument based on the angle of the cup face is order to guide final cup implanation

Purpose. The purpose of this study was to determine whether intra-operative identification of osseous ridge anatomy (lateral intercondylar “residents” ridge and lateral bifurcate ridge) could be used to reliably define and reconstruct individuals' native femoral ACL attachments in both single-bundle (SB) and double-bundle (DB) cases. Methods. Pre-and Post-operative 3D, surface rendered, CT reconstructions of the lateral intercondylar notch were obtained for 15 patients undergoing ACL reconstruction (11 Single bundle, 4 Double-bundle or Isolated bundle augmentations). Morphology of native ACL femoral attachment was defined from ridge anatomy on the pre-operative scans. Centre's of the ACL attachment, AM and PL bundles were recorded using the Bernard grid and Amis' circle methods. During reconstruction soft tissue was carefully removed from the lateral notch wall with RF coblation to preserve and visualise osseous ridge anatomy. For SB reconstructions the femoral tunnel was sited centrally on the lateral bifurcate ridge, equidistant between the lateral intercondylar ridge and posterior cartilage margin. For DB reconstructions tunnels were located either side of the bifurcate ridge, leaving a 2mm bony bridge. Post-operative 3D CTs were obtained within 6 weeks post-op to correlate tunnel positions with pre-op native morphology. Results. Pre-op native ACL attachment site morphology was very similar to previous in-vitro studies: the mean centre was found at 27% along Blumensaat's line (range 19-33%) and 38% the width of the lateral femoral condyle (range 31-43%). Despite the variability between individuals there was close correlation between pre-operative localization of the femoral attachment centre and position of single bundle ACL reconstructions tunnels on the post-op CT (R=0.92). Similar results were observed for double-bundle and isolated bundle augment reconstructions. Conclusion. ACL attachment site morphology varies between individuals. Intra-operative localization of the osseous landmarks (lateral intercondylar and bifurcate ridges) appears to lead to accurate, individualised anatomical tunnel placement whether using single or double-bundle reconstruction techniques

Growth factors produced by inflammatory cells and mesenchymal progenitors are required for proper bone regeneration. Signaling pathways activated downstream of these proteins work in concert and synergistically to drive osteoblast and/or chondrocyte differentiation. While dysregulation can result in abnormal healing, activating these pathways in the correct spatiotemporal context can enhance healing. Bone morphogenetic protein (BMP) signaling is well-recognized as being required for bone regeneration, and BMP is used clinically to enhance bone healing. However, it is imperative to develop new therapeutics that can be used alone or in conjunction with BMP to drive even more robust healing. Notch signaling is another highly conserved signaling pathway involved in tissue development and regeneration. Our work has explored Notch signaling during osteoblastogenesis and bone healing using both in vitro studies with human primary mesenchymal progenitor cells and in vivo studies with genetically modified mouse models. Notch signaling is required and sufficient for osteoblast differentiation, and is required for proper bone regeneration. Indeed, intact Notch signaling through the Jagged-1 ligand is required for BMP induced bone formation. On-going work continues to explore the intersection between BMP and Notch signaling, and determining cell types that express Notch receptors and Notch ligands during bone healing. Our long-term objective is to develop Notch signaling as a clinical therapy to repair bone

Aims. This study aimed to investigate the optimal sagittal positioning of the uncemented femoral component in total knee arthroplasty to minimize the risk of aseptic loosening and periprosthetic fracture. Methods. Ten different sagittal placements of the femoral component, ranging from -5 mm (causing anterior notch) to +4 mm (causing anterior gap), were analyzed using finite element analysis. Both gait and squat loading conditions were simulated, and Von Mises stress and interface micromotion were evaluated to assess fracture and loosening risk. Results. During gait, varied sagittal positioning did not lead to excessive Von Mises stress or micromotion. However, under squat conditions, posterior positioning (-4 and -5 mm) resulted in stress exceeding 150 MPa at the femoral notch, indicating potential fracture risk. Conversely, +1 mm and 0 mm sagittal positions demonstrated minimal interface micromotion. Conclusion. Slightly anterior sagittal positioning (+1 mm) or neutral positioning (0 mm) effectively reduced stress concentration at the femoral notch and minimized interface micromotion. Thus, these positions are deemed suitable to decrease the risk of aseptic loosening and periprosthetic femoral fracture

Aims. Posterior column plating through the single anterior approach reduces the morbidity in acetabular fractures that require stabilization of both the columns. The aim of this study is to assess the effectiveness of posterior column plating through the anterior intrapelvic approach (AIP) in the management of acetabular fractures. Methods. We retrospectively reviewed the data from R G Kar Medical College, Kolkata, India, from June 2018 to April 2023. Overall, there were 34 acetabulum fractures involving both columns managed by medial buttress plating of posterior column. The posterior column of the acetabular fracture was fixed through the AIP approach with buttress plate on medial surface of posterior column. Mean follow-up was 25 months (13 to 58). Accuracy of reduction and effectiveness of this technique were measured by assessing the Merle d’Aubigné score and Matta’s radiological grading at one year and at latest follow-up. Results. Immediate postoperative radiological Matta’s reduction accuracy showed anatomical reduction (0 to 1 mm) in 23 cases (67.6%), satisfactory (2 to 3 mm) in nine (26.4%), and unsatisfactory (> 3 mm) in two (6%). Merle d’Aubigné score at the end of one year was calculated to be excellent in 18 cases (52.9%), good in 11 (32.3%), fair in three (8.8%), and poor in two (5.9%). Matta’s radiological grading at the end of one year was calculated to be excellent in 16 cases (47%), good in nine (26.4%), six in fair (17.6%), and three in poor (8.8%). Merle d’Aubigné score at latest follow-up deteriorated by one point in some cases, but the grading remained the same; Matta’s radiological grading at latest follow-up also remained unchanged. Conclusion. Stabilization of posterior column through AIP by medial surface plate along the sciatic notch gives good stability to posterior column, and at the same time can avoid morbidity of the additional lateral window. Cite this article: Bone Jt Open 2024;5(2):147–153

The incisura fibularis (IF) provides intrinsic stability to the ankle joint complex by interlocking the distal tibia and fibula. Despite a high frequency of ligamentous ankle injuries, scant attention has been given to the morphology of the IF morphology incisura fibularis in the onset and development of these lesions. Therefore, we systematically reviewed the relation between ligamentous ankle disorders and the morphometrics of the IF. A systematic literature search was conducted on following databases: PubMed, Embase and Web of Science. Search terms consisted of ‘ankle trauma’, ‘ankle injury’, ‘ankle sprain’, ‘ankle fracture’, ‘tibiofibular’, ‘fibular notch’, ‘fibular incisura’, ‘incisura fibularis’, ‘morphometric analysis’, ‘ankle syndesmosis’, ‘syndesmotic stability’. The evaluation instrument developed by Hawker et al. was used to assess the quality of the selected studies. This protocol was performed according to the PRISMA guidelines and is registered on PROSPERO (CRD42021282862). Nineteen studies were included and consisted of prospective cohort (n=1), retrospective comparative (n=10), and observational (n=8) study design. Comparative studies have found certain morphological characteristics in patients with ankle instability. Several studies (n=5) have correlated a shallow IF depth with a higher incidence of ankle injury. A significant difference has also been found concerning the incisura height and angle (n=3): a shorter incisura and more obtuse angle have been noted in patients with ankle sprains. The mean Hawker score was 28 out of 36 (range=24-31). A shallower IF is associated with ligamentous ankle lesions and might be due to a lower osseous resistance against tibiofibular displacement. However, these results should be interpreted in light of moderate methodological quality and should always be correlated with clinical findings. Further prospective studies are needed to further assess the relation between the incisura morphometrics and ligamentous disorders of the ankle joint. Keywords: ankle instability, ankle injury, incisura fibularis, fibular notch, tibiofibular morphometrics, ankle syndesmosis

Glenoid bone grafting in reverse total shoulder arthroplasty (RTSA) has emerged as an effective method of restoring bone stock in the presence of complex glenoid bone loss, yet there is limited published evidence on efficacy. The aim of this study was to conduct an analysis of clinical and radiographic outcomes associated with glenoid bone grafting in primary RTSA. Patients who underwent a primary RTSA with glenoid bone grafting were retrospectively identified from the databases of two senior shoulder surgeons. Inclusion criteria included minimum of 12 months clinical and/or radiographical follow up. Patients underwent preoperative clinical and radiographic assessment. Graft characteristics (source, type, preparation), range of movement (ROM), patient-reported outcome measures (Oxford Shoulder Scores [OSS]), and complications were recorded. Radiographic imaging was used to analyse implant stability, graft incorporation, and notching by two independent reviewers. Between 2013 and 2021, a total of 53 primary RTSA procedures (48 patients) with glenoid bone grafting were identified. Humeral head autograft was used in 51 (96%) of cases. Femoral head allograft was utilised in two cases. Depending on the morphology of glenoid bone loss, a combination of structural (corticocancellous) and non-structural (cancellous) grafts were used to restore glenoid bone stock and the joint line. All grafts were incorporated at review. The mean post-operative OSS was significantly higher than the pre-operative OSS (40 vs. 22, p < 0.001). ROM was significantly improved post-operatively. One patient is being investigated for residual activity-related shoulder pain. This patient also experienced scapular notching resulting in the fracturing of the inferior screw. One patient experienced recurrent dislocations but was not revised. Overall, at short term follow up, glenoid bone grafting was effective in addressing glenoid bone loss with excellent functional and clinical outcomes when used for complex bone loss in primary RTSA. The graft incorporation rate was high, with an associated low complication rate

This study aims to assess the fracture mechanics of type-2 diabetic (T2D) femoral bone using innovative site-specific tests, whilst also examining the cortical and trabecular bone microarchitecture from various regions using micro-computed tomography (CT) of the femur as the disease progresses. Male [Zucker Diabetic Fatty (ZDF: fa/fa) (T2D) and Zucker Lean (ZL: fa/+) (Control)] rats were euthanized at 12-weeks of age, thereafter, right and left femora were dissected (Right femora: n = 6, per age, per condition; Left femora: n=8-9, per age, per condition). Right femurs were notched in the posterior of the midshaft. Micro-CT was used to scan the proximal femur, notched and unnotched femoral midshaft (cortical) of the right femur and the distal metaphysis (trabecular) of the left femur to investigate microarchitecture and composition. Right femurs were fracture toughness tested to measure the stress intensity factor (Kic) followed by a sideways fall test using a custom-made rig to investigate femoral neck mechanical properties. There was no difference in trabecular and cortical tissue material density (TMD) between T2D and control rats. Cortical thickness was unchanged, but trabeculae were thinner (p<0.01) in T2D rats versus controls. However, T2D rats had a greater number of trabeculae (p<0.05) although trabecular spacing was not different to controls. T2D rats had a higher connectivity distribution (p<0.05) and degree of anisotropy (p<0.05) in comparison to controls. There was no difference in the mechanical properties between strains. At 12-weeks of age, rats are experiencing early-stage T2Ds and the disease impact is currently not very clear. Structural and material properties are unchanged between strains, but the trabecular morphology shows that T2D rats have more trabecular struts present in order to account for the thinner trabeculae

Abstract. Objective. Radial to axillary nerve and spinal accessory (XI) to suprascapular nerve (SSN) transfers are standard procedures to restore function after C5 brachial plexus dysfunction. The anterior approach to the SSN may miss concomitant pathology at the suprascapular notch and sacrifices lateral trapezius function, resulting in poor restoration of shoulder external rotation. A posterior approach allows decompression and visualisation of the SSN at the notch and distal coaptation of the medial XI branch. The medial triceps has a double fascicle structure that may be coapted to both the anterior and posterior division of the axillary nerve, whilst preserving the stabilising effect of the long head of triceps at the glenohumeral joint. Reinnervation of two shoulder abductors and two external rotators may confer advantages over previous approaches with improved external rotation range of motion and strength. Methods. Review of the clinical outcomes of 22 patients who underwent a double nerve transfer from XI and radial nerves. Motor strength was evaluated using the MRC scale and grade 4 was defined as the threshold for success. Results. 18/22 patients had adequate follow-up (Mean: 29.5 months). Of these, 72.2% achieved ≥grade 4 power of shoulder abduction and a mean range of motion of 103°. 64.7% achieved ≥grade 4 external rotation with a mean range of motion of 99.6°. Conclusions. The results suggest the use of the combined nerve transfer for restoration of shoulder function via a posterior approach, involving the medial head branch of triceps to the axillary nerve and the XI to SSN

Introduction. Distal femur fractures around a total knee arthroplasty (TKA) are a growing problem for orthopaedic surgeons. The purpose of this study was to identify risks of reoperation for nonunion following open reduction and internal fixation of TKA periprosthetic distal femur fractures (PDFF). Method. Patients with PDFF (AO 33A-C[VB1, C1, D1], Su types 1-3) managed operatively with open reduction and internal fixation (ORIF) were retrospectively reviewed. Exclusion criteria were acute management with a distal femur replacement, less than 6 months of follow-up, and lack of injury or follow-up radiographs. The primary outcome measure was reoperation to achieve bony union. Comparisons were made between cases that did and did not require a reoperation to achieve union. Univariate analysis was used to identify factors to be analyzed in multivariate analysis to determine independent risk factors for the primary outcome. Result. A total of 77 patients met inclusion criteria. Union rate was 69/77 (89.6%). There were no differences between the groups for age, sex, BMI, comorbidities, Su classification, open injury, or mechanism of injury. Multivariate analysis identified risks for nonunion including post-operative malalignment (OR 1.41; CI 1.20-1.64; p<0.001), notching pre-operatively (OR 1.22; CI 1.04-1.42; p=0.012), presence of screws through fracture line (OR 1.28; CI 1.17-1.39; p<0.001), plate length <12 holes (OR 1.16; CI 1.02-1.33; p=0.024) and screw density greater than 0.4 (OR 2.18; CI 1.25-3.78; p=0.006). Conclusion. The reoperation rate to promote union was 10.4%. The study identified post-operative malalignment, notching pre-operatively, presence of screws through fracture line, plate length <12 holes, and proximal screw density greater than 40% as independent risk factors for nonunion

Introduction. The aim of this radiographic study was to define the anatomical axis joint centre distance (aJCD) and anatomical axis joint centre ratio (aJCR) of the distal femur in the coronal plane for skeletally mature individuals. Materials and Methods. A cross-sectional radiographic study was conducted to calculate the horizontal distances between the anatomical axis and the centre of the knee at the level of the intercondylar notch and the joint line. Ratios relating these points to the width of the femur were then calculated. Results. A total of 164 radiographs were included: 91 male (55.5%) and 73 female patients (44.5%) with a mean age of 44.9 ± 18.0 years, with 79 right (48.2%) and 85 left (51.8%). The intercondylar width mean was 75.4 ± 6.8mm, the median aJCD at the notch was 3.6mm (interquartile range, IQR 2.1 – 5.1), the median aJCD at the joint line was 4.7mm (IQR 3.5 – 6.3), the aJCR at the notch 45.1 ± 2.7, and the aJCR at the joint line 43.5 ± 2.7. The intercondylar width was significantly different (p<0.001) between males (79.5 ± 5.0 mm) and females (70.4 ± 5.1 mm). A significant difference between the aJCR at the notch (p=0.003) and the aJCR at the joint line (p=0.002) was observed in males and females. No differences between the aJCD at the notch or aJCD at the joint line was observed between males versus females, left versus right and those younger versus those older than 65 years. Conclusions. This is the first objective description of the anatomic axis joint centre ratio (aJCR) of the distal femur in the coronal plane. This ratio can be used to aid the planning and execution of distal femoral deformity correction, retrograde femoral nailing, and total knee arthroplasty