The aetiology and pathophysiology of non-union is still unclear, but in this condition there is an abnormal bone metabolism. The paracrine matrix RAS has been implicated in the regulation of bone remodeling and injury responses, possibly via its effects on kinins. The influence of the local RAS or the genetic influence of the ACE/ BK2R genes to bone remodelling may thus be central to the disorder, or augmented in these conditions. We thus compared the distribution of the ACE I/D and BK2R “+9/-9” functional polymorphisms in patients with non-union and compared them to appropriate control. Gene analysis was performed on buccal cells collected from all subjects and the data was analysed for 59 patients (46 males, 13 females; mean age 40.1±15.7 years) with non-union and 81 control subjects (49 males, 32 females; mean age 51.4±22.81 years. The overall genotype distribution was consistent with Hardy-Wein-berg equilibrium for the overall and individual groups for ACE (p0.16), B1BKR (p0.68) and B2BKR genotypes (p0.12). As the -9 allele is associated with greater gene transcription and higher mRNA expression of the receptor we combined the -9/-9 homozygous and -9/+9 heterozygous groups and compared them with the homozygous +9/+9 groups. This showed a significant difference between the non-union and control groups, with the +9/+9 homozygous being less prominent in the former (p=0.03). The B2BKR -9 allele is associated with the incidence of non-union in fracture healing, in this first study to address this question. We found no association with either the ACE I/D or B1BKR genotypes. In conclusion, with previous findings that the absence of the -9 allele of the B2BKR +9/-9 polymorphism is associated with greater gene transcription and higher mRNA expression of the receptor our findings are suggestive that increased BK activity via the B2BKR may predispose to the development of non-union

Aim. Although non-union is a devastating and costly consequence of trauma for the child, family and society it is felt to be a rare complication in children. Currently there is no data available in the literature regarding its incidence either per fracture or per head of population. Should we be taking paediatric fracture non-union more seriously regarding research, resource allocation and informed consent? Our aim was to determine the incidence of non-union per child and per fracture. Method. In Scotland Information Services Division (NHS Scotland) records every inpatient admission by ICD-10 diagnosis. As almost all fracture non-unions require intervention ISD provides accurate non-union figures by site and age. However, many fractures are treated as outpatients. Using local data of overall fracture numbers we were able to calculate a ratio of inpatient to total fracture numbers and apply this nationally. Results. Over a 5-year period there were 180 cases of non-union between the ages of 0–14 years, (4.21/100,000pa) and an incidence of 15,335 fractures/100,000pa giving an overall risk of 0.24% non-union per fracture. The risk of non-union per fracture did not change throughout childhood but notably increased in the late teenage years (15–19yrs). Both the incidence of fractures and non-union were far greater in boys, however incidence of non-union per fracture was similar in both sexes in childhood. Non-union per fracture was twice as frequent in the lower than upper limb, this trend reversed in the 15–19 year age group. Conclusion. The annual incidence of fractures in children is 15.3%, more frequent in the upper than lower limb; increasing with age, particularly in boys. The risk of non-union is around 1/400 per upper limb and 1/250 per lower limb fracture in childhood. Fracture non-union is rare in the paediatric population but even so 4.2 cases would be expected per 100,000 population or 240 cases per 100,000 fractures

Introduction. Fracture non-union is a devastating cause of patient morbidity. The cost of NU treatment ranges from £7,000 to £79,000. With an estimated 11,700 cases in the UK pa the financial implications are huge, potentially costing several hundreds of million of pounds annually. Successful outcome in the management of non-union is based upon correctly identifying the underlying cause(s) and addressing them appropriately. Aim. The aim of this study was to assess the causative factors in non-union in order to optimize the management of non-union. The causes of NU were categorized into 4 groups (infection, dead bone/gap, host factors, mechanical). Method. 100 consecutive patients who had surgery for long bone non-union were analysed. Information was obtained from the patient clinic visits, notes, radiographs and laboratory results. The cause(s) of the non-union were identified, recorded and divided into 4 groups; host, mechanical, dead bone/gap at NU site and infection. Results. The mean age at time of injury was 41.4(±16.7)years; male/female ratio was 3:1, 80% were lower limb (52% of all cases were tibial). 69% were high energy, 38% were open. 26% of patients had a single attributable cause, 59% had two causes, 14% had three causes and one had all four. Mechanical causation was found in 56% of cases, dead bone/gap in 50%, host factors in 44%, infection in 40% of patients. 5.7% of the infections were unexpected new/occult positive findings. 73% of patients with previously treated infection but without ongoing infection had multiple positive cultures. Conclusion/discussion. Surgical procedures for non-union often address a single aspect yet 74% had more than one attributable cause. With a 6% occult infection rate multiple tissue samples for microbiology and pathology investigation should be carried out routinely in every patient with non-union. The multi-factorial nature of non-union makes meticulous patient assessment vital to maximise the chance of treatment success

Fracture repair is a wound healing process that in young healthy patients usually proceeds to uncomplicated union. However, the healing cascade is delayed with increasing age, medication and certain diseases such as rheumatoid arthritis. Recently the important role of the immune system in fracture repair has become apparent within the emerging subject of Osteoimmunology. Patients with rheumatoid arthritis have an altered immune system and therefore we have investigated the hypothesis that patients with rheumatoid arthritis have a higher incidence of non-union after a fracture compared to patients without rheumatoid arthritis. Method: The Edinburgh Royal Infirmary computer database was searched over a 10 year period (May 1996- May 2006) to identify all patients with non-union out of the total number of patients presenting with fractures. These patients groups were then subdivided into patients that had and did not have rheumatoid arthritis. Patients were excluded if they were lost to follow up, or if the fracture either occurred before the May 1996 or management continued passed May 2006. In this study non-union was defined as failure to heal within expected timescale and lack of progression at serial x-rays (all non-union were diagnosed at least 3 months from fracture). Results: From May 1996 through to May 2006, 8,456 patients with fracture were defined. 71 of these patients with fractures had rheumatoid arthritis. Of these patients 63 had union of their fractures whilst 8 patients developed non-union of their fracture (11.3%). In a total of 8385 non rheumatoid arthritis patients 164 developed non-union of their fracture compared to 8221 patients who had union of their fractures (2%). Comparison between these two patient groups suggests rheumatoid arthritis patients are more likely to develop non-union of traumatic fractures (Chi squared test, p value < 0.001). Patients with rheumatoid arthritis who progressed to non-union were on the following medication, Gold (1), Indomethacin (1), Non steroidal anti-inflammatories (4), Combination analgesia (2), Antihypertensives (2), Omeprazole (1) and Thyroxine (1). Discussion: The results from this study suggest that patients with rheumatoid arthritis have a greater incidence of non-union after a fracture compared to patients without rheumatoid arthritis. This maybe due to the abnormal immune system in rheumatoid arthritis patients. However rheumatoid arthritis patients are often on a number of medications and these drugs rather than the innate alteration of the immune system may be responsible for the altered healthy response. However whether as a result of the rheumatoid arthritis itself or the medication, our study demonstrates a higher non-union rate in the rheumatoid arthritis patients and this needs to be taken into account when treating rheumatoid arthritis patients with fractures

Background. Proximal humeral fractures are common and a minority develop non-union, which can result in pain and disability. We aimed to identify the risk factors and quantify the prevalence of non-union. Methods. A thirteen-year retrospective study of 7039 patients with proximal humeral fractures was performed and a database created. 246 patients with non-union were compared to a control group to identify risk factors. Logistic regression analyses were performed to identify significant variables obtained at presentation to predict non-union. Results. The crude rate of non-union after any proximal humeral fracture is 3.5%, rising to 5.6% after excluding patients with isolated tuberosity fractures or those who underwent primary fixation. 179 patients with non-union were compared to a control group of 295 patients whose fractures healed. There was no significant difference between the groups and the entire study population in terms of age, gender and mechanism of injury. Univariate and multivariate logistic regression analyses identified 3 significant predictors for non-union: displacement of fracture (p<0.001); having a two-part fracture (p = 0.045); and varus angulation of the humeral head at injury (p<0.001). Conclusions. The prevalence of non-union of proximal humeral fractures (3.2/100,000population/year) is higher than previously appreciated and a modified classification (ongoing) is needed to include the identified risk factors

Introduction and Objectives: Septic non-union can present a variety of problems for the surgeon, the most common being loss of bone continuity and persistence of infection. When conventional treatments fail we begin to use new bone tissue engineering techniques. The aim of this study is to present our experience over the last 5 years with 50 cases of infected non-union in which we used BMP-7. Materials and Methods: Between 2002 and 2007 we used BMP-7 in 50 patients according to the protocol established by Friedlaender in 2001. Each patient was treated with allograft and BMP-7 and the same surgical technique was used in every case. Follow-up exams were carried out every 2 months with different control X-rays, analysis and cultures were performed to assess the evolution of consolidation and the end of infection. Results: We achieved the desired consolidation in almost 70% of cases with good functionality of the affected limbs and freedom from infection. On the other hand, in 30% of cases we did not achieve expected consolidation and we saw that infection still persisted. Discussion and Conclusions: The most critical and influential parameters affecting the end-result of treatment of infected non-union with BMP-7 are persistence of infection, poor vascularization, inadequate stabilization, and defective coverage of the subcutaneous tissue adjacent to the non-union focus

Summary Statement. Treatment of non-union is a highly demanding field with respect to bone healing. BMP 7 is a useful, wide-ranged tool in treating non-union of the foot and benign bone tumors. It represents a low-risk procedure with a high level of reliability. Introduction. Treatment of non-union is a highly demanding field with respect to bone healing. Treatment of tibial fracture non-union with the bone morphogenetic protein 7 (BMP-7) has been successfully reported. BMP 7 is a recombinant human protein produced in ovary cells of the Chinese hamster. It is responsible for the differentiation of mesenchymal stem cells from the periost, muscle and sponious bone and stimulates bone formation. It is the aim of our study to investigate the use of BMP 7 for other locations than the tibia, such as the foot and benign bone tumors. We strive for union or revision in each medical case. Patients & Methods. At our clinic we applied BMP-7 to 13 patients (9 patients with non-union, 4 patients with benign bone cysts). 9 patients with non-union of the foot (4 forefoot, 1 midfoot, 3 hindfoot, 1 tibia) were surgically treated by resection, stabilisation, and application of BMP 7. The study included 5 men and 4 women at an average age of 58,4 years (range 33 – 80), 13 previous surgeries had been carried out. The period of follow up was on average 16.3 months (5 – 40 months). The indication for using BMP-7 instead of autologous bone graft was poor local blood supply, poor local soft tissue because of previous interventions and risk factors like smoking and diabetes. Following an indicated open biopsy, the 4 cases of benign bone tumors (1 juvenile bone cyst of the talus, 1 osteofibrose dysplasia of the proximal tibia and 2 juvenile bone cysts of the proximal humerus) were all treated with resection, followed by an application of BMP-7 and external or internal fixation. In addition two received bone grafting and two received cortisone. The average age of the tumor group was 16,75 years (11–24 years, 2 male, 2 female). Results. At follow-up all patients were satisfied with respect to pain and function, no operative complications had occurred and bone fusion had finished in 7 patients after 3 months. One ankle joint had a fibrous fusion but was free of pain. One arthrodesis of the first metatarsophalangeal joint was turned into a resection arthroplasty, today the patient is free of pain and uses a normal shoe. Both bone cysts have the radiological evidence of rehabilitation. At one humeruscyst we removed the TENS-nails without complications. We had no complications like heterotopic ossification, local erythema or pressure sensitivity. Discussion/Conclusion. These results show that BMP 7 is a useful, wide-ranged tool in treating non-union of the foot and benign bone tumors. It represents a low-risk procedure with a high level of reliability

Introduction. The Ilizarov method for non-union comprises a range of treatment protocols designed to generate tissue, correct deformity, eradicate infection and secure union. The choice of specific reconstruction method is difficult, but should depend on the biological and mechanical needs of the non-union. We present a prospective series of patients with non-union of the tibia managed using a treatment algorithm based on the Ilizarov method and the viability of the non-union. Patients and methods. Forty-four patients (34 men and 10 women) were treated with 26 viable and 18 non-viable non-unions. Mean duration of non-union was 19 months (range 2-168). 25 patients had associated limb deformity and 37 cases were infected. 42 patients had undergone at least one previous operation. Bone resection was dictated by the presence of non-viable and infected tissue. Four Ilizarov protocols were used (monofocal distraction in 18 cases, monofocal compression in 11 cases, bifocal compression-distraction in 10 cases and 5 bone transports) depending on the stiffness of the non-union or the presence of segmental defect. Results. Union was achieved in 40 cases (91%) with Ilizarov method alone. Infection was eradicated in 35 cases (95%). Monofocal distraction produced union in all 18 stiff non-unions with little morbidity. Monofocal compression was successful in only 82% of mobile non-unions but failed to eradicate infection in 2 of 10 cases. Bifocal techniques allowed infection-free union in all 15 difficult segmental infected non-unions but required prolonged treatment times and bone grafting to docking sites. Complications included pin infection, hindfoot stiffness, refracture, one below-knee amputation and residual limb length discrepancy. Conclusion. We do not recommend monofocal compression in the treatment of infected, mobile non-unions. Distraction (monofocal or bifocal) was effective and is associated with high rates of clearance of infection

Purpose: To study the results of treatment of symptomatic non-union with endoprosthesis at the Royal Orthopaedic Hospital. Methods: Between 1987 & 2005, 17patients were treated with massive endoprosthesis for non-union. We performed a retrospective review of these case notes. Results: Mean age at diagnosis was 63years (range 36–86). Location of non-union was distal femur in 9, proximal femur in 4, proximal humerus in 2, proximal tibia in 1, distal humerus in 1. The majority of the patients had received prior multiple operations before endoprosthetic surgery. Four patients had obvious infection confirmed by histology and/or microbiology prior to surgery. Endoprosthetic Reconstruction was performed as a 1 stage procedure in 13 and as a 2 stage in 4. Complications occurred in 5 patients. These included recurrence of infection in 1, persistent pain in 1, aseptic loosening in 1, periprosthetic fracture in 1 and a non ST myocardial infarction in 1. At the last follow-up, (mean 5years, range 1–18years) majority of patients achieved good range of motion and good mobility. Conclusion: We conclude that endoprosthetic replacement is a reasonable option for treatment of end-stage non-union in carefully selected patients. Adequate mobility and function can be achieved in majority of patients following such treatment

Background. Understanding of the pathogenetic mechanisms of non-union can not ignore bone remodelling and its cascade of processes at cellular and biochemical levels culminating in an incomplete structural and functional restoration of the damaged bone. Osteoprotegerin (OPG) is expressed by osteoblasts and functions as a decoy receptor that is able to control and to regulate osteoclastogenesis and therefore to prevent bone resorption. The objectives of our study were: to investigate OPG serum levels in shaft fractures non-union compared to controls; to assess the use of OPG as a marker for the early identification of fracture non-unions. Material and Methods. OPG serum levels were determined in 25 male patients (aged between 20–59 years, mean 35.44 ± 11.53) with a shaft fracture non-union at the time of minimum six months (mean 16.83 ± 10.87) since trauma and age matched with 25 male controls patients (aged 20–59 mean 35.44 ± 11.76) with a shaft fracture healed. All patients were correctly operated with different types of synthesis for complex fractures of a long bone (humerus, femur, tibia). Osteocalcin, bone isoenzyme of alkaline phosphatase and deoxypyridino-line (DPD) were also measured. Results. OPG levels were significantly higher in non-union cases compared to age matched controls (mean 10.17 ± 3.08 vs 8.54 ± 1.18 U/L; p=0.0084). DPD level was significantly higher in cases respect to controls (mean 7.9 ± 2.74 vs 3.8 ± 1.00 nmolDPD/mmol urinary creatinine excretion; p=0.0001). ROC analysis and the classification for probability cut-off show a very good negative predictive value (84%) for a cut-off of OPG 10 U/L, indicating that all patients having OPG lower than 10 U/L are probably free of non-union. Similarly, for an increase of 1 U/L of OPG there is an increase of probability of being a case of 92%. Higher OPG levels clearly carries a higher risk of non-union, thus indicating the usefulness of OPG evaluation in the follow-up of fractured patients. Larger groups will allow the estimation of the correct level of OPG threshold by age, which we are now able to estimate of about 8 U/L for young patients and 10 U/L for older ones in our population. Conclusion. Shaft fracture non-union may occur following appropriate osteosynthesis in consequence of a condition of altered bone osteoclastic activity. OPG could be directly involved in the pathogenesis of shaft fractures non-union and seems to be an accurate predictive marker in non-union evaluation

Conservative management remains the gold standard for many fractures of the humeral diaphysis with union rates of over 90% often quoted. Success with closed management however is not universal. Phase 1. A retrospective review of all conservatively managed fractures between 2001 and 2005 was undertaken to investigate a suspected high non-union rate and identify possible causes. The overall non-union rate was 39.2% (11 of 28 cases). There was no difference in axial distraction at presentation, however following application of cast there was significantly more distraction in the non-union group (1.2 v 5.09mm, p<0.01). Changes to practise. All humeral fractures were admitted, lightweight U-slabs were applied by a technician, distraction was avoided, patients abstained from NSAIDS, consultant reviewed radiographs before discharge and patients were converted early to functional brace. Phase 2. Prospective collection of data over the following two year period showed a decrease in the amount of distraction when first placed in cast (2.73 v 0.74, p<0.05), a reduction in NSAID use (89% v 38%, p<0.01) and earlier conversion to brace (37 v 20 days p<0.01). These changes to practise led to a dramatic reduction in non-union rate from 39.2% to 4.9% (p<0.01). Conclusion. Over-distraction at first application of cast is a causal factor in the development of non-union. Lightweight cast, avoidance of distraction, abstinence from NSAIDS and early conversion to functional brace is recommended. The initial surgical management of the patient who displays evidence of distraction will prevent evolution of non-union with conservative management. This will avoid lengthy delays in the treatment of the non-union and also help to prevent secondary stiffness in adjacent joints and disuse osteopenia

Introduction: Infected non-union in the forearm is a rare and challenging situation. It can result in persistent deformity, shortening, bone loss, joint stiffness and disability. Secondary procedures are often required for correction of bone defects and deformity. Bone transport may be the only realistic method of treatment. Case presentation: 56-year-old gentleman referred with an infected non-union of left distal radius. He underwent bone debridement with ilizarov frame application for distraction osteogenesis. After a period of one month, a longitudinal transport wire was inserted through the distal segment to the proximal segment and distraction was carried using this wire. This was supplemented by iliac crest bone graft and OP-1 substitute at docking stage. The frame was removed at 18 months, following which he sustained a refracture. ORIF with bone graft was performed. Finally a good consolidation was achieved. There was about 50% loss in pronation and supination and about 15 degrees short of full extension at the final followup. Another 57-year-old gentleman referred for an infected non-union of the ulna with a severe bone defect. He was treated with a TSF application and corticotomy for distraction osteosynthesis. There has been a satisfactory progress in the bone transport and recently underwent a docking procedure with bone graft insertion. Discussion: Post traumatic infected non-union with segmental bone defect in the forearm can be successfully managed with bone transport. Unlike tibia, where this procedure is commonly done, forearm bones have a complex soft tissue envelope which can rule out the use of external transport, especially in the radius. We found the longitudinal wire technique useful for transport of radius. Internal fixation can be used to salvage initial failures, provided that infection and substantial bone defects have been eliminated. This treatment is intensive and difficult for patient and surgeon

Definitions and perceptions of good and poor outcome vary between patients and surgeons, and perceived inadequate outcome can lead to litigation. We investigated outcomes of litigation claims relating to non-union and deformity following lower limb long bone fractures from 1995 to 2010. The database of all 10456 claims related to Trauma and Orthopaedic Surgery was obtained from the NHS Litigation Authority. Data was searched for “deformity, non-union and mal-union”, excluding spine, arthroplasty, foot and upper limb surgery. The type of complaint, whether defended or not, and costs was analysed. 241 claims met our criteria, 204 of which were closed, and 37 unsettled. Deformity/mal-union constituted 97, and non-union 143. Coronal/sagittal deformity cost £4.2 million, mean £45,487 (60% received compensation). Rotational mal-unions cost £1.6 million, mean £114,263 (87% received compensation). Non-union cost £5.3 million, mean £75,866 (60% received compensation). Mean legal fees for coronal/sagittal deformity was £18,772, rotational deformity £37,384, and non-union £24,680. The total cost of litigation was £12.2 million, with a mean of £59,597 per settled claim. The mean pay-out for all confirmed negligence/liability was £56,046 (£1,300–£500,000, median £21,500) per case. Non-union is an accepted complication following fracture surgery. However, this does not mitigate against non-union being seen as representing a poor standard of care. While it is unclear whether the payouts reflect a defensive culture or were due to avoidable errors, and notwithstanding the limitations of the database, we argue that failure of the index surgery should prompt a referral to a specialist centre. The cosmetic appearances of rotational malalignment results in higher compensation, reinforcing outward perception of outcome as being more important than harmful effects. We also note that the database sometimes contained conflicting and incomplete data, and make a case for standardisation of this component of the outcome process to allow for learning and reflection

The purpose of this study is to describe the use of intramedullary distraction coupled with an additional osteotomy to achieve union with simultaneous deformity correction and lengthening in femoral non-union. Femoral non-union is a difficult problem often associated with shortening, angulation, and mal-rotation. We report the use of an intramedullary distraction device, with additional osteotomy, to achieve union, restore femoral length and alignment. Simple distraction in femoral non-union is often ineffective, possibly because the non-union site is relatively avascular. Osteotomy is known to increase blood flow and, with lengthening, promote union through distraction histiogenesis. 7 patients with posttraumatic diaphyseal femoral non-union with shortening were studied. Pre-operative planning included long leg standing views, with CT to measure mal-rotation. 6 patients were treated with the Intramedullary Skeletal Kinetic Distractor (ISKD) with an osteotomy distant from non-union site within the parameters required for the device. One patient underwent distraction without osteotomy. Patients were followed to union. Complications and adjuvant interventions were recorded. All 7 patients with femoral non-union treated with ISKD were included and followed up. Patients treated with osteotomy united at average of 9 months with satisfactory deformity correction and lengthening. However patient who underwent pure distraction failed to unite. Complications included failure to lengthen, requiring manipulation, and delayed consolidation of regenerate requiring bone graft. The procedure was well tolerated. The initial results of the management of femoral non-union with deformity by intramedullary distraction coupled with osteotomy are encouraging. Complications were minor and readily manageable. We believe there is an important role for this method in the management of femoral non-unions associated with deformity and length discrepancy

Stabilization and bone grafting are the basic principles in the treatment of fracture non-union, however, infection is always a concern. Percutaneous bone marrow grafting has been suggested as an alternative, which provides a source of osteogenic cells with osteoinductive effect. This prospective study evaluates the efficacy of percutanous bone marrow grafting in patients with tibial non-union while on the waiting list for open surgical procedures. 21 adult patients with established tibial non-union were recruited. The average age of fracture non-union was 12 months (range 6–36). Infected cases, deformed non-unions and gap non-unions were excluded. Eleven were hypertrophic and ten atrophic type of non-union. Under local anaesthesia, bone marrow was aspirated from the iliac crests using a 16 G sternal puncture needle. 3–5ml marrow was aspirated and injected immediately into and about the non-union site. Subsequent aspirations were performed 1 cm posterior to the previous site until a maximum of 15 ml marrow was injected. Patients were immobilised in a plaster cast. Radiographs were repeated at 6 weeks interval. A second injection was repeated at 6 weeks if there was no evidence of callus formation. The procedure was considered a failure, if there was no union at six weeks following the third injection. Bone marrow could not be aspirated in one patient. 19 patients were followed up clinically and radiologically until there was definite bone union or failure. Bone union was achieved in 15 patients out of 20 (75%), with an average time to union following the first injection 14 weeks (range 6–22 ). Two of the patients needed only one injection, nine needed two injections, and four patients needed three injections to unite. 4 patients (20%) showed no evidence of union. There were no complications at the donor or recipient site. We conclude that percutanous bone marrow grafting is a safe, simple, and reliable method of treating tibial non-union with minimal deformity

Background. Non-union has traditionally been considered a rare complication following the non-operative management of clavicle fractures. A growing body of evidence has demonstrated higher rates of non-union in adults with displaced fractures. However, the variables that predict non-union in these patients remain unclear. We evaluated the prevalence and risk factors for non-union following displaced midshaft clavicle fractures in a large consecutive series of patients managed non-operatively in our Unit. Materials and Methods. 1097 consecutive adults (mean age 26.1yrs) with displaced midshaft clavicle fractures treated non-operatively in our Unit were included. All patients were interviewed and examined by an orthopaedic trauma surgeon and underwent radiological assessment within a week of injury. All patients were managed in a simple sling for two weeks followed by early mobilization. All patients were followed-up until clinical and radiological confirmation of union. Non-union was defined clinically as the presence of pain or mobility of the fracture segments on stressing, and radiologically as failure of cortical bridging by 6 months. Results. 198 (18%) of patients had evidence of non-union at 6 months. Patient factors significantly associated with non-union included increasing age, smoking and the presence of medical comorbidities (p<0.05). Injury-related factors associated with non-union included Increasing fragment translation and displacement, and a severe pattern of injury (Edinburgh 2B2: comminuted segmental fracture)(p<0.01). Conclusions. We present the largest series reporting the prevalence and risk factors for non-union following conservatively treated, displaced midshaft clavicle fractures. These fractures can no longer be viewed as a single clinical entity, but as a spectrum of injuries each requiring individualized assessment and treatment. Increased understanding of the outcomes of these injuries will enable clinicians to better identify those patients that may be better served with primary operative reconstruction

Non-union has traditionally been considered a rare complication following the non-operative management of clavicle fractures. Recent studies demonstrate higher rates of non-union in adults with displaced fractures, yet the variables predicting non-union remain unclear. We evaluated the prevalence and risk factors for non-union following displaced midshaft clavicle fractures in a large consecutive series of patients managed non-operatively. 1097 consecutive adults (mean age 26.1yrs) with displaced midshaft clavicle fractures treated non-operatively in our Unit were included. All patients were interviewed, examined and underwent radiological assessment within a week of injury. All patients were managed in a sling for two weeks followed by early mobilization. All patients were followed-up until clinical and radiological confirmation of union. Non-union was defined clinically as pain or mobility of the fracture segments on stressing, and radiologically as failure of cortical bridging by 6 months. 198 (18%) of patients had evidence of non-union at 6 months. Patient factors associated with non-union included increasing age, smoking and the presence of medical comorbidities (p<0.05). Injury-related factors associated with non-union included increasing fragment translation and displacement, and injury pattern (Edinburgh 2B2: comminuted segmental fracture)(p<0.01). We present the largest series reporting prevalence and risk factors for non-union following conservatively treated, displaced midshaft clavicle fractures. These fractures can no longer be viewed as a single clinical entity, but as a spectrum of injuries each requiring individualized assessment and treatment. Increased understanding of the outcomes of these injuries will enable clinicians to better identify those patients that may be better served with primary operative reconstruction

The symptomatic non-union of the scaphoid, if left untreated, will eventually lead to established arthritis and by that time important alterations in carpal geometry will have occurred. The aim of this paper is to study the carpal geometry in patients with symptomatic scaphoid non-union without arthritis or with early arthritic changes. The pre-operative x-rays of 58 patients were retrospectively reviewed and x-rays of 35 of those fulfilling strict criteria for true projections were included (32 posteroanterior and 31 lateral views). Patients’ mean age was 31.3 years and mean time from fracture 50.4 months. The x-rays were digitized and measured using CAD methodology. The measured variables concerned the carpal height, possible displacement of the carpal bones and carpal instability. The non-unions were classified according to the Herbert and Fisher classification and were further categorized in two subgroups concerning the absence (14) or presence (21) of early arthritic changes in the radio-carpal or in one of the mid-carpal articulations (patients with established or generalized arthritis were excluded). In total (and varying according to the method of measurement) up to 28% of the patients were presented with an affected carpal height, up to 17% with ulnar translocation of the wrist and up to 48% with a DISI pattern of instability. 62.5% of the patients (including patients without radiologicaly obvious arthritis) had increased radial height and radial inclination. After statistical analysis (ANOVA and regression analysis) no significant differences have been found between the morphological groups or between the two subgroups concerning early arthritis. A tendency of the lunate to translocate both in the coronal and the sagital plain simultaneously was found and the measurement methods were correlated. In conclusion the carpal geometry in scaphoid non-union although altered does not seem to change significantly with the appearance of early arthritis and from this point of view treating non-union with early arthritis with bone grafting and osteosynthesis or even with additional radial osteotomy seems justified

The incidence of non-union in the long bones varies with each bone and with the methods of treating acute fractures. Several factors have been implicated as the cause of non-union, most of which are inherent in the nature of the fracture. High-velocity open fractures with skin or bone loss, distraction at the fracture site, and an inadequate external or internal fixation increase the incidence of non-union in fractures. Weber and Cech classify non-unions as two types – hypervascular and avascular. Hypervascular non-unions can be treated by stable fixation of the fragments alone, whereas the avascular type requires decortication and bone grafting for healing. Reamed intramedulary nailing is an effective technique for management of the tibial shaft aseptic non-union for both types. Twenty tibial non-unions were treated with a reamed intramedullary nail. The initial fracture management consisted of a cast in seven patients (35%), external fixation in four (20%), plate osteosynthesis in four (20%), and unreamed nailing in five (25%). The time from injury to nailing averaged 32 weeks. Patients were followed for an average of 16 months. All non-unions united uneventfully and functional results were excellent. Contraindications are a history of prior acute infection or excessive shortening due to bone loss. Reamed intramedullary nailing is an effective, relatively low-risk technique for the management of non-union of the tibia. The closed technique should be used when possible. When necessary, open alignment should be executed with minimal dissection. Osteotomy of the fibula is a necessary component of this technique and bone grafting is indicated in cases of avascular non-union

Tibial non-union causes significant morbidity and functional impairment. Circular frames are valuable tools in the treatment of non-union, however prolonged treatment often causes patients increased morbidity due to pin site problems together with personal and emotional strains. The purpose of this study was to assess patient centred outcomes following treatment of tibial non-union in circular frame. We identified 21 patients who had undergone treatment of tibial non-union using a circular frame. Patients were sent questionnaires utilising the Enneking scoring system and EQ-5D general health questionnaire. Fourteen patients responded. There were 3 females, mean age was 48.2 years. The average number of previous operations was 1.2. All patients went on to achieve union with a mean 10.1 months (6–20) in frame. The mean Enneking score was 58.0% (34.3–77.1). Two patients were enthusiastic about their treatment, two liked it, three were satisfied, four accepted and would do it again while three accepted it but would not do it again. The Euroqol questionnaire results showed that 8 patients had some difficulty with mobility, 10 had some difficulty with usual activities and 12 moderate pain. There was no significant difference in the EQ VAS score of overall health state for treated patients compared with predicted scores for an age and sex matched UK population (77.7 vs 83.1, p=0.07). Our study shows that many patients undergoing limb salvage with circular frames for tibial non-union continue to have clinically significant symptoms, however the majority would undergo similar treatment again and we found no difference in overall health state compared with age and sex matched predicted scores. Circular frames are undoubtedly a valuable tool in the management of non-union however patients should be given realistic counselling regarding the treatment and expected outcome