Computer Assisted Surgery (CAS) and Patient Specific Instrumentation (PSI) have been reported to increase accuracy and predictability of tumour resections. The technically demanding
Objectives. Using a simple classification method, we aimed to estimate the collapse rate due to osteonecrosis of the femoral head (ONFH) in order to develop treatment guidelines for
Torsional deformities are increasingly recognized as an additional factor in young patients with hip pain resulting from pincer- and cam-deformities. For example decreased femoral torsion can worsen an anterior Femoroacetabular impingement (FAI) conflict while an increased torsion can be beneficial with the same configuration. It is unknown how often torsional deformities are present in young patients presenting with hip pain that are eligible for joint preserving surgery. We questioned (1) what is the prevalence of a pathological femoral torsion in hips with FAI or hip dysplasia? (2) which hip disorders are associated with an abnormal torsion? An IRB-approved retrospective study of 463 consecutive symptomatic FAI patients (538 hips) and a MRI or CT scan on which femoral torsion could be measured was performed (‘study group'). Out of 915 MRI we excluded 377 hips. The study group was divided into 11 groups: Dysplasia (< 22° LCE), retroversion, anteverted hips, overcoverage (LCE angle 36–39°), severe overcoverage (LCE>39°), cam (>50° alpha angle), mixed FAI, varus- (<125° CCD angle), valgus- (>139° CCD), Perthes-hips and hips with no obvious pathology. The ‘control group' of normal hips consisted of 35 patients (35 hips) without radiographic signs of osteoarthritis or hip pain wich was used for a previous study. Femoral antetorsion was measured according to Tönnis et al. as the angle between the axis of the femoral neck and the posterior axis of the femoral condyles. Normal femoral torsion was defined by Tönnis et al. as angles 10–25° while decreased resp. increased torsion was defined as <5° and >25°. Statistical analysis was performed using analysis of variances (ANOVA).Introduction
Methods
Aims. Although there are various pelvic osteotomies for acetabular dysplasia of the hip, shelf operations offer effective and minimally invasive osteotomy. Our study aimed to assess outcomes following modified Spitzy shelf acetabuloplasty. Methods. Between November 2000 and December 2016, we retrospectively evaluated 144 consecutive hip procedures in 122 patients a minimum of five years after undergoing modified Spitzy shelf acetabuloplasty for acetabular dysplasia including osteoarthritis (OA). Our follow-up rate was 92%. The mean age at time of surgery was 37 years (13 to 58), with a mean follow-up of 11 years (5 to 21). Advanced OA (Tönnis grade ≥ 2) was present preoperatively in 16 hips (11%). The preoperative lateral centre-edge angle ranged from -28° to 25°. Survival was determined by Kaplan-Meier analysis, using conversions to total hip arthroplasty as the endpoint. Risk factors for joint space narrowing less than 2 mm were analyzed using a Cox proportional hazards model. Results. The mean Merle d'Aubigné clinical score improved from 11.6 points (6 to 17) preoperatively to 15.9 points (12 to 18) at the last follow-up. The survival rates were 95% (95% confidence interval (CI) 91 to 99) and 86% (95% CI 50 to 97) at ten and 15 years. Multivariate Cox regression identified three factors associated with radiological OA progression: age (hazard ratio (HR) 2.85, 95% CI 1.05 to 7.76; p = 0.0398), preoperative joint space (HR 2.41, 95% CI 1.35 to 4.29; p = 0.0029), and preoperative OA (HR 8.34, 95% CI 0.94 to 73.77; p = 0.0466). Conclusion. Modified Spitzy shelf acetabuloplasty is an effective
Aims. The aim of this study was to investigate whether anterior pelvic plane-pelvic tilt (APP-PT) is associated with distinct hip pathomorphologies. We asked: is there a difference in APP-PT between young symptomatic patients being evaluated for joint preservation surgery and an asymptomatic control group? Does APP-PT vary among distinct acetabular and femoral pathomorphologies? And does APP-PT differ in symptomatic hips based on demographic factors?. Methods. This was an institutional review board-approved, single-centre, retrospective, case-control, comparative study, which included 388 symptomatic hips in 357 patients who presented to our tertiary centre for joint preservation between January 2011 and December 2015. Their mean age was 26 years (SD 2; 23 to 29) and 50% were female. They were allocated to 12 different morphological subgroups. The study group was compared with a control group of 20 asymptomatic hips in 20 patients. APP-PT was assessed in all patients based on supine anteroposterior pelvic radiographs using validated HipRecon software. Values in the two groups were compared using an independent-samples t-test. Multiple regression analysis was performed to examine the influences of diagnoses and demographic factors on APP-PT. The minimal clinically important difference (MCID) for APP-PT was defined as > 1 SD. Results. There were no significant differences in APP-PT between the control group and the overall group (1.1° (SD 3.0°; -4.9° to 5.9°) vs 1.8° (SD 3.4°; -6.9° to 13.2°); p = 0.323). Acetabular retroversion and overcoverage groups showed higher mean APP-PTs compared with the control group (p = 0.001 and p = 0.014) and were the only diagnoses with a significant influence on APP-PT in the stepwise multiple regression analysis. All differences were below the MCID. The age, sex, height, weight, and BMI showed no influence on APP-PT. Conclusion. APP-PT showed no radiologically significant variation across different pathomorphologies of the hip in patients being assessed for
Purpose: Spontaneous osteonecrosis of the knee is a potentially greatly debilitating condition. While success has been reported with non-operative treatment of this disorder in its earliest stages, knee arthroplasty is the only viable modality if allowed to progress to condylar collapse. The purpose of this report is to review the etiologic and pathophysiologic principles of spontaneous osteonecrosis of the knee, to present our experience with joint-preserving surgical treatment of this condition, and finally to introduce a treatment algorithm developed based on this knowledge. Method: Seventeen patients with a clinical and/or radiographic a diagnosis of spontaneous osteonecrosis of the knee, and exclusion of secondary osteonecrosis, who failed non-operative modalities were treated with
Objectives. Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) is a novel MRI-based technique with intravenous contrast agent that allows an objective quantification of biochemical cartilage properties. It enables a ‘monitoring' of the loss of cartilage glycosaminoglycan content which ultimately leads to osteoarthritis. Data regarding the longitudinal change of cartilage property after joint preserving hip surgery is sparse. We asked (1) if and how the dGEMRIC-index changes in patients undergoing open/arthroscopic treatment of femoroacetabular impingement (FAI) one year postoperatively compared to a control group of patients with non-operative treatment; (2) and if a change correlates with the clinical short term outcome. Methods. IRB-approved prospective comparative longitudinal study of two groups involving a total of 61 hips in 55 symptomatic patients with FAI. The ‘operative' group consisted of patients that underwent open/arthroscopic treatment of their pathomorphology. The ‘non-operative' group consisted of conservatively treated patients. Groups were comparable for preoperative radiographic arthritis (Tönnis score), preoperative HOOS- and WOMAC-scores and baseline dGEMRIC indices. All patients eligible for evaluation had preoperative radiographs and dGEMRIC scans at baseline and repeated dGEMRIC scans using the same scanner and protocol. (1) dGEMRIC indices of femoral and acetabular cartilage were assessed separately on the initial and follow-up dGEMRIC scans. Radial images were reformatted from a 3D T1 map for measurements. Regions of interest were placed manually peripherally and centrally within the cartilage based on anatomical landmarks at the 12 ‘hour' position of the clcok-face with the help of radial high-resolution PD-weighted MR images. (2) Patient-reported outcome was evaluated at baseline and at 1 year follow-up: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Hip disability and Osteoarthritis Outcome Score (HOOS). Statistical analysis included Student's t-Tests, Mann-Whitney U-tests and Wilcoxon signed-rank tests (p<0.05). Results. On the acetabular side, the dGEMRIC index decreased significantly (p<0.05) in 17/20 (85%) zones respectively in 21/24 (88%) of femoral zones in the operated group [Fig. 1]. In the non-operative group, no acetabular zone and 2/24 (8%) femoral zones presented with a significant drop [Fig. 2]. After one year the WOMAC and the HOOS scores significantly improved (58±42 to 33±42; p= 0.007 respectively 63±16 to 74±18; p= 0.028) for the operative group, while there was no change (55±45 to 48±50; p= 0.825 respectively 63±14 to 66±19; p= 0.816) for the non-operative group. Discussion. Interestingly
Introduction. The goal of
Background: Osteoarthritis (OA) is a progressive degenerative condition that causes pain and impairs the mobility of more than 10% of the UK population. Over 50,000 total knee replacements (TKR) are carried out each year for patients with the most severe symptoms. The aim of this study was to assess if markers of protein damage in the synovial fluid and plasma of patients with OA increase with severity of symptoms. These markers may then be of use in assessing disease presence and progression to assist with subsequent management. Proteins damaged by glycation (modified by sugars) and oxidation undergo cellular proteolysis. The proteolytic debris thereby formed - called glycation and oxidation free adducts (glycated and oxidised amino acids) - is released into the synovium and plasma for urinary excretion. In this study the concentrations of the glycation free adducts, Nε-carboxymethyl-lysine (CML) and methylglyoxal-derived hydroimidazolone (MG-H1), and the oxidation free adduct methionine sulfoxide (MetSO) were measured in the synovial fluid and plasma of patients with severe OA (sOA) and early-stage OA (eOA). Methods: Patients were recruited from those attending the Rheumatology clinics at Ipswich Hospital, Ipswich and the Orthopaedic clinics at University Hospital, Coventry. Volunteer subjects were recruited to the normal healthy control group. The age (years; mean ± SD) for patient and control subject groups was: controls 45 ± 6 (n = 8), sOA 70 ± 12 (n = 8), eOA 50 ± 14 (n = 6). Patients found to have eOA changes (Outerbridge grade I/II) during routine arthroscopy were recruited to the eOA group. Synovial fluid and venous blood samples were taken with informed consent. All synovial fluid samples were taken from the knee joint. The concentrations of glycation and oxidation free adducts were assayed by stable isotopic dilution analysis liquid chromatography with tandem mass spectrometric detection (LC-MS/MS) in ultrafiltrate of synovial fluid and plasma. Significance of difference between study groups was assessed by ANOVA and Student’s t-test. Results: The concentrations (nM; mean ± SD) of MetSO, CML and MG-H1 in synovial fluid were all markedly increased in OA patients with more severe disease. MetSO free adduct: eOA 459 ± 107 and sOA 2889 ± 1064 (p<
0.001). CML free adduct: eOA 77 ± 24 and 224 ± 51 (p<
0.001). MG-H1 free adduct: eOA 387 ± 182 and sOA 674 ±199 (p<
0.05). Analysis of plasma of these patients also showed increases in the concentrations of corresponding glycation and oxidation free adducts compared to those of normal healthy controls. Discussion: The concentration of glycation and oxidation free adducts increased with severity of symptoms in the synovial fluid of patients with OA. This probably occurs by down regulation of protective gene expression in OA. Measurement of plasma protein glycation and oxidation free adducts may be useful in assessing progression and severity of OA. In the future, these markers may guide non-operative management and facilitate earlier
This systematic review and meta-analysis was conducted to compare open reduction and internal fixation (ORIF) with primary arthrodesis (PA) in the treatment of Lisfranc injuries, regarding patient-reported outcome measures (PROMs), and risk of secondary surgery. The aim was to conclusively determine the best available treatment based on the most complete and recent evidence available. A systematic search was conducted in PubMed, Cochrane Controlled Register of Trials (CENTRAL), EMBASE, CINAHL, PEDro, and SPORTDiscus. Additionally, ongoing trial registers and reference lists of included articles were screened. Risk of bias (RoB) and level of evidence were assessed using the Cochrane risk of bias tools and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool. The random and fixed-effect models were used for the statistical analysis.Aims
Methods
In the native hip, the hip capsular ligaments tighten at the limits of range of hip motion and may provide a passive stabilizing force to protect the hip against edge loading. In this study we quantified the stabilizing force vectors generated by capsular ligaments at extreme range of motion (ROM), and examined their ability to prevent edge loading. Torque-rotation curves were obtained from nine cadaveric hips to define the rotational restraint contributions of the capsular ligaments in 36 positions. A ligament model was developed to determine the line-of-action and effective moment arms of the medial/lateral iliofemoral, ischiofemoral, and pubofemoral ligaments in all positions. The functioning ligament forces and stiffness were determined at 5 Nm rotational restraint. In each position, the contribution of engaged capsular ligaments to the joint reaction force was used to evaluate the net force vector generated by the capsule.Aims
Methods
We compared the clinical outcomes of curved intertrochanteric varus osteotomy (CVO) with bone impaction grafting (BIG) with CVO alone for the treatment of osteonecrosis of the femoral head (ONFH). This retrospective comparative study included 81 patients with ONFH; 37 patients (40 hips) underwent CVO with BIG (BIG group) and 44 patients (47 hips) underwent CVO alone (CVO group). Patients in the BIG group were followed-up for a mean of 12.2 years (10.0 to 16.5). Patients in the CVO group were followed-up for a mean of 14.5 years (10.0 to 21.0). Assessment parameters included the Harris Hip Score (HHS), Oxford Hip Score (OHS), Japanese Orthopaedic Association Hip-Disease Evaluation Questionnaire (JHEQ), complication rates, and survival rates, with conversion to total hip arthroplasty (THA) and radiological failure as the endpoints.Aims
Methods
As our understanding of hip function and disease improves, it is evident that the acetabular fossa has received little attention, despite it comprising over half of the acetabulum’s surface area and showing the first signs of degeneration. The fossa’s function is expected to be more than augmenting static stability with the ligamentum teres and being a templating landmark in arthroplasty. Indeed, the fossa, which is almost mature at 16 weeks of intrauterine development, plays a key role in hip development, enabling its nutrition through vascularization and synovial fluid, as well as the influx of chondrogenic stem/progenitor cells that build articular cartilage. The pulvinar, a fibrofatty tissue in the fossa, has the same developmental origin as the synovium and articular cartilage and is a biologically active area. Its unique anatomy allows for homogeneous distribution of the axial loads into the joint. It is composed of intra-articular adipose tissue (IAAT), which has adipocytes, fibroblasts, leucocytes, and abundant mast cells, which participate in the inflammatory cascade after an insult to the joint. Hence, the fossa and pulvinar should be considered in decision-making and surgical outcomes in hip preservation surgery, not only for their size, shape, and extent, but also for their biological capacity as a source of cytokines, immune cells, and chondrogenic stem cells. Cite this article: