Introduction: Unicompartmental knee arthroplasty (UKA) is a proven for treatment of knee osteoarthritis (OA). Survival rates have been found comparable with total knee arthroplasty (TKA) in specialty hospitals series, but registry based studies show worse results of survival of UKA. High BMI, age of the patient, patellofemoral arthritis or learning curve have been found to have only mild consequences to the survival rates. Original indications for Oxford UKA in OA are severe pain and full thickness cartilage loss with bone-on-bone contact in the medial side. After widespread use of UKA surgeons are broadening their indications. Purpose of this study was to evaluate the influence of preoperative degree of OA on survival rate of UKA. Material and Methods: 113 knees in 103 patients were operated with Oxford phase 3 UKA. We evaluated all the patient data retrospectively and patient age, body mass index (BMI), sex, earlier arthroscopies, operation time, follow-up time, preoperative medial joint space widths, reoperations and survival of UKA was recorded. Results: The mean age of the patients was 58 years (38–81) and mean follow-up time was 47 months (3–114). 22 UKAs were revised and the overall survival rate was 80.5%. 68% of revised knees have had undergone arthroscopy before UKA to confirm existence of arthritis. Odds ratio for female gender was statistically non-significant 1.59 (95% CI 0.57–4.45, p=0.46,). For BMI and patient’s age, the association remained non-significant with odds ratios of 1.07 (95% CI 0.98–1.17, p=0.14) and 0.96 (95% CI 0.90–1.02, p=0.19). Patients were divided four sub-groups according medial joint space width (medial joint space width ≤2 mm and > 2 mm) and Lateral/medial joint space width ratio (L/M-ratio ≤2.5 and > 2.5). Over 2 mm medial joint space width or L/M-ratio less than 2.5 were found significant risk factors for revisions, odds ratios being 6.00 (95% CI 2.12–17.00, p< 0.01) and 7.88 (95% CI 2.76–22.54, p< 0.01), respectively. Discussion: Nowadays UKAs are performed on patients with mild OA against the original indications. In more severe OA varus alignment of the knee causes mechanical overload to the medial compartment, which is well corrected by UKA. Also it is possible that in the cases of prolonged knee pain caution is focused incorrectly to mild OA, which is typical radiological finding even in asymptomatic middle aged and elderly patients. Also in the early phase of OA it is impossible to estimate progression of cartilage damage in other two compartments. In conclusion we suggest that not to extend original indication of UKA and patient should have true medial bone-on-bone OA in preoperative radiographs. Performing UKA for patients with medial joint space width over 2 mm or L/M-ratio less than 2.5 should be concerned particularly careful

Introduction. Three-dimensional (3D) morphological understanding of the hip joint, specifically the joint space and surrounding anatomy, including the proximal femur and the pelvis bone, is crucial for a range of orthopedic diagnoses and surgical planning. While deep learning algorithms can provide higher accuracy for segmenting bony structures, delineating hip joint space formed by cartilage layers is often left for subjective manual evaluation. This study compared the performance of two state-of-the-art 3D deep learning architectures (3D UNET and 3D UNETR) for automated segmentation of proximal femur bone, pelvis bone, and hip joint space with single and multi-class label segmentation strategies. Method. A dataset of 56 3D CT images covering the hip joint was used for the study. Two bones and hip joint space were manually segmented for training and evaluation. Deep learning models were trained and evaluated for a single-class approach for each label (proximal femur, pelvis, and the joint space) separately, and for a multi-class approach to segment all three labels simultaneously. A consistent training configuration of hyperparameters was used across all models by implementing the AdamW optimizer and Dice Loss as the primary loss function. Dice score, Root Mean Squared Error, and Mean Absolute Error were utilized as evaluation metrics. Results. Both the models performed at excellent levels for single-label segmentations in bones (dice > 0.95), but single-label joint space performance remained considerably lower (dice < 0.87). Multi-class segmentations remained at lower performance (dice < 0.88) for both models. Combining bone and joint space labels may have introduced a class imbalance problem in multi-class models, leading to lower performance. Conclusion. It is not clear if 3D UNETR provides better performance as the selection of hyperparameters was the same across the models and was not optimized. Further evaluations will be needed with baseline UNET and nnUNET modeling architectures

Scaphoid fractures are a common injury accounting for more than 58% of all carpal bone fractures(1,2). Biomechanical studies have suggested that scaphoid mal-union may lead to altered carpal contact mechanics causing decreased motion, pain and arthritis(1,2). The severity of mal-union required to cause deleterious effects has yet to be established. This limits the ability to define surgical indications or impacts on prevention of posttraumatic arthritis. Computed tomography has been shown to be a useful in determining the 3D implications of altered bony alignment on the joint contact mechanics of surrounding joints. The objective of this study was to report mid-term follow-up image-based outcomes of patients with scaphoid mal-unions to determine the extent to which arthritic changes and decreased joint space is present after a minimum of 4 years following fracture. Participants (n=14) who had previously presented with a mal-united scaphoid fracture (indicated by a Height:Length Ratio >0.6) between November 2005 and November 2013 were identified and contacted. A short-arm thumb spica case was used to treat X patients and X required surgical management. Baseline and follow-up CT images, were performed with the wrist in radial deviation and positioned such that the long axis of the scaphoid was perpendicular to the axis of the scanner. Three-dimensional inter-bone distance (joint space), a measure of joint congruency and 3D alignment, was quantified from reconstructed CT bone models of the distal radius, scaphoid, lunate, capitate, trapezium and trapezoid from both the baseline and follow-up scans(3). Repeated measures ANOVA was used to detect differences in contact area (mm2) between baseline and follow-up CT's for the radioscaphoid, scaphocapitate and scaphotrapezium-trapezoid joint. The average age of participants was 43.1 years (16–64 years old). There was significant loss of joint space, indicated by a greater joint contact area 3–4 years post fracture, between baseline and follow-up reconstruction models, at the scaphocapitate (mean difference: 21.5±146mm2, p=0.007) and scaphotrapezoid joints (mean difference: 18.4 ±28.6mm2, 0.042). Significant differences in the measured contact area was not found for the radioscaphoid (0.153) and scaphotrapezium joints (0.72). Additionally, the scaphoid, qualitatively, appears to track in the vorsal direction in the majority of patients following fracture. Increased joint contact area in the scaphocapitate and scaphotrapezoid joint 3–4 years following fracture results from decreased 3D joint space and overall narrowing. Joint space narrowing, while not significantly different for all joints examined, was reduced for all joints surrounding the scaphoid. Decreased joint space and increased contact area detectable within this short interval might be suggestive of a trajectory for developing arthritis in the longer term, and illustrates the potential value of these measures for early detection. Longer term follow-up and correlation to clinical outcomes are needed to determine the importance of early joint space narrowing, and to identify those most at risk

Introduction. Although surgical remedies tend to be the long-term solutions for patients with osteoarthritis (OA), many alternatives exist that offer the potential to slow progression, alleviate pain, and/or restore function. One such option is the unloader OA knee brace. The objective of this study was to assess the in vivo medial joint space narrowing with and without the brace during weight-bearing portion of gait. Methods. Twenty subjects were evaluated after being clinically assessed by a single surgeon to be bone-on-bone on the medial side. In vivo gait kinematics were collected using a validated 3D-to-2D fluoroscopic registration technique (Figure 1). Subjects were asked to first walk on a treadmill without a brace (Figure 2), and then, after a qualified technician fit a properly sized brace to each subject, they were asked to walk again (Figure 3). In vivo fluoroscopic images were captured and registered at heel-strike (HS) and mid stance (MS) for both scenarios. CT scans were used to acquire the patient-specific bone models that were used in the registration process. Results. All twenty subjects experienced a positive increase in medial joint space and verbally stated their knee pain lessened while wearing the brace. The average medial joint space change was 1.7±0.8 mm (3.1 max, 0.3 min) at HS and 1.6±0.8 mm (3.7 max, 0.4 min) at MS (Figure 4). Five patients experienced more than 2.5 mm of medial joint space change when wearing the unloader brace, indicating substantial effectiveness of the brace. Conclusion. While previous unloader brace studies have focused on outcome scores and patient satisfaction to analyze brace effectiveness, this study quantifiably demonstrated improvement in joint space narrowing due to the unloader brace. These results suggest that unloader braces may provide benefit in the interim when symptoms of OA are present prior to need for surgical intervention. For any figures or tables, please contact the authors directly

INTRODUCTION. Controversy exists regarding the ability of unicompartmental knee arthroplasty (UKA) to restore native knee kinematics, with some studies suggesting native kinematics are restored in most or all patients after UKA. 1–3. , while others indicate UKA fails to restore native knee kinematics. 4,5. Previous analysis of UKA articular contact kinematics focused on the replaced compartment. 2,5. , neglecting to assess the effects of the arthroplasty on the contralateral compartment which may provide insight to future pathology such as accelerated degeneration due to overload. 6. or a change in the location of cartilage contact. 7. The purpose of this study was to assess the ability of medial UKA to restore native knee kinematics, contact patterns, and lateral compartment dynamic joint space. We hypothesized that medial UKA restores knee kinematics, compartmental contact patterns, and lateral compartment dynamic joint space. METHODS. Six patients who received fixed-bearing medial UKA consented to participate in this IRB-approved study. All patients (4 M, 2 F; average age 62 ± 6 years) completed pre-surgical (3 weeks before) and post-surgical (7±2 months) testing. Synchronized biplane radiographs were collected at 100 images per second during three repetitions of a chair rise movement (Figure 1). Motion of the femur, tibia, and implants were tracked using an automated volumetric model-based tracking process that matches subject-specific 3D models of the bones and prostheses to the biplane radiographs with sub-millimeter accuracy. 8. Anatomic coordinate systems were created within the femur and tibia. 9. and used to calculate tibiofemoral kinematics. 10. Additional outcome measures included the center of contact in the medial and lateral compartments, and the lateral compartment dynamic joint space (i.e. the distance between subchondral bone surfaces). 11. The results of the three movement trials were averaged for each knee in each test session. All outcome measures were interpolated at 5° increments of knee extension (Figure 2). The average differences between knees at corresponding flexion angles were analyzed using paired t-tests with significance set at p < 0.05. RESULTS. The UKA knee was in 5.3° more varus than the contralateral knee prior to surgery (p=0.005). After surgery, the UKA knee was in 4.9° more valgus than before surgery (p=0.005). The UKA knee was 4.3° more externally rotated than the contralateral knee post-surgery (p=0.05) (Table 1). No significant differences were observed between knees or pre- to post-surgery in lateral compartment dynamic joint space or the center of contact in the medial and lateral tibia compartments (Table 1). DISCUSSION. These results suggest that medial UKA can restore native knee varus without significantly altering lateral compartment joint space or contact location during the chair rise movement. For any figures or tables, please contact the authors directly

Aims. To explore the clinical relevance of joint space width (JSW) narrowing on standardized-flexion (SF) radiographs in the assessment of cartilage degeneration in specific subregions seen on MRI sequences in knee osteoarthritis (OA) with neutral, valgus, and varus alignments, and potential planning of partial knee arthroplasty. Methods. We retrospectively reviewed 639 subjects, aged 45 to 79 years, in the Osteoarthritis Initiative (OAI) study, who had symptomatic knees with Kellgren and Lawrence grade 2 to 4. Knees were categorized as neutral, valgus, and varus knees by measuring hip-knee-angles on hip-knee-ankle radiographs. Femorotibial JSW was measured on posteroanterior SF radiographs using a special software. The femorotibial compartment was divided into 16 subregions, and MR-tomographic measurements of cartilage volume, thickness, and subchondral bone area were documented. Linear regression with adjustment for age, sex, body mass index, and Kellgren and Lawrence grade was used. Results. We studied 345 neutral, 87 valgus, and 207 varus knees. Radiological JSW narrowing was significantly (p < 0.01) associated with cartilage volume and thickness in medial femorotibial compartment in neutral (r = 0.78, odds ratio (OR) 2.33) and varus knees (r = 0.86, OR 1.92), and in lateral tibial subregions in valgus knees (r = 0.87, OR 3.71). A significant negative correlation was found between JSW narrowing and area of subchondral bone in external lateral tibial subregion in valgus knees (r = −0.65, p < 0.01) and in external medial tibial subregion in varus knees (r = −0.77, p < 0.01). No statistically significant correlation was found in anterior and posterior subregions. Conclusion. SF radiographs can be potentially used for initial detection of cartilage degeneration as assessed by MRI in medial and lateral but not in anterior or posterior subregions. Cite this article: Bone Joint Res 2021;10(3):173–187

Purpose: Radial head replacement with a prosthesis that is too thick has been reported to be associated with stiffness, pain and capitellar wear. Radiographic widening of the lateral ulnohumeral joint following radial head replacement has been used as a criterion to diagnose overstuffing of the radiocapitellar joint. The purpose of this study was to show that widening of the lateral ulnohumeral joint is a normal anatomic variant and therefore cannot be used conclusively to diagnose radiocapitellar joint overstuffing. Methods: Fifty normal standardized anteroposterior elbow radiographs from 50 patients with a mean age of 48 years were reviewed to evaluate variations in the joint space between the medial and lateral facets of the ulnohumeral joint. Using computer software at 4x magnification (GE, Fairfield, CT), two lines were drawn perpendicular to the lateral ulnohumeral joint and two lines perpendicular to the medial ulnohumeral joint. The difference in length of these two lines was used to assess how parallel the lateral and medial joint spaces are. The lengths of the two lines were averaged to compare lateral joint space thickness to medial joint space thickness. Results: The width of the lateral ulnohumeral joint space (3.6mm & #61617; 0.8mm) was greater than the medial ulnohumeral joint space (2.8mm & #61617; 0.5mm) (p< 0.001). The lengths of the two medial joint space perpendicular lines were similar (p> 0.05), indicating the medial joint space is normally parallel. The lengths of the lateral joint space perpendicular lines were greater laterally (p= 0.02), indicating the lateral joint is not normally parallel. Conclusions: The lateral ulnohumeral joint space is often wider than the medial ulnohumeral joint space on an anteroposteror radiograph of the normal elbow. While the medial ulnohumeral joint space is usually parallel, the lateral ulnohumeral joint space may be non-parallel and wider laterally, therefore, lateral joint space widening is not a reliable indicator of radiocapitellar joint overstuffing. A non-parallel medial ulnohumeral joint space may be suggestive of possible overstuffing of a radial head arthroplasty, however, comparison radiographs of the uninjured elbow is likely the best investigation to consider when overstuffing is suspected

Purpose: The aetiology of primary omarthrosis is still unclear. Typical radiological changes are joint space narrowing and the development of caudal osteophytes. The objective of the study is the analysis of the joint space of the shoulder in four different age groups. Materials and Methods: Retrospective analysis of n=342 standardized X-rays (2002–2009) (true ap, axillary). Inclusion criteria: normal adulthood group I (n=60), instability group II (n=53), calcifying tendonitis of the supraspinatus tendon group III (n=109), advanced primary omarthrosis group IV (n=120). Measurement of joint space at three levels (ap: superior, central, inferior; axillary: anterior, central, posterior). Two independent measurements. Statistical analysis SPSS 17.0: U-Test acc. Mann and Whitney. Bivariate correlation analysis (Spearman), partial correlation analysis, intraclass correlation coefficient. Results: Mean age group I 17.84±1.54, group II 31.6±11.8, group III 48.2±8.0, group IV 66.43 ±9.74 (p=0.001). Measurement joint space: interobserver reliability excellent in the ap-projection (r=0.887–0.910) and in the axillary projection (r=0.879–0.886). Joint space group I: 4.79mm±0.84 superior ap, 4.28mm±0.75 central ap, 4.57mm±0.80 inferior ap, 6.59mm±1.44 anterior axillary, 6.12mm±1.09 central axillary and 7.03mm±1.17 posterior axillary; group II: 3.78mm±0.99 superior ap, 3.12mm±0.73 central ap, 3.38mm±0.80 inferior ap, 3.92mm±1.08 anterior axillary, 3.92mm±0.77 central axillary and 4.79mm±1.18 posterior axillary; group III: 3.43mm±1.06 superior ap, 2.87mm±0.80 central ap, 3.25mm±0.79 inferior ap, 3.95mm±0.83 anterior axillary, 3.34mm±0.84 central axillary and 4.05mm±0.84 posterior axillary; group IV: 2.00mm±1.40 superior ap, 1.47mm±1.07 central ap, 1.48mm±1.93 inferior ap, 3.01mm±2.22 anterior axillary, 1.08mm±1.12 central axillary and 1.17mm±1.04 posterior axillary. The differences between the four groups for the joint space width are all statistically significant with p< 0.001 (except the difference between group I and group II for ap-central, ap-inferior and axillary anterior). There is a significant negative correlation (r= −0,579–0,813) between the joint space width and patients age at all measured levels in both projections (p< 0.001). This negative correlation is only little smaller (r= −0,430–0,655) but still clearly significant for all measurements, if the patients with present osteoarthritis (group III) are excluded. Conclusion: The data of the study show a decrease of joint space width in group I–IV in all measurements. This effect is negatively correlated with age. The data suggest that the decrease in joint space with loss of cartilage cover is an age-dependant process which is independent from the presence of osteoarthritis. This is in contrast to historical findings but in concordance with recent basic studies about cartilage ageing

Introduction: Evaluation of the hip joint space was performed in patients with Legg-Calve-Perthes disease in this study. Materials and Methods: Seventy-eight patients (85 affected hips and 71 unaffected hips) with LCP disease were reviewed respectively to evaluate widening of the hip joint space, the extent of epiphyseal subchondral fracture, and metaphyseal changes. The mean age of the patients was 7.4 years (range, 3–13 years). There were 27 hips at the initial stage, 23 at the fragmentation stage, and 11 at the healing stage. The metaphyseal changes in MRI scans were classified as no change, marrow edema, false cyst, and true cyst. The false cyst was defined as a cyst located at the epiphysis, physis, and metaphysis. The true cyst was defined as a cyst located within the metaphysis. Results:The widened medial joint space at the initial stage was filled with overgrown cartilage of the femoral head and acetabulum on Magnetic Resonance Imaging (MRI) and radiographs. At the fragmentation stage, there was both overgrown cartilage and markedly widened true medial joint space, which was filled with an amount of joint fluid and hypertrophied synovial tissue. Widening of the true medial joint space at the initial stage had no correlation with lateral subluxation, whereas there was a definite correlation at the fragmentation stage. In the healing stage, coxa magna contributed to lateral subluxation rather than the widening of the false medial joint space, because it had decreased or normalized because of ossification of this overgrown cartilage and normalization of the synovial hypertrophy. The overall proportion of agreement was conducted by two groups of observers according to different classification systems. The results for Catterall groups 2, 3, and 4 showed 70% agreement with the Salter-Thompson classification, 65% with the MRI classification, and 75% in the Catterall classification. The subchondral fracture line had a prognostic significance in 17 of 20 hips (85%). The MRI had a prognostic significance in 10 of 20 hips (50%). Among 85 hips, there were no changes in 32 hips, marrow edema in 13 hips, false cysts in 28 hips, and true cysts in 12 hips. Discussion: The hips without metaphyseal change had less involvement of the epiphysis compared to the hips with the metaphyseal change. Metaphyseal cysts disappeared on radiographs and MRI scans during the healing or remodeling stage

Introduction. Chronic uneven distribution of forces over the articular cartilage, which are present in OA, has been shown to be a risk factor for the development of OA. Certain regions of the articular cartilage will be exposed to increased chronic peak loads, whereas other regions encounter a corresponding relative reduction of transmitted forces. This has a well known influence on cartilage viability and is a precursor of degenerative progression. Congruence of joints has an important impact on force distribution across articular surfaces. Therefore, tibiofemoral incongruence could lead to alterations of load distribution and ultimately to progressive degenerative changes. In clinical practice the routine method for evaluation of progressive OA is analysis of joint space width (JSW) using weight bearing radiographs. Recent studies have suggested that JSW has a strong positive correlation with cartilage compression, volume and meniscal extrusion. Lateral unicondylar knee arthroplasty (UKA) has gained increasing popularity over the last decade in the treatment of isolated unicompartmental osteoarthritis (OA). However, progressive degenerative alterations of the medial compartment following lateral unicompartmental knee arthroplasty remains a leading cause of revision surgery. Therefore, the purpose of this study is to evaluate the medial compartment congruence (MCC) and joint space width (JSW) alterations following lateral UKA. Methods. The MCC of 53 knees following lateral UKA was evaluated on pre- and postoperative radiographs and compared to 41 healthy knees, using an Interative Closest Point (ICP) algorithm. The ICP algorithm calculated the Congruence Index (CI) by performing a rigid transformation that best aligns the digitized tibial and femoral surfaces (figure 1A). Inner, middle and outer JSW was measured by subdividing the medial compartment into four quarters on weight bearing tunnel view radiographs pre- and postoperatively (figure 1B). Results. The measured CI of the healthy control group was 0.99. The pre-operative CI of knees undergoing lateral UKA was 0.92, which significantly improved to 0.96 (p<0.0001) post-operatively (figure 2). Post-operatively the inner JSW increased (p=0.006) and the outer decreased (p=0.002). JSW was restored post-operatively since no significant differences were noted in all three measured post-operative JSW locations compared to the control group (figure 3). Conclusion. Our data suggests that lateral UKA improves MCC and normalizes JSW of the medial compartment, potentially preventing osteoarthritic progression in the uninvolved medial compartment

Objectives. An important measure for the diagnosis and monitoring of knee osteoarthritis is the minimum joint space width (mJSW). This requires accurate alignment of the x-ray beam with the tibial plateau, which may not be accomplished in practice. We investigate the feasibility of a new mJSW measurement method from stereo radiographs using 3D statistical shape models (SSM) and evaluate its sensitivity to changes in the mJSW and its robustness to variations in patient positioning and bone geometry. Materials and Methods. A validation study was performed using five cadaver specimens. The actual mJSW was varied and images were acquired with variation in the cadaver positioning. For comparison purposes, the mJSW was also assessed from plain radiographs. To study the influence of SSM model accuracy, the 3D mJSW measurement was repeated with models from the actual bones, obtained from CT scans. Results. The SSM-based measurement method was more robust (consistent output for a wide range of input data/consistent output under varying measurement circumstances) than the conventional 2D method, showing that the 3D reconstruction indeed reduces the influence of patient positioning. However, the SSM-based method showed comparable sensitivity to changes in the mJSW with respect to the conventional method. The CT-based measurement was more accurate than the SSM-based measurement (smallest detectable differences 0.55 mm versus 0. 82 mm, respectively). Conclusion. The proposed measurement method is not a substitute for the conventional 2D measurement due to limitations in the SSM model accuracy. However, further improvement of the model accuracy and optimisation technique can be obtained. Combined with the promising options for applications using quantitative information on bone morphology, SSM based 3D reconstructions of natural knees are attractive for further development. Cite this article: E. A. van IJsseldijk, E. R. Valstar, B. C. Stoel, R. G. H. H. Nelissen, N. Baka, R. van’t Klooster, B. L. Kaptein. Three dimensional measurement of minimum joint space width in the knee from stereo radiographs using statistical shape models. Bone Joint Res 2016;320–327. DOI: 10.1302/2046-3758.58.2000626

Background/Objective: Since estrogen receptors (ERα/ERβ) were identified in human chondrocytes, animal-and experimental studies have demonstrated the importance of continued estrogen production for the integrity of articular cartilage. However, human epidemiological support of the hypothesis has been inconclusive. The present study investigated the relationship between reduced bone mineral densities (BMD), as a surrogate parameter of endogenous estrogen status – assessed by digital x-ray radiogrammetry (DXR), and reduced minimum hip joint space width (JSW). Methods: Standardised hand radiographs of the Copenhagen Osteoarthritis Study cohort of 3.913 adults (1.470M/2.443F) with a mean age of 60 years (range, 18–92), were analysed by the X-Posure. ™. digital software v. 2.0 (Sectra-Pronosco). The system is operator independent. From 1.200 individual measurements per radiograph mean BMD was calculated. Minimum hip joint JSW was assessed in standardized, pelvic radiographs. Results: DXR-BMD decreased in both men and women after the age of 45 years, progressively more so in women. While minimum hip JSW in men remained relatively unaltered throughout life, a marked decline in female minimum hip JSW after 45 years was observed. We found moderate, but highly significant relationships between reduced BMD and reduced hip JSW in women (p < 0.001), adjusted for age and dysplastic joint incongruity. Conclusion: We believe that the present study supports the hypothetical relationship between reduced estrogen levels and hip joint space width reduction in women

The purpose of this study was to determine the effect of sectioning the relevant soft tissues and a TKA on the medial and lateral knee joint gap.

Twelve intact lower extremity cadaveric specimens (mean (SD) age 76.5 (11.6) years) were tested. A custom designed knee tensioner was developed that allowed the separate application of forces to the medial and lateral components of the knee. The distance between the bottom of the load cell and the top of a compression rod was measured with digital calipers (precision = 0.1mm). Loads of 100N and 200N were then applied to each compartment and the resulting displacement was measured. The two loads were applied to the knee in the following conditions: i) All soft tissues intact; ii) an arthrotomy; iii) ACL sectioned; iv) PCL sectioned; v) release of the mid-coronal tissues; and vi) TKA. Finally, tensions were applied for all conditions from 90° to 0° of knee flexion in 30° increments.

There was a significant effect of soft tissue release on the magnitude of the gap at the 100N load application, such that there was an increase in the when the mid-coronal MCL release was performed compared to the intact (2.2mm) and arthrotomy (1.75mm) conditions. With respect to the 200N load application there was a statistically significant tissue release effect, where differences were detected between the mid-coronal MCL release and intact (3.04mm) and arthrotomy conditions (2.31mm). At the 100N load there was a significance increase in the gap compared to the intact knee. There was also a significant condition by knee angle interaction where the gap was approximately 4mm larger following the TKA compared to the intact condition when the knee was flexed at 90°. Furthermore, there was a statistically significant 4.8mm and 3.8mm difference between 90° and 0° and 60° and 0° of knee flexion respectively, for the TKA condition only. At the 200N load application the gap width increased significantly by 2.5mm following the TKA. Finally, there was a significant condition by knee angle interaction where the change in gap width increased significantly from the intact (7.54mm) to the TKA condition (13.88mm) at 90° of knee flexion. There was a statistically significant difference in the TKA condition between 60° and 0° of knee flexion.

Releasing the soft tissues increases the gap between the tibia and femur, when compared to the intact condition, with significance occurring only following the mid-coronal release. Furthermore, the TKA did not return the knee to its intact state as was evident by the significant difference between the TKA and intact conditions. This suggests that the resulting kinematics may not accurately match those pre-surgery resulting in un-physiological motion patterns and the possibility of early failure and revision.

Purpose. It is well known that meniscus extrusion is associated with structural progression of knee OA. However, it is unknown whether medial meniscus extrusion promotes cartilage loss in specific femorotibial subregions, or whether it is associated with a increase in cartilage thickness loss throughout the entire femorotibial compartment. We applied quantitative MRI-based measurements of subregional cartilage thickness (change) and meniscus position, to address the above question in knees with and without radiographic joint space narrowing (JSN). Methods. 60 participants with unilateral medial OARSI JSN grade 1–3, and contralateral knee OARSI JSN grade 0 were drawn from the Osteoarthritis Initiative. Manual segmentation of the medial tibial and weight-bearing medial femoral cartilage was performed, using baseline and 1-year follow-up sagittal double echo steady-state (DESS) MRI, and proprietary software (Chondrometrics GmbH, Ainring, Germany). Segmentation of the entire medial meniscus was performed with the same software, using baseline coronal DESS images. Longitudinal cartilage loss was computed for 5 tibial (central, external, internal, anterior, posterior) and 3 femoral (central, external, internal) subregions. Meniscus position was determined as the % area of the entire meniscus extruding the tibial plateau medially and the distance between the external meniscus border and the tibial cartilage in an image located 4mm posterior to the central image (a location commonly used for semi-quantitative meniscus scoring). The relationship between meniscus position and cartilage loss was assessed using Pearson (r) correlation coefficients, for knees with JSN and without JSN. Results. The percentage of knees showing a quantitative value of >3mm medial meniscus extrusion was 50% in JSN knees, and only 12% in noJSN knees. The 1-year cartilage loss in the medial femorotibial compartment was 74±182µm (2.0%) in JSN knees, and 26±120µm (0.8%) in noJSN knees. There was a significant correlation between cartilage loss throughout the entire femorotibial compartment (MFTC) and extrusion area in JSN knees but not for noJSN knees. Also, the extrusion distance measured 4mm posterior to the central slice was not significantly correlated with MFTC cartilage loss. The strongest (negative) correlation between meniscus position and subregional femorotibial cartilage loss (r=−0.36) was observed for the external medial tibia. In contrast, no significant relationship was seen in the central tibia. No significant relationship was found in other tibial subregions, except for the anterior medial tibia, but only in JSN knees (r=−0.27). Correlation coefficients for the femoral subregions were generally smaller than those for tibial subregions, with only the internal medial weight-bearing femur attaining statistical significance (r =−0.26). Conclusions. The current results show that the relationship between meniscus extrusion and cartilage loss differs substantially between femorotibial subregions. The correlation was strongest for the external medial tibia, a region that is physiologically covered by the medial meniscus. It was less for other tibial and femoral subregions, including the central medial tibia, a region that exhibited similar rates of cartilage loss as the external subregion. The findings suggest that external tibia may be particularly vulnerable to cartilage tissue loss once the meniscus extrudes and the surface is “exposed” to direct, non-physiological, cartilage-cartilage contact

Aims. The preventive effects of bisphosphonates on articular cartilage in non-arthritic joints are unclear. This study aimed to investigate the effects of oral bisphosphonates on the rate of joint space narrowing in the non-arthritic hip. Methods. We retrospectively reviewed standing whole-leg radiographs from patients who underwent knee arthroplasties from 2012 to 2020 at our institute. Patients with previous hip surgery, Kellgren–Lawrence grade ≥ II hip osteoarthritis, hip dysplasia, or rheumatoid arthritis were excluded. The rate of hip joint space narrowing was measured in 398 patients (796 hips), and the effects of the use of bisphosphonates were examined using the multivariate regression model and the propensity score matching (1:2) model. Results. A total of 45 of 398 (11.3%) eligible patients were taking an oral bisphosphonate at the time of knee surgery, with a mean age of 75.8 years (SD 6.2) in bisphosphonate users and 75.7 years (SD 6.8) in non-users. The mean joint space narrowing rate was 0.04 mm/year (SD 0.11) in bisphosphonate users and 0.12 mm/year (SD 0.25) in non-users (p < 0.001). In the multivariate model, age (standardized coefficient = 0.0867, p = 0.016) and the use of a bisphosphonate (standardized coefficient = −0.182, p < 0.001) were associated with the joint space narrowing rate. After successfully matching 43 bisphosphonate users and 86 non-users, the joint narrowing rate was smaller in bisphosphonate users (p < 0.001). Conclusion. The use of bisphosphonates is associated with decreased joint degeneration in non-arthritic hips after knee arthroplasty. Bisphosphonates slow joint degeneration, thus maintaining the thickness of joint cartilage in the normal joint or during the early phase of osteoarthritis. Cite this article: Bone Joint Res 2022;11(11):826–834

Management of ankle arthritis in young patients is challenging. Although ankle arthrodesis gives consistent pain relief, it leads to loss of function and adjacent joint arthritis. Ankle joint distraction (AJD) has been shown to give good outcomes in adults with osteoarthritis or post-traumatic arthritis. The efficacy in children or young adults and those with juvenile idiopathic arthritis is less well evidenced. Clinical notes and radiographs of all patients (n=6) managed with AJD in one tertiary referral centre were retrospectively reviewed. Radiographs were taken pre-surgery, intra-operatively, 1 month following frame removal and at the last follow up, tibiotalar joint space was assessed using ImageJ software. Measurements were taken at the medial, middle and lateral talar dome using frame components as reference. Radiographic data for patients with a good clinical outcome was compared with those who did not. At time of surgery mean age was 16.1 years (12 – 25 years). Mean follow up was 3.4 years (1.5 – 5.9 years). Indications were juvenile idiopathic arthritis (4) post-traumatic (1) and post-infective arthritis (1). Three patients at last follow up had a good clinical outcome. Two patients required revision to arthrodesis (1.3 and 2.4 years following distraction). One patient had spontaneous fusion. One patient required oral antibiotics for pin site infection. Inter-observer reliability was 95%. Mean joint space was 1.17mm (SD = 0.87mm) pre-operatively which increased to 6.72mm (SD = 2.23mm) at the time of distraction and 2.09mm (SD = 1.14mm) at the time of removal. At one-year follow up, mean joint space was 1.96mm (SD = 1.97mm). Outcomes following AJD in this population are variable although significant benefits were demonstrated for 50% of the patients in this series. Radiographic joint space preoperatively did not appear to be associated with need for arthrodesis. Further research in larger groups of young patients is required

In this study, we aimed to investigate tibiofemoral and allograft loading parameters after OCA transplantation using tibial plateau shell grafts to characterize the clinically relevant biomechanics that may influence joint kinematics and OCA osseointegration after transplantation. The study was designed to test the hypothesis that there are significant changes in joint loading after tibial plateau OCA transplantation that may require unique post-operative rehabilitation regimens in patients to restore balance in the knee joint. Fresh-frozen cadaveric knees (n=6) were thawed and mounted onto a 6 DOF KUKA robot. Specimens were size matched to +2 mm for the medial-to-lateral width of the medial tibial hemiplateaus. Three specimens served as allograft recipient knees and three served as donor knees. Recipient knees were first tested in their native state and then tested with size-matched medial tibial hemiplateau shell grafts (n=3) prepared from the donor knees using custom-cut tab-in-slot and subchondral drilling techniques. Tekscan sensors were placed in the joint spaces to evaluate the loading conditions under 90N biaxial loading at full extension of the knee before and after graft placement. The I-Scan system used in conjunction analyzed the total force, pressure distribution, peak pressure, and center of force within the joint space. Data demonstrated significant difference (p<0.05) in joint space loading after graft implantation compared to controls in both lateral and medial tibial plateaus. The I-Scan pressure mapping system displayed changes in femoral condylar contact points as well. The results demonstrated that joint space loading was significantly different (p<0.05) between all preoperative and postoperative cadaveric specimens. Despite the best efforts to size match grafts, slight differences in the host's joint geometry resulted in shifts of contact areas between the tibial plateau and femoral condyle therefore causing either an increase or decrease in pressure measured by the sensor. This concludes that accuracy in graft size matching is extremely important to restoring close to normal loading across the joint and this can be further ensured through postoperative care customized to the patient after OCA surgery

Aims. Although there are various pelvic osteotomies for acetabular dysplasia of the hip, shelf operations offer effective and minimally invasive osteotomy. Our study aimed to assess outcomes following modified Spitzy shelf acetabuloplasty. Methods. Between November 2000 and December 2016, we retrospectively evaluated 144 consecutive hip procedures in 122 patients a minimum of five years after undergoing modified Spitzy shelf acetabuloplasty for acetabular dysplasia including osteoarthritis (OA). Our follow-up rate was 92%. The mean age at time of surgery was 37 years (13 to 58), with a mean follow-up of 11 years (5 to 21). Advanced OA (Tönnis grade ≥ 2) was present preoperatively in 16 hips (11%). The preoperative lateral centre-edge angle ranged from -28° to 25°. Survival was determined by Kaplan-Meier analysis, using conversions to total hip arthroplasty as the endpoint. Risk factors for joint space narrowing less than 2 mm were analyzed using a Cox proportional hazards model. Results. The mean Merle d'Aubigné clinical score improved from 11.6 points (6 to 17) preoperatively to 15.9 points (12 to 18) at the last follow-up. The survival rates were 95% (95% confidence interval (CI) 91 to 99) and 86% (95% CI 50 to 97) at ten and 15 years. Multivariate Cox regression identified three factors associated with radiological OA progression: age (hazard ratio (HR) 2.85, 95% CI 1.05 to 7.76; p = 0.0398), preoperative joint space (HR 2.41, 95% CI 1.35 to 4.29; p = 0.0029), and preoperative OA (HR 8.34, 95% CI 0.94 to 73.77; p = 0.0466). Conclusion. Modified Spitzy shelf acetabuloplasty is an effective joint-preserving surgery with a wide range of potential indications. Cite this article: Bone Jt Open 2023;4(12):932–941

Varus malalignment increases the susceptibility of cartilage to mechanical overloading, which stimulates catabolic metabolism to break down the extracellular matrix and lead to osteoarthritis (OA). The altered mechanical axis from the hip, knee to ankle leads to knee joint pain and ensuing cartilage wear and deterioration, which impact millions of the aged population. Stabilization of the remaining damaged cartilage, and prevention of further deterioration, could provide immense clinical utility and prolong joint function. Our previous work showed that high tibial osteotomy (HTO) could shift the mechanical stress from an imbalanced status to a neutral alignment. However, the underlying mechanisms of endogenous cartilage stabilization after HTO remain unclear. We hypothesize that cartilage-resident mesenchymal stem cells (MSCs) dampen damaged cartilage injury and promote endogenous repair in a varus malaligned knee. The goal of this study is to further examine whether HTO-mediated off-loading would affect human cartilage-resident MSCs' anabolic and catabolic metabolism. This study was approved by IACUC at Xi'an Jiaotong University. Patients with medial compartment OA (52.75±6.85 yrs, left knee 18, right knee 20) underwent open-wedge HTO by the same surgeons at one single academic sports medicine center. Clinical data was documented by the Epic HIS between the dates of April 2019 and April 2022 and radiographic images were collected with a minimum of 12 months of follow-up. Medial compartment OA with/without medial meniscus injury patients with unilateral Kellgren /Lawrence grade 3–4 was confirmed by X-ray. All incisions of the lower extremity healed well after the HTO operation without incision infection. Joint space width (JSW) was measured by uploading to ImageJ software. The Knee injury and Osteoarthritis Outcome Score (KOOS) toolkit was applied to assess the pain level. Outerbridge scores were obtained from a second-look arthroscopic examination. RNA was extracted to quantify catabolic targets and pro-inflammatory genes (QiaGen). Student's t test for two group comparisons and ANOVA analysis for differences between more than 2 groups were utilized. To understand the role of mechanical loading-induced cartilage repair, we measured the serial changes of joint space width (JSW) after HTO for assessing the state of the cartilage stabilization. Our data showed that HTO increased the JSW, decreased the VAS score and improved the KOOS score significantly. We further scored cartilage lesion severity using the Outerbridge classification under a second-look arthroscopic examination while removing the HTO plate. It showed the cartilage lesion area decreased significantly, the full thickness of cartilage increased and mechanical strength was better compared to the pre-HTO baseline. HTO dampened medial tibiofemoral cartilage degeneration and accelerate cartilage repair from Outerbridge grade 2 to 3 to Outerbridge 0 to 1 compared to untreated varus OA. It suggested that physical loading was involved in HTO-induced cartilage regeneration. Given that HTO surgery increases joint space width and creates a physical loading environment, we hypothesize that HTO could increase cartilage composition and collagen accumulation. Consistent with our observation, a group of cartilage-resident MSCs was identified. Our data further showed decreased expression of RUNX2, COL10 and increased SOX9 in MSCs at the RNA level, indicating that catabolic activities were halted during mechanical off-loading. To understand the role of cartilage-resident MSCs in cartilage repair in a biophysical environment, we investigated the differentiation potential of MSCs under 3-dimensional mechanical loading conditions. The physical loading inhibited catabolic markers (IL-1 and IL-6) and increased anabolic markers (SOX9, COL2). Knee-preserved HTO intervention alleviates varus malalignment-related knee joint pain, improves daily and recreation function, and repairs degenerated cartilage of medial compartment OA. The off-loading effect of HTO may allow the mechanoregulation of cartilage repair through the differentiation of endogenous cartilage-derived MSCs

Introduction. Orthopedics is experiencing a significant transformation with the introduction of technologies such as robotics and apps. These, integrated into the post-operative rehabilitation process, promise to improve clinical outcomes, patient satisfaction, and the overall efficiency of the healthcare system. This study examines the impact of an app called Mymobility and intra-operative data collected via the ROSA® robotic system on the functional recovery of patients undergoing robot-assisted knee arthroplasty. Method. The study was conducted at a single center from 2020 to 2023. Data from 436 patients were included, divided into “active” patients (active users of Mymobility) and “non-active” patients. Clinical analyses and satisfaction surveys were carried out on active patients. The intra-operative parameters recorded by ROSA® were correlated with the Patient-Reported Outcome Measures (PROMs) collected via Mymobility. Result. Intra-operative data showed significant correlations with PROMs for the 48 active patients, highlighting the importance of parameters such as medial joint space and ligament laxity. No significant differences were observed between the sexes, but a positive correlation was detected between age and PROMs. The data analysis indicated that an increased medial joint space and reduced ligament laxity are associated with better PROMs. The adoption of Mymobility remained limited, with only 10% of patients fully utilizing the app. Critical factors have been identified to improve recruitment, engagement, and overall experience with the platform. Conclusion. The integration of technologies such as Mymobility and ROSA® in post-operative rehabilitation offers numerous advantages, including the objectification of data, active patient involvement, and personalized care. Challenges remain related to costs, patient compliance, and demographic limitations. Nevertheless, these technologies represent a milestone in modern peri-operative management, being able to improve clinical outcomes and the quality of care