Small animal models of fracture repair primarily investigate
indirect fracture healing via external callus formation. We present
the first described rat model of direct fracture healing. A rat tibial osteotomy was created and fixed with compression
plating similar to that used in patients. The procedure was evaluated
in 15 cadaver rats and then Objectives
Methods
Fracture of the lateral process of the talus (FLPT) is one of the common, yet frequently missed, fractures in snow boarders and can cause severe long-term disability if not treated properly. This fracture has been thought to result from dorsiflexion and inversion combined with axial loading. This assumption is based on injury mechanism reported by patients and anatomical studies and has not been supported by experimental data. We have to understand the mechanism of fracture generation in order to identify potential preventive strategies in
The purpose of this study was to create a novel The metatarsophalangeal joints of 12 fresh cadaveric bovine feet were skinned and dissected aseptically, and cultured for up to four weeks. Dynamic movement was applied using a custom-made machine on six joints, with the others cultured under static conditions. Chondrocyte viability and matrix glycosaminoglycan (GAG) content were evaluated by the cell viability probes, 5-chloromethylfluorescein diacetate (CMFDA) and propidium iodide (PI), and dimethylmethylene blue (DMMB) assay, respectively.Objectives
Methods