To compare posterior cruciate ligament substituting (PCS) total knee arthroplasty (TKA) and posterior cruciate ligament retaining (PCR) total knee arthroplasty (TKA) to determine if greater overall flexion is obtained with the PCS TKA versus the PCR TKA at two year postoperative follow up. Secondarily, to determine whether there is a difference in the recovery of range of motion over time between the two groups from initial presentation, to discharge, and to follow up visits at three months, one year, and two years. Prospective, randomised double-blind clinical trial consisting of one hundred male and female patients scheduled for primary TKA. Sample size allows detection of a difference of six degrees of knee range of motion using two-tailed tests, =0.05, and 0.20 (80% power). SCORPIO PCL substituting total knee system and the SCORPIO PCL retaining total knee system were implanted for evaluation in this study. Patients were assessed at initial presentation, at postoperative discharge from hospital, and at follow up visits at three months, one year and two years for flexion knee range of motion. Additional data were collected utilizing the WOMAC Osteoarthritis Index, the Knee Society Clinical Rating Scale, the SF-36, and the Knee Society Radiographic Evaluation as well as data on length of stay and surgical time. Subjects were similar in demographic characteristics and all measurements at the baseline initial assessment. No differences were seen in knee flexion at two year follow up as measured using an independent t-test (p> 0.05). Recovery of knee range of motion over time was not different as measured using a two way repeated measures ANOVA (p=0.88 for group effect). Postoperative flexion and recovery of kneww range of motion was not altered following TKA by using PCS or PCR prostheses

Objectives. Congenital cruciate ligament deficiency is a rare condition that may occur in isolation or in association with longitudinal limb deficiencies such as fibular hemimelia or proximal femoral focal deficiency. Often anomalies of the menisci and their attachments can be very abnormal and impact on surgical management by standard techniques. Arthroscopic surgical knee reconstruction is undertaken to improve symptomatic instability and/or to stabilise and protect the knee for future planned limb lengthening surgery. The aim of this study is to evaluate the arthroscopic findings of patients undergoing surgery for congenital cruciate ligament deficiency, and specifically to determine the frequency and types of meniscal anatomical variations seen in these cases. Methods. Patients undergoing surgery for congenital cruciate ligament deficiency were identified from a prospectively collated database. Diagnosis was confirmed through review of the clinical notes and imaging. Operative notes and 4K saved arthroscopic images and video recordings for these cases were reviewed. Results. Over a six-year period (July 2017 – September 2023), 42 patients underwent surgery for congenital ligament deficiency and tibiofemoral instability (45 surgical episodes). Median age of patients at time of surgery was 10 years (range 4 – 17 years). The most frequent diagnosis was congenital longitudinal limb deficiency syndromes in 27 cases, with the most frequent being fibular hemimelia. Isolated congenital ligament deficiency without any other associated extra-articular manifestations occurred in 11 cases. Absence of meniscal root attachments or hypertrophy of meniscofemoral ligaments acting as ‘pseudo-cruciates’ were seen in over 25% of patients. In isolated ACL deficiency these were injured causing onset of instability symptoms and pain following trauma. Often these abnormal structures required addressing to allow surgical reconstruction. Conclusions. Our findings demonstrate that there are often meniscal variations seen in association with congenital absence or hypoplasia of the cruciate ligaments. In these patients hypertrophied meniscofemoral ligaments may act as cruciate-like structures and play a role in providing a degree of sagittal plane stability to the knee. However, when the knee becomes unstable to the point that cruciate ligament reconstruction is indicated, these meniscal variants may often require stabilisation using complex meniscal root repair techniques or variations to standard cruciate ligament reconstruction techniques to accommodate the variant anatomy

Purpose: At a time when total knee arthroplasty (TKA) with an ultra-congruent tibial plateau or a mobile plateau are advocated by many, the question is whether TKA with a fixed plateau preserving the posterior cruciate ligament (PCL) should be abandoned. We analysed the results of 500 Wallaby I TKA with preservation of the PCL and presenting asymmetrical and divergent femoral condyles with a fixed, also assymetrical tibial plateau, at mean follow-up of seven years (1–10). Material and methods: This prospective multicentric study was performed by junior and senior surgeons. Mean patient age was 70.11 years and 91.4% of the patients had primary or secondary degenerative disease. Prior surgery had been performed in 130 knees, mainly for osteotomy (n=40, mostly tibial) and revision of uni-compartmental or total prostheses (n=18). The mean preoperative IKS knee score was 26.11 points, the function score was 29.54. Preoperative alignment was correct for 11.26% of the knees, 27.16% presented > 4° valgus and 61.56% > 3° varus. Nearly all tibial and patellar pieces were cemented. 5.8% of the femoral pieces were not cemented. A prosthesis was implanted on the patella in all knees except four. There were two early infections, one popliteal sciatic paralysis and twelve wound healing problems. General mobilisation under general anaesthesia was performed in 53 knees (10.6%). Results: Twenty-two patients were not retained for analysis, fifteen lost to follow-up and seven deceased at one year. Among the 478 knees followed for one to ten years, there were six late infections (1.25%), one aseptic bipolar loosening (0.2%), 25 patellar fractures (5.23%) including three which required revision (two cerclage, one prosthesis removal), three periprosthetic femur fractures without effect on the clinical or radiographic outcome, one traumatic tear of the medial collateral ligament, and two secondary tears of the PCL without clinical consequences. There were no revisions for instability, generally considered the most frequent reason for TKA revision. The mean postoperative IKS score was 90.6 points and the function score was 59.7 points basically due to patient age and comorbidity. The eight-year survival (Kaplan-Meier method) was 98.2% (95%CI: 99.4–96.9) irrespective of the reason for revision and 99.2% (95%CI 100–98.4%) if the revision was performed for a mechanical problem. Radiographically, more than 70% of the knees were aligned (between 3° valgus and 2° varus) and more than 90% were between 5° valgus and 5° varus. Although it was difficult to measure radiographically polyethylene wear, there was only one case of > 2 mm wear with osteolysis found in 50 knees selected randomly among the knees with more than seven years follow-up. Conclusion: This study, like others reported by authors preserving the PCL, show that preservation of the PCL limits the risk of instability, allowing excellent clinical and radiographic outcome without important polyethylene wear, opening perspectives for good long-term results

Introduction. Ideally, a patient receiving a unicondylar knee replacement will have fully functional anterior and posterior cruciate ligaments. When at least one of the cruciate ligaments is not fully functional, femoral and tibial implant contact position can potentially increase along the anterior-posterior (AP) axis. Where unicondylar implant wear testing typically uses AP resistance assuming fully functional cruciate ligaments, the authors used reduced AP resistance intended to simulate deficient cruciate ligaments. Methods. Optetrak Logic® Uni (Exactech Inc, Gainesville, FL USA) unicondylar test specimens featuring an all-UHMWPE tibial component and a cobalt chromium femoral component were used in this study. The system has a semi-constrained articular geometry. Testing was conducted at an independent testing facility (EndoLab GMBH, Thansau, Rosenheim, Germany). A four-station knee simulator was used (EndoLab knee simulator) with two unicondylar knee implants per station, giving a total of eight test specimens. Two different tibial fixation designs (keeled and peg) with identical articulating surfaces were tested. Tibial test specimens were 6 mm in thickness. Unloaded soak controls were stored in distilled water at 37°C. The test was conducted according to ISO 14243–1: 2009 [1]. Test specimens were immersed in calf serum (PAA GmBH, Cölbe, LOT B00111-5126) with a protein content of 20 g/l. Custom polyurethane molds allowed for individual component measurement. Per the ISO 14243-1, a 7% medial offset was incorporated into the set-up. The unicondylar knee implants were set at neutral position in extension. Tibial rotational restraint was 0.36 Nm/° and zero when the test specimen was within ± 6° of the reference position. This test was conducted with an AP resistance of 9.3N/mm to maximize AP displacement and simulate deficient cruciate ligaments. Typical unicondylar knee wear testing is conducted with an AP resistance of 44N/mm, which assumes functional cruciate ligaments. Results. Wear data was separated by component design (keeled and peg) as well as for medial and lateral placement [Table 1]. There was no significant difference between lateral components but there was for medial components. This difference could be due to the small sample size. Contact area of the UHMWPE tibial components was elliptical, with the longer portion along the AP axis. Mean wear rates were comparable to historical unicondylar knee systems tested at the same laboratory using the standard AP resistance (i.e., 44 N/mm). Discussion/Conclusion. This study demonstrated using an AP resistance 9.3 N/mm to simulate the presence of deficient cruciate ligaments in a unicondylar knee wear test produced similar wear rates and greater AP displacement when compared to testing using an AP resistance of 44 N/mm, which assumes functioning ligaments. This being said, design and material information about historical unicondylar knee systems tested are not known, so a direct comparison cannot be made. Performing unicondylar knee wear tests with reduced AP resistance could provide realistic wear information for devices implanted in patients without fully functioning cruciate ligaments

Poor availability of allografts in South Africa has led to an increased use of synthetic augmentation to stabilize knee joints in the treatment of knee dislocations. This study aims to evaluate multiligament knee injuries treated with a posterior cruciate ligament internal brace. The study included patients with knee dislocations who were treated with a PCL internal brace. The internal brace involved the insertion of a synthetic suture tape, which was drilled into the femoral and tibial footprint. Chronic injuries were excluded. Patient-reported outcome scores (PROMs), range of motion, stress X-Rays, and MRI scans were reviewed to assess outcomes. Acceptable outcomes were defined as a Lysholm score of 84 or more, with grade II laxity in no more than one ligament and a range of motion from full extension to 90° or more. The study included eight patients, with a median age of 42, of which five were female. None of the patients had knee flexion less than 90° or an extension deficit of more than 20°. PROMs indicated acceptable outcomes (EQ5D, Tegner Lysholm). Stress radiographs showed less than 7mm (Grade I) of posterior translation laxity in all patients. Four patients underwent MRI scans 1–2 years after the initial surgery, which revealed healing of the PCL in all patients. However, increased signal in a continuous ligament suggested only partial healing in two patients. Tunnel widening of 200% and 250% was noted around the tibial and femoral PCL footprints, respectively. All patients demonstrated stable knees and acceptable PROMs. Tunnel widening was observed in all patients who had MRI scans. Factors such as suspensory fixation, anisometric tunnel position, and the absence of PCL tear repair may have contributed to the tunnel widening

The consideration of the individual knee ligament attachments is crucial for the application of patient specific musculoskeletal models in the clinical routine, e.g. in knee arthroplasty. Commonly, the pre-operative planning is based on CT images, where no soft tissue information is available. The goal of this study was to evaluate the accuracy of a full automatic and robust mesh morphing method that estimates locations of cruciate ligament attachments on the basis of training data. The cruciate ligament attachments from 6 (n=6) different healthy male subjects (BH 184±6cm, BW 90±10kg) were identified in MRI-datasets by a clinical expert. The insertion areas were exported as point clouds and the centres of gravitation served as approximations of the attachments. These insertion points were used to annotate mean shapes of femur and tibia. The mean shapes were built up from 332 training data sets each. The surface data were obtained from CT scans by performing an automatic segmentation followed by manual cleaning steps. The mean shapes were computed by selecting a data set randomly and aligning this reference rigidly to each of the remaining data sets. The data were fitted using the non-rigid ICP variant (N-ICP-A). Due to this morphing step, point correspondences were established. By morphing a mean shape to the target geometries, including the cruciate ligament attachments, the distribution of the insertions on the original mean shape was obtained. Subsequently, a statistical mean was computed (annotated mean). The annotated mean shape was again morphed to the target data sets and the deviations of the respective predicted insertion points from the measured insertion points were computed. The training data was successfully morphed to all 6 subjects in an automatic manner with virtually no distance error (10-5 mm). The mean distance between the measured and morphed ligament attachments was highest for the ACL in the femur (4.26±1.48 mm) and lowest for PCL in the tibia (1.63±0.36 mm). The highest deviation was observed for femoral ACL (6.93 mm). In this study, a morphing based approach was presented to predict origins and insertions of the knee ligaments on the basis of CT-data, exemplarily shown for the cruciate ligaments. It has been demonstrated, that the N-ICP-A is applicable to predict the attachments automatic and robust with a high accuracy. This might help to improve patient-specific biomechanical models and their integration in the clinical routine

Abstract. Cranial cruciate ligament (CrCL) disease/rupture causes pain and osteoarthritis (OA) in dogs. α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-2 and kainate (KA)-1 glutamate receptors (GluR) and the excitatory amino acid transporter-1 (EAAT-1) and EAAT-3 are expressed in joint tissues from OA patients and rodent arthritis models and represent potential therapeutic targets. Objectives. To evaluate glutamate signalling in canine diseased and normal CrCL and meniscus by immunohistochemistry (IHC). Methods. Surgical waste (CrCL, n=5 and medial meniscus, n=3) were obtained from canines with CrCL disease (RCVS ethics approval:2017/14/Alves) and normal analogous tissues (n=2). IHC optimization was performed for rabbit polyclonal (AMPA-2:ab52176, KA-1:ab67402, EAAT-1:ab416) and monoclonal (EAAT-3:ab124802) antibodies from Abcam. IHC was optimised over antibody dilutions from 1:100 to 1:5000 alongside equivalent IgG isotype controls (ab37415 and ab172730) and negative controls (TBS/Tween buffer without primary antibodies). IHC staining was compared in diseased and normal tissues and disclosed with 3,3’-Diaminobenzidine (DAB). Results. Specific immunostaining was observed for all primary antibodies, at concentrations between 2.0×10. −4. mg/mL to 1.0×10. −2. mg/mL, depending on the tissue and primary antibody. All GluR and transporters were expressed in the cellular membrane, in the normal and diseased CrCL and meniscus. Healthy CrCL showed a well-organized microstructure, with normal positively labelled ligamentocytes, whereas diseased CrCL microstructure was disrupted, with many positively stained fibroblastic cells in the epiligamentous region and evident neovascularization, indicative of ongoing repair. The normal and diseased meniscal tissues showed similar chondrocytes-like cells labelling and microstructure. Negative controls demonstrated no labelling. Conclusions. GluR and transporters expression is altered in canine diseased CrCLs, implicating glutamate signalling in this pathology. Since AMPA/KA GluR antagonists alleviate joint degeneration in post-traumatic OA in rodent models, they may be useful for the treatment of CrCL disease in dogs, as well as translated to other veterinary and human orthopaedic diseases

Purpose: Injury of both cruciate ligaments raises difficult therapeutic problems in trauma victims. The severity of such lesions is related to the context of multiple trauma and to the general regional context associating vascular and neurological injury. Therapeutic management should be multidisciplinary to determine the appropriate strategy. Orthopaedic treatment should take into account the different diagnostic and therapeutic aspects. The purpose of this work was to detail ligament injuries observed and to assess results of treatments proposed. Material and methods: This retrospective series included 20 patients (14 men and 6 women), mean age 33 years (18–54). Five had multiple trauma with head injuries and multiple fractures. The initial diagnosis was traumatic knee dislocation in 14 patients. Seven patients underwent emergency vascular explorations with subsequent femoropopliteal bypass (n=3). Neurological lesions included three cases of complete section of the lateral popliteal sciatic. Orthopaedic treatment was used in three cases. We used external fixation for two months on the average in three patients. Six others underwent surgery (less than eight days after injury) after obtaining an MRI. The surgical strategy was based on several arguments: age, general status, level of the ligament injury. Three patients underwent secondary surgery on the anterior cruciate ligament. Outcome was assessed at a mean follow-up of 36 months (20–60). The clinical assessment of the objective result was based on frontal and sagittal laxity. The subjective result and the level of sports activities were also recorded. Radiographically, we studied the standard x-rays in single leg stance and also the stress images using telos with anterior then posterior drawer. Results: Excepting one case of amputation necessary due to the vascular and nervous injuries, orthopaedic treatment allowed an acceptable functional result in sedentary patients: good frontal stability and minimal anteroposterior residual laxity. Fourteen athletes underwent emergency surgery to repair the posterior cruciate ligament: posterior approaches in eight knees with injury of the floor with no posterior drawer at last follow-up; anterior approaches in six knees for suture of the posterior cruciate ligament and insertion of a synthetic ligament tutor with anterior cruciate ligament repair during the same operative time (two floor reinsertions, one patellar tendon plasty, and three Cho plasties). The stability of the posterior pivot was excellent but the tibial reinsertions of the anterior cruciate ligament failed. Seven knees required mobilisation under general anaesthesia 2.5 months later. Three knees underwent secondary anterior cruciate repair using the Kenneth Jones technique with negative Lachmann at last follow-up. Discussion: Excepting vascular and neurological emergencies dictating the initial therapeutic attitude, our orthopaedic management was based on a detailed identification of the lesion using emergency MRI: anterior or posterior approach, anterior cruciate repair technique dependng on association with peripheral ligament injury. Good results in terms of posterior laxity were achieved in this series, confirming the importance of emergency repair of the posterior cruciate. If the medial ligaments are intact, the anterior cruciate can be repaired in the emergency setting with a Cho plasy. In other situations, we prefer waiting before surgical repair of the anterior pivot

Aim: The purpose of study was to analyse osseous changes of tibial spine in radiographs of knees with aplasia of cruciate ligament. Methods: 13 patients with aplasia of cruciate ligament and respective x-rays were examined and analysed. Diagnosis were proofen by MRI or Arthroscopy. Moreover we checked patients with anterior and complete aplasia of cruciate ligament (s) separately. Results: We found typical signs of hypolasia and aplasia of intercondylar eminence in radiagraphs which correlate with anterior or complete aplasia of cruciate ligaments. These changes we classiþed in 3 types. Conclusion: Using this classiþcation it is possible to get a strong indication for aplasia of cruciate ligament only on the basis of x-rays

Background:. For the past four decades controversy surrounds the decision to retain or sacrifice the posterior cruciate ligament during a total knee arthroplasty. To our knowledge no study has been done to describe the effect of releasing the PCL on the range of motion of the knee. Study design:. Case series. Methods:. Computer navigation data (Brainlab) was obtained intra-operatively from thirty patients at total knee arthroplasty. Coronal alignment, maximal passive knee extension and maximal passive flexion was captured before and after release of the PCL. Results:. Releasing the posterior cruciate ligament led to an increase in maximal extension in all patients (av 3,6°) and a decrease in coronal deformity in 63%. The surprising finding was an increase in maximal knee flexion (av 5°, range 0 to 10°.) The increase in maximal flexion was statistically significant. Conclusion:. Sacrificing the posterior cruciate ligament alters the kinematics of the knee and the resultant increase in knee flexion might explain why cruciate sacrificing total knee arthroplasty has superior flexion compared to cruciate retaining designs

The issue of preservation or sacrifice of the posterior cruciate ligament in total knee arthroplasty remains unresolved. We report the results of 200 consecutive total knee arthroplasties performed at our hospital under the direction of the senior author. Pre-operatively, patients were randomly chosen to receive either a Kinemax (posterior cruciate retaining) or a Press-Fit-Condylar (posterior cruciate sacrificing) prosthesis. We implanted 97 Kinemax and 103 Press-Fit-Condylar prostheses which were prospectively followed-up by clinical and radiographic assessment. Review at mean follow-up of 2.7 years showed a satisfactory clinical result in both groups [Surace, et al., 1994]. We present the results of our further review, with maximum follow-up of over nine years (mean: 5.9 years). Revision of the implant has been performed in five knees (three Kinemax and two Press-Fit-Condylar). The polythene spacer had to be replaced in one patient with a Press-Fit-Condylar implant. Patients were assessed with the Hospital for Special Surgery Knee Score and radiologically assessed with the Knee Society Roentgenographic Evaluation and Scoring System. Pre-operative demographics and disease states of the patients were similar, with an average Hospital for Special Surgery Knee Score of 63. At the latest assessment the average knee score was good (85). Remarkably, the mean knee score for the posterior cruciate sacrifice and the PCL groups remains similar (mean: 85). Radiographic evaluation demonstrated that the prosthetic components of both groups were in comparable alignment. The posterior cruciate ligament retained (Kinemax) patient group showed a mean 5.9 degrees of the valgus angle at the knee. The angle in the posterior cruciate ligament sacrifice (PFC implant) group was 6.2 degrees. Evaluation of the radiolucent depths below the femoral, tibial and any patella component showed a mean total depth of 1.5 mm (pcl retaining) and 1.7 mm (pcl sacrificing). Our study presents a quantitative perspective of the results of total knee replacement with proven implant systems and performed in a general orthopaedic unit by both consultants and surgeons in training. The Kinemax (Howmedica) and Press-Fit-Condylar (DePuy Johnson and Johnson) implant systems have both previously demonstrated good results and continue to be available with little subsequent modification. To our knowledge, there have been no other large prospectively randomised studies of posterior cruciate ligament preservation or sacrifice in total knee replacement

Post traumatic myositisossificans is a benign condition of heterotropic ossification of unknown aetiology which typically is related to trauma from a single blow or repeated episodes of microtrauma. We describe an unusual case of myositis ossificans which developed as a complication at the donor site for hamstring autologous graft used in open anterior and posterior cruciate repair and posterolateral corner reconstruction in a 15 year old girl. Case report: A 15 year old girl sustained a closed traumatic dislocation of her left knee when she fell from a trampoline. She underwent emergency manipulation under anaesthetic and closed reduction followed by MRI scan which showed a complete disruption of the lateral collateral ligament complex, posterolateral corner injury, complete tears of the anterior and posterior cruciate ligaments and a partial tear of the medial collateral ligament. 13 days later she had an open reconstruction of her anterior and posterior cruciate ligaments with allograft and a repair of popliteus and lateral structures with Larson reinforcement with controlateral hamstring autologous graft. Eight months following open reconstruction the patient represented to her primary care practitioner with a painful lump in the postero-medial controlateral right thigh. MRI study showed that there was a lobulated hypervascular appearance with a thin enhancing rim of low signal on all sequences indicating calcification. An xray revealed a calcified mass consistent with the diagnosis of myositis ossificans. Discussion and conclusion: To date we have found no reported cases of myositis ossificans occurring as a result of surgery to harvest hamstring autograft in the setting of ligament reconstruction about the knee. We believe that this is an unusual complication of the donor site which needs awareness amongst clinicians involved in primary and revision cruciate ligament reconstruction. We suggest that a management strategy of surveillance for this lesion is appropriate and excision biopsy should be reserved for specific indications such as malignant features on imaging or mass effect

High-flexion knee replacements have been developed to accommodate a large range of motion (ROM > 120°) after total knee arthroplasty (TKA). Femoral rollback or posterior translation of the femoral condyles during knee flexion is essential to maximise ROM and to avoid bone-implant impingement during deep knee flexion. The posterior cruciate ligament (PCL) has been described as the main contributor to femoral rollback. In posterior-stabilised TKA designs the PCL is substituted by a post-cam mechanism. The main objective of this study was to analyse the mechanical interaction between the PCL and a highflexion cruciate-retaining knee replacement during deep knee flexion. For this purpose, the mechanical performance of the high-flexion cruciate-retaining TKA design was evaluated and compared with two control designs including a highflexion posterior-stabilised design. Materials & Methods: Prosthetic knee kinematics and kinetics were computed using a three-dimensional dynamic finite element (FE) model of the knee joint. The FE knee model consisted of a distal femur, a proximal tibia and fibula, a quadriceps and patella tendon, a non-resurfaced patella, TKA components and a posterior cruciate ligament in case cruciate-retaining designs were evaluated. Tibio-femoral and patello-femoral contact were defined in the FE knee model and the polyethylene insert was modelled as a non-linear elastic-plastic material. Three different rotating platform TKA systems were analysed in this study: the high-flexion cruciate-retaining PFC Sigma CR150, the high-flexion posterior-stabilised PFC Sigma RP-F and the conventional cruciate-retaining PFC Sigma RP (Depuy, J& J, UK). Both the polyethylene stress characteristics and the tibio-femoral contact locations were evaluated during a squatting movement (ROM = 50° – 150°). Results: During deep knee flexion (ROM > 120°), the high-flexion cruciate-retaining TKA design showed a lower peak contact stress (74.7 MPa) than the conventional cruciate-retaining design (96.5 MPa). The posterior-stabilized high-flexion TKA design demonstrated the lowest peak contact stress at the condylar contact interface (54.2 MPa), although the post was loaded higher (77.4 MPa). All three TKA designs produced femoral rollback in the normal flexion range (ROM ≤ 120°), whereas the cruciate-retaining designs showed a paradoxical anterior movement of the femoral condyles during high-flexion. Discussion: PCL retention is a challenging surgical aim and affects the prosthetic knee load and kinematics as shown in this study. In addition, for adequate functioning the PCL should not be too tight or too lax after surgery. Hence, we investigated the effect of PCL laxity on the prosthetic performance and the best-balanced PCL was used in our simulations. Although PCL balancing is not an issue for posterior-stabilized TKA, we found the tibial post to be loaded relatively high for this implant type

Introduction: Much debate exists regarding sparing or sacrificing the posterior cruciate ligament (PCL). The posterior cruciate ligament is said to maintain proprioception and stabilization post knee arthroplasty. Substitution of the PCL can require more femoral bone resection, but is thought to improve range of motion. Release of the PCL can restore extension and enhance flexion through greater femoral rollback. Bicruciate implants potentially offer greater flexion and enhanced stability. Each implant design with mechanical instruments requires a different surgical technique making it difficult to directly compare the patient and surgical outcomes. Computer navigation eliminates the differences in implantation between the various implant designs and theoretically allows a more direct comparison of implants based on design characteristics and not surgical technique. The purpose of this paper is to review four different implant designs implanted by a single surgeon with a computer assisted, gap balancing technique to determine if there was any difference in patient outcome. Methods: A total of 504 implants consisting of posterior cruciate sparing (PFC-RP), PCL substituting (PFC-RPC), PCL sacrificing (LCS) and bicruciate (Journey) implants performed by a single surgeon were reviewed. The PFC-RP group (260) was the largest, followed by the LCS (124), the PFC-RPF (80) and the Journey Knee (40). Outcomes reviewed were range of motion, function, pain and radiographic data to include alignment and evidence of radiolucency. Results: Demographic data of groups compared included 175 men and 329 women. Mean ages ranged from 61 to 74 years. Preoperative scores among all groups were similar with the cruciate substituting group slightly lower in function, flexion and with more pain before surgery. Overall function improved across all groups through two years, with better scores in the Journey and LCS implants (77 and 73 points) versus RPF (47) and PFC retaining group at (68) at one year (A perfect score is 100). Flexion values were comparable between all groups at one and two year intervals with Journey the highest mean flexion (116 degrees) at one year and with the PFC-RP offering the highest mean flexion at the two year mark (115 degrees). The RPF group at the one year mark had more pain overall (28) versus the other three groups (Journey 45, LCS 42, Sigma RP 45). No patients in any group were revised for instability. Other surgical complications were equal in each group. Discussion: While the PCL substituting knee patients (PFC-RPF) had lower pain, function and flexion at 12 months compared to all other groups, they started with lower overall knee scores. After accounting for the differences in patients preoperatively, no difference could be found between implant designs when implanted with a similar surgical technique employing a computer assisted gap balancing protocol

Abstract. Cranial cruciate ligament (CrCL) disease in dogs causes pain and osteoarthritis (OA) and surgical treatment does not prevent OA progression. Glutamate receptor (GluR) antagonists alleviate pain and degeneration in rodent models of OA, but it is unknown whether they are a suitable treatment for dogs. Understanding GluR signalling in CrCL disease may lead to novel therapeutics in both veterinary and human medicine. Objectives. To determine whether age, breed, sex, weight, and therapeutic(s) influence lameness and pre-operative radiographic OA scoring in dogs with CrCL disease and whether GluRs are expressed, in this disease. Methods. Surgical waste (CrCL and medial meniscus), clinical data, stifle radiographs, lameness scores (1–4, mild-unloading limb) were obtained with full informed consent (RCVS ethics approval, ref: 2017/14/Alves). OA scoring was performed on radiographs [VCOT, 2017, 30(6):377–384, 15–60, normal-severe OA], and α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-2 and kainate (KA)-1 GluR expression compared in diseased versus control tissues by immunohistochemistry (IHC). Results. We studied 25 dogs (various breeds, 4.88±3.02 years; 44% male; 56% female; 27.13±9.12kg). At the time of surgery, 44% dogs were on meloxicam alone, 40% on other therapeutic(s) and 16% on no therapeutics. Linear regression showed that OA score (mean 21.72±3.47) did not correlate with lameness score (mean 1.98±1.08), age or weight (p values of 0.7483, 0.4597, 0.1463; R. 2. values of 0.004563, 0.02400, 0.08951, respectively). Radiographic OA scores and lameness scores did not differ between therapeutic groups (one-way ANOVA, p=0.9229 and p=0.5541, respectively). GluRs (AMPA-2/KA-1) were expressed in CrCL and medial meniscus, with increased labelling in the CrCL epiligamentous region in diseased tissues, where microanatomy was disrupted. Conclusions. In this population, OA scores do not correlate with lameness scores, age, weight, and therapeutics at the time of surgery. Variable GluR expression in diseased tissues implicates glutamate signalling in this pathology. Declaration of Interest. (b) declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported:I declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project

Introduction: The amount of loading on the cruciate ligaments depends on the tension of the external muscular structures. In vivo studies using EMG have observed a proprioreceptive eccentric co-contraction of the hamstrings during isokinetic knee extension motion. This antagonistic co-contraction increases the quadriceps force necessary to produce the same extension moment on the knee, whereas the loading on the anterior cruciate ligament was measured to be reduced, with the loading on the posterior cruciate ligament to be increased. The objective of this study was thus to investigate the effect of simulated proprioreceptive co-contraction of the hamstrings muscles on quadriceps force, as well as on the relative loading on the cruciate ligament structures during knee extension under dynamic conditions and physiologic loads. Methods: Five fresh frozen knee specimen were tested in isokinetic extension. Bow shaped loading transducers were fixed in the medial fibres of the anterior (ACL) and posterior cruciate ligament (PCL). The test cycle simulated an isokinetic extension cycle from 120 degrees of flexion to full extension, a hydraulic cylinder thereby applied sufficient force to the quadriceps tendon in a closed-loop control cycle to produce a constant extension moment of 31 Nm about the knee. A second hydraulic cylinder simulated a 200 N co-contraction force of the hamstrings tendons. The loading on the ACL and PCL was first measured in the absence of hamstrings force, and subsequently under constant co-contractive flexion force. Results: In the absence of hamstring tension, the maximum quadriceps force was 1190 N ( SD 204 N) at 105 degrees of knee flexion. The loading on the ACL was reduced at larger flexion angles, the loading pattern of the PCL showed an inverse relationship with less loading at full extension. The maximum loading in the ACL was 161 N (SD138 N) and maximum tension in the PCL was 38.2 N (SD 34.9). With hamstring co-contraction, maximum quadriceps force increased 19.9 % ( SD 21.0% p= 0.33), maximum tension in the ACL decreased 71.9% (SD 74.3%, p=0.03), and maximum tension in the PCL increased 73.0% (SD 40.9%, p=0.03). Discussion: This experimental setup enabled direct in vitro measurement of ACL and PCL loading during simulated isokinetic extension motions. The loading on the ACL was dependent on the knee flexion angle. We observed that co-contraction of the hamstrings reduces loading on the anterior cruciate ligament without a significant concomitant increasing the quadriceps muscle force. Our results support the hypothesis that antagonistic co-contraction of the hamstrings during extension of the knee provides an important protective function. In contrast, loading in the posterior cruciate ligament increased during hamstring activation at higher knee flexion angles

The role of posterior cruciate ligament (PCL) in total knee replacement (TKR) has been a matter of debate for long time and remains controversial. In this study, the effect of posterior cruciate ligament (PCL) sacrifice on the tibiofemoral joint gap was analysed in 30 varus osteoarthritic knees undergoing posterior stabilized total knee replacement. Medial soft tissue was released and bone cut was made without preserving the bone segment of tibial PCL insertion. Then the medial and lateral joint gaps in full extension and 90□& lsaquo; flexion were measured before and after PCL sacrifice using a tensioning device (V-STAT tensor(tm), Zimmer). After PCL sacrifice, the flexion gap significantly increased both in medial and lateral side (4.8 □} 0.4 and 4.5 □} 0.4 mm respectively, mean □} SE) compared to those seen in the extension gap (0.9 □} 0.2 and 0.8 □} 0.2 mm, p < 0.001 ANOVA). There was no significant difference between the changes in the medial and lateral gap (p = 0.493). In conclusion, results of this intraoperative measurement showed that PCL sacrifice leads to a selective increase in the size of flexion gap by an average of 4.7 mm whereas it had little impact on the correction of varus deformity. These findings provided insights as for the role and necessity of PCL sacrifice in the correction of varus and flexion deformity. Because the flexion gap surpassed the unchanged extension gap during PCL sacrifice, PCL release could be used as a surgical technique to balance the gaps without additional bone cut

Objectives. Because posterior cruciate ligament (PCL) resection makes flexion gaps wider in total knee replacement (TKR), preserving or sacrificing a PCL affects the gap equivalence; however, there are no criteria for the PCL resection that consider gap situations of each knee. This study aims to investigate gap characteristics of knees and to consider the criteria for PCL resection. Methods. The extension and flexion gaps were measured, first with the PCL preserved and subsequently with the PCL removed (in cases in which posterior substitute components were selected). The PCL preservation or sacrifice was solely determined by the gap measurement results, without considering other functions of the PCL such as ‘roll back.’. Results. Wide variations were observed in the extension and flexion gaps. The flexion gaps were significantly larger than the extension gaps. Cases with 18 mm or more flexion gap and with larger flexion than extension gap were implanted with cruciate retaining component. A posterior substitute component was implanted with the other cases. Conclusions. In order to make adequate gaps, it is important to decide whether to preserve the PCL based on the intra-operative gap measurements made with the PCL intact. Cite this article: Bone Joint Res 2014;3:95–100

Aims. A functional anterior cruciate ligament (ACL) or posterior cruciate ligament (PCL) has been assumed to be required for patients undergoing unicompartmental knee arthroplasty (UKA). However, this assumption has not been thoroughly tested. Therefore, this study aimed to assess the biomechanical effects exerted by cruciate ligament-deficient knees with medial UKAs regarding different posterior tibial slopes. Methods. ACL- or PCL-deficient models with posterior tibial slopes of 1°, 3°, 5°, 7°, and 9° were developed and compared to intact models. The kinematics and contact stresses on the tibiofemoral joint were evaluated under gait cycle loading conditions. Results. Anterior translation increased in ACL-deficient UKA cases compared with intact models. In contrast, posterior translation increased in PCL-deficient UKA cases compared with intact models. As the posterior tibial slope increased, anterior translation of ACL-deficient UKA increased significantly in the stance phase, and posterior translation of PCL-deficient UKA increased significantly in the swing phase. Furthermore, as the posterior tibial slope increased, contact stress on the other compartment increased in cruciate ligament-deficient UKAs compared with intact UKAs. Conclusion. Fixed-bearing medial UKA is a viable treatment option for patients with cruciate ligament deficiency, providing a less invasive procedure and allowing patient-specific kinematics to adjust posterior tibial slope. Patient selection is important, and while AP kinematics can be compensated for by posterior tibial slope adjustment, rotational stability is a prerequisite for this approach. ACL- or PCL-deficient UKA that adjusts the posterior tibial slope might be an alternative treatment option for a skilled surgeon. Cite this article: Bone Joint Res 2022;11(7):494–502

To investigate the effectiveness of avulsion fracture of tibial insertion of posterior cruciate ligament using the safe postero-medial approach through analyzing the clinical and radiographic outcomes. We treated 14 cases of acute PCL tibial avulsion fracture with “safe postero-medial approach”. The PCL and avulsion bony fragment was fixed with 1 cannuated screw and washer. The patients were assessed clinically and radiographically at 3 months, 6 months, and 12 months. Clinical examination for each visit included assessment of the knee range of motion, using goniometer and the posterior drawer test. The patients were evaluated according to the Lysholm and Tegner rating scales. Patients were followed-up for 12 to 16 months. X-ray showed that satisfactory reducdtion and bony healing was achieved in all cases. There was no neurovascular complication. All patients had negative posterior drawer tests. Excellent outcomes were reported by all patients with the Lysholm score system. And there was no signicant difference between the Tegner scores before injury and last follow-up. Surgical treatment of acute tibial avulsion fracture of the PCL with this approach can restore the stability and fuction of the joint safely in most patients without neurovascular complication. Therefore “safe postero-medial approach” may be suitable for the treatment of isolated tibial avulsion fracture of the PCL