Purpose of the study: Leg length discrepancy after THA is a common complication and source of recurrent complaints from patients. To date, no reliable and reproducible technique has come forward to enable accurate quantification of all radiological parameters of the lower limb. Nevertheless, preoperative planning for hip arthroplasty requires knowledge of many limb parameters, in particularly leg length discrepancy, femoral offset, or the head-neck angle. The most widely used method is to use the 2D radiographs. The EOS system uses two digitalised 2D images taken orthogonally in a weight-bearing position to enable 3D reconstruction of the lower limb. The inter- and intraoperator reproducibility has been studied and validated. The purpose of our study was to compare the inter- and intra-operator reproducibilities of the measures taken on the standard full-length x-ray and those determined on the 3D EOS reconstructions. Material and method: Twenty-five patients scheduled for THA were included in this study (50 lower limbs). Two independent operators determine the measures on the AP EOS view and on the 3D reconstructions obtained from two orthogonal EOS images. The following parameters were measured: femur length, tibia length, limb length, HKA, HKS, femoral offset, neck-shaft angle, head diameter, and length of the femoral neck. Each observer performed two series of measurements. Interobserver reproducibility was assessed with the intraclass correlation coefficient (CI: 95%). Student’s t test was used to compare the clinical parameters measured on the 2D and 3D images. Results: Inter- and intraobserver reproducibility were 0.867 and 0.903 on the 2D x-rays and 0.911 and 0.940 on the 3D reconstructions. The better reproducibility of the EOS reconstruction was confirmed for all parameters tested in this study. Comparison of the 3D and 2D measurements revealed significant differences. Discussion: Our study demonstrated that measurements made on EOS 3D reconstructions offer better inter- and intraobserver reproducibility than those made on the standard AP view. In addition, the 3D reconstruction takes into consideration of the projection of the anatomic structures in the plane of the AP radiograph. The EOS appears to be a pertinent tool giving reliable results for the pre- and postoperative work-up for arthroplasty of the lower limb

Personalized three-dimensional (3D) femoral geometry is a great aid in the surgical planning. X-ray image is still essential to diagnose and plan surgery in total hip replacement due to its lower cost and lower dose of radiation than computer tomography (CT). The purpose of the current study is to improve 3D reconstruction process using conventional X-ray images incorporating the anatomical parameters for building up the femoral model. For 3D reconstruction, the personalized femoral appearance and parameters were firstly prepared from X-ray images and the referential CT model with anatomical parameters was modified as follows: the axial scaling, shearing transformation and radial scaling. In this study, the reconstruction algorithm was applied to X-ray images obtained from the 28 years old male. The current study showed that this 3D reconstruction technique is clinically useful and feasible because this method was based on anatomical parameters and used for whole femur. This result can provide the basic model of individual femur for using finite element method of hip or knee joint, and designing the customized hip and knee implant. In addition, this result can be applied to the visualized 3D model with more effective parameters of individual femur in the surgery navigation system

Aims. The aim of this study was to establish a reliable method for producing 3D reconstruction of sonographic callus. Methods. A cohort of ten closed tibial shaft fractures managed with intramedullary nailing underwent ultrasound scanning at two, six, and 12 weeks post-surgery. Ultrasound capture was performed using infrared tracking technology to map each image to a 3D lattice. Using echo intensity, semi-automated mapping was performed to produce an anatomical 3D representation of the fracture site. Two reviewers independently performed 3D reconstructions and kappa coefficient was used to determine agreement. A further validation study was undertaken with ten reviewers to estimate the clinical application of this imaging technique using the intraclass correlation coefficient (ICC). Results. Nine of the ten patients achieved union at six months. At six weeks, seven patients had bridging callus of ≥ one cortex on the 3D reconstruction and when present all achieved union. Compared to six-week radiographs, no bridging callus was present in any patient. Of the three patients lacking sonographic bridging callus, one went onto a nonunion (77.8% sensitive and 100% specific to predict union). At 12 weeks, nine patients had bridging callus at ≥ one cortex on 3D reconstruction (100%-sensitive and 100%-specific to predict union). Presence of sonographic bridging callus on 3D reconstruction demonstrated excellent reviewer agreement on ICC at 0.87 (95% confidence interval 0.74 to 0.96). Conclusion. 3D fracture reconstruction can be created using multiple ultrasound images in order to evaluate the presence of bridging callus. This imaging modality has the potential to enhance the usability and accuracy of identification of early fracture healing. Cite this article: Bone Joint Res 2021;10(12):759–766

Detailed preoperative planning is essential for open reduction and internal fixation of acetabular fractures if a successful outcome is to be achieved. Decisions such as patient positioning, approach, reduction techniques and implant positioning are greatly influenced by fracture pattern and displacement. These fractures are frequently complex and a thorough understanding of their 3-Dimensional (3D) form is necessary for pre-operative decision making. A combination of biplanar x-rays, 2 Dimensional CT scans (Axial, Sagittal and Coronal multi-plane reformats) and, more recently, 3D CT reconstructions are provided routinely. However, the 3D reconstructions are provided to surgeons as static 2D pictures of the 3D model (up to 6 different views), rather than a true 3D representation. In this study we used dynamic 3D models to provide additional information to surgeons. The 3D models were generated on a standard desktop or laptop computer and can be used in the operating theatre (Osirix Dicom viewing software). These true 3D reconstructions allow the surgeon to manipulate the model himself in real time so that the fracture can be viewed at any angle and overlying fragments removed to expose deeper structures. 3 experienced consultant pelvic trauma surgeons reviewed plain radiographs and 2D Pelvic CT scans from 20 acetabular fractures. They were asked to make a preoperative plan with regard to fracture classification and planned surgical approach(s). At separate, time-spaced, sittings they were provided with a 3D Static and 3D Dynamic CT reconstruction in addition. They were blinded to any previous plan and the patients’ details. A comparison was then made with regard to surgical plan and the time taken to make that plan with or without access to dynamic 3D models. The additional information provided by dynamic 3D modelling was found to reduce planning time and, in some cases, change the surgical plan

Purpose: Partial epiphysiodesis of the growth plate due to physeal aggression is a common problem in paediatric patients. Surgical management requires precise imaging. We recall other imaging techniques currently employed and describe a novel method for studying the characteristic features of epiphysiodesis bridges of the growth plate: 3D-magnetic resonance imaging (3D-MRI). Material and methods: We analysed retrospectively MRI series of 27 epiphysiodesis bridges in 23 children (ten boys and thirteen girls) aged 11.3 years (range 2.5 – 15). We recorded information concerning the cause of the physeal aggression, the joint involved, the type of bony bridge (Ogden classification), the clinical deformation, and the proposed treatment. The 27 bridges were studied on coronal MRI acquired with echo-gradient and fat suppression sequences. Data were processed with a manual 3D reconstruction program in 15 minutes to precisely define the localisation, the volume, and the morphology of the bony bridge and the active physis. Results: The epiphysiodeses were caused by trauma (65%), iatrogenic aggression (17%), ischemia-infection (purpura fulminans) (9%), juxta-physeal essential cyst (4.5%), and unknown causes (4.5%). Eighty-seven percent involved a lower limb joint, 75% of which involved the tibia. The surface of the epiphysiodesis bridge covered 20% of the physis. The bridges were peripheral (46.5%), central (46.5%), and linear (7%). Discussion: It is difficult to determine the position and the 3D relations of an epiphysiodesis bridge in a healthy active physis with imaging techniques such as plain x-rays, scintigraphy, tomography and computed tomography. The 3D-MRI method described here provides a sure way to distinguish the active growth plate which gives a high intensity signal and the epiphyseal bridge which gives a low intensity signal. Morphological (size, form) and topographic characteristics of the bony bridge and the physis can be described with precision facilitating therapeutic decision making and guiding surgery. The lack of radiation risk is also an advantage of MRI. Conclusion: The quality of the images obtained, the safety of MRI and the easy interpretation of 3D reconstructions makes this imaging technique an excellent method for pre-therapeutic analysis of epiphysiodesis bridges

Open reduction and internal fixation of acetabular fractures demands detailed preoperative planning, and given their frequent complexity, a thorough understanding of their three-dimensional (3D) form is necessary. This study aims to assess if the use of dynamic 3D models will improve preoperative planning of acetabular fractures. In this study, three experienced pelvic trauma surgeons were provided with computer based dynamic 3D models in addition to preoperative radiographs, CT scans and static 3D reconstructions of 17 acetabular fractures operatively managed at the Royal Melbourne Hospital. Surgeons, blinded to any previous operative plan or patient detail, then classified fracture type and made preoperative surgical plans. Comparison was then made to classification and operative approach documented in the patient's operation notes. Comparison was then made with regard to surgical plan and planning time with or without access to dynamic 3D models. In complex cases the additional information provided by dynamic 3D modelling was found to reduce planning time and, in some cases, change the surgical plan. For complex acetabular fractures we recommend that surgeons should have access to computer-based dynamic 3D models of the injuries for pre-operative planning

Anterior shoulder instability is associated with osseous defects of the glenoid and/or humeral head (Hill-Sachs lesions). These defects can contribute to the pathology of instability by engaging together. There is a need to continue to develop methods to preoperatively identify engaging Hill-Sachs lesions for determining appropriate surgical management.

The objective was to created a working moveable 3D CT model that allows the user to move the shoulder joint into various positions to assess the relationship between the Hill-Sachs lesion and the anterior glenoid rim. This technique was applied to a cohort series of 14 patients with recurrent anterior dislocation: 4 patients had undergone osteoarticular allografting of Hill-Sachs lesions and 10 control patients had undergone CT scanning to quantify bone loss but had no treatment to address bony pathology. A biomechanical analysis was performed to rotate each 3D model using local coordinate systems through a functional range using an open-source 3D animation program, Blender (Amsterdam, Netherlands). A Hill-Sachs lesion was considered “dynamically” engaging if the angle between the lesion's long axis and anterior glenoid was parallel.

In the classical vulnerable position of the shoulder (abduction=90, external rotation=0–135), none of the Hill-Sachs lesions aligned with the anterior glenoid in any of our patients (Figure 1). Therefore, we considered there to be a “low risk” of engagement in these critical positions, as the non-parallel orientation represents a lack of true articular arc mismatch and is unlikely to produce joint instability. We then expanded our search and simulated shoulder positions throughout a physiological range of motion for all groups and found that 100% of the allograft patients and 70% of the controls had positions producing alignment and were “high risk” of engagement (p = 0.18) (Table 1). We also found that the allograft group had a greater number of positions that would engage (mean 4 ± 1 positions of engagement) compared to our controls (mean 2 ± 2 positions of engagement, p = 0.06).

We developed a 3D animated paradigm to dynamically and non-invasively visualize a patient's anatomy and determine the clinical significance of a Hill-Sachs lesion using open source software and CT images. The technique demonstrated in this series of patients showed multiple shoulder positions that align the Hill-Sachs and glenoid axes that do not necessarily meet the traditional definition of engagement. Identifying all shoulder positions at risk of “engaging”, in a broader physiological range, may have critical implications towards selecting the appropriate surgical management of bony defects. We do not claim to doubt the classic conceptual definition of engagement, but we merely introduce a technique that accounts for the dynamic component of shoulder motion, and in doing so, avoid limitations of a static criteria assumed traditional definition (like size and location of lesion). Further investigations are planned and will help to further validate the clinical utility of this method.

For any figures or tables, please contact the authors directly.

Introduction: Articular cartilage injuries cause pain and disability and lead to early osteoarthritis. Autologous chondrocytes implantation (ACI) demonstrated long-term clinical benefit. However, clinical application of ACI is laborious requiring arthrotomy of the knee, harvest of a periosteal flap from a secondary surgery site and suturing over the cartilage lesion. Use of the periosteal flap often leads to tissue hypertrophy requiring an arthroscopic intervention. BioCart™II is a new matrix-assisted autologous chondrtocytes implant. The autologous cells, propagated with a unique growth factor variant, are delivered within a biocompatible and biodegradable scaffold made of human fibrin and hyaluronic acid. BioCart™II eliminates the need for a periosteal flap and enables implantation by a minimally invasive procedure thus significantly simplifying surgery and reducing rehabilitation time.

Methods: Chondrocytes were obtained from cartilage tissue using enzymatic digestion. The cells were then expanded in medium supplemented with a fibroblast growth factor (FGF) variant. Chondrogenic potential of the cultured chondrocytes was determined by in vitro high density pellet culture. The pellet cultures were analyzed for expression of cartilage specific markers by PCR and histology. Distribution of the cells within the fibrin-hyaluronic acid scaffold was studied by histology using H& E staining, presence of proteoglycans and collagen types I and II (Col-I, II) was determined by specific stains and immunohistochemistry (IHC).

Results: Cells cultured in the presence of the FGF variant exhibit a dramatic increase in proliferation rate compared with untreated cells. The chondrogenic potential of cells cultured for 4, 7, and 10 days in the presence of the growth factor were tested by pellet culture. Cells cultured for 4 days did not form a hyaline-like pellet, while cells cultured for 7 and 10 days form pellets with hyaline like structure which express proteoglycans and collagen type II. Col-II expression determined by real time PCR was significantly increased compared with Col-I in the pellets indicating the regeneration of hyaline cartilage phenotype. Pellet culture of chondrocytes cultured in the presence of the growth factor formed a much larger pellet and expressed more proteoglycans than pellet of cells cultured without the growth factor. Histological analysis of implants immediately post seeding demonstrate the chondrocytes are distributed throughout the fibrin-hyalronic acid scaffold. Expression of Col-II but not Col-I was observed within the scaffold by IHC.

Discussion: We present a new articular cartilage repair implant composed of autologous cells embedded within a fibrin and hyaluronic acid scaffold. Fibrin which is the natural scaffold for wound healing is used as the implant building material thereby mimicking the body’s natural healing process. The porous open channel structure of the scaffold allows for an immediate three-dimensional distribution of the cells within the scaffold to promote full thickness repair Use of the FGF variant allows implantation of BioCart™II within two to three weeks from the cartilage biopsy and increases the regenerative potential of the implant. BioCart™II is currently in clinical studies for the treatment of knee cartilage injuries.

Introduction

In clinical routine surgeons depend largely on 2D x-ray radiographs and their experience to plan and evaluate surgical interventions around the knee joint. Numerous studies have shown that pure 2D x-ray radiography based measurements are not accurate due to the error in determining accurate radiography magnification and the projection characteristics of 2D radiographs. Using 2D x-ray radiographs to plan 3D knee joint surgery may lead to component misalignment in Total Knee Arthroplasty (TKA) or to over- or under-correction of the mechanical axis in Lower Extremity Osteotomy (LEO).

Recently we developed a personalized X-ray reconstruction-based planning and post-operative treatment evaluation system called “iLeg” for TKA or LEO. Based on a patented X-ray image calibration cage and a unique 2D–3D reconstruction technique, iLeg can generate accurate patient-specific 3D models of a complete lower extremity from two standing X-rays for true 3D planning and evaluation of surgical interventions at the knee joint. The goal of this study is to validate the accuracy of this newly developed system using digitally reconstructed radiographs (DRRs) generated from CT data of cadavers.

Recently we developed a personalised X-ray reconstruction-based planning and post-operative treatment evaluation system called iLeg for total knee arthroplasty or lower extremity osteotomy. Based on a patented X-ray image calibration cage and a unique 2D-3D reconstruction technique, iLeg can generate accurate patient-specific 3D models of a complete lower extremity from two standing X-rays for true 3D planning and evaluation of surgical interventions at the knee joint. The goal of this study is to validate the accuracy of this newly developed system using digitally reconstructed radiographs (DRRs) generated from CT data of 12 cadavers (24 legs). Our experimental results demonstrated an overall reconstruction accuracy of 1.3±0.2mm.

Introduction: Reversed prostheses implantation requires screwing of the glenoid component with prefixed angles. This study is to determine anatomical angles of scapula that take part in reversed prostheses implantation.

Material and method: Seventy-three 3-dimensional computed tomography of the scapula and 108 scapular dry specimens were analyzed. Mean age of the CT-3D serie was of 52.59 years old (ranging from 16 to 84). There were 46 females and 27 males. The following measures were made on each patient: length of the neck of the inferior glenoid, angle between the glenoid surface and the upper posterior column of the scapula, angle between the major craneo-caudal glenoid axis and the base of the coracoid process and angle between the major craneo-caudal glenoid axis and the upper posterior column of the scapula. Measures were performed in the AP view as well as in the posterior view of the scapula.

Results: The length of the neck of the anterior glenoid was classified into two groups named ‘short-neck’ and ‘long-neck’ for both three-dimensional computed tomography and cadaveric scapulas with statistically significant differences between both groups (p< 0,001 for the three-dimensional computed tomography scapulas and p=0,034 for the cadaveric group). The angle between the glenoid surface and the upper posterior column of the scapula was also classified into two different types: type I (52° ranging from 48° to 57°) and type II (64° ranging from 60° to 70°) with statistically significant differences between both groups (p< 0,001 for the three-dimensional computed tomography scapulas and p< 0,001 for the cadaveric group). The angle between the major craneo-caudal glenoid axis and the center of the base of the coracoid process averaged 18,25° (ranging 13° from to 27°). The angle between the major craneo-caudal glenoid axis and the upper posterior column of the scapula averaged 8° (ranging 5° from to 18°).

Conclusions:

- scapulas can be classified into two groups regarding the angle between the glenoid surface and the upper posterior column of the scapula with significant differences between them.

Accurate reconstruction of the knee pose from two X-Ray images will allow the study pre-operative kinematics (for custom prosthesis design) and the post-operative evaluation of the intervention.

We used a SSM of the distal femur, based on 24 MRI datasets, from which the mean model and its modes of variation were defined. On the SSM, N landmarks in predefined positions were defined. The user identifies the same landmarks on two X-ray projections. Back-projecting the X-ray from the identified landmarks pixel to the corresponding source, each landmark position in the 3D space is reconstructed and the mean model pose initialised with a corresponding points registration. The silhouette of the SSM is projected on each X-ray image, which is automatically segmented in order to define the bone contours. With a Robust Point Matching algorithm based on Thin Plate Splines the projected silhouette points are deformed to better approximate the contour. For each contour point, the associated silhouette point is computed. We back-projected the ray from each contour point to the source and find on each ray the point with minimum distance to the silhouette. The cost function is the squared sum of the distances for both images. After a first optimisation of the pose, we perform a shape optimisation to find the correct weights for the SSM.

To evaluate our algorithm, we used two Digitally Reconstructed Radiographs (DRR) created as projections at 90° from a CT dataset. The CT based model was reconstructed and the landmarks were defined on it with a rigid registration of the SSM. In order to validate the robustness of our reconstruction method, a random uniform noise distribution (0–50 mm on each direction) was added on each landmark. The reconstruction accuracy was measured as the distance between each reconstructed landmark and the ground truth defined on the CT.

Results show that the population of the errors for the noise levels from 0 to 30 is similar: only the population with 50 mm noise is significantly different from the results obtained with other noise levels.

We can conclude that with a noise level below 50 mm the algorithm is able to return the correct pose of the femur, while with higher noise the initial distribution of the landmarks in the 3D space prevents the correct outcome of the algorithm. The user should select the landmarks within a range of 50 mm on the 3D representation, that is half the dimension of the bounding box containing the model. We can assume that in the real case it will be more difficult to select the proper position of the landmarks, but our method proved to be robust even with misplaced landmarks.

Limb length disparity is a frequent complication after hip surgery inducing many surgeon-patients conflicts. To date no study has been able to precisely quantify such limb length disparity. EOS® system, currently validated to measure lower limb parameters, allows from two bi-dimensional numerical orthogonal radiographies in standing position to obtain a tri-dimensional reconstruction of lower limbs. A computerized system achieves the parameters calculation.

The aim of this study is to precisely measure the limb length disparities and the other hip parameters following total hip arthroplasty surgical procedure, by using a standard X-rays and using EOS® three-dimensional reconstructions.

Twenty-eight patients programmed for total hip arthroplasty have been included (i.e. thirty lower limbs). Two independent performers have carried out twice the measures either on standard X-rays and using three-dimensional reconstructions of the lower limb disparities prior and after the surgical procedure.

The inter and intra-observer reproducibility for the measure of the lower limb disparities have been of the EOS® measures have been respectively of 0.854 and 0.865 and for the standard X-rays of 0.717 and 0.726.

Mean length disparity observed was before Total Hip Arthroplasty of −0.328 cm (0.705; −1.266/0.530) and was of 0.088 mm (1.326; −1.635/0.632) after. We are able to decrease the lower limbs disparity in 69.1% and for the average of 0,416cm.

Using EOS® system has allowed assessing with greater precision the possibility to restore equal lower limb length.

This assessment has permitted introducing a new planning procedure including EOS® imaging associated to the fusion of the prosthetic tri-dimensional image in order to achieve adequate lower limb length.

Aims. Successful cell therapy in hip osteonecrosis (ON) may help to avoid ON progression or total hip arthroplasty (THA), but the achieved bone regeneration is unclear. The aim of this study was to evaluate amount and location of bone regeneration obtained after surgical injection of expanded autologous mesenchymal stromal cells from the bone marrow (BM-hMSCs). Methods. A total of 20 patients with small and medium-size symptomatic stage II femoral head ON treated with 140 million BM-hMSCs through percutaneous forage in the EudraCT 2012-002010-39 clinical trial were retrospectively evaluated through preoperative and postoperative (three and 12 months) MRI. Then, 3D reconstruction of the original lesion and the observed postoperative residual damage after bone regeneration were analyzed and compared per group based on treatment efficacy. Results. The mean preoperative lesion volume was 18.7% (SD 10.2%) of the femoral head. This reduced to 11.6% (SD 7.5%) after three months (p = 0.015) and 3.7% (SD 3%) after one year (p < 0.001). Bone regeneration in healed cases represented a mean 81.2% (SD 13.8%) of the initial lesion volume at one year. Non-healed cases (n = 1 stage progression; n = 3 THAs) still showed bone regeneration but this did not effectively decrease the ON volume. A lesion size under mean 10% (SD 6%) of the femoral head at three months predicted no ON stage progression at one year. Regeneration in the lateral femoral head (C2 under Japanese Investigation Committee (JCI) classification) and in the central and posterior regions of the head was predominant in cases without ON progression. Conclusion. Bone regeneration was observed in osteonecrotic femoral heads three months after expanded autologous BM-hMSC injection, and the volume and location of regeneration indicated the success of the therapy. Cite this article: Bone Joint Res 2022;11(12):881–889

Among the advanced technology developed and tested for orthopaedic surgery, the Rizzoli (IOR) has a long experience on custom-made design and implant of devices for joint and bone replacements. This follows the recent advancements in additive manufacturing, which now allows to obtain products also in metal alloy by deposition of material layer-by-layer according to a digital model. The process starts from medical image, goes through anatomical modelling, prosthesis design, prototyping, and final production in 3D printers and in case post-production. These devices have demonstrated already to be accurate enough to address properly the specific needs and conditions of the patient and of his/her physician. These guarantee also minimum removal of the tissues, partial replacements, no size related issues, minimal invasiveness, limited instrumentation. The thorough preparation of the treatment results also in a considerable shortening of the surgical and of recovery time. The necessary additional efforts and costs of custom-made implants seem to be well balanced by these advantages and savings, which shall include the lower failures and revision surgery rates. This also allows thoughtful optimization of the component-to-bone interfaces, by advanced lattice structures, with topologies mimicking the trabecular bone, possibly to promote osteointegration and to prevent infection. IOR's experience comprises all sub-disciplines and anatomical areas, here mentioned in historical order. Originally, several systems of Patient-Specific instrumentation have been exploited in total knee and total ankle replacements. A few massive osteoarticular reconstructions in the shank and foot for severe bone fractures were performed, starting from mirroring the contralateral area. Something very similar was performed also for pelvic surgery in the Oncology department, where massive skeletal reconstructions for bone tumours are necessary. To this aim, in addition to the standard anatomical modelling, prosthesis design, technical/technological refinements, and manufacturing, surgical guides for the correct execution of the osteotomies are also designed and 3D printed. Another original experience is about en-block replacement of vertebral bodies for severe bone loss, in particular for tumours. In this project, technological and biological aspects have also been addressed, to enhance osteointegration and to diminish the risk of infection. In our series there is also a case of successful custom reconstruction of the anterior chest wall. Initial experiences are in progress also for shoulder and elbow surgery, in particular for pre-op planning and surgical guide design in complex re-alignment osteotomies for severe bone deformities. Also in complex flat-foot deformities, in preparation of surgical corrections, 3D digital reconstruction and 3D printing in cheap ABS filaments have been valuable, for indication, planning of surgery and patient communication; with special materials mimicking bone strength, these 3D physical models are precious also for training and preparation of the surgery. In Paediatric surgery severe multi planar & multifocal deformities in children are addressed with personalized pre-op planning and custom cutting-guides for the necessary osteotomies, most of which require custom allografts. A number of complex hip revision surgeries have been performed, where 3D reconstruction for possible final solutions with exact implants on the remaining bone were developed. Elective surgery has been addressed as well, in particular the customization of an original total ankle replacement designed at IOR. Also a novel system with a high-tibial-osteotomy, including a custom cutting jig and the fixation plate was tested. An initial experience for the design and test of custom ankle & foot orthotics is also in progress, starting with 3D surface scanning of the shank and foot including the plantar aspect. Clearly, for achieving these results, multi-disciplinary teams have been formed, including physicians, radiologists, bioengineers and technologists, working together for the same goal

3D accurate measurements of the skeletal structures of the foot, in physiological and impaired subjects, are now possible using Cone-Beam CT (CBCT) under real-world loading conditions. In detail, this feature allows a more realistic representation of the relative bone-bone interactions of the foot as they occur under patient-specific body weight conditions. In this context, varus/valgus of the hindfoot under altered conditions or the thinning of plantar tissues that occurs with advancing age are among the most complex and interesting to represent, and numerous measurement proposals have been proposed. This study aims to analyze and compare these measurements from CBCT in weight-bearing scans in a clinical population. Sixteen feet of diabetic patients and ten feet with severe adult flatfoot acquired before/after corrective surgery underwent CBCT scans (Carestream, USA) while standing on the leg of interest. Corresponding 3D shapes of each bone of the shank and hindfoot were reconstructed (Materialise, Belgium). Six different techniques found in the literature were used to calculate the varus/valgus deformity, i.e., the inclination of the hindfoot in the frontal plane of the shank, and the distance between the ground and the metatarsal heads was calculated along with different solutions for the identification of possible calcifications. Starting with an accurate 3D reconstruction of the skeletal structures of the foot, a wide range of measurements representing the same angle of hindfoot alignment were found, some of them very different from each other. Interesting correlations were found between metatarsal height and subject age, significant in diabetic feet for the fourth and fifth metatarsal bones. Finally, CBCT allows 3D assessment of foot deformities under loaded conditions. The observed traditional measurement differences and new measurement solutions suggest that clinicians should consider carefully the anatomical and functional concepts underlying measurement techniques when drawing clinical and surgical conclusions

Biomedical imaging is essential in the diagnosis of musculoskeletal pathologies and postoperative evaluations. In this context, Cone-Beam technology-based Computed Tomography (CBCT) can make important contributions in orthopaedics. CBCT relies on divergent cone X-rays on the whole field of view and a rotating source-detector element to generate three-dimensional (3D) volumes. For the lower limb, they can allow acquisitions under real loading conditions, taking the name Weight-Bearing CBCT (WB-CBCT). Assessments at the foot, ankle, knee, and at the upper limb, can benefit from it in situations where loading is critical to understanding the interactions between anatomical structures. The present study reports 4 recent applications using WB-CBCT in an orthopaedic centre. Patient scans by WB-CBCT were collected for examinations of the lower limb in monopodal standing position. An initial volumetric reconstruction is obtained, and the DICOM file is segmented to obtain 3D bone models. A reference frame is then established on each bone model by virtual landmark palpation or principal component analysis. Based on the variance of the model point cloud, this analysis automatically calculates longitudinal, vertical and mid-lateral axes. Using the defined references, absolute or relative orientations of the bones can be calculated in 3D. In 19 diabetic patients, 3D reconstructed bone models of the foot under load were combined with plantar pressure measurement. Significant correlations were found between bone orientations, heights above the ground, and pressure values, revealing anatomic areas potentially prone to ulceration. In 4 patients enrolled for total ankle arthroplasty, preoperative 3D reconstructions were used for prosthetic design customization, allowing prosthesis-bone mismatch to be minimized. 20 knees with femoral ligament reconstruction were acquired with WB-CBCT and standard CT (in unloading). Bone reconstructions were used to assess congruency angle and patellar tilt and TT-TG. The values obtained show differences between loading and unloading, questioning what has been observed so far. Twenty flat feet were scanned before and after Grice surgery. WB-CBCT allowed characterization of the deformity and bone realignment after surgery, demonstrating the complexity and multi-planarity of the pathology. These applications show how a more complete and realistic 3D geometric characterization of the of lower limb bones is now possible in loading using WB-CBCT. This allows for more accurate diagnoses, surgical planning, and postoperative evaluations, even by automatisms. Other applications are in progress

Introduction. Stand to sit pelvis kinematics is commonly considered as a rotation around the bicoxofemoral axis. However, abnormal kinematics could occur for patients with musculoskeletal disorders affecting the hip-spine complex. The aim of this study is to perform a quantitative analysis of the stand to sit pelvis kinematics using 3D reconstruction from bi-planar x-rays. Materials and Methods. Thirty healthy volunteers as a control group (C), 30 patients with hip pathology (Hip) and 30 patients with spine pathology (Spine) were evaluated. All subjects underwent standing and sitting full-body bi-planar x-rays. 3D reconstruction was performed in each configuration and then translated such as the middle of the line joining the center of each acetabulum corresponds to the origin. Rigid registration quantified the finite helical axis (FHA) describing the transition between standing and sitting with two specific parameters. The orientation angle (OA) is the signed 3D angle between FHA and bicoxofemoral axis and the rotation angle (RA) represents the signed angle around FHA. Pelvic incidence, sacral slope and pelvic tilt were also measured. After checking normality of distribution, parameters were compared statistically between the 3 groups (p<0.05). Results. The mean value of the orientation angle in control group was −1.8° (SD 10.8°, range −26° to 25°). The mean value of the OA was 0.3° (SD 12.3°, range to −31° to 37°) in Hip group and −4.7° (SD 21.5°, range −86° to 38°) in Spine group. There was no significant difference in mean OA among groups. However, the more subnormal and abnormal patients were in Spine group compared to C and Hip groups. The mean value of the rotation angle in C group was 18.1° (SD 9.1°, range 5° to 43°). There was significant difference in RA between Hip and Spine groups (21.1° (SD 8.0°) and 16.0° (SD 10.7°), respectively) (p=0.04). Conclusion. This study highlights new informations obtained by the quantitative analysis of pelvis rotation between standing and sitting in healthy, hip pathology patients and spine pathology patients using 3D reconstruction from bi-planar radiographs. Hip and spine pathologies affect stand to sit pelvic kinematics. Surgeons should be aware of potential abnormal stand to sit transition in such clinical situations. This improved assessment of the pelvic rotational adaptation could lead to a more personalized approach for the planning of hip prostheses

INTRODUCTION. To assess and compare the effect of new orthopedic surgical procedures, in vitro evaluation remains critical during the pre-clinical validation. Focusing on reconstruction surgery, the ability to restore normal kinematics and stability is thereby of primary importance. Therefore, several simulators have been developed to study the kinematics and create controlled boundary conditions. To simultaneously capture the kinematics in six degrees of freedom as outlined by Grood & Suntay, markers are often rigidly connected to the moving bone segments. The position of these markers can subsequently be tracked while their position relative to the bones is determined using computed tomography (CT) of the test specimen with the markers attached. Although this method serves as golden standard, it clearly lacks real-time feedback. Therefore, this paper presents the validation of a newly developed real-time framework to assess knee kinematics at the time of testing. MATERIALS & METHODS. A total of five cadaveric fresh frozen lower limb specimens have been used to quantitatively assess the difference between the golden standard, CT based, method and the newly developed real-time method. A schematic of the data flow for both methods. Prior to testing, both methods require a CT scan of the full lower limb. During the tests, the proximal femur and distal tibia are necessarily resected to fit the knees in the test setup, thus also removing the anatomical landmarks needed to evaluate their mechanical axis. Subsequently, a set of three passive markers are rigidly attached to the femur and tibia, referred to as M3F and M3T respectively. For the CT based method, the marker positions are captured during the tests and a second CT scan is eventually performed to link the marker positions to the knee anatomy. Using in-house developed software, this allowed to offline evaluate the knee kinematics in six degrees of freedom by combining both CT datasets with the tracked marker positions. For the newly developed real-time method, a calibration procedure is first performed. This calibration aims to link the position of the 3D reconstructed bone and landmarks with the attached markers. A set of bone surface points is therefore registered. These surface points are obtained by tracking the position of a pen while touching the bone surface. The pen's position is thereby tracked by three rigidly attached markers, denoted M3P. The position of the pen tip is subsequently calculated from the known pen geometry. The iterative closest point (ICP) algorithm is then used to match the 3D reconstructed bone to the registered surface points. Two types of 3D reconstructions have therefore been considered. First, the original reconstructions were used, obtained from the CT data. Second, a modified reconstruction was used. This modification accounted for the finite radius (r = 1.0 mm) of the registration pen, by shifting the surface nodes 1.0 mm along the direction of the outer surface normal. During the tests, the positions of the femur and tibia markers are tracked and streamed in real-time to an in-house developed, Matlab based software framework (MathWorks Inc., Natick, Massachussets, USA). This software framework simultaneously calculates the bone positions and knee kinematics in six degrees of freedom, displaying this information to the surgeons and operators. To assess the accuracy, all knee specimens have been subjected to passive flexion-extension movement ranging from 0 to 120 degrees of flexion. For each degree of freedom, the average root mean square (RMS) difference between both measurement methods has been evaluated during this movement. In addition, the distribution of the registered surface points has been assessed along the principal directions of the uniformly meshed 3D reconstructions (average mesh size of 1.0 mm). RESULTS. The root mean square difference between both measurements indicates a strong dependency on the variance of the registered points. This dependency is particularly pronounced when using the original 3D reconstructions in combination with the ICP algorithm, with an R. 2. = 0.76 and 0.85 for the translational and rotational degrees of freedom respectively. When using the modified 3D reconstructions, which compensates for the finite radius of the marker tip, this dependency becomes negligible (R. 2. = 0.10 and 0.05). Using this modified 3D reconstruction, the average difference between both measurements is also reduced to an average value of 1.20 degrees and 1.47 mm. DISCUSSION. The difference in kinematic parameters between both measurement techniques is an order of magnitude lower than the claimed accuracy of the motion tracking cameras. However, the difference is in line with the inter- and intra- observer variability when identifying bony landmarks around the knee. Since these landmarks are essential to calculate knee kinematics, it is understood that the proposed real-time system is sufficiently accurate to study these kinematics

Background. Radiological and clinical results of total shoulder arthroplasty are dependent upon ability to accurately measure and correct glenoid version. There are a variety of imaging modalities and computer-assisted reconstruction programmes that are employed with varying degrees of success. We have compared three freely available modalities: unformatted 2D CT; formatted 2D CT; and 3D CT reconstructions. Methods. A retrospective analysis of 20 shoulder CT scans was performed. Glenoid version was measured at the estimated mid-point of the glenoid from unformatted 2D CT scans (Scapula body method) and again following formatting of 2D CT scans in the plane of the scapula (Friedman method). 3D scapula reconstructions were also performed by downloading CT DICOM images to OSIRIX 6 and plotting ROI points on Friedman's axis to most accurately define glenoid version. Both measurements taken from 2D CT were compared to those from 3D CT. Eleven CT scans were of male patients, 9 female. Mean age was 55.2 years (Range: 23–77 years). Fourteen scans were performed for trauma, 6 for arthroplasty. Twelve scans were of the left shoulder. Results. Mean glenoid version as measured on: unformatted 2D CT was −4.51 degrees (−29.67 – 7.22 degrees); formatted 2D CT was −2.04 degrees (−36.96 – 9.72 degrees); and on 3D reconstructions was −3.01 degrees (−32.57 – 14.33 degrees). Sixty percent of measurements taken on formatted 2D CT were within 3 degrees of those taken on 3D reconstructions, with 85% within 5 degrees. This proportion fell to 30% and 50% respectively on unformatted 2D CT. Discussion. In this small study measurements of glenoid version taken on formatted 2D CT demonstrated greater accuracy than unformatted 2D CT when comparing to 3D reconstruction measurements as the gold standard. Although we demonstrated no significant statistical difference between measurements in this pilot study we believe significance will be obtained as we increase our sample size