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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 87 - 87
1 Sep 2012
Knight D Alves C Wedge J
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Background

Habitual hip subluxation and dislocation is a potentially disabling feature of Trisomy 21. We describe long-term outcomes following precise use of the femoral varus derotation osteotomy to achieve and maintain hip stability and community ambulation.

Methods

All individuals with Trisomy 21, who had hip surgery at Toronto's Hospital for Sick Children between 1998 and 2008, were searched using the hospital databases.

16 hips in 9 children aged less than 10 years, were identified. All had a femoral varus derotation osteotomy (VDRO) with a target femoral neck shaft angle (NSA) of 105° and less than 20° external rotation. All were performed by the senior author JHW. The clinical notes and radiographs were reviewed from presentation to final follow up.

Continuous variables were assessed for normality with the d'Agostino Pearson test. Normally distributed variables are presented as means with 95% confidence intervals. Pre and postoperative means were compared using the student's t-test for paired samples.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_VII | Pages 5 - 5
1 Mar 2012
Knight D Alves C Wedge J
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Purpose

Habitual hip subluxation and dislocation is a potentially disabling feature of Trisomy 21 and we describe long-term outcomes following the precise use of femoral varus derotation osteotomy.

Methods

16 consecutive hips, 9 children, with Trisomy 21 aged =10 years, were identified from hospital databases. Clinical notes and radiographs from presentation to final follow-up were reviewed.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_VII | Pages 3 - 3
1 Mar 2012
Knight D Alves C Holroyd B Alman B Howard A
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Purpose We report the long term outcome of a minimally invasive technique avoiding the risks associated with open reduction and bone grafting in paediatric lateral condyle fracture non-unions.

Methods The Toronto Hospital for Sick Children's radiology database was searched to isolate all those who sustained a lateral condyle elbow fracture and had developed a non-union between the years 1998 and 2008. This identified 16 patients who had undergone percutaneous fixation for the treatment of their non union. Each individuals clinical notes and radiographs were reviewed from presentation to final follow-up.

Results Median age at injury was 5.1 (3.2, 7.2) in the successful and 2.8 (2.1, 4.7) in the unsuccessful groups (p=0.18). 11 patients (68.7%) had been initially managed non-operatively. Median time from injury to non-union diagnosis was 15.7 weeks in the successful, and 225.5 weeks in the unsuccessful group (p=0.039).

Mean time to union post fixation was 16.2 weeks (+/- 6.74) and mean time to surgery was 5.2 weeks (+/- 4.11). Surgery was successful, defined as radiological and clinical union, in 12 of 16 patients (75%). 43.8% had metalwork removal and no cases of avascular necrosis were reported.

Conclusion We have demonstrated this technique to be successful in those non-unions addressed within 16 weeks from initial injury to diagnosis. We had 4 failures, these occurred in patients whose non-unions were diagnosed more than 31 weeks from the time of injury (31; 68; 383; 427 weeks). Each of these failures had been managed non-operatively as part of their primary treatment plan.

Percutaneous fixation is feasible and safe. Patients not achieving union were diagnosed significantly later. There was a trend towards successfully treated patients being younger.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 362 - 363
1 Mar 2004
Martin D Ashcroft P Hutchison J Knight D Ledingham W Gibson P
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Aims: To study prospectively the characteristic migration of four different cemented femoral stems using Radiostereometry. Methods: 96 patients undergoing cemented femoral hip replacement for osteoarthritis were randomised to receive an Exeter (Howmedica Stryker), Ultima Tapered Polished Stem [TPS], Ultima straight stem [USS] (Johnson and Johnson) or Charnley Elite (Depuy/Johnson and Johnson) stem. RSA migration measurements were performed postoperatively and at 6,12,18 and 24 months post surgery using the UMRSA system. Results: Two signiþcantly distinct patterns of distal migration in the y direction (subsidence) were seen, compatible with previous studies. Tapered stems subsided rapidly by six months, Exeter 0.85mm (±0.15) UTPS 0.85mm (±0.15), stabilising by 2 years, Exeter 1.3mm (±0.35), UTPS 1.2mm (±0.25). The USS and Elite designs showed lower migrations of 0.1mm (±0.1) and 0.15 (±0.15) mm at six and 0.25mm (±0.15) and 0.35mm (±0.15) at 24 months. For migrations and rotations in other directions, differences were seen between prostheses with the same design concept. Whilst both the UTPS and Exeter exhibited posterior migration of the head, by 24 months this was expressed as a rotation about the transverse axis for the TPS and the axial axis for the Exeter. The Elite and USS differed in rates of posterior migration and varus tilt. Conclusions: Patterns of migration for stems with the same design concept may vary due to subtle differences in prosthesis shape. These variations produce a distinct migration Ç signature È for each stem.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 71 - 71
1 Jan 2004
Downing MR Ashcroft P Lawrie D Hutchison J Knight D Ledingham W Gibson P
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Aims: To study prospectively the characteristic migration of four different cemented femoral stems using Radiostereometry.

Methods: 96 patients undergoing cemented femoral hip replacement for osteoarthritis were randomised to receive an Exeter (Howmedica Stryker), Ultima Tapered Polished Stem [TPS], Ultima straight stem [USS] (Johnson and Johnson) or Charnley Elite (Depuy/Johnson and Johnson) stem. RSA migration measurements were performed at postoperatively and at 6,12,18 and 24 months post surgery using the UMRSA system enhanced with locally developed software.

Results: Two significantly distinct patterns of distal migration in the y direction (subsidence) were seen compatible with previous studies. Tapered stems subsided rapidly by six months Exeter 0.85mm (+/−0.15) UTPS 0.85mm (+/−0.15) stabilising by 2 years Exeter 1.3mm(+/−0.35), UTPS 1.2mm(+/−0.25). The USS and Elite designs showed lower migrations of 0.1mm (+/−0.1) and 0.15 (+/−0.15) mm at six and 0.25mm(+/−0.15) and 0.35mm (+/−0.15) 24 months. For migrations and rotations in other directions differences were seen between prostheses with the same design concept. Whilst both the UTPS and Exeter exhibited posterior migration of the head, by 24 months this was expressed as a rotation about the transverse axis for the TPS and the axial axis for the Exeter. The Elite and USS differed in rates of posterior migration and varus tilt.

Conclusions: Patterns of migration for stems with the same design concept may vary due to subtle differences in prosthesis shape. These variations produce a distinct migration “signature” for each stem.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_II | Pages 100 - 100
1 Feb 2003
Knight D Gilbert FJ Gillan MGC Andrew J Grant AM Wardlaw D
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The role of MRI or CT in the management of patients with LBP, for whom there is no clear clinical indication for the use of sophisticated imaging, is uncertain. The aim of The Scottish Back Trial was to determine whether early use of MRI or CT influences clinical management and outcome of patients with LBP and whether it is cost-effective.

Elective patients were new referrals to orthopaedic or neurosurgeons with symptomatic lumbar spine disorders (without ‘red flags’). After obtaining informed consent, patients were randomised to ‘early imaging’ (imaging as soon as practicable) or ‘delayed, selective imaging’ (imaging only if an imperative clinical indication developed). Principal outcomes measures were the SF-36, questionnaire, the Aberdeen LBP Scale and the EQ-5D. Patients completed questionnaires at trial entry and after 8 and 24 months.

From 15 hospitals, 2657 patients were assessed and 783 were recruited and randomised. Eight months and twenty-four months after trial entry, comparison of data abstracted from case notes indicated that, apart from the use of imaging, both groups had received similar clinical management. At follow-up, an improvement in health status, as measured by the SF-36 and Aberdeen LBP Scale, was reported by both groups. At 24 months, there was a statistically significant but small difference in favour of the ‘early imaging’ group (p=0. 002) as measured by the Aberdeen LBP Scale but no difference in the SF-36 except a marginal improvement in the bodily pain subscale.

The use of MRI or CT imaging for this group of LBP patients did not significantly affect their management. The clinical significance of the marginal improvement in health status in the ‘early imaging’ group is uncertain. The results of the cost-effectiveness analysis may clarify whether a policy of ‘early imaging’ would be a cost effective use of resources.