Abstract
Introduction: The long term success of impaction grafting depends on the remodelling process during incorporation. This project was designed to characterise any differences in the biochemical markers of bone turnover following revision hip arthroplasty performed with or without impaction grafting.
Methods: 87 patients undergoing revision hip arthroplasty were entered into this prospective study and grouped according to whether impaction allograft was used or not. Biochemical markers of bone turnover were assessed pre-operatively and post-operatively on day 2, day 9, week 6, 6 months and 1 year. Osteocalcin, pro-collagen type-I N-terminal propeptide and bone specific alkaline phosphatase were measured as bone formation markers. C-telopeptide, pyridinoline and deoxypyridinoline were measured as bone resorption markers.
Results: All patients had a successful radiological and clinical outcome at one year. 50 patients with radiologically defined host-graft union were compared with 37 patients who did not receive allograft. Markers of bone formation tended to rise by day 9 but the rise in osteocalcin was delayed in the graft group and was significantly lower at 6 months in comparison to the non-graft group (p=0.002). Alkaline phosphatase levels remained significantly elevated at one year in the graft group (p=0.027) whilst levels in the non-graft group had normalised. Markers of bone resorption also rise in both groups but with no significant differences between the groups.
Discussion: Following impaction grafting, new bone formation may be delayed in comparison to revisions performed without graft. The pattern of markers of bone resorption did not differ significantly between the groups suggesting that there is no large scale resorption of the impacted allograft in these cases.
These results provide a biochemical insight into the bone formation and bone resorption processes during allograft incorporation.
Correspondence should be addressed to Ms Larissa Welti, Scientific Secretary, EFORT Central Office, Technoparkstrasse 1, CH-8005 Zürich, Switzerland
