Abstract
Introduction: The purpose of this retrospective study is to compare long-term whole blood metal ion concentrations (Co, Cr, Ni, Mo) between two different metal-on-metal total hip arthroplasties and a metal-on-polyethylene control group, in relationship with physical activity.
Materials and methods: Between 1996 and 2000, different conventional prosthetic designs were implanted at our hospital. For this study, three groups were chosen according to the bearing surfaces used. Patients who had undergone other surgical interventions with implantation of potential sources of Cr/Co were excluded. Patients taking medication or dietary supplements containing Cr/Co were also excluded. In group 1, 17 patients with a 28 mm metal-on-metal bearing, type Metasul (Zimmer), were included. Group 2 comprised 11 patients with a 28 mm metal-on-metal bearing, type M2a (Biomet). The control group consisted of 9 patients with a 28 mm metal-on-polyethylene bearing in combination with a cemented CoCr stem. The three groups were demographically comparable. The postoperative clinical performance was evaluated using the Harris hip score and the Merle-dAubigne score. The activity level was measured using the Baecke questionnaire. Whole blood samples were taken in a standardized way and analysed by high resolution inductively coupled plasma mass spectrometer analysis.
Results: At an average follow-up of 4 years, the mean Harris Hip Score was 88.35 in group 1, 82.64 in group 2 and 90.89 in the control group. The mean Baecke Activity Score was 7.32 in group 1, 5.51 in group 2 and 6.49 in the control group. The mean Cr level was 0.27 in group 1, 0.63 in group 2 and 0.19 in the control group. The mean Co level was 0.63 in group 1, 1.06 in group 2 and 0.51 in the control group. The mean Ni level was 1.11 in group 1, 1.10 in group 2 and 1.31 in the control group. The mean Mo level was 0.65 in group 1, 0.77 in group 2 and 0.56 in the control group.
Conclusions: At a minimum follow-up of 4 years, no statistically significant differences were seen in clinical outcomes among the three groups. The only statistically significant difference in metal ion concentration among the three groups was observed for the Cr concentration between the M2a group and the metal-on-polyethylene group. There is also a positive correlation between the ion concentrations (Cr and Co) on the one hand and the activity level and Body Mass Index on the other.
Theses abstracts were prepared by Professor Roger Lemaire. Correspondence should be addressed to EFORT Central Office, Freihofstrasse 22, CH-8700 Küsnacht, Switzerland.
