The prevention of peridural adhesions: A COMPARATIVE LONG-TERM HISTOMORPHOMETRIC STUDY USING A BIODEGRADABLE BARRIER AND A FAT GRAFT

J. J. Quist; W. J. A. Dhert; B. P. Meij; W. J. Visser; F. C. Oner; H. A. W. Hazewinkel; A. J. Verbout

doi:10.1302/0301-620X.80B3.0800520

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The prevention of peridural adhesions

A COMPARATIVE LONG-TERM HISTOMORPHOMETRIC STUDY USING A BIODEGRADABLE BARRIER AND A FAT GRAFT

J. J. Quist
W. J. A. Dhert
B. P. Meij
W. J. Visser
F. C. Oner
H. A. W. Hazewinkel
A. J. Verbout

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The prevention of peridural adhesions

Quist JJ, Dhert WJA, Meij BP, et al. The prevention of peridural adhesions. J Bone Joint Surg Br. 1998;80-B(3):520-526. doi:10.1302/0301-620X.80B3.0800520

Quist, J. J., et al. “The prevention of peridural adhesions.” The Journal of Bone & Joint Surgery British Volume, vol. 80-B, no. 3, 1998, pp. 520-526., https://doi.org/10.1302/0301-620X.80B3.0800520

Quist, J. J., Dhert, W. J. A., Meij, B. P., Visser, W. J., Oner, F. C., Hazewinkel, H. A. W., & Verbout, A. J. (1998). The prevention of peridural adhesions. The Journal of Bone & Joint Surgery British Volume, 80-B(3), 520-526. https://doi.org/10.1302/0301-620X.80B3.0800520

Quist, J. J., Dhert, W. J. A., Meij, B. P., Visser, W. J., Oner, F. C., Hazewinkel, H. A. W. et al. (1998) “The prevention of peridural adhesions.” The Journal of Bone & Joint Surgery British Volume, 80-B(3), pp. 520-526. Available at: https://doi.org/10.1302/0301-620X.80B3.0800520

Quist, J. J., W. J. A. Dhert, B. P. Meij, W. J. Visser, F. C. Oner, H. A. W. Hazewinkel, and A. J. Verbout. “The prevention of peridural adhesions.” The Journal of Bone & Joint Surgery British Volume 80-B, no. 3 (1998): 520-526. https://doi.org/10.1302/0301-620X.80B3.0800520

Quist JJ, Dhert WJA, Meij BP, Visser WJ, Oner FC, Hazewinkel HAW, et al. The prevention of peridural adhesions. J Bone Joint Surg Br. 1998 May 1;80-B(3):520-526. https://doi.org/10.1302/0301-620X.80B3.0800520

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Abstract

We studied peridural fibrosis in 16 dogs after laminectomies at the L2, L4 and L6 levels. They received either a free fat graft, a biodegradable mechanical barrier (polyethylene oxide (PEO)/polybutylene terephthalate (PBT) copolymer), or no treatment. The animals were killed after 4, 12, 26 and 52 weeks.

Histomorphometry showed extensive and consistent peridural fibrosis in control and PEO/PBT groups. Fat grafts produced significantly less fibrous tissue, but the presence of the fat graft in the bony defect prevented closure. Degradation of the PEO/PBT barrier resulted in the formation of more fibrous tissue.

We conclude that up to one year a free fat graft is effective in reducing the amount of peridural scarring.

Correspondence should be sent to Dr W. J. A. Dhert.

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