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Wrist and HandFocus On...

Finger osteoarthritis

T.A. Coughlin, T. Cresswell
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Introduction

Osteoarthritis (OA) is a common condition that affects all the joints of the hand. It is estimated that the prevalence of hand pain is between 12% and 21% in the general population; in the elderly much of this is because of OA.1,2 In the hand, OA should be thought of as a syndrome where there is often little correlation between pain and the severity of radiological changes. As many as 70% of female patients over the age of 80 years exhibit radiological changes at the distal interphalangeal joint (DIPJ)3 but many of these patients with apparently severe arthritis radiologically will have few associated symptoms.

The management of the condition is complex with initial therapy generally being conservative. However, there is a range of surgical interventions available, including arthrodesis and escalating up to total joint arthroplasty.

Signs and Symptoms

In primary OA of the hand the DIPJ is the most commonly affected, followed by the proximal interphalangeal joint (PIPJ) and then the metacarpophalangeal joint (MCPJ). The condition develops gradually with advancing age although it is sometimes seen in the younger population. There are many factors that have been shown to be associated with OA of the hand, but the exact aetiology has not yet been elucidated. A family history is often present and this is especially true for younger patients.4 Causes of secondary OA include a history of trauma, gout, soft-tissue laxity and immunological changes. Whatever the causative factor, the result is destruction of the articular cartilage associated with little inflammatory response within the surrounding soft tissues.

The symptoms associated with OA of the hand are variable. Pain is often the presenting complaint because of an inflammatory synovitis early on in the disease process. There is gradual onset of deformity and loss of function as the OA progresses. Over time, pain may become less of a feature, with deformity being the major complaint. Stiffness and diminished strength are also common findings.

Osteoarthritis of the hand is strongly associated with the formation of Heberden’s nodes at the DIPJ and, more rarely, Bouchard’s nodes at the PIPJ.5 These are clinically obvious localised lumps of uncertain origin. They appear in two varieties, those lateral to the joint line and those in the midline over the joint. Midline nodes have been shown to be traction spurs in the extensor tendon in response to tension or contracture in the structure and are, therefore, not true osteophytes. In contrast, lateral nodes are always associated with true osteophytes, beginning their development as chondrophytes lateral to the joint margin. They grow in the path of least resistance and are of varying morphology around the joint line.

In the general population lateral osteophytes tend to develop most frequently in the dominant hand and are twice as common in the second and third phalanges of the fourth and fifth fingers.6 These sites correspond to the areas of greatest force as they are used in precision grip.

Ganglion cysts are also associated with OA of the hand. They form when irritated, degenerate, the articular tissue bulges and seals off, thereby forming a cystic structure. Ganglion cysts are most commonly multiloculated, as they develop over time, conglomerating to form a larger structure.7 They most commonly present on the dorsum of the wrist but can also occur within the flexor tendon sheath. They are called mucous cysts when found around the DIPJ (Fig. 1). Occasionally, ganglion cysts are found within bone when they are called intraosseous cysts; the most common sites are the scaphoid (Fig. 2) and lunate.

Fig. 1. Photograph of the clinical appearance of a large mucous cyst of the distal interphalangeal joint.

Fig. 2. Posteroanterior radiological view of the wrist demonstrating an interosseous cyst of the scaphoid.

When patients present with pain and clinical or radiological signs of a ganglion cyst, it is important to establish whether it is the cyst itself that is painful, or the osteoarthritic process which may be underlying it. The cyst may in fact be symptomless, in which case surgical removal may not treat the underlying cause of a patient’s pain.

Diagnosis

The mainstay of diagnosis in OA is the plain radiograph. Ideally, posteroanterior (PA), oblique and lateral views should be obtained. Brewerton views8 are special views which may also be useful in the assessment of early OA by allowing subtle changes on the metacarpal heads and phalangeal bases to be seen.9 Brewerton views are taken with the MCPJ flexed to 65°, with the dorsum of the proximal phalanx lying on the cassette and the beam passing 15° from the midline towards the radial side.

The radiological changes of OA in the hand are similar to other joints and include joint space narrowing, subchondral sclerosis, cysts and osteophytes (Fig. 3).

Fig. 3. Radiograph showing different stages of osteoarthritis in the proximal and distal interphalangeal joints of the index and middle fingers. The most advanced changes are present at the distal interphalangeal joint of the middle finger with large lateral osteophytes and destruction of the joint space.

In cases where radiological findings are equivocal then an isotope bone scan may show hot spots before plain radiological changes develop. An isotope bone scan may also be positive in early cases of inflammatory arthritis and does not differentiate between that and OA. Similarly, MRI may be used in some patients.10 It carries the added benefit of demonstrating the integrity of the soft tissues and the articular surface, an important consideration with many arthroplasty options.

Treatment Options

Initial therapy is non-operative, with the aim of reducing pain and swelling and delaying further destruction of the joint.11 Drug therapy for pain can consist of routine analgesia, non-steroidal anti-inflammatories drugs (NSAIDs) being especially useful, although serious side-effects in the presence of gastrointestinal and/or reversible airway disease may limit their use in some patients.

Intra-articular injections of steroid and local anaesthetic can be used to good effect although frequent use is usually avoided as evidence shows there may be chondral toxicity associated with both local anaesthetic and steroid.12,13 Indeed, the toxicity of intra-articular steroid is compounded by the presence of local anaesthetic.14

When medical therapy fails there are two main surgical options - arthrodesis and arthroplasty.

Arthrodesis

Arthrodesis fuses the joint in a functional position and is most commonly used in the index and middle fingers, the main function of these digits being with pinching movements. However, fusion of the PIPJ will reduce function in the digit by up to 50%; this may be unsatisfactory to some patients and demand careful counselling and patient selection. It is, however, an effective method of treating patients with significant joint instability associated with arthritis.

Arthrodesis may be effected using screw fixation or tension-band wiring (Fig. 4).3,15 Some studies put the rate of nonunion as high as 10% after surgical intervention,16 although others put rate after tension-band wiring as low as 1%.17 Should nonunion develop, most cases are asymptomatic, with the development of a fibrous, stable bridge. Other complications of arthrodesis include skin necrosis, cold intolerance, altered feeling and prominence of metalwork.

Fig. 4. Radiograph showing a tension-band fusion of the distal interphalangeal joint of the middle finger.

For functional reasons a fusion is positioned in slight flexion at the DIPJ. At the PIPJ an increasing degree of flexion is preferred, increasing from around 20° at the index finger to 40° at the little finger.

A rare complication of arthrodesis is Quadrigia syndrome18 which is caused by tethering of the flexor digitorum profundus (FDP) tendon by scar tissue post-operatively. This leads to a variable loss of flexion in all fingers as tethering of one FDP prevents some or all of the FDP tendons from shortening, thereby preventing a full fist from being formed.19

Arthroplasty

The aim of an arthroplasty is to prevent pain but also to retain a useful degree of function in the digit. There are three basic designs of implant; hinged, flexible and resurfacing prostheses. Arthroplasty should be considered early, before the joint and stabilising tissues have become too degenerated, in order to give a good functional outcome.

Hinged prostheses designed by Brannon and Klein20 were the first to be implanted in significant numbers, starting in the late 1950s. There have been many designs but the results are generally poor. Major problems encountered include fracture, loosening and bone resorption around the prostheses. Although variable, the post-operative range of movement is often restricted.

Flexible silicon implants are used in inflammatory arthritis or in those patients where a large degree of joint destruction is seen leading to instability.

Resurfacing prostheses (Figs. 5 and 6) allow flexion, extension, abduction and adduction of the joint to be maintained.21 They were designed to transfer some of the load passing through the prosthesis to the stabilising soft-tissue structures surrounding it. A prerequisite of their use is, therefore, the presence of normal tendons and intact ligaments. This may exclude many patients, as disruption of the collateral ligaments is a common feature of OA of the hand. It is especially important that resurfacing prostheses are used early on in the disease process, before deformity is too advanced.

Fig. 5. Radiograph showing the Avanta SR MCP resurfacing prosthesis of the metacarpophalangeal joint of the index finger.

Fig. 6. Radiograph showing a proximal interphalangeal joint replacement with an arthrodesis having also been carried out on the distal interphalangeal joint. This is the Osteotech pyrocarbon, unlinked, resurfacing-type prosthesis and again requires intact soft-tissue stabilising structures.19

 

References

1. Zhang Y, Niu, J, Kelly-Hayes M, Chaisson CE, Aliabadi P, Felson DT. Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: the Framingham Study. Am J Epidemiol 2002;156:1021-7.

2. Dahaghin S, Bierma-Zeinstra SM, Reijman M, Pols HA, Hazes JM, Koes BW. Prevalence and determinants of one month hand pain and hand related disability in the elderly (Rotterdam study). Ann Rheum Dis 2005;64:99-104.

3. Uhl RL. Proximal interphalangeal joint arthrodesis using the tension band technique. J Hand Surg [Am] 2007;32:914-7.

4. Jonsson H, Manolescu I, Stefansson SE, et al. The inheritance of hand osteoarthritis in Iceland. Arthritis Rheum 2003;48:391-5.

5. Alexander CJ. Heberden’s and Bouchard’s nodes. Ann Rheum Dis 1999;58:675-8.

6. Buckland-Wright JC, Macfarlane DG, Lynch JA. Osteophytes in the osteoarthritic hand: their incidence, size, distribution, and progression. Ann Rheum Dis 1991;50:627-30.

7. Soren A. Pathogenesis and treatment of ganglion. Clin Orthop 1966;48:173-9.

8. Brewerton DA. A tangenital radiographic projection for demonstrating involvement of metacarpal heads in rheumatoid arthritis. Br J Radiol 1967;40:233-4.

9. Hartley RM, Liang MH, Weissman BN, Sosman JL, Katz R, Charlton JR. The value of conventional views and radiographic magnification in evaluating early rheumatoid arthritis. Arthritis Rheum 1984;27:744-51.

10. Tan AL, Grainger AJ, Tanner SF, et al. High-resolution magnetic resonance imaging for the assessment of hand osteoarthritis. Arthritis Rheum 2005;52:2355-65.

11. Docken WP. Clinical features and medical management of osteoarthritis at the hand and wrist. Hand Clin 1987;3:337-49.

12. Chu CR, Coyle CH, Chu CT, et al. In vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilage. J Bone Joint Surg [Am] 2010;92-A:599-608.

13. Grishko V, Xu M, Wilson G, Pearsall AW 4th. Apoptosis and mitochondrial dysfunction in human chondrocytes following exposure to lidocaine, bupivacaine, and ropivacaine. J Bone Joint Surg [Am] 2010;92:609-18.

14. Seshadri V, Coyle CH, Chu CR. Lidocaine potentiates the chondrotoxicity of methylprednisolone. Arthroscopy 2009;25:337-47.

15. Leibovic SJ. Instructional Course Lecture. Arthrodesis of the interphalangeal joints with headless compression screws. J Hand Surg Am 2007;32:1113-9.

16. Stern PJ. Fulton DB. Distal interphalangeal joint arthrodesis: an analysis of complications. J Hand Surg Am 1992;17:1139-45.

17. Uhl RL, Schneider LH. Tension band arthrodesis of finger joints: A retrospective review of 76 consecutive cases. J Hand Surg Am 1992;17:518-22.

18. Verdan C. Syndrome of Quadrigia. Surg Clin North Am 1960;40:425-6.

19. Horton TC, Sauerland S, Davis TR. The effect of flexor digitorum profundus quadriga on grip strength. J Hand Surg Eur 2007;32:130-4.

20. Brannon EW, Klein G. Experience with a Finger-Joint Prosthesis. J Bone and Joint Surg [Am] 1959:41-A:87.

21. Linscheid RL, Murray PM, Vidal MA, Beckenbaugh RD. Development of a surface replacement arthroplasty for proximal interphalangeal joints. J Hand Surg [Am] 1997;22:286-98.